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Q9UKF5

- ADA29_HUMAN

UniProt

Q9UKF5 - ADA29_HUMAN

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Protein
Disintegrin and metalloproteinase domain-containing protein 29
Gene
ADAM29
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.

GO - Molecular functioni

  1. metalloendopeptidase activity Source: InterPro
  2. metallopeptidase activity Source: ProtInc
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. spermatogenesis Source: ProtInc
Complete GO annotation...

Protein family/group databases

MEROPSiM12.981.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 29
Short name:
ADAM 29
Alternative name(s):
Cancer/testis antigen 73
Short name:
CT73
Gene namesi
Name:ADAM29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:207. ADAM29.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini194 – 674481Extracellular Reviewed prediction
Add
BLAST
Transmembranei675 – 69521Helical; Reviewed prediction
Add
BLAST
Topological domaini696 – 820125Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis.

Organism-specific databases

PharmGKBiPA24524.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Propeptidei19 – 193175 By similarity
PRO_0000029134Add
BLAST
Chaini194 – 820627Disintegrin and metalloproteinase domain-containing protein 29
PRO_0000029135Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi217 – 2171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi307 ↔ 384 By similarity
Glycosylationi320 – 3201N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi347 ↔ 369 By similarity
Disulfide bondi349 ↔ 354 By similarity
Glycosylationi368 – 3681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi428 – 4281N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi455 ↔ 475 By similarity
Glycosylationi469 – 4691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi538 – 5381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi545 – 5451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi558 – 5581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi564 – 5641N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi625 ↔ 636 By similarity
Disulfide bondi630 ↔ 642 By similarity
Disulfide bondi644 ↔ 653 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9UKF5.
PaxDbiQ9UKF5.
PRIDEiQ9UKF5.

PTM databases

PhosphoSiteiQ9UKF5.

Expressioni

Tissue specificityi

Expressed specifically in testes.

Gene expression databases

ArrayExpressiQ9UKF5.
BgeeiQ9UKF5.
CleanExiHS_ADAM29.
GenevestigatoriQ9UKF5.

Organism-specific databases

HPAiHPA014159.

Interactioni

Protein-protein interaction databases

MINTiMINT-252736.
STRINGi9606.ENSP00000352177.

Structurei

3D structure databases

ProteinModelPortaliQ9UKF5.
SMRiQ9UKF5. Positions 197-618, 629-655.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini198 – 390193Peptidase M12B
Add
BLAST
Domaini397 – 48387Disintegrin
Add
BLAST
Domaini625 – 65430EGF-like
Add
BLAST
Repeati739 – 74791
Repeati748 – 75692
Repeati757 – 76593
Repeati766 – 77494
Repeati775 – 78395
Repeati784 – 79296
Repeati793 – 80197
Repeati802 – 81098
Repeati811 – 81999

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni739 – 819819 X 9 AA approximate repeats
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi484 – 624141Cys-rich
Add
BLAST
Compositional biasi669 – 6757Poly-Lys

Sequence similaritiesi

Contains 1 disintegrin domain.
Contains 1 EGF-like domain.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG297875.
HOGENOMiHOG000230883.
HOVERGENiHBG006978.
InParanoidiQ9UKF5.
KOiK16069.
OMAiSCAIVTF.
OrthoDBiEOG7KWSGW.
PhylomeDBiQ9UKF5.
TreeFamiTF314733.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform Alpha (identifier: Q9UKF5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKMLLLLHCL GVFLSCSGHI QDEHPQYHSP PDVVIPVRIT GTTRGMTPPG    50
WLSYILPFGG QKHIIHIKVK KLLFSKHLPV FTYTDQGAIL EDQPFVQNNC 100
YYHGYVEGDP ESLVSLSTCF GGFQGILQIN DFAYEIKPLA FSTTFEHLVY 150
KMDSEEKQFS TMRSGFMQNE ITCRMEFEEI DNSTQKQSSY VGWWIHFRIV 200
EIVVVIDNYL YIRYERNDSK LLEDLYVIVN IVDSILDVIG VKVLLFGLEI 250
WTNKNLIVVD DVRKSVHLYC KWKSENITPR MQHDTSHLFT TLGLRGLSGI 300
GAFRGMCTPH RSCAIVTFMN KTLGTFSIAV AHHLGHNLGM NHDEDTCRCS 350
QPRCIMHEGN PPITKFSNCS YGDFWEYTVE RTKCLLETVH TKDIFNVKRC 400
GNGVVEEGEE CDCGPLKHCA KDPCCLSNCT LTDGSTCAFG LCCKDCKFLP 450
SGKVCRKEVN ECDLPEWCNG TSHKCPDDFY VEDGIPCKER GYCYEKSCHD 500
RNEQCRRIFG AGANTASETC YKELNTLGDR VGHCGIKNAT YIKCNISDVQ 550
CGRIQCENVT EIPNMSDHTT VHWARFNDIM CWSTDYHLGM KGPDIGEVKD 600
GTECGIDHIC IHRHCVHITI LNSNCSPAFC NKRGICNNKH HCHCNYLWDP 650
PNCLIKGYGG SVDSGPPPKR KKKKKFCYLC ILLLIVLFIL LCCLYRLCKK 700
SKPIKKQQDV QTPSAKEEEK IQRRPHELPP QSQPWVMPSQ SQPPVTPSQS 750
HPQVMPSQSQ PPVTPSQSQP RVMPSQSQPP VMPSQSHPQL TPSQSQPPVT 800
PSQRQPQLMP SQSQPPVTPS 820
Length:820
Mass (Da):92,759
Last modified:April 17, 2007 - v3
Checksum:iAA2FB11342A884C9
GO
Isoform Beta (identifier: Q9UKF5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     750-803: Missing.

Show »
Length:766
Mass (Da):86,983
Checksum:iACA4BEDFA700ABA5
GO
Isoform Gamma (identifier: Q9UKF5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     763-787: VTPSQSQPRVMPSQSQPPVMPSQSH → QNLFLFSFSISDCVLNFRLLYLQAT
     788-820: Missing.

Show »
Length:787
Mass (Da):89,460
Checksum:i2B0E5E7C496B8C9D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311P → L in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036148
Natural varianti72 – 721L → F in a melanoma cell line. 1 Publication
VAR_066322
Natural varianti89 – 891I → M in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066323
Natural varianti111 – 1111E → K in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication
VAR_066324
Natural varianti112 – 1121S → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication
VAR_066325
Natural varianti115 – 1151S → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication
VAR_066326
Natural varianti131 – 1311D → N in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066327
Natural varianti176 – 1761E → K in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066328
Natural varianti205 – 2051V → I in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036149
Natural varianti234 – 2341S → F in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066329
Natural varianti257 – 2571I → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication
VAR_066330
Natural varianti305 – 3051G → E in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066331
Natural varianti345 – 3451D → N in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066332
Natural varianti403 – 4031G → D in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066333
Natural varianti434 – 4341G → D in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication
VAR_066334
Natural varianti503 – 5031E → K in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. 1 Publication
VAR_066335
Natural varianti533 – 5331H → Y in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication
VAR_066336

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei750 – 80354Missing in isoform Beta.
VSP_005491Add
BLAST
Alternative sequencei763 – 78725VTPSQ…PSQSH → QNLFLFSFSISDCVLNFRLL YLQAT in isoform Gamma.
VSP_005492Add
BLAST
Alternative sequencei788 – 82033Missing in isoform Gamma.
VSP_005493Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti196 – 1961H → Y in AAF22163. 1 Publication
Sequence conflicti744 – 7441P → H in AAF22163. 1 Publication
Sequence conflicti748 – 7481S → Y in AAF22163. 1 Publication
Sequence conflicti753 – 7531Q → R in AAF03777. 1 Publication
Sequence conflicti764 – 7641T → M in AAF03777. 1 Publication
Sequence conflicti769 – 7735QPRVM → HPQLT in AAF03777. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF171929 mRNA. Translation: AAF03777.1.
AF171930 mRNA. Translation: AAF03778.1.
AF171931 mRNA. Translation: AAF03779.1.
AF134708 mRNA. Translation: AAF22163.1.
AK292410 mRNA. Translation: BAF85099.1.
AC105914 Genomic DNA. Translation: AAY41055.1.
CH471056 Genomic DNA. Translation: EAX04727.1.
CH471056 Genomic DNA. Translation: EAX04728.1.
CCDSiCCDS3823.1. [Q9UKF5-1]
RefSeqiNP_001124175.1. NM_001130703.1. [Q9UKF5-1]
NP_001124176.1. NM_001130704.1. [Q9UKF5-1]
NP_001124177.1. NM_001130705.1. [Q9UKF5-1]
NP_001265054.1. NM_001278125.1. [Q9UKF5-1]
NP_001265055.1. NM_001278126.1. [Q9UKF5-1]
NP_001265056.1. NM_001278127.1. [Q9UKF5-1]
NP_055084.3. NM_014269.4. [Q9UKF5-1]
XP_005262761.1. XM_005262704.1. [Q9UKF5-1]
XP_005262762.1. XM_005262705.2. [Q9UKF5-1]
UniGeneiHs.126838.

