Q9UKG4 (S13A4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 13 member 4

Alternative name(s):
Na(+)/sulfate cotransporter SUT-1
NaS2

Gene names

Name:	SLC13A4
Synonyms:	SUT1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	626 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV). Ref.1 Ref.6
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Highly expressed in placenta and testis with intermediate levels in brain and lower levels in heart, thymus and liver. Ref.1 Ref.6
Miscellaneous	Transport is inhibited by thiosulfate, phosphate, molybdate, selenate and tungstate. Not inhibited by oxalate, citrate, succinate, phenol red or 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS).
Sequence similarities	Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Sodium transport Symport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sulfate transport Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	sodium:sulfate symporter activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 626	626	Solute carrier family 13 member 4		PRO_0000172495
Regions
	Transmembrane	13 – 33	21	Helical; Potential
	Transmembrane	52 – 72	21	Helical; Potential
	Transmembrane	77 – 97	21	Helical; Potential
	Transmembrane	113 – 133	21	Helical; Potential
	Transmembrane	274 – 294	21	Helical; Potential
	Transmembrane	309 – 329	21	Helical; Potential
	Transmembrane	372 – 392	21	Helical; Potential
	Transmembrane	414 – 434	21	Helical; Potential
	Transmembrane	466 – 486	21	Helical; Potential
	Transmembrane	499 – 519	21	Helical; Potential
	Transmembrane	543 – 563	21	Helical; Potential
	Transmembrane	590 – 610	21	Helical; Potential
Natural variations
	Natural variant	451	1	P → S. Corresponds to variant rs36004833 [ dbSNP | Ensembl ].		VAR_057193
Experimental info
	Sequence conflict	198	1	E → DR in AAF05907. Ref.1
	Sequence conflict	245	1	P → R in AAH30689. Ref.5
	Sequence conflict	539	1	L → M in AAF05907. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9UKG4 [UniParc]. Last modified January 20, 2009. Version 2. Checksum: D84A18376DFAFA2B	FASTA	626	69,358
	10 20 30 40 50 60 MGLLQGLLRV RKLLLVVCVP LLLLPLPVLH PSSEASCAYV LIVTAVYWVS EAVPLGAAAL 70 80 90 100 110 120 VPAFLYPFFG VLRSNEVAAE YFKNTTLLLV GVICVAAAVE KWNLHKRIAL RMVLMAGAKP 130 140 150 160 170 180 GMLLLCFMCC TTLLSMWLSN TSTTAMVMPI VEAVLQELVS AEDEQLVAGN SNTEEAEPIS 190 200 210 220 230 240 LDVKNSQPSL ELIFVNEESN ADLTTLMHNE NLNGVPSITN PIKTANQHQG KKQHPSQEKP 250 260 270 280 290 300 QVLTPSPRKQ KLNRKYRSHH DQMICKCLSL SISYSATIGG LTTIIGTSTS LIFLEHFNNQ 310 320 330 340 350 360 YPAAEVVNFG TWFLFSFPIS LIMLVVSWFW MHWLFLGCNF KETCSLSKKK KTKREQLSEK 370 380 390 400 410 420 RIQEEYEKLG DISYPEMVTG FFFILMTVLW FTREPGFVPG WDSFFEKKGY RTDATVSVFL 430 440 450 460 470 480 GFLLFLIPAK KPCFGKKNDG ENQEHSLGTE PIITWKDFQK TMPWEIVILV GGGYALASGS 490 500 510 520 530 540 KSSGLSTWIG NQMLSLSSLP PWAVTLLACI LVSIVTEFVS NPATITIFLP ILCSLSETLH 550 560 570 580 590 600 INPLYTLIPV TMCISFAVML PVGNPPNAIV FSYGHCQIKD MVKAGLGVNV IGLVIVMVAI 610 620 NTWGVSLFHL DTYPAWARVS NITDQA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules." Girard J.-P., Baekkevold E.S., Feliu J., Brandtzaeg P., Amalric F. Proc. Natl. Acad. Sci. U.S.A. 96:12772-12777(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Tissue: Endothelial cell.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"Functional characterization and genomic organization of the human Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4)." Markovich D., Regeer R.R., Kunzelmann K., Dawson P.A. Biochem. Biophys. Res. Commun. 326:729-734(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF169301 mRNA. Translation: AAF05907.1. AC091736 Genomic DNA. No translation available. CH236950 Genomic DNA. Translation: EAL24058.1. CH471070 Genomic DNA. Translation: EAW83858.1. BC030689 mRNA. Translation: AAH30689.1.
IPI	IPI00915985.
RefSeq	NP_036582.2. NM_012450.2.
UniGene	Hs.200022. Hs.490241.
3D structure databases
ProteinModelPortal	Q9UKG4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000297282.
PTM databases
PhosphoSite	Q9UKG4.
Polymorphism databases
DMDM	221222500.
Proteomic databases
PaxDb	Q9UKG4.
PRIDE	Q9UKG4.
Protocols and materials databases
DNASU	26266.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000354042; ENSP00000297282; ENSG00000164707.
GeneID	26266.
KEGG	hsa:26266.
UCSC	uc003vta.3. human.
Organism-specific databases
CTD	26266.
GeneCards	GC07M135365.
H-InvDB	HIX0025275.
HGNC	HGNC:15827. SLC13A4.
HPA	HPA048582.
MIM	604309. gene.
neXtProt	NX_Q9UKG4.
PharmGKB	PA38045.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0471.
HOGENOM	HOG000278432.
HOVERGEN	HBG055339.
InParanoid	Q9UKG4.
KO	K14444.
OMA	KKPCFGK.
OrthoDB	EOG4VHK64.
PhylomeDB	Q9UKG4.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules. REACT_20633. Bile salt and organic anion SLC transporters.
Gene expression databases
Bgee	Q9UKG4.
CleanEx	HS_SLC13A4.
Genevestigator	Q9UKG4.
GermOnline	ENSG00000164707. Homo sapiens.
Family and domain databases
InterPro	IPR001898. Na/sul_symport. [Graphical view]
Pfam	PF00939. Na_sulph_symp. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	26266.
NextBio	48537.
SOURCE	Search...

Entry information

Entry name

S13A4_HUMAN

Accession

Primary (citable) accession number: Q9UKG4
Secondary accession number(s): A4D1Q4, Q8N631

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	January 20, 2009
Last modified:	April 3, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.