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Q9UKG4

- S13A4_HUMAN

UniProt

Q9UKG4 - S13A4_HUMAN

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Protein

Solute carrier family 13 member 4

Gene

SLC13A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV).2 Publications

GO - Molecular functioni

  1. sodium:sulfate symporter activity Source: ProtInc

GO - Biological processi

  1. sodium ion transmembrane transport Source: GOC
  2. sulfate transport Source: ProtInc
  3. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_20646. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Protein family/group databases

TCDBi2.A.47.1.14. the divalent anion:na(+) symporter (dass) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 4
Alternative name(s):
Na(+)/sulfate cotransporter SUT-1
NaS2
Gene namesi
Name:SLC13A4
Synonyms:SUT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:15827. SLC13A4.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38045.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 626626Solute carrier family 13 member 4PRO_0000172495Add
BLAST

Proteomic databases

PaxDbiQ9UKG4.
PRIDEiQ9UKG4.

PTM databases

PhosphoSiteiQ9UKG4.

Expressioni

Tissue specificityi

Highly expressed in placenta and testis with intermediate levels in brain and lower levels in heart, thymus and liver.2 Publications

Gene expression databases

BgeeiQ9UKG4.
CleanExiHS_SLC13A4.
ExpressionAtlasiQ9UKG4. baseline.
GenevestigatoriQ9UKG4.

Organism-specific databases

HPAiHPA048582.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000297282.

Structurei

3D structure databases

ProteinModelPortaliQ9UKG4.
SMRiQ9UKG4. Positions 40-158, 270-600.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence AnalysisAdd
BLAST
Transmembranei274 – 29421HelicalSequence AnalysisAdd
BLAST
Transmembranei309 – 32921HelicalSequence AnalysisAdd
BLAST
Transmembranei372 – 39221HelicalSequence AnalysisAdd
BLAST
Transmembranei414 – 43421HelicalSequence AnalysisAdd
BLAST
Transmembranei466 – 48621HelicalSequence AnalysisAdd
BLAST
Transmembranei499 – 51921HelicalSequence AnalysisAdd
BLAST
Transmembranei543 – 56321HelicalSequence AnalysisAdd
BLAST
Transmembranei590 – 61021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0471.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ9UKG4.
KOiK14444.
OMAiKKPCFGK.
OrthoDBiEOG7G1V5S.
PhylomeDBiQ9UKG4.
TreeFamiTF312913.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UKG4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLLQGLLRV RKLLLVVCVP LLLLPLPVLH PSSEASCAYV LIVTAVYWVS
60 70 80 90 100
EAVPLGAAAL VPAFLYPFFG VLRSNEVAAE YFKNTTLLLV GVICVAAAVE
110 120 130 140 150
KWNLHKRIAL RMVLMAGAKP GMLLLCFMCC TTLLSMWLSN TSTTAMVMPI
160 170 180 190 200
VEAVLQELVS AEDEQLVAGN SNTEEAEPIS LDVKNSQPSL ELIFVNEESN
210 220 230 240 250
ADLTTLMHNE NLNGVPSITN PIKTANQHQG KKQHPSQEKP QVLTPSPRKQ
260 270 280 290 300
KLNRKYRSHH DQMICKCLSL SISYSATIGG LTTIIGTSTS LIFLEHFNNQ
310 320 330 340 350
YPAAEVVNFG TWFLFSFPIS LIMLVVSWFW MHWLFLGCNF KETCSLSKKK
360 370 380 390 400
KTKREQLSEK RIQEEYEKLG DISYPEMVTG FFFILMTVLW FTREPGFVPG
410 420 430 440 450
WDSFFEKKGY RTDATVSVFL GFLLFLIPAK KPCFGKKNDG ENQEHSLGTE
460 470 480 490 500
PIITWKDFQK TMPWEIVILV GGGYALASGS KSSGLSTWIG NQMLSLSSLP
510 520 530 540 550
PWAVTLLACI LVSIVTEFVS NPATITIFLP ILCSLSETLH INPLYTLIPV
560 570 580 590 600
TMCISFAVML PVGNPPNAIV FSYGHCQIKD MVKAGLGVNV IGLVIVMVAI
610 620
NTWGVSLFHL DTYPAWARVS NITDQA
Length:626
Mass (Da):69,358
Last modified:January 20, 2009 - v2
Checksum:iD84A18376DFAFA2B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981E → DR in AAF05907. (PubMed:10535998)Curated
Sequence conflicti245 – 2451P → R in AAH30689. (PubMed:15489334)Curated
Sequence conflicti539 – 5391L → M in AAF05907. (PubMed:10535998)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti451 – 4511P → S.
Corresponds to variant rs36004833 [ dbSNP | Ensembl ].
VAR_057193

