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Protein

Disintegrin and metalloproteinase domain-containing protein 29

Gene

ADAM29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.

GO - Molecular functioni

  • metalloendopeptidase activity Source: InterPro
  • metallopeptidase activity Source: ProtInc

GO - Biological processi

  • spermatogenesis Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168594-MONOMER.

Protein family/group databases

MEROPSiM12.981.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 29
Short name:
ADAM 29
Alternative name(s):
Cancer/testis antigen 73
Short name:
CT73
Gene namesi
Name:ADAM29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:207. ADAM29.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini194 – 674ExtracellularSequence analysisAdd BLAST481
Transmembranei675 – 695HelicalSequence analysisAdd BLAST21
Topological domaini696 – 820CytoplasmicSequence analysisAdd BLAST125

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis.

Organism-specific databases

DisGeNETi11086.
OpenTargetsiENSG00000168594.
PharmGKBiPA24524.

Polymorphism and mutation databases

BioMutaiADAM29.
DMDMi145559438.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000002913419 – 193By similarityAdd BLAST175
ChainiPRO_0000029135194 – 820Disintegrin and metalloproteinase domain-containing protein 29Add BLAST627

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi217N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi307 ↔ 384By similarity
Glycosylationi320N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi347 ↔ 369By similarity
Disulfide bondi349 ↔ 354By similarity
Glycosylationi368N-linked (GlcNAc...)Sequence analysis1
Glycosylationi428N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi455 ↔ 475By similarity
Glycosylationi469N-linked (GlcNAc...)Sequence analysis1
Glycosylationi538N-linked (GlcNAc...)Sequence analysis1
Glycosylationi545N-linked (GlcNAc...)Sequence analysis1
Glycosylationi558N-linked (GlcNAc...)Sequence analysis1
Glycosylationi564N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi625 ↔ 636By similarity
Disulfide bondi630 ↔ 642By similarity
Disulfide bondi644 ↔ 653By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UKF5.
PeptideAtlasiQ9UKF5.
PRIDEiQ9UKF5.

PTM databases

PhosphoSitePlusiQ9UKF5.

Expressioni

Tissue specificityi

Expressed specifically in testes.

Gene expression databases

BgeeiENSG00000168594.
CleanExiHS_ADAM29.
ExpressionAtlasiQ9UKF5. baseline and differential.
GenevisibleiQ9UKF5. HS.

Organism-specific databases

HPAiHPA014159.

Interactioni

Protein-protein interaction databases

MINTiMINT-252736.
STRINGi9606.ENSP00000352177.

Structurei

3D structure databases

ProteinModelPortaliQ9UKF5.
SMRiQ9UKF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini198 – 390Peptidase M12BPROSITE-ProRule annotationAdd BLAST193
Domaini397 – 483DisintegrinPROSITE-ProRule annotationAdd BLAST87
Domaini625 – 654EGF-likeAdd BLAST30
Repeati739 – 74719
Repeati748 – 75629
Repeati757 – 76539
Repeati766 – 77449
Repeati775 – 78359
Repeati784 – 79269
Repeati793 – 80179
Repeati802 – 81089
Repeati811 – 81999

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni739 – 8199 X 9 AA approximate repeatsAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi484 – 624Cys-richAdd BLAST141
Compositional biasi669 – 675Poly-Lys7

Sequence similaritiesi

Contains 1 disintegrin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.Curated
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
GeneTreeiENSGT00760000118888.
HOGENOMiHOG000230883.
HOVERGENiHBG006978.
InParanoidiQ9UKF5.
KOiK16069.
OMAiKDPCCLS.
OrthoDBiEOG091G03BZ.
PhylomeDBiQ9UKF5.
TreeFamiTF314733.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: Q9UKF5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMLLLLHCL GVFLSCSGHI QDEHPQYHSP PDVVIPVRIT GTTRGMTPPG
60 70 80 90 100
WLSYILPFGG QKHIIHIKVK KLLFSKHLPV FTYTDQGAIL EDQPFVQNNC
110 120 130 140 150
YYHGYVEGDP ESLVSLSTCF GGFQGILQIN DFAYEIKPLA FSTTFEHLVY
160 170 180 190 200
KMDSEEKQFS TMRSGFMQNE ITCRMEFEEI DNSTQKQSSY VGWWIHFRIV
210 220 230 240 250
EIVVVIDNYL YIRYERNDSK LLEDLYVIVN IVDSILDVIG VKVLLFGLEI
260 270 280 290 300
WTNKNLIVVD DVRKSVHLYC KWKSENITPR MQHDTSHLFT TLGLRGLSGI
310 320 330 340 350
GAFRGMCTPH RSCAIVTFMN KTLGTFSIAV AHHLGHNLGM NHDEDTCRCS
360 370 380 390 400
QPRCIMHEGN PPITKFSNCS YGDFWEYTVE RTKCLLETVH TKDIFNVKRC
410 420 430 440 450
GNGVVEEGEE CDCGPLKHCA KDPCCLSNCT LTDGSTCAFG LCCKDCKFLP
460 470 480 490 500
SGKVCRKEVN ECDLPEWCNG TSHKCPDDFY VEDGIPCKER GYCYEKSCHD
510 520 530 540 550
RNEQCRRIFG AGANTASETC YKELNTLGDR VGHCGIKNAT YIKCNISDVQ
560 570 580 590 600
CGRIQCENVT EIPNMSDHTT VHWARFNDIM CWSTDYHLGM KGPDIGEVKD
610 620 630 640 650
GTECGIDHIC IHRHCVHITI LNSNCSPAFC NKRGICNNKH HCHCNYLWDP
660 670 680 690 700
PNCLIKGYGG SVDSGPPPKR KKKKKFCYLC ILLLIVLFIL LCCLYRLCKK
710 720 730 740 750
SKPIKKQQDV QTPSAKEEEK IQRRPHELPP QSQPWVMPSQ SQPPVTPSQS
760 770 780 790 800
HPQVMPSQSQ PPVTPSQSQP RVMPSQSQPP VMPSQSHPQL TPSQSQPPVT
810 820
PSQRQPQLMP SQSQPPVTPS
Length:820
Mass (Da):92,759
Last modified:April 17, 2007 - v3
Checksum:iAA2FB11342A884C9
GO
Isoform Beta (identifier: Q9UKF5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     750-803: Missing.