Genome annotation databases

EnsembliENST00000359240; ENSP00000352177; ENSG00000168594. [Q9UKF5-1]
ENST00000404450; ENSP00000384229; ENSG00000168594. [Q9UKF5-1]
ENST00000445694; ENSP00000414544; ENSG00000168594. [Q9UKF5-1]
ENST00000514159; ENSP00000423517; ENSG00000168594. [Q9UKF5-1]
GeneIDi11086.
KEGGihsa:11086.
UCSCiuc003iuc.3. human. [Q9UKF5-1]

Polymorphism databases

DMDMi145559438.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF171929 mRNA. Translation: AAF03777.1 .
AF171930 mRNA. Translation: AAF03778.1 .
AF171931 mRNA. Translation: AAF03779.1 .
AF134708 mRNA. Translation: AAF22163.1 .
AK292410 mRNA. Translation: BAF85099.1 .
AC105914 Genomic DNA. Translation: AAY41055.1 .
CH471056 Genomic DNA. Translation: EAX04727.1 .
CH471056 Genomic DNA. Translation: EAX04728.1 .
CCDSi CCDS3823.1. [Q9UKF5-1 ]
RefSeqi NP_001124175.1. NM_001130703.1. [Q9UKF5-1 ]
NP_001124176.1. NM_001130704.1. [Q9UKF5-1 ]
NP_001124177.1. NM_001130705.1. [Q9UKF5-1 ]
NP_001265054.1. NM_001278125.1. [Q9UKF5-1 ]
NP_001265055.1. NM_001278126.1. [Q9UKF5-1 ]
NP_001265056.1. NM_001278127.1. [Q9UKF5-1 ]
NP_055084.3. NM_014269.4. [Q9UKF5-1 ]
XP_005262761.1. XM_005262704.1. [Q9UKF5-1 ]
XP_005262762.1. XM_005262705.2. [Q9UKF5-1 ]
UniGenei Hs.126838.

3D structure databases

ProteinModelPortali Q9UKF5.
SMRi Q9UKF5. Positions 197-618, 629-655.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-252736.
STRINGi 9606.ENSP00000352177.

Protein family/group databases

MEROPSi M12.981.

PTM databases

PhosphoSitei Q9UKF5.

Polymorphism databases

DMDMi 145559438.

Proteomic databases

MaxQBi Q9UKF5.
PaxDbi Q9UKF5.
PRIDEi Q9UKF5.

Protocols and materials databases

DNASUi 11086.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359240 ; ENSP00000352177 ; ENSG00000168594 . [Q9UKF5-1 ]
ENST00000404450 ; ENSP00000384229 ; ENSG00000168594 . [Q9UKF5-1 ]
ENST00000445694 ; ENSP00000414544 ; ENSG00000168594 . [Q9UKF5-1 ]
ENST00000514159 ; ENSP00000423517 ; ENSG00000168594 . [Q9UKF5-1 ]
GeneIDi 11086.
KEGGi hsa:11086.
UCSCi uc003iuc.3. human. [Q9UKF5-1 ]

Organism-specific databases

CTDi 11086.
GeneCardsi GC04P175751.
HGNCi HGNC:207. ADAM29.
HPAi HPA014159.
MIMi 604778. gene.
neXtProti NX_Q9UKF5.
PharmGKBi PA24524.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG297875.
HOGENOMi HOG000230883.
HOVERGENi HBG006978.
InParanoidi Q9UKF5.
KOi K16069.
OMAi SCAIVTF.
OrthoDBi EOG7KWSGW.
PhylomeDBi Q9UKF5.
TreeFami TF314733.

Miscellaneous databases

ChiTaRSi ADAM29. human.
GenomeRNAii 11086.
NextBioi 42152.
PROi Q9UKF5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UKF5.
Bgeei Q9UKF5.
CleanExi HS_ADAM29.
Genevestigatori Q9UKF5.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProi IPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view ]
Pfami PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view ]
PRINTSi PR00289. DISINTEGRIN.
SMARTi SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view ]
SUPFAMi SSF57552. SSF57552. 1 hit.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show testis-specific gene expression."
    Cerretti D.P., DuBose R.F., Black R.A., Nelson N.
    Biochem. Biophys. Res. Commun. 263:810-815(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA; BETA AND GAMMA).
    Tissue: Testis.
  2. "Molecular cloning and mapping of a novel ADAM gene (ADAM29) to human chromosome 4."
    Xu R., Cai J., Xu T., Zhou W., Ying B., Deng K., Zhao S., Li C.
    Genomics 62:537-539(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
    Tissue: Testis.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma."
    Wei X., Moncada-Pazos A., Cal S., Soria-Valles C., Gartner J., Rudloff U., Lin J.C., Rosenberg S.A., Lopez-Otin C., Samuels Y.
    Hum. Mutat. 32:E2148-E2175(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN CUTANEOUS MELANOMA, VARIANTS PHE-72; MET-89; LYS-111; PHE-112; PHE-115; ASN-131; LYS-176; PHE-234; PHE-257; GLU-305; ASN-345; ASP-403; ASP-434; LYS-503 AND TYR-533, CHARACTERIZATION OF VARIANTS LYS-111; PHE-112; PHE-115; PHE-257; ASP-434 AND LYS-503.
  7. Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-31 AND ILE-205.

Entry informationi

Entry nameiADA29_HUMAN
AccessioniPrimary (citable) accession number: Q9UKF5
Secondary accession number(s): Q4W5F3
, Q9UHP1, Q9UKF3, Q9UKF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: April 17, 2007
Last modified: July 9, 2014
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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