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF169301 mRNA. Translation: AAF05907.1.
AC091736 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24058.1.
CH471070 Genomic DNA. Translation: EAW83858.1.
BC030689 mRNA. Translation: AAH30689.1.
CCDSiCCDS5840.1.
RefSeqiNP_036582.2. NM_012450.2.
UniGeneiHs.200022.
Hs.490241.

Genome annotation databases

EnsembliENST00000354042; ENSP00000297282; ENSG00000164707.
GeneIDi26266.
KEGGihsa:26266.
UCSCiuc003vta.3. human.

Polymorphism databases

DMDMi221222500.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF169301 mRNA. Translation: AAF05907.1 .
AC091736 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24058.1 .
CH471070 Genomic DNA. Translation: EAW83858.1 .
BC030689 mRNA. Translation: AAH30689.1 .
CCDSi CCDS5840.1.
RefSeqi NP_036582.2. NM_012450.2.
UniGenei Hs.200022.
Hs.490241.

3D structure databases

ProteinModelPortali Q9UKG4.
SMRi Q9UKG4. Positions 40-158, 270-600.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000297282.

Protein family/group databases

TCDBi 2.A.47.1.14. the divalent anion:na(+) symporter (dass) family.

PTM databases

PhosphoSitei Q9UKG4.

Polymorphism databases

DMDMi 221222500.

Proteomic databases

PaxDbi Q9UKG4.
PRIDEi Q9UKG4.

Protocols and materials databases

DNASUi 26266.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354042 ; ENSP00000297282 ; ENSG00000164707 .
GeneIDi 26266.
KEGGi hsa:26266.
UCSCi uc003vta.3. human.

Organism-specific databases

CTDi 26266.
GeneCardsi GC07M135365.
H-InvDB HIX0025275.
HGNCi HGNC:15827. SLC13A4.
HPAi HPA048582.
MIMi 604309. gene.
neXtProti NX_Q9UKG4.
PharmGKBi PA38045.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0471.
GeneTreei ENSGT00550000074480.
HOGENOMi HOG000278432.
HOVERGENi HBG055339.
InParanoidi Q9UKG4.
KOi K14444.
OMAi KKPCFGK.
OrthoDBi EOG7G1V5S.
PhylomeDBi Q9UKG4.
TreeFami TF312913.

Enzyme and pathway databases

Reactomei REACT_20646. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Miscellaneous databases

GenomeRNAii 26266.
NextBioi 48537.
PROi Q9UKG4.
SOURCEi Search...

Gene expression databases

Bgeei Q9UKG4.
CleanExi HS_SLC13A4.
ExpressionAtlasi Q9UKG4. baseline.
Genevestigatori Q9UKG4.

Family and domain databases

InterProi IPR001898. Na/sul_symport.
[Graphical view ]
Pfami PF00939. Na_sulph_symp. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules."
    Girard J.-P., Baekkevold E.S., Feliu J., Brandtzaeg P., Amalric F.
    Proc. Natl. Acad. Sci. U.S.A. 96:12772-12777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Endothelial cell.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Functional characterization and genomic organization of the human Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4)."
    Markovich D., Regeer R.R., Kunzelmann K., Dawson P.A.
    Biochem. Biophys. Res. Commun. 326:729-734(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiS13A4_HUMAN
AccessioniPrimary (citable) accession number: Q9UKG4
Secondary accession number(s): A4D1Q4, Q8N631
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 20, 2009
Last modified: October 29, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Transport is inhibited by thiosulfate, phosphate, molybdate, selenate and tungstate. Not inhibited by oxalate, citrate, succinate, phenol red or 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3