Show »
Length:766
Mass (Da):86,983
Checksum:iACA4BEDFA700ABA5
GO
Isoform Gamma (identifier: Q9UKF5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     763-787: VTPSQSQPRVMPSQSQPPVMPSQSH → QNLFLFSFSISDCVLNFRLLYLQAT
     788-820: Missing.

Show »
Length:787
Mass (Da):89,460
Checksum:i2B0E5E7C496B8C9D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196H → Y in AAF22163 (PubMed:10644455).Curated1
Sequence conflicti744P → H in AAF22163 (PubMed:10644455).Curated1
Sequence conflicti748S → Y in AAF22163 (PubMed:10644455).Curated1
Sequence conflicti753Q → R in AAF03777 (PubMed:10512762).Curated1
Sequence conflicti764T → M in AAF03777 (PubMed:10512762).Curated1
Sequence conflicti769 – 773QPRVM → HPQLT in AAF03777 (PubMed:10512762).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03614831P → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs544557652dbSNPEnsembl.1
Natural variantiVAR_06632272L → F in a melanoma cell line. 1 Publication1
Natural variantiVAR_06632389I → M in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_066324111E → K in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 PublicationCorresponds to variant rs267600087dbSNPEnsembl.1
Natural variantiVAR_066325112S → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication1
Natural variantiVAR_066326115S → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication1
Natural variantiVAR_066327131D → N in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_066328176E → K in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_036149205V → I in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs772388824dbSNPEnsembl.1
Natural variantiVAR_066329234S → F in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_066330257I → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 PublicationCorresponds to variant rs140083180dbSNPEnsembl.1
Natural variantiVAR_066331305G → E in a cutaneous metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant rs267600089dbSNPEnsembl.1
Natural variantiVAR_066332345D → N in a cutaneous metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant rs267600090dbSNPEnsembl.1
Natural variantiVAR_066333403G → D in a cutaneous metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant rs150047888dbSNPEnsembl.1
Natural variantiVAR_066334434G → D in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 PublicationCorresponds to variant rs267600091dbSNPEnsembl.1
Natural variantiVAR_066335503E → K in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication1
Natural variantiVAR_066336533H → Y in a cutaneous metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant rs267600093dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005491750 – 803Missing in isoform Beta. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_005492763 – 787VTPSQ…PSQSH → QNLFLFSFSISDCVLNFRLL YLQAT in isoform Gamma. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_005493788 – 820Missing in isoform Gamma. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171929 mRNA. Translation: AAF03777.1.
AF171930 mRNA. Translation: AAF03778.1.
AF171931 mRNA. Translation: AAF03779.1.
AF134708 mRNA. Translation: AAF22163.1.
AK292410 mRNA. Translation: BAF85099.1.
AC105914 Genomic DNA. Translation: AAY41055.1.
CH471056 Genomic DNA. Translation: EAX04727.1.
CH471056 Genomic DNA. Translation: EAX04728.1.
CCDSiCCDS3823.1. [Q9UKF5-1]
RefSeqiNP_001124175.1. NM_001130703.1. [Q9UKF5-1]
NP_001124176.1. NM_001130704.1. [Q9UKF5-1]
NP_001124177.1. NM_001130705.1. [Q9UKF5-1]
NP_001265054.1. NM_001278125.1. [Q9UKF5-1]
NP_001265055.1. NM_001278126.1. [Q9UKF5-1]
NP_001265056.1. NM_001278127.1. [Q9UKF5-1]
NP_055084.3. NM_014269.4. [Q9UKF5-1]
XP_011529858.1. XM_011531556.1. [Q9UKF5-1]
XP_011529859.1. XM_011531557.1. [Q9UKF5-1]
XP_011529861.1. XM_011531559.1. [Q9UKF5-1]
XP_011529862.1. XM_011531560.1. [Q9UKF5-1]
XP_011529863.1. XM_011531561.1. [Q9UKF5-1]
UniGeneiHs.126838.

Genome annotation databases

EnsembliENST00000359240; ENSP00000352177; ENSG00000168594. [Q9UKF5-1]
ENST00000404450; ENSP00000384229; ENSG00000168594. [Q9UKF5-1]
ENST00000445694; ENSP00000414544; ENSG00000168594. [Q9UKF5-1]
ENST00000514159; ENSP00000423517; ENSG00000168594. [Q9UKF5-1]
ENST00000615367; ENSP00000484862; ENSG00000168594. [Q9UKF5-1]
ENST00000618444; ENSP00000478469; ENSG00000168594. [Q9UKF5-1]
GeneIDi11086.
KEGGihsa:11086.
UCSCiuc003iuc.3. human. [Q9UKF5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171929 mRNA. Translation: AAF03777.1.
AF171930 mRNA. Translation: AAF03778.1.
AF171931 mRNA. Translation: AAF03779.1.
AF134708 mRNA. Translation: AAF22163.1.
AK292410 mRNA. Translation: BAF85099.1.
AC105914 Genomic DNA. Translation: AAY41055.1.
CH471056 Genomic DNA. Translation: EAX04727.1.
CH471056 Genomic DNA. Translation: EAX04728.1.
CCDSiCCDS3823.1. [Q9UKF5-1]
RefSeqiNP_001124175.1. NM_001130703.1. [Q9UKF5-1]
NP_001124176.1. NM_001130704.1. [Q9UKF5-1]
NP_001124177.1. NM_001130705.1. [Q9UKF5-1]
NP_001265054.1. NM_001278125.1. [Q9UKF5-1]
NP_001265055.1. NM_001278126.1. [Q9UKF5-1]
NP_001265056.1. NM_001278127.1. [Q9UKF5-1]
NP_055084.3. NM_014269.4. [Q9UKF5-1]
XP_011529858.1. XM_011531556.1. [Q9UKF5-1]
XP_011529859.1. XM_011531557.1. [Q9UKF5-1]
XP_011529861.1. XM_011531559.1. [Q9UKF5-1]
XP_011529862.1. XM_011531560.1. [Q9UKF5-1]
XP_011529863.1. XM_011531561.1. [Q9UKF5-1]
UniGeneiHs.126838.

3D structure databases

ProteinModelPortaliQ9UKF5.
SMRiQ9UKF5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-252736.
STRINGi9606.ENSP00000352177.

Protein family/group databases

MEROPSiM12.981.

PTM databases

PhosphoSitePlusiQ9UKF5.

Polymorphism and mutation databases

BioMutaiADAM29.
DMDMi145559438.

Proteomic databases

PaxDbiQ9UKF5.
PeptideAtlasiQ9UKF5.
PRIDEiQ9UKF5.

Protocols and materials databases

DNASUi11086.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359240; ENSP00000352177; ENSG00000168594. [Q9UKF5-1]
ENST00000404450; ENSP00000384229; ENSG00000168594. [Q9UKF5-1]
ENST00000445694; ENSP00000414544; ENSG00000168594. [Q9UKF5-1]
ENST00000514159; ENSP00000423517; ENSG00000168594. [Q9UKF5-1]
ENST00000615367; ENSP00000484862; ENSG00000168594. [Q9UKF5-1]
ENST00000618444; ENSP00000478469; ENSG00000168594. [Q9UKF5-1]
GeneIDi11086.
KEGGihsa:11086.
UCSCiuc003iuc.3. human. [Q9UKF5-1]

Organism-specific databases

CTDi11086.
DisGeNETi11086.
GeneCardsiADAM29.
HGNCiHGNC:207. ADAM29.
HPAiHPA014159.
MIMi604778. gene.
neXtProtiNX_Q9UKF5.
OpenTargetsiENSG00000168594.
PharmGKBiPA24524.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
GeneTreeiENSGT00760000118888.
HOGENOMiHOG000230883.
HOVERGENiHBG006978.
InParanoidiQ9UKF5.
KOiK16069.
OMAiKDPCCLS.
OrthoDBiEOG091G03BZ.
PhylomeDBiQ9UKF5.
TreeFamiTF314733.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168594-MONOMER.

Miscellaneous databases

ChiTaRSiADAM29. human.
GenomeRNAii11086.
PROiQ9UKF5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168594.
CleanExiHS_ADAM29.
ExpressionAtlasiQ9UKF5. baseline and differential.
GenevisibleiQ9UKF5. HS.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADA29_HUMAN
AccessioniPrimary (citable) accession number: Q9UKF5
Secondary accession number(s): Q4W5F3
, Q9UHP1, Q9UKF3, Q9UKF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: April 17, 2007
Last modified: November 2, 2016
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.