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Q9UKF5

- ADA29_HUMAN

UniProt

Q9UKF5 - ADA29_HUMAN

Protein

Disintegrin and metalloproteinase domain-containing protein 29

Gene

ADAM29

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 3 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.

    GO - Molecular functioni

    1. metalloendopeptidase activity Source: InterPro
    2. metallopeptidase activity Source: ProtInc
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. spermatogenesis Source: ProtInc

    Protein family/group databases

    MEROPSiM12.981.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 29
    Short name:
    ADAM 29
    Alternative name(s):
    Cancer/testis antigen 73
    Short name:
    CT73
    Gene namesi
    Name:ADAM29
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:207. ADAM29.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis.

    Organism-specific databases

    PharmGKBiPA24524.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 193175By similarityPRO_0000029134Add
    BLAST
    Chaini194 – 820627Disintegrin and metalloproteinase domain-containing protein 29PRO_0000029135Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi307 ↔ 384By similarity
    Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi347 ↔ 369By similarity
    Disulfide bondi349 ↔ 354By similarity
    Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi455 ↔ 475By similarity
    Glycosylationi469 – 4691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi538 – 5381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi558 – 5581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi564 – 5641N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi625 ↔ 636By similarity
    Disulfide bondi630 ↔ 642By similarity
    Disulfide bondi644 ↔ 653By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9UKF5.
    PaxDbiQ9UKF5.
    PRIDEiQ9UKF5.

    PTM databases

    PhosphoSiteiQ9UKF5.

    Expressioni

    Tissue specificityi

    Expressed specifically in testes.

    Gene expression databases

    ArrayExpressiQ9UKF5.
    BgeeiQ9UKF5.
    CleanExiHS_ADAM29.
    GenevestigatoriQ9UKF5.

    Organism-specific databases

    HPAiHPA014159.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-252736.
    STRINGi9606.ENSP00000352177.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UKF5.
    SMRiQ9UKF5. Positions 197-618, 629-655.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini194 – 674481ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini696 – 820125CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei675 – 69521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini198 – 390193Peptidase M12BPROSITE-ProRule annotationAdd
    BLAST
    Domaini397 – 48387DisintegrinPROSITE-ProRule annotationAdd
    BLAST
    Domaini625 – 65430EGF-likeAdd
    BLAST
    Repeati739 – 74791
    Repeati748 – 75692
    Repeati757 – 76593
    Repeati766 – 77494
    Repeati775 – 78395
    Repeati784 – 79296
    Repeati793 – 80197
    Repeati802 – 81098
    Repeati811 – 81999

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni739 – 819819 X 9 AA approximate repeatsAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi484 – 624141Cys-richAdd
    BLAST
    Compositional biasi669 – 6757Poly-Lys

    Sequence similaritiesi

    Contains 1 disintegrin domain.PROSITE-ProRule annotation
    Contains 1 EGF-like domain.Curated
    Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG297875.
    HOGENOMiHOG000230883.
    HOVERGENiHBG006978.
    InParanoidiQ9UKF5.
    KOiK16069.
    OMAiSCAIVTF.
    OrthoDBiEOG7KWSGW.
    PhylomeDBiQ9UKF5.
    TreeFamiTF314733.

