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Q9UKG4 (S13A4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 13 member 4
Alternative name(s):
Na(+)/sulfate cotransporter SUT-1
NaS2
Gene names
Name:SLC13A4
Synonyms:SUT1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length626 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV). Ref.1 Ref.6

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Highly expressed in placenta and testis with intermediate levels in brain and lower levels in heart, thymus and liver. Ref.1 Ref.6

Miscellaneous

Transport is inhibited by thiosulfate, phosphate, molybdate, selenate and tungstate. Not inhibited by oxalate, citrate, succinate, phenol red or 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS).

Sequence similarities

Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. [View classification]

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 626626Solute carrier family 13 member 4
PRO_0000172495

Regions

Transmembrane13 – 3321Helical; Potential
Transmembrane52 – 7221Helical; Potential
Transmembrane77 – 9721Helical; Potential
Transmembrane113 – 13321Helical; Potential
Transmembrane274 – 29421Helical; Potential
Transmembrane309 – 32921Helical; Potential
Transmembrane372 – 39221Helical; Potential
Transmembrane414 – 43421Helical; Potential
Transmembrane466 – 48621Helical; Potential
Transmembrane499 – 51921Helical; Potential
Transmembrane543 – 56321Helical; Potential
Transmembrane590 – 61021Helical; Potential

Natural variations

Natural variant4511P → S.
Corresponds to variant rs36004833 [ dbSNP | Ensembl ].
VAR_057193

Experimental info

Sequence conflict1981E → DR in AAF05907. Ref.1
Sequence conflict2451P → R in AAH30689. Ref.5
Sequence conflict5391L → M in AAF05907. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9UKG4 [UniParc].

Last modified January 20, 2009. Version 2.
Checksum: D84A18376DFAFA2B

FASTA62669,358
        10         20         30         40         50         60 
MGLLQGLLRV RKLLLVVCVP LLLLPLPVLH PSSEASCAYV LIVTAVYWVS EAVPLGAAAL 

        70         80         90        100        110        120 
VPAFLYPFFG VLRSNEVAAE YFKNTTLLLV GVICVAAAVE KWNLHKRIAL RMVLMAGAKP 

       130        140        150        160        170        180 
GMLLLCFMCC TTLLSMWLSN TSTTAMVMPI VEAVLQELVS AEDEQLVAGN SNTEEAEPIS 

       190        200        210        220        230        240 
LDVKNSQPSL ELIFVNEESN ADLTTLMHNE NLNGVPSITN PIKTANQHQG KKQHPSQEKP 

       250        260        270        280        290        300 
QVLTPSPRKQ KLNRKYRSHH DQMICKCLSL SISYSATIGG LTTIIGTSTS LIFLEHFNNQ 

       310        320        330        340        350        360 
YPAAEVVNFG TWFLFSFPIS LIMLVVSWFW MHWLFLGCNF KETCSLSKKK KTKREQLSEK 

       370        380        390        400        410        420 
RIQEEYEKLG DISYPEMVTG FFFILMTVLW FTREPGFVPG WDSFFEKKGY RTDATVSVFL 

       430        440        450        460        470        480 
GFLLFLIPAK KPCFGKKNDG ENQEHSLGTE PIITWKDFQK TMPWEIVILV GGGYALASGS 

       490        500        510        520        530        540 
KSSGLSTWIG NQMLSLSSLP PWAVTLLACI LVSIVTEFVS NPATITIFLP ILCSLSETLH 

       550        560        570        580        590        600 
INPLYTLIPV TMCISFAVML PVGNPPNAIV FSYGHCQIKD MVKAGLGVNV IGLVIVMVAI 

       610        620 
NTWGVSLFHL DTYPAWARVS NITDQA 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules."
Girard J.-P., Baekkevold E.S., Feliu J., Brandtzaeg P., Amalric F.
Proc. Natl. Acad. Sci. U.S.A. 96:12772-12777(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Endothelial cell.
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"Functional characterization and genomic organization of the human Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4)."
Markovich D., Regeer R.R., Kunzelmann K., Dawson P.A.
Biochem. Biophys. Res. Commun. 326:729-734(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF169301 mRNA. Translation: AAF05907.1.
AC091736 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24058.1.
CH471070 Genomic DNA. Translation: EAW83858.1.
BC030689 mRNA. Translation: AAH30689.1.
CCDSCCDS5840.1.
RefSeqNP_036582.2. NM_012450.2.
UniGeneHs.200022.
Hs.490241.

3D structure databases

ProteinModelPortalQ9UKG4.
SMRQ9UKG4. Positions 40-158, 270-600.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000297282.

Protein family/group databases

TCDB2.A.47.1.14. the divalent anion:na(+) symporter (dass) family.

PTM databases

PhosphoSiteQ9UKG4.

Polymorphism databases

DMDM221222500.

Proteomic databases

PaxDbQ9UKG4.
PRIDEQ9UKG4.

Protocols and materials databases

DNASU26266.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000354042; ENSP00000297282; ENSG00000164707.
GeneID26266.
KEGGhsa:26266.
UCSCuc003vta.3. human.

Organism-specific databases

CTD26266.
GeneCardsGC07M135365.
H-InvDBHIX0025275.
HGNCHGNC:15827. SLC13A4.
HPAHPA048582.
MIM604309. gene.
neXtProtNX_Q9UKG4.
PharmGKBPA38045.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0471.
HOGENOMHOG000278432.
HOVERGENHBG055339.
InParanoidQ9UKG4.
KOK14444.
OMAKKPCFGK.
OrthoDBEOG7G1V5S.
PhylomeDBQ9UKG4.
TreeFamTF312913.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_20633. Bile salt and organic anion SLC transporters.

Gene expression databases

BgeeQ9UKG4.
CleanExHS_SLC13A4.
GenevestigatorQ9UKG4.

Family and domain databases

InterProIPR001898. Na/sul_symport.
[Graphical view]
PfamPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi26266.
NextBio48537.
PROQ9UKG4.
SOURCESearch...

Entry information

Entry nameS13A4_HUMAN
AccessionPrimary (citable) accession number: Q9UKG4
Secondary accession number(s): A4D1Q4, Q8N631
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 20, 2009
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM