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Q9UKF5

- ADA29_HUMAN

UniProt

Q9UKF5 - ADA29_HUMAN

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Protein

Disintegrin and metalloproteinase domain-containing protein 29

Gene

ADAM29

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.

GO - Molecular functioni

  1. metalloendopeptidase activity Source: InterPro
  2. metallopeptidase activity Source: ProtInc
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. spermatogenesis Source: ProtInc
Complete GO annotation...

Protein family/group databases

MEROPSiM12.981.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 29
Short name:
ADAM 29
Alternative name(s):
Cancer/testis antigen 73
Short name:
CT73
Gene namesi
Name:ADAM29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:207. ADAM29.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini194 – 674481ExtracellularSequence AnalysisAdd
BLAST
Transmembranei675 – 69521HelicalSequence AnalysisAdd
BLAST
Topological domaini696 – 820125CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis.

Organism-specific databases

PharmGKBiPA24524.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 193175By similarityPRO_0000029134Add
BLAST
Chaini194 – 820627Disintegrin and metalloproteinase domain-containing protein 29PRO_0000029135Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi307 ↔ 384By similarity
Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi347 ↔ 369By similarity
Disulfide bondi349 ↔ 354By similarity
Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi455 ↔ 475By similarity
Glycosylationi469 – 4691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi538 – 5381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi558 – 5581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi564 – 5641N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi625 ↔ 636By similarity
Disulfide bondi630 ↔ 642By similarity
Disulfide bondi644 ↔ 653By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9UKF5.
PaxDbiQ9UKF5.
PRIDEiQ9UKF5.

PTM databases

PhosphoSiteiQ9UKF5.

Expressioni

Tissue specificityi

Expressed specifically in testes.

Gene expression databases

BgeeiQ9UKF5.
CleanExiHS_ADAM29.
ExpressionAtlasiQ9UKF5. baseline.
GenevestigatoriQ9UKF5.

Organism-specific databases

HPAiHPA014159.

Interactioni

Protein-protein interaction databases

MINTiMINT-252736.
STRINGi9606.ENSP00000352177.

Structurei

3D structure databases

ProteinModelPortaliQ9UKF5.
SMRiQ9UKF5. Positions 197-618.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini198 – 390193Peptidase M12BPROSITE-ProRule annotationAdd
BLAST
Domaini397 – 48387DisintegrinPROSITE-ProRule annotationAdd
BLAST
Domaini625 – 65430EGF-likeAdd
BLAST
Repeati739 – 74791
Repeati748 – 75692
Repeati757 – 76593
Repeati766 – 77494
Repeati775 – 78395
Repeati784 – 79296
Repeati793 – 80197
Repeati802 – 81098
Repeati811 – 81999

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni739 – 819819 X 9 AA approximate repeatsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi484 – 624141Cys-richAdd
BLAST
Compositional biasi669 – 6757Poly-Lys

Sequence similaritiesi

Contains 1 disintegrin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.Curated
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG297875.
GeneTreeiENSGT00760000118888.
HOGENOMiHOG000230883.
HOVERGENiHBG006978.
InParanoidiQ9UKF5.
KOiK16069.
OMAiSCAIVTF.
OrthoDBiEOG7KWSGW.
PhylomeDBiQ9UKF5.
TreeFamiTF314733.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform Alpha (identifier: Q9UKF5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMLLLLHCL GVFLSCSGHI QDEHPQYHSP PDVVIPVRIT GTTRGMTPPG
60 70 80 90 100
WLSYILPFGG QKHIIHIKVK KLLFSKHLPV FTYTDQGAIL EDQPFVQNNC
110 120 130 140 150
YYHGYVEGDP ESLVSLSTCF GGFQGILQIN DFAYEIKPLA FSTTFEHLVY
160 170 180 190 200
KMDSEEKQFS TMRSGFMQNE ITCRMEFEEI DNSTQKQSSY VGWWIHFRIV
210 220 230 240 250
EIVVVIDNYL YIRYERNDSK LLEDLYVIVN IVDSILDVIG VKVLLFGLEI
260 270 280 290 300
WTNKNLIVVD DVRKSVHLYC KWKSENITPR MQHDTSHLFT TLGLRGLSGI
310 320 330 340 350
GAFRGMCTPH RSCAIVTFMN KTLGTFSIAV AHHLGHNLGM NHDEDTCRCS
360 370 380 390 400
QPRCIMHEGN PPITKFSNCS YGDFWEYTVE RTKCLLETVH TKDIFNVKRC
410 420 430 440 450
GNGVVEEGEE CDCGPLKHCA KDPCCLSNCT LTDGSTCAFG LCCKDCKFLP
460 470 480 490 500
SGKVCRKEVN ECDLPEWCNG TSHKCPDDFY VEDGIPCKER GYCYEKSCHD
510 520 530 540 550
RNEQCRRIFG AGANTASETC YKELNTLGDR VGHCGIKNAT YIKCNISDVQ
560 570 580 590 600
CGRIQCENVT EIPNMSDHTT VHWARFNDIM CWSTDYHLGM KGPDIGEVKD
610 620 630 640 650
GTECGIDHIC IHRHCVHITI LNSNCSPAFC NKRGICNNKH HCHCNYLWDP
660 670 680 690 700
PNCLIKGYGG SVDSGPPPKR KKKKKFCYLC ILLLIVLFIL LCCLYRLCKK
710 720 730 740 750
SKPIKKQQDV QTPSAKEEEK IQRRPHELPP QSQPWVMPSQ SQPPVTPSQS
760 770 780 790 800
HPQVMPSQSQ PPVTPSQSQP RVMPSQSQPP VMPSQSHPQL TPSQSQPPVT
810 820
PSQRQPQLMP SQSQPPVTPS
Length:820
Mass (Da):92,759
Last modified:April 17, 2007 - v3
Checksum:iAA2FB11342A884C9
GO
Isoform Beta (identifier: Q9UKF5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     750-803: Missing.

Show »
Length:766
Mass (Da):86,983
Checksum:iACA4BEDFA700ABA5
GO
Isoform Gamma (identifier: Q9UKF5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     763-787: VTPSQSQPRVMPSQSQPPVMPSQSH → QNLFLFSFSISDCVLNFRLLYLQAT
     788-820: Missing.

Show »
Length:787
Mass (Da):89,460
Checksum:i2B0E5E7C496B8C9D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti196 – 1961H → Y in AAF22163. (PubMed:10644455)Curated
Sequence conflicti744 – 7441P → H in AAF22163. (PubMed:10644455)Curated
Sequence conflicti748 – 7481S → Y in AAF22163. (PubMed:10644455)Curated
Sequence conflicti753 – 7531Q → R in AAF03777. (PubMed:10512762)Curated
Sequence conflicti764 – 7641T → M in AAF03777. (PubMed:10512762)Curated
Sequence conflicti769 – 7735QPRVM → HPQLT in AAF03777. (PubMed:10512762)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311P → L in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036148
Natural varianti72 – 721L → F in a melanoma cell line. 1 Publication
VAR_066322
Natural varianti89 – 891I → M in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066323
Natural varianti111 – 1111E → K in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication
VAR_066324
Natural varianti112 – 1121S → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication
VAR_066325
Natural varianti115 – 1151S → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication
VAR_066326
Natural varianti131 – 1311D → N in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066327
Natural varianti176 – 1761E → K in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066328
Natural varianti205 – 2051V → I in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036149
Natural varianti234 – 2341S → F in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066329
Natural varianti257 – 2571I → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication
VAR_066330
Natural varianti305 – 3051G → E in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066331
Natural varianti345 – 3451D → N in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066332
Natural varianti403 – 4031G → D in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066333
Natural varianti434 – 4341G → D in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication
VAR_066334
Natural varianti503 – 5031E → K in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication
VAR_066335
Natural varianti533 – 5331H → Y in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066336

