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Q9UKG4

- S13A4_HUMAN

UniProt

Q9UKG4 - S13A4_HUMAN

Protein

Solute carrier family 13 member 4

Gene

SLC13A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (20 Jan 2009)
      Previous versions | rss
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    Functioni

    Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV).2 Publications

    GO - Molecular functioni

    1. sodium:sulfate symporter activity Source: ProtInc

    GO - Biological processi

    1. sodium ion transmembrane transport Source: GOC
    2. sulfate transport Source: ProtInc
    3. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_20646. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

    Protein family/group databases

    TCDBi2.A.47.1.14. the divalent anion:na(+) symporter (dass) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 13 member 4
    Alternative name(s):
    Na(+)/sulfate cotransporter SUT-1
    NaS2
    Gene namesi
    Name:SLC13A4
    Synonyms:SUT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:15827. SLC13A4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38045.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 626626Solute carrier family 13 member 4PRO_0000172495Add
    BLAST

    Proteomic databases

    PaxDbiQ9UKG4.
    PRIDEiQ9UKG4.

    PTM databases

    PhosphoSiteiQ9UKG4.

    Expressioni

    Tissue specificityi

    Highly expressed in placenta and testis with intermediate levels in brain and lower levels in heart, thymus and liver.2 Publications

    Gene expression databases

    BgeeiQ9UKG4.
    CleanExiHS_SLC13A4.
    GenevestigatoriQ9UKG4.

    Organism-specific databases

    HPAiHPA048582.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000297282.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UKG4.
    SMRiQ9UKG4. Positions 40-158, 270-600.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei274 – 29421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei309 – 32921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei372 – 39221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei414 – 43421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei466 – 48621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei499 – 51921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei543 – 56321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei590 – 61021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0471.
    HOGENOMiHOG000278432.
    HOVERGENiHBG055339.
    InParanoidiQ9UKG4.
    KOiK14444.
    OMAiKKPCFGK.
    OrthoDBiEOG7G1V5S.
    PhylomeDBiQ9UKG4.
    TreeFamiTF312913.

    Family and domain databases

    InterProiIPR001898. Na/sul_symport.
    [Graphical view]
    PfamiPF00939. Na_sulph_symp. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UKG4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLLQGLLRV RKLLLVVCVP LLLLPLPVLH PSSEASCAYV LIVTAVYWVS    50
    EAVPLGAAAL VPAFLYPFFG VLRSNEVAAE YFKNTTLLLV GVICVAAAVE 100
    KWNLHKRIAL RMVLMAGAKP GMLLLCFMCC TTLLSMWLSN TSTTAMVMPI 150
    VEAVLQELVS AEDEQLVAGN SNTEEAEPIS LDVKNSQPSL ELIFVNEESN 200
    ADLTTLMHNE NLNGVPSITN PIKTANQHQG KKQHPSQEKP QVLTPSPRKQ 250
    KLNRKYRSHH DQMICKCLSL SISYSATIGG LTTIIGTSTS LIFLEHFNNQ 300
    YPAAEVVNFG TWFLFSFPIS LIMLVVSWFW MHWLFLGCNF KETCSLSKKK 350
    KTKREQLSEK RIQEEYEKLG DISYPEMVTG FFFILMTVLW FTREPGFVPG 400
    WDSFFEKKGY RTDATVSVFL GFLLFLIPAK KPCFGKKNDG ENQEHSLGTE 450
    PIITWKDFQK TMPWEIVILV GGGYALASGS KSSGLSTWIG NQMLSLSSLP 500
    PWAVTLLACI LVSIVTEFVS NPATITIFLP ILCSLSETLH INPLYTLIPV 550
    TMCISFAVML PVGNPPNAIV FSYGHCQIKD MVKAGLGVNV IGLVIVMVAI 600
    NTWGVSLFHL DTYPAWARVS NITDQA 626
    Length:626
    Mass (Da):69,358
    Last modified:January 20, 2009 - v2
    Checksum:iD84A18376DFAFA2B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti198 – 1981E → DR in AAF05907. (PubMed:10535998)Curated
    Sequence conflicti245 – 2451P → R in AAH30689. (PubMed:15489334)Curated
    Sequence conflicti539 – 5391L → M in AAF05907. (PubMed:10535998)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti451 – 4511P → S.
    Corresponds to variant rs36004833 [ dbSNP | Ensembl ].
    VAR_057193

