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Protein

Solute carrier family 13 member 4

Gene

SLC13A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV).2 Publications

GO - Molecular functioni

GO - Biological processi

  • sulfate transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164707-MONOMER.
ReactomeiR-HSA-433137. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Protein family/group databases

TCDBi2.A.47.1.14. the divalent anion:na(+) symporter (dass) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 4
Alternative name(s):
Na(+)/sulfate cotransporter SUT-1
NaS2
Gene namesi
Name:SLC13A4
Synonyms:SUT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:15827. SLC13A4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Transmembranei499 – 519HelicalSequence analysisAdd BLAST21
Transmembranei543 – 563HelicalSequence analysisAdd BLAST21
Transmembranei590 – 610HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26266.
OpenTargetsiENSG00000164707.
PharmGKBiPA38045.

Polymorphism and mutation databases

BioMutaiSLC13A4.
DMDMi221222500.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001724951 – 626Solute carrier family 13 member 4Add BLAST626

Proteomic databases

EPDiQ9UKG4.
PaxDbiQ9UKG4.
PRIDEiQ9UKG4.

PTM databases

iPTMnetiQ9UKG4.
PhosphoSitePlusiQ9UKG4.

Expressioni

Tissue specificityi

Highly expressed in placenta and testis with intermediate levels in brain and lower levels in heart, thymus and liver.2 Publications

Gene expression databases

BgeeiENSG00000164707.
CleanExiHS_SLC13A4.
ExpressionAtlasiQ9UKG4. baseline and differential.
GenevisibleiQ9UKG4. HS.

Organism-specific databases

HPAiHPA048582.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000297282.

Structurei

3D structure databases

ProteinModelPortaliQ9UKG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1281. Eukaryota.
COG0471. LUCA.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ9UKG4.
KOiK14444.
OMAiIFVNEDT.
OrthoDBiEOG091G092X.
PhylomeDBiQ9UKG4.
TreeFamiTF312913.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UKG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLQGLLRV RKLLLVVCVP LLLLPLPVLH PSSEASCAYV LIVTAVYWVS
60 70 80 90 100
EAVPLGAAAL VPAFLYPFFG VLRSNEVAAE YFKNTTLLLV GVICVAAAVE
110 120 130 140 150
KWNLHKRIAL RMVLMAGAKP GMLLLCFMCC TTLLSMWLSN TSTTAMVMPI
160 170 180 190 200
VEAVLQELVS AEDEQLVAGN SNTEEAEPIS LDVKNSQPSL ELIFVNEESN
210 220 230 240 250
ADLTTLMHNE NLNGVPSITN PIKTANQHQG KKQHPSQEKP QVLTPSPRKQ
260 270 280 290 300
KLNRKYRSHH DQMICKCLSL SISYSATIGG LTTIIGTSTS LIFLEHFNNQ
310 320 330 340 350
YPAAEVVNFG TWFLFSFPIS LIMLVVSWFW MHWLFLGCNF KETCSLSKKK
360 370 380 390 400
KTKREQLSEK RIQEEYEKLG DISYPEMVTG FFFILMTVLW FTREPGFVPG
410 420 430 440 450
WDSFFEKKGY RTDATVSVFL GFLLFLIPAK KPCFGKKNDG ENQEHSLGTE
460 470 480 490 500
PIITWKDFQK TMPWEIVILV GGGYALASGS KSSGLSTWIG NQMLSLSSLP
510 520 530 540 550
PWAVTLLACI LVSIVTEFVS NPATITIFLP ILCSLSETLH INPLYTLIPV
560 570 580 590 600
TMCISFAVML PVGNPPNAIV FSYGHCQIKD MVKAGLGVNV IGLVIVMVAI
610 620
NTWGVSLFHL DTYPAWARVS NITDQA
Length:626
Mass (Da):69,358
Last modified:January 20, 2009 - v2
Checksum:iD84A18376DFAFA2B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198E → DR in AAF05907 (PubMed:10535998).Curated1
Sequence conflicti245P → R in AAH30689 (PubMed:15489334).Curated1
Sequence conflicti539L → M in AAF05907 (PubMed:10535998).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057193451P → S.Corresponds to variant rs36004833dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169301 mRNA. Translation: AAF05907.1.
AC091736 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24058.1.
CH471070 Genomic DNA. Translation: EAW83858.1.
BC030689 mRNA. Translation: AAH30689.1.
CCDSiCCDS5840.1.
RefSeqiNP_001305121.1. NM_001318192.1.
NP_036582.2. NM_012450.3.
UniGeneiHs.490241.

Genome annotation databases

EnsembliENST00000354042; ENSP00000297282; ENSG00000164707.
GeneIDi26266.
KEGGihsa:26266.
UCSCiuc003vta.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169301 mRNA. Translation: AAF05907.1.
AC091736 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24058.1.
CH471070 Genomic DNA. Translation: EAW83858.1.
BC030689 mRNA. Translation: AAH30689.1.
CCDSiCCDS5840.1.
RefSeqiNP_001305121.1. NM_001318192.1.
NP_036582.2. NM_012450.3.
UniGeneiHs.490241.

3D structure databases

ProteinModelPortaliQ9UKG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000297282.

Protein family/group databases

TCDBi2.A.47.1.14. the divalent anion:na(+) symporter (dass) family.

PTM databases

iPTMnetiQ9UKG4.
PhosphoSitePlusiQ9UKG4.

Polymorphism and mutation databases

BioMutaiSLC13A4.
DMDMi221222500.

Proteomic databases

EPDiQ9UKG4.
PaxDbiQ9UKG4.
PRIDEiQ9UKG4.

Protocols and materials databases

DNASUi26266.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354042; ENSP00000297282; ENSG00000164707.
GeneIDi26266.
KEGGihsa:26266.
UCSCiuc003vta.4. human.

Organism-specific databases

CTDi26266.
DisGeNETi26266.
GeneCardsiSLC13A4.
H-InvDBHIX0025275.
HGNCiHGNC:15827. SLC13A4.
HPAiHPA048582.
MIMi604309. gene.
neXtProtiNX_Q9UKG4.
OpenTargetsiENSG00000164707.
PharmGKBiPA38045.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1281. Eukaryota.
COG0471. LUCA.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ9UKG4.
KOiK14444.
OMAiIFVNEDT.
OrthoDBiEOG091G092X.
PhylomeDBiQ9UKG4.
TreeFamiTF312913.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164707-MONOMER.
ReactomeiR-HSA-433137. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Miscellaneous databases

ChiTaRSiSLC13A4. human.
GenomeRNAii26266.
PROiQ9UKG4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164707.
CleanExiHS_SLC13A4.
ExpressionAtlasiQ9UKG4. baseline and differential.
GenevisibleiQ9UKG4. HS.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS13A4_HUMAN
AccessioniPrimary (citable) accession number: Q9UKG4
Secondary accession number(s): A4D1Q4, Q8N631
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 20, 2009
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Transport is inhibited by thiosulfate, phosphate, molybdate, selenate and tungstate. Not inhibited by oxalate, citrate, succinate, phenol red or 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.