Q9UKF5 (ADA29_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Disintegrin and metalloproteinase domain-containing protein 29
Short name=ADAM 29

Alternative name(s):
Cancer/testis antigen 73
Short name=CT73

Gene names

Name:

ADAM29

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	820 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Expressed specifically in testes.
Involvement in disease	Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis.
Sequence similarities	Contains 1 disintegrin domain. Contains 1 EGF-like domain. Contains 1 peptidase M12B domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: InterPro spermatogenesis Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro metallopeptidase activity Traceable author statement Ref.1. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform Alpha (identifier: Q9UKF5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Beta (identifier: Q9UKF5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     750-803: Missing.

Isoform Gamma (identifier: Q9UKF5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     763-787: VTPSQSQPRVMPSQSQPPVMPSQSH → QNLFLFSFSISDCVLNFRLLYLQAT
     788-820: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 193	175	By similarity		PRO_0000029134
	Chain	194 – 820	627	Disintegrin and metalloproteinase domain-containing protein 29		PRO_0000029135
Regions
	Topological domain	194 – 674	481	Extracellular Potential
	Transmembrane	675 – 695	21	Helical; Potential
	Topological domain	696 – 820	125	Cytoplasmic Potential
	Domain	198 – 390	193	Peptidase M12B
	Domain	397 – 483	87	Disintegrin
	Domain	625 – 654	30	EGF-like
	Repeat	739 – 747	9	1
	Repeat	748 – 756	9	2
	Repeat	757 – 765	9	3
	Repeat	766 – 774	9	4
	Repeat	775 – 783	9	5
	Repeat	784 – 792	9	6
	Repeat	793 – 801	9	7
	Repeat	802 – 810	9	8
	Repeat	811 – 819	9	9
	Region	739 – 819	81	9 X 9 AA approximate repeats
	Compositional bias	484 – 624	141	Cys-rich
	Compositional bias	669 – 675	7	Poly-Lys
Amino acid modifications
	Glycosylation	217	1	N-linked (GlcNAc...) Potential
	Glycosylation	320	1	N-linked (GlcNAc...) Potential
	Glycosylation	368	1	N-linked (GlcNAc...) Potential
	Glycosylation	428	1	N-linked (GlcNAc...) Potential
	Glycosylation	469	1	N-linked (GlcNAc...) Potential
	Glycosylation	538	1	N-linked (GlcNAc...) Potential
	Glycosylation	545	1	N-linked (GlcNAc...) Potential
	Glycosylation	558	1	N-linked (GlcNAc...) Potential
	Glycosylation	564	1	N-linked (GlcNAc...) Potential
	Disulfide bond	307 ↔ 384		By similarity
	Disulfide bond	347 ↔ 369		By similarity
	Disulfide bond	349 ↔ 354		By similarity
	Disulfide bond	455 ↔ 475		By similarity
	Disulfide bond	625 ↔ 636		By similarity
	Disulfide bond	630 ↔ 642		By similarity
	Disulfide bond	644 ↔ 653		By similarity
Natural variations
	Alternative sequence	750 – 803	54	Missing in isoform Beta.		VSP_005491
	Alternative sequence	763 – 787	25	VTPSQ…PSQSH → QNLFLFSFSISDCVLNFRLL YLQAT in isoform Gamma.		VSP_005492
	Alternative sequence	788 – 820	33	Missing in isoform Gamma.		VSP_005493
	Natural variant	31	1	P → L in a colorectal cancer sample; somatic mutation. Ref.7		VAR_036148
	Natural variant	72	1	L → F in a melanoma cell line. Ref.6		VAR_066322
	Natural variant	89	1	I → M in a cutaneous metastatic melanoma sample; somatic mutation. Ref.6		VAR_066323
	Natural variant	111	1	E → K in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. Ref.6		VAR_066324