    Family and domain databases

    Gene3Di3.40.390.10. 1 hit.
    4.10.70.10. 1 hit.
    InterProiIPR006586. ADAM_Cys-rich.
    IPR001762. Blood-coag_inhib_Disintegrin.
    IPR018358. Disintegrin_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR002870. Peptidase_M12B_N.
    [Graphical view]
    PfamiPF08516. ADAM_CR. 1 hit.
    PF00200. Disintegrin. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    [Graphical view]
    PRINTSiPR00289. DISINTEGRIN.
    SMARTiSM00608. ACR. 1 hit.
    SM00050. DISIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF57552. SSF57552. 1 hit.
    PROSITEiPS50215. ADAM_MEPRO. 1 hit.
    PS00427. DISINTEGRIN_1. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform Alpha (identifier: Q9UKF5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKMLLLLHCL GVFLSCSGHI QDEHPQYHSP PDVVIPVRIT GTTRGMTPPG    50
    WLSYILPFGG QKHIIHIKVK KLLFSKHLPV FTYTDQGAIL EDQPFVQNNC 100
    YYHGYVEGDP ESLVSLSTCF GGFQGILQIN DFAYEIKPLA FSTTFEHLVY 150
    KMDSEEKQFS TMRSGFMQNE ITCRMEFEEI DNSTQKQSSY VGWWIHFRIV 200
    EIVVVIDNYL YIRYERNDSK LLEDLYVIVN IVDSILDVIG VKVLLFGLEI 250
    WTNKNLIVVD DVRKSVHLYC KWKSENITPR MQHDTSHLFT TLGLRGLSGI 300
    GAFRGMCTPH RSCAIVTFMN KTLGTFSIAV AHHLGHNLGM NHDEDTCRCS 350
    QPRCIMHEGN PPITKFSNCS YGDFWEYTVE RTKCLLETVH TKDIFNVKRC 400
    GNGVVEEGEE CDCGPLKHCA KDPCCLSNCT LTDGSTCAFG LCCKDCKFLP 450
    SGKVCRKEVN ECDLPEWCNG TSHKCPDDFY VEDGIPCKER GYCYEKSCHD 500
    RNEQCRRIFG AGANTASETC YKELNTLGDR VGHCGIKNAT YIKCNISDVQ 550
    CGRIQCENVT EIPNMSDHTT VHWARFNDIM CWSTDYHLGM KGPDIGEVKD 600
    GTECGIDHIC IHRHCVHITI LNSNCSPAFC NKRGICNNKH HCHCNYLWDP 650
    PNCLIKGYGG SVDSGPPPKR KKKKKFCYLC ILLLIVLFIL LCCLYRLCKK 700
    SKPIKKQQDV QTPSAKEEEK IQRRPHELPP QSQPWVMPSQ SQPPVTPSQS 750
    HPQVMPSQSQ PPVTPSQSQP RVMPSQSQPP VMPSQSHPQL TPSQSQPPVT 800
    PSQRQPQLMP SQSQPPVTPS 820
    Length:820
    Mass (Da):92,759
    Last modified:April 17, 2007 - v3
    Checksum:iAA2FB11342A884C9
    GO
    Isoform Beta (identifier: Q9UKF5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         750-803: Missing.

    Show »
    Length:766
    Mass (Da):86,983
    Checksum:iACA4BEDFA700ABA5
    GO
    Isoform Gamma (identifier: Q9UKF5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         763-787: VTPSQSQPRVMPSQSQPPVMPSQSH → QNLFLFSFSISDCVLNFRLLYLQAT
         788-820: Missing.

    Show »
    Length:787
    Mass (Da):89,460
    Checksum:i2B0E5E7C496B8C9D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti196 – 1961H → Y in AAF22163. (PubMed:10644455)Curated
    Sequence conflicti744 – 7441P → H in AAF22163. (PubMed:10644455)Curated
    Sequence conflicti748 – 7481S → Y in AAF22163. (PubMed:10644455)Curated
    Sequence conflicti753 – 7531Q → R in AAF03777. (PubMed:10512762)Curated
    Sequence conflicti764 – 7641T → M in AAF03777. (PubMed:10512762)Curated
    Sequence conflicti769 – 7735QPRVM → HPQLT in AAF03777. (PubMed:10512762)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti31 – 311P → L in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036148
    Natural varianti72 – 721L → F in a melanoma cell line. 1 Publication
    VAR_066322
    Natural varianti89 – 891I → M in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066323
    Natural varianti111 – 1111E → K in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication
    VAR_066324
    Natural varianti112 – 1121S → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication
    VAR_066325
    Natural varianti115 – 1151S → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication
    VAR_066326
    Natural varianti131 – 1311D → N in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066327
    Natural varianti176 – 1761E → K in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066328
    Natural varianti205 – 2051V → I in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036149
    Natural varianti234 – 2341S → F in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066329
    Natural varianti257 – 2571I → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication
    VAR_066330
    Natural varianti305 – 3051G → E in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066331
    Natural varianti345 – 3451D → N in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066332
    Natural varianti403 – 4031G → D in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066333
    Natural varianti434 – 4341G → D in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication
    VAR_066334
    Natural varianti503 – 5031E → K in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication
    VAR_066335
    Natural varianti533 – 5331H → Y in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_066336