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei750 – 80354Missing in isoform Beta. 1 PublicationVSP_005491Add
BLAST
Alternative sequencei763 – 78725VTPSQ…PSQSH → QNLFLFSFSISDCVLNFRLL YLQAT in isoform Gamma. 1 PublicationVSP_005492Add
BLAST
Alternative sequencei788 – 82033Missing in isoform Gamma. 1 PublicationVSP_005493Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171929 mRNA. Translation: AAF03777.1.
AF171930 mRNA. Translation: AAF03778.1.
AF171931 mRNA. Translation: AAF03779.1.
AF134708 mRNA. Translation: AAF22163.1.
AK292410 mRNA. Translation: BAF85099.1.
AC105914 Genomic DNA. Translation: AAY41055.1.
CH471056 Genomic DNA. Translation: EAX04727.1.
CH471056 Genomic DNA. Translation: EAX04728.1.
CCDSiCCDS3823.1. [Q9UKF5-1]
RefSeqiNP_001124175.1. NM_001130703.1. [Q9UKF5-1]
NP_001124176.1. NM_001130704.1. [Q9UKF5-1]
NP_001124177.1. NM_001130705.1. [Q9UKF5-1]
NP_001265054.1. NM_001278125.1. [Q9UKF5-1]
NP_001265055.1. NM_001278126.1. [Q9UKF5-1]
NP_001265056.1. NM_001278127.1. [Q9UKF5-1]
NP_055084.3. NM_014269.4. [Q9UKF5-1]
XP_005262761.1. XM_005262704.1. [Q9UKF5-1]
XP_005262762.1. XM_005262705.2. [Q9UKF5-1]
UniGeneiHs.126838.

Genome annotation databases

EnsembliENST00000359240; ENSP00000352177; ENSG00000168594. [Q9UKF5-1]
ENST00000404450; ENSP00000384229; ENSG00000168594. [Q9UKF5-1]
ENST00000445694; ENSP00000414544; ENSG00000168594. [Q9UKF5-1]
ENST00000514159; ENSP00000423517; ENSG00000168594. [Q9UKF5-1]
ENST00000615367; ENSP00000484862; ENSG00000168594. [Q9UKF5-1]
ENST00000618444; ENSP00000478469; ENSG00000168594. [Q9UKF5-1]
GeneIDi11086.
KEGGihsa:11086.
UCSCiuc003iuc.3. human. [Q9UKF5-1]

Polymorphism databases

DMDMi145559438.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171929 mRNA. Translation: AAF03777.1 .
AF171930 mRNA. Translation: AAF03778.1 .
AF171931 mRNA. Translation: AAF03779.1 .
AF134708 mRNA. Translation: AAF22163.1 .
AK292410 mRNA. Translation: BAF85099.1 .
AC105914 Genomic DNA. Translation: AAY41055.1 .
CH471056 Genomic DNA. Translation: EAX04727.1 .
CH471056 Genomic DNA. Translation: EAX04728.1 .
CCDSi CCDS3823.1. [Q9UKF5-1 ]
RefSeqi NP_001124175.1. NM_001130703.1. [Q9UKF5-1 ]
NP_001124176.1. NM_001130704.1. [Q9UKF5-1 ]
NP_001124177.1. NM_001130705.1. [Q9UKF5-1 ]
NP_001265054.1. NM_001278125.1. [Q9UKF5-1 ]
NP_001265055.1. NM_001278126.1. [Q9UKF5-1 ]
NP_001265056.1. NM_001278127.1. [Q9UKF5-1 ]
NP_055084.3. NM_014269.4. [Q9UKF5-1 ]
XP_005262761.1. XM_005262704.1. [Q9UKF5-1 ]
XP_005262762.1. XM_005262705.2. [Q9UKF5-1 ]
UniGenei Hs.126838.