	Natural variant	112	1	S → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. Ref.6		VAR_066325
	Natural variant	115	1	S → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. Ref.6		VAR_066326
	Natural variant	131	1	D → N in a cutaneous metastatic melanoma sample; somatic mutation. Ref.6		VAR_066327
	Natural variant	176	1	E → K in a cutaneous metastatic melanoma sample; somatic mutation. Ref.6		VAR_066328
	Natural variant	205	1	V → I in a colorectal cancer sample; somatic mutation. Ref.7		VAR_036149
	Natural variant	234	1	S → F in a cutaneous metastatic melanoma sample; somatic mutation. Ref.6		VAR_066329
	Natural variant	257	1	I → F in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. Ref.6		VAR_066330
	Natural variant	305	1	G → E in a cutaneous metastatic melanoma sample; somatic mutation. Ref.6		VAR_066331
	Natural variant	345	1	D → N in a cutaneous metastatic melanoma sample; somatic mutation. Ref.6		VAR_066332
	Natural variant	403	1	G → D in a cutaneous metastatic melanoma sample; somatic mutation. Ref.6		VAR_066333
	Natural variant	434	1	G → D in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. Ref.6		VAR_066334
	Natural variant	503	1	E → K in a cutaneous metastatic melanoma sample; somatic mutation; increases the adhesion of melanoma cells to collagens I and IV. Ref.6		VAR_066335
	Natural variant	533	1	H → Y in a cutaneous metastatic melanoma sample; somatic mutation. Ref.6		VAR_066336
Experimental info
	Sequence conflict	196	1	H → Y in AAF22163. Ref.2
	Sequence conflict	744	1	P → H in AAF22163. Ref.2
	Sequence conflict	748	1	S → Y in AAF22163. Ref.2
	Sequence conflict	753	1	Q → R in AAF03777. Ref.1
	Sequence conflict	764	1	T → M in AAF03777. Ref.1
	Sequence conflict	769 – 773	5	QPRVM → HPQLT in AAF03777. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform Alpha [UniParc]. Last modified April 17, 2007. Version 3. Checksum: AA2FB11342A884C9	FASTA	820	92,759
	10 20 30 40 50 60 MKMLLLLHCL GVFLSCSGHI QDEHPQYHSP PDVVIPVRIT GTTRGMTPPG WLSYILPFGG 70 80 90 100 110 120 QKHIIHIKVK KLLFSKHLPV FTYTDQGAIL EDQPFVQNNC YYHGYVEGDP ESLVSLSTCF 130 140 150 160 170 180 GGFQGILQIN DFAYEIKPLA FSTTFEHLVY KMDSEEKQFS TMRSGFMQNE ITCRMEFEEI 190 200 210 220 230 240 DNSTQKQSSY VGWWIHFRIV EIVVVIDNYL YIRYERNDSK LLEDLYVIVN IVDSILDVIG 250 260 270 280 290 300 VKVLLFGLEI WTNKNLIVVD DVRKSVHLYC KWKSENITPR MQHDTSHLFT TLGLRGLSGI 310 320 330 340 350 360 GAFRGMCTPH RSCAIVTFMN KTLGTFSIAV AHHLGHNLGM NHDEDTCRCS QPRCIMHEGN 370 380 390 400 410 420 PPITKFSNCS YGDFWEYTVE RTKCLLETVH TKDIFNVKRC GNGVVEEGEE CDCGPLKHCA 430 440 450 460 470 480 KDPCCLSNCT LTDGSTCAFG LCCKDCKFLP SGKVCRKEVN ECDLPEWCNG TSHKCPDDFY 490 500 510 520 530 540 VEDGIPCKER GYCYEKSCHD RNEQCRRIFG AGANTASETC YKELNTLGDR VGHCGIKNAT 550 560 570 580 590 600 YIKCNISDVQ CGRIQCENVT EIPNMSDHTT VHWARFNDIM CWSTDYHLGM KGPDIGEVKD 610 620 630 640 650 660 GTECGIDHIC IHRHCVHITI LNSNCSPAFC NKRGICNNKH HCHCNYLWDP PNCLIKGYGG 670 680 690 700 710 720 SVDSGPPPKR KKKKKFCYLC ILLLIVLFIL LCCLYRLCKK SKPIKKQQDV QTPSAKEEEK 730 740 750 760 770 780 IQRRPHELPP QSQPWVMPSQ SQPPVTPSQS HPQVMPSQSQ PPVTPSQSQP RVMPSQSQPP 790 800 810 820 VMPSQSHPQL TPSQSQPPVT PSQRQPQLMP SQSQPPVTPS
	Isoform Beta [UniParc]. Checksum: ACA4BEDFA700ABA5	FASTA	766	86,983