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei750 – 80354Missing in isoform Beta. 1 PublicationVSP_005491Add
    BLAST
    Alternative sequencei763 – 78725VTPSQ…PSQSH → QNLFLFSFSISDCVLNFRLL YLQAT in isoform Gamma. 1 PublicationVSP_005492Add
    BLAST
    Alternative sequencei788 – 82033Missing in isoform Gamma. 1 PublicationVSP_005493Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF171929 mRNA. Translation: AAF03777.1.
    AF171930 mRNA. Translation: AAF03778.1.
    AF171931 mRNA. Translation: AAF03779.1.
    AF134708 mRNA. Translation: AAF22163.1.
    AK292410 mRNA. Translation: BAF85099.1.
    AC105914 Genomic DNA. Translation: AAY41055.1.
    CH471056 Genomic DNA. Translation: EAX04727.1.
    CH471056 Genomic DNA. Translation: EAX04728.1.
    CCDSiCCDS3823.1. [Q9UKF5-1]
    RefSeqiNP_001124175.1. NM_001130703.1. [Q9UKF5-1]
    NP_001124176.1. NM_001130704.1. [Q9UKF5-1]
    NP_001124177.1. NM_001130705.1. [Q9UKF5-1]
    NP_001265054.1. NM_001278125.1. [Q9UKF5-1]
    NP_001265055.1. NM_001278126.1. [Q9UKF5-1]
    NP_001265056.1. NM_001278127.1. [Q9UKF5-1]
    NP_055084.3. NM_014269.4. [Q9UKF5-1]
    XP_005262761.1. XM_005262704.1. [Q9UKF5-1]
    XP_005262762.1. XM_005262705.2. [Q9UKF5-1]
    UniGeneiHs.126838.

    Genome annotation databases

    EnsembliENST00000359240; ENSP00000352177; ENSG00000168594. [Q9UKF5-1]
    ENST00000404450; ENSP00000384229; ENSG00000168594. [Q9UKF5-1]
    ENST00000445694; ENSP00000414544; ENSG00000168594. [Q9UKF5-1]
    ENST00000514159; ENSP00000423517; ENSG00000168594. [Q9UKF5-1]
    GeneIDi11086.
    KEGGihsa:11086.
    UCSCiuc003iuc.3. human. [Q9UKF5-1]

    Polymorphism databases

    DMDMi145559438.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF171929 mRNA. Translation: AAF03777.1 .
    AF171930 mRNA. Translation: AAF03778.1 .
    AF171931 mRNA. Translation: AAF03779.1 .
    AF134708 mRNA. Translation: AAF22163.1 .
    AK292410 mRNA. Translation: BAF85099.1 .
    AC105914 Genomic DNA. Translation: AAY41055.1 .
    CH471056 Genomic DNA. Translation: EAX04727.1 .
    CH471056 Genomic DNA. Translation: EAX04728.1 .
    CCDSi CCDS3823.1. [Q9UKF5-1 ]
    RefSeqi NP_001124175.1. NM_001130703.1. [Q9UKF5-1 ]
    NP_001124176.1. NM_001130704.1. [Q9UKF5-1 ]
    NP_001124177.1. NM_001130705.1. [Q9UKF5-1 ]
    NP_001265054.1. NM_001278125.1. [Q9UKF5-1 ]
    NP_001265055.1. NM_001278126.1. [Q9UKF5-1 ]
    NP_001265056.1. NM_001278127.1. [Q9UKF5-1 ]
    NP_055084.3. NM_014269.4. [Q9UKF5-1 ]
    XP_005262761.1. XM_005262704.1. [Q9UKF5-1 ]
    XP_005262762.1. XM_005262705.2. [Q9UKF5-1 ]
    UniGenei Hs.126838.

    3D structure databases

    ProteinModelPortali Q9UKF5.
    SMRi Q9UKF5. Positions 197-618, 629-655.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-252736.
    STRINGi 9606.ENSP00000352177.

