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Protein

Solute carrier family 13 member 4

Gene

SLC13A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV).2 Publications

Miscellaneous

Transport is inhibited by thiosulfate, phosphate, molybdate, selenate and tungstate. Not inhibited by oxalate, citrate, succinate, phenol red or 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS).

GO - Molecular functioni

GO - Biological processi

  • anion transmembrane transport Source: GO_Central
  • sulfate transport Source: ProtInc

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters

Protein family/group databases

TCDBi2.A.47.1.14 the divalent anion:na(+) symporter (dass) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 4
Alternative name(s):
Na(+)/sulfate cotransporter SUT-1
NaS2
Gene namesi
Name:SLC13A4
Synonyms:SUT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000164707.15
HGNCiHGNC:15827 SLC13A4
MIMi604309 gene
neXtProtiNX_Q9UKG4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Transmembranei499 – 519HelicalSequence analysisAdd BLAST21
Transmembranei543 – 563HelicalSequence analysisAdd BLAST21
Transmembranei590 – 610HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26266
OpenTargetsiENSG00000164707
PharmGKBiPA38045

Polymorphism and mutation databases

BioMutaiSLC13A4
DMDMi221222500

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001724951 – 626Solute carrier family 13 member 4Add BLAST626

Proteomic databases

EPDiQ9UKG4
PaxDbiQ9UKG4
PeptideAtlasiQ9UKG4
PRIDEiQ9UKG4

PTM databases

iPTMnetiQ9UKG4
PhosphoSitePlusiQ9UKG4

Expressioni

Tissue specificityi

Highly expressed in placenta and testis with intermediate levels in brain and lower levels in heart, thymus and liver.2 Publications

Gene expression databases

BgeeiENSG00000164707
CleanExiHS_SLC13A4
ExpressionAtlasiQ9UKG4 baseline and differential
GenevisibleiQ9UKG4 HS

Organism-specific databases

HPAiHPA048582

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ9UKG4, 25 interactors
STRINGi9606.ENSP00000297282

Structurei

3D structure databases

ProteinModelPortaliQ9UKG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1281 Eukaryota
COG0471 LUCA
GeneTreeiENSGT00550000074480
HOGENOMiHOG000278432
HOVERGENiHBG055339
InParanoidiQ9UKG4
KOiK14444
OMAiKKPCFGK
OrthoDBiEOG091G092X
PhylomeDBiQ9UKG4
TreeFamiTF312913

Family and domain databases

InterProiView protein in InterPro
IPR001898 SLC13A/DASS
PfamiView protein in Pfam
PF00939 Na_sulph_symp, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UKG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLQGLLRV RKLLLVVCVP LLLLPLPVLH PSSEASCAYV LIVTAVYWVS
60 70 80 90 100
EAVPLGAAAL VPAFLYPFFG VLRSNEVAAE YFKNTTLLLV GVICVAAAVE
110 120 130 140 150
KWNLHKRIAL RMVLMAGAKP GMLLLCFMCC TTLLSMWLSN TSTTAMVMPI
160 170 180 190 200
VEAVLQELVS AEDEQLVAGN SNTEEAEPIS LDVKNSQPSL ELIFVNEESN
210 220 230 240 250
ADLTTLMHNE NLNGVPSITN PIKTANQHQG KKQHPSQEKP QVLTPSPRKQ
260 270 280 290 300
KLNRKYRSHH DQMICKCLSL SISYSATIGG LTTIIGTSTS LIFLEHFNNQ
310 320 330 340 350
YPAAEVVNFG TWFLFSFPIS LIMLVVSWFW MHWLFLGCNF KETCSLSKKK
360 370 380 390 400
KTKREQLSEK RIQEEYEKLG DISYPEMVTG FFFILMTVLW FTREPGFVPG
410 420 430 440 450
WDSFFEKKGY RTDATVSVFL GFLLFLIPAK KPCFGKKNDG ENQEHSLGTE
460 470 480 490 500
PIITWKDFQK TMPWEIVILV GGGYALASGS KSSGLSTWIG NQMLSLSSLP
510 520 530 540 550
PWAVTLLACI LVSIVTEFVS NPATITIFLP ILCSLSETLH INPLYTLIPV
560 570 580 590 600
TMCISFAVML PVGNPPNAIV FSYGHCQIKD MVKAGLGVNV IGLVIVMVAI
610 620
NTWGVSLFHL DTYPAWARVS NITDQA
Length:626
Mass (Da):69,358
Last modified:January 20, 2009 - v2
Checksum:iD84A18376DFAFA2B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198E → DR in AAF05907 (PubMed:10535998).Curated1
Sequence conflicti245P → R in AAH30689 (PubMed:15489334).Curated1
Sequence conflicti539L → M in AAF05907 (PubMed:10535998).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057193451P → S. Corresponds to variant dbSNP:rs36004833Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169301 mRNA Translation: AAF05907.1
AC091736 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24058.1
CH471070 Genomic DNA Translation: EAW83858.1
BC030689 mRNA Translation: AAH30689.1
CCDSiCCDS5840.1
RefSeqiNP_001305121.1, NM_001318192.1
NP_036582.2, NM_012450.3
UniGeneiHs.490241

Genome annotation databases

EnsembliENST00000354042; ENSP00000297282; ENSG00000164707
GeneIDi26266
KEGGihsa:26266
UCSCiuc003vta.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS13A4_HUMAN
AccessioniPrimary (citable) accession number: Q9UKG4
Secondary accession number(s): A4D1Q4, Q8N631
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 20, 2009
Last modified: February 28, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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