3D structure databases

ProteinModelPortali Q9UKF5.
SMRi Q9UKF5. Positions 197-618.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-252736.
STRINGi 9606.ENSP00000352177.

Protein family/group databases

MEROPSi M12.981.

PTM databases

PhosphoSitei Q9UKF5.

Polymorphism databases

DMDMi 145559438.

Proteomic databases

MaxQBi Q9UKF5.
PaxDbi Q9UKF5.
PRIDEi Q9UKF5.

Protocols and materials databases

DNASUi 11086.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359240 ; ENSP00000352177 ; ENSG00000168594 . [Q9UKF5-1 ]
ENST00000404450 ; ENSP00000384229 ; ENSG00000168594 . [Q9UKF5-1 ]
ENST00000445694 ; ENSP00000414544 ; ENSG00000168594 . [Q9UKF5-1 ]
ENST00000514159 ; ENSP00000423517 ; ENSG00000168594 . [Q9UKF5-1 ]
ENST00000615367 ; ENSP00000484862 ; ENSG00000168594 . [Q9UKF5-1 ]
ENST00000618444 ; ENSP00000478469 ; ENSG00000168594 . [Q9UKF5-1 ]
GeneIDi 11086.
KEGGi hsa:11086.
UCSCi uc003iuc.3. human. [Q9UKF5-1 ]

Organism-specific databases

CTDi 11086.
GeneCardsi GC04P175751.
HGNCi HGNC:207. ADAM29.
HPAi HPA014159.
MIMi 604778. gene.
neXtProti NX_Q9UKF5.
PharmGKBi PA24524.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG297875.
GeneTreei ENSGT00760000118888.
HOGENOMi HOG000230883.
HOVERGENi HBG006978.
InParanoidi Q9UKF5.
KOi K16069.
OMAi SCAIVTF.
OrthoDBi EOG7KWSGW.
PhylomeDBi Q9UKF5.
TreeFami TF314733.

Miscellaneous databases

ChiTaRSi ADAM29. human.
GenomeRNAii 11086.
NextBioi 42152.
PROi Q9UKF5.
SOURCEi Search...

Gene expression databases

Bgeei Q9UKF5.
CleanExi HS_ADAM29.
ExpressionAtlasi Q9UKF5. baseline.
Genevestigatori Q9UKF5.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProi IPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view ]
Pfami PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view ]
PRINTSi PR00289. DISINTEGRIN.
SMARTi SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view ]
SUPFAMi SSF57552. SSF57552. 1 hit.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show testis-specific gene expression."
    Cerretti D.P., DuBose R.F., Black R.A., Nelson N.
    Biochem. Biophys. Res. Commun. 263:810-815(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA; BETA AND GAMMA).
    Tissue: Testis.
  2. "Molecular cloning and mapping of a novel ADAM gene (ADAM29) to human chromosome 4."
    Xu R., Cai J., Xu T., Zhou W., Ying B., Deng K., Zhao S., Li C.
    Genomics 62:537-539(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
    Tissue: Testis.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma."
    Wei X., Moncada-Pazos A., Cal S., Soria-Valles C., Gartner J., Rudloff U., Lin J.C., Rosenberg S.A., Lopez-Otin C., Samuels Y.
    Hum. Mutat. 32:E2148-E2175(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN CUTANEOUS MELANOMA, VARIANTS PHE-72; MET-89; LYS-111; PHE-112; PHE-115; ASN-131; LYS-176; PHE-234; PHE-257; GLU-305; ASN-345; ASP-403; ASP-434; LYS-503 AND TYR-533, CHARACTERIZATION OF VARIANTS LYS-111; PHE-112; PHE-115; PHE-257; ASP-434 AND LYS-503.
  7. Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-31 AND ILE-205.

Entry informationi

Entry nameiADA29_HUMAN
AccessioniPrimary (citable) accession number: Q9UKF5
Secondary accession number(s): Q4W5F3
, Q9UHP1, Q9UKF3, Q9UKF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: April 17, 2007
Last modified: November 26, 2014
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3