    Protein family/group databases

    MEROPSi M12.981.

    PTM databases

    PhosphoSitei Q9UKF5.

    Polymorphism databases

    DMDMi 145559438.

    Proteomic databases

    MaxQBi Q9UKF5.
    PaxDbi Q9UKF5.
    PRIDEi Q9UKF5.

    Protocols and materials databases

    DNASUi 11086.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359240 ; ENSP00000352177 ; ENSG00000168594 . [Q9UKF5-1 ]
    ENST00000404450 ; ENSP00000384229 ; ENSG00000168594 . [Q9UKF5-1 ]
    ENST00000445694 ; ENSP00000414544 ; ENSG00000168594 . [Q9UKF5-1 ]
    ENST00000514159 ; ENSP00000423517 ; ENSG00000168594 . [Q9UKF5-1 ]
    GeneIDi 11086.
    KEGGi hsa:11086.
    UCSCi uc003iuc.3. human. [Q9UKF5-1 ]

    Organism-specific databases

    CTDi 11086.
    GeneCardsi GC04P175751.
    HGNCi HGNC:207. ADAM29.
    HPAi HPA014159.
    MIMi 604778. gene.
    neXtProti NX_Q9UKF5.
    PharmGKBi PA24524.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG297875.
    HOGENOMi HOG000230883.
    HOVERGENi HBG006978.
    InParanoidi Q9UKF5.
    KOi K16069.
    OMAi SCAIVTF.
    OrthoDBi EOG7KWSGW.
    PhylomeDBi Q9UKF5.
    TreeFami TF314733.

    Miscellaneous databases

    ChiTaRSi ADAM29. human.
    GenomeRNAii 11086.
    NextBioi 42152.
    PROi Q9UKF5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UKF5.
    Bgeei Q9UKF5.
    CleanExi HS_ADAM29.
    Genevestigatori Q9UKF5.

    Family and domain databases

    Gene3Di 3.40.390.10. 1 hit.
    4.10.70.10. 1 hit.
    InterProi IPR006586. ADAM_Cys-rich.
    IPR001762. Blood-coag_inhib_Disintegrin.
    IPR018358. Disintegrin_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR002870. Peptidase_M12B_N.
    [Graphical view ]
    Pfami PF08516. ADAM_CR. 1 hit.
    PF00200. Disintegrin. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    [Graphical view ]
    PRINTSi PR00289. DISINTEGRIN.
    SMARTi SM00608. ACR. 1 hit.
    SM00050. DISIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57552. SSF57552. 1 hit.
    PROSITEi PS50215. ADAM_MEPRO. 1 hit.
    PS00427. DISINTEGRIN_1. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show testis-specific gene expression."
      Cerretti D.P., DuBose R.F., Black R.A., Nelson N.
      Biochem. Biophys. Res. Commun. 263:810-815(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA; BETA AND GAMMA).
      Tissue: Testis.
    2. "Molecular cloning and mapping of a novel ADAM gene (ADAM29) to human chromosome 4."
      Xu R., Cai J., Xu T., Zhou W., Ying B., Deng K., Zhao S., Li C.
      Genomics 62:537-539(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
      Tissue: Testis.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
      Tissue: Testis.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma."
      Wei X., Moncada-Pazos A., Cal S., Soria-Valles C., Gartner J., Rudloff U., Lin J.C., Rosenberg S.A., Lopez-Otin C., Samuels Y.
      Hum. Mutat. 32:E2148-E2175(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN CUTANEOUS MELANOMA, VARIANTS PHE-72; MET-89; LYS-111; PHE-112; PHE-115; ASN-131; LYS-176; PHE-234; PHE-257; GLU-305; ASN-345; ASP-403; ASP-434; LYS-503 AND TYR-533, CHARACTERIZATION OF VARIANTS LYS-111; PHE-112; PHE-115; PHE-257; ASP-434 AND LYS-503.
    7. Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-31 AND ILE-205.

    Entry informationi

    Entry nameiADA29_HUMAN
    AccessioniPrimary (citable) accession number: Q9UKF5
    Secondary accession number(s): Q4W5F3
    , Q9UHP1, Q9UKF3, Q9UKF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 133 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3