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF169301 mRNA. Translation: AAF05907.1.
    AC091736 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24058.1.
    CH471070 Genomic DNA. Translation: EAW83858.1.
    BC030689 mRNA. Translation: AAH30689.1.
    CCDSiCCDS5840.1.
    RefSeqiNP_036582.2. NM_012450.2.
    UniGeneiHs.200022.
    Hs.490241.

    Genome annotation databases

    EnsembliENST00000354042; ENSP00000297282; ENSG00000164707.
    GeneIDi26266.
    KEGGihsa:26266.
    UCSCiuc003vta.3. human.

    Polymorphism databases

    DMDMi221222500.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF169301 mRNA. Translation: AAF05907.1 .
    AC091736 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24058.1 .
    CH471070 Genomic DNA. Translation: EAW83858.1 .
    BC030689 mRNA. Translation: AAH30689.1 .
    CCDSi CCDS5840.1.
    RefSeqi NP_036582.2. NM_012450.2.
    UniGenei Hs.200022.
    Hs.490241.

    3D structure databases

    ProteinModelPortali Q9UKG4.
    SMRi Q9UKG4. Positions 40-158, 270-600.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000297282.

    Protein family/group databases

    TCDBi 2.A.47.1.14. the divalent anion:na(+) symporter (dass) family.

    PTM databases

    PhosphoSitei Q9UKG4.

    Polymorphism databases

    DMDMi 221222500.

    Proteomic databases

    PaxDbi Q9UKG4.
    PRIDEi Q9UKG4.

    Protocols and materials databases

    DNASUi 26266.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354042 ; ENSP00000297282 ; ENSG00000164707 .
    GeneIDi 26266.
    KEGGi hsa:26266.
    UCSCi uc003vta.3. human.

    Organism-specific databases

    CTDi 26266.
    GeneCardsi GC07M135365.
    H-InvDB HIX0025275.
    HGNCi HGNC:15827. SLC13A4.
    HPAi HPA048582.
    MIMi 604309. gene.
    neXtProti NX_Q9UKG4.
    PharmGKBi PA38045.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0471.
    HOGENOMi HOG000278432.
    HOVERGENi HBG055339.
    InParanoidi Q9UKG4.
    KOi K14444.
    OMAi KKPCFGK.
    OrthoDBi EOG7G1V5S.
    PhylomeDBi Q9UKG4.
    TreeFami TF312913.

    Enzyme and pathway databases

    Reactomei REACT_20646. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

    Miscellaneous databases

    GenomeRNAii 26266.
    NextBioi 48537.
    PROi Q9UKG4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UKG4.
    CleanExi HS_SLC13A4.
    Genevestigatori Q9UKG4.

    Family and domain databases

    InterProi IPR001898. Na/sul_symport.
    [Graphical view ]
    Pfami PF00939. Na_sulph_symp. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules."
      Girard J.-P., Baekkevold E.S., Feliu J., Brandtzaeg P., Amalric F.
      Proc. Natl. Acad. Sci. U.S.A. 96:12772-12777(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Endothelial cell.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Functional characterization and genomic organization of the human Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4)."
      Markovich D., Regeer R.R., Kunzelmann K., Dawson P.A.
      Biochem. Biophys. Res. Commun. 326:729-734(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiS13A4_HUMAN
    AccessioniPrimary (citable) accession number: Q9UKG4
    Secondary accession number(s): A4D1Q4, Q8N631
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: January 20, 2009
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Transport is inhibited by thiosulfate, phosphate, molybdate, selenate and tungstate. Not inhibited by oxalate, citrate, succinate, phenol red or 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3