	10 20 30 40 50 60 MKMLLLLHCL GVFLSCSGHI QDEHPQYHSP PDVVIPVRIT GTTRGMTPPG WLSYILPFGG 70 80 90 100 110 120 QKHIIHIKVK KLLFSKHLPV FTYTDQGAIL EDQPFVQNNC YYHGYVEGDP ESLVSLSTCF 130 140 150 160 170 180 GGFQGILQIN DFAYEIKPLA FSTTFEHLVY KMDSEEKQFS TMRSGFMQNE ITCRMEFEEI 190 200 210 220 230 240 DNSTQKQSSY VGWWIHFRIV EIVVVIDNYL YIRYERNDSK LLEDLYVIVN IVDSILDVIG 250 260 270 280 290 300 VKVLLFGLEI WTNKNLIVVD DVRKSVHLYC KWKSENITPR MQHDTSHLFT TLGLRGLSGI 310 320 330 340 350 360 GAFRGMCTPH RSCAIVTFMN KTLGTFSIAV AHHLGHNLGM NHDEDTCRCS QPRCIMHEGN 370 380 390 400 410 420 PPITKFSNCS YGDFWEYTVE RTKCLLETVH TKDIFNVKRC GNGVVEEGEE CDCGPLKHCA 430 440 450 460 470 480 KDPCCLSNCT LTDGSTCAFG LCCKDCKFLP SGKVCRKEVN ECDLPEWCNG TSHKCPDDFY 490 500 510 520 530 540 VEDGIPCKER GYCYEKSCHD RNEQCRRIFG AGANTASETC YKELNTLGDR VGHCGIKNAT 550 560 570 580 590 600 YIKCNISDVQ CGRIQCENVT EIPNMSDHTT VHWARFNDIM CWSTDYHLGM KGPDIGEVKD 610 620 630 640 650 660 GTECGIDHIC IHRHCVHITI LNSNCSPAFC NKRGICNNKH HCHCNYLWDP PNCLIKGYGG 670 680 690 700 710 720 SVDSGPPPKR KKKKKFCYLC ILLLIVLFIL LCCLYRLCKK SKPIKKQQDV QTPSAKEEEK 730 740 750 760 IQRRPHELPP QSQPWVMPSQ SQPPVTPSQR QPQLMPSQSQ PPVTPS
	Isoform Gamma [UniParc]. Checksum: 2B0E5E7C496B8C9D	FASTA	787	89,460
	10 20 30 40 50 60 MKMLLLLHCL GVFLSCSGHI QDEHPQYHSP PDVVIPVRIT GTTRGMTPPG WLSYILPFGG 70 80 90 100 110 120 QKHIIHIKVK KLLFSKHLPV FTYTDQGAIL EDQPFVQNNC YYHGYVEGDP ESLVSLSTCF 130 140 150 160 170 180 GGFQGILQIN DFAYEIKPLA FSTTFEHLVY KMDSEEKQFS TMRSGFMQNE ITCRMEFEEI 190 200 210 220 230 240 DNSTQKQSSY VGWWIHFRIV EIVVVIDNYL YIRYERNDSK LLEDLYVIVN IVDSILDVIG 250 260 270 280 290 300 VKVLLFGLEI WTNKNLIVVD DVRKSVHLYC KWKSENITPR MQHDTSHLFT TLGLRGLSGI 310 320 330 340 350 360 GAFRGMCTPH RSCAIVTFMN KTLGTFSIAV AHHLGHNLGM NHDEDTCRCS QPRCIMHEGN 370 380 390 400 410 420 PPITKFSNCS YGDFWEYTVE RTKCLLETVH TKDIFNVKRC GNGVVEEGEE CDCGPLKHCA 430 440 450 460 470 480 KDPCCLSNCT LTDGSTCAFG LCCKDCKFLP SGKVCRKEVN ECDLPEWCNG TSHKCPDDFY 490 500 510 520 530 540 VEDGIPCKER GYCYEKSCHD RNEQCRRIFG AGANTASETC YKELNTLGDR VGHCGIKNAT 550 560 570 580 590 600 YIKCNISDVQ CGRIQCENVT EIPNMSDHTT VHWARFNDIM CWSTDYHLGM KGPDIGEVKD 610 620 630 640 650 660 GTECGIDHIC IHRHCVHITI LNSNCSPAFC NKRGICNNKH HCHCNYLWDP PNCLIKGYGG 670 680 690 700 710 720 SVDSGPPPKR KKKKKFCYLC ILLLIVLFIL LCCLYRLCKK SKPIKKQQDV QTPSAKEEEK 730 740 750 760 770 780 IQRRPHELPP QSQPWVMPSQ SQPPVTPSQS HPQVMPSQSQ PPQNLFLFSF SISDCVLNFR LLYLQAT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show testis-specific gene expression." Cerretti D.P., DuBose R.F., Black R.A., Nelson N. Biochem. Biophys. Res. Commun. 263:810-815(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA; BETA AND GAMMA). Tissue: Testis.
[2]	"Molecular cloning and mapping of a novel ADAM gene (ADAM29) to human chromosome 4." Xu R., Cai J., Xu T., Zhou W., Ying B., Deng K., Zhao S., Li C. Genomics 62:537-539(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA). Tissue: Testis.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA). Tissue: Testis.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma." Wei X., Moncada-Pazos A., Cal S., Soria-Valles C., Gartner J., Rudloff U., Lin J.C., Rosenberg S.A., Lopez-Otin C., Samuels Y. Hum. Mutat. 32:E2148-E2175(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN CUTANEOUS MELANOMA, VARIANTS PHE-72; MET-89; LYS-111; PHE-112; PHE-115; ASN-131; LYS-176; PHE-234; PHE-257; GLU-305; ASN-345; ASP-403; ASP-434; LYS-503 AND TYR-533, CHARACTERIZATION OF VARIANTS LYS-111; PHE-112; PHE-115; PHE-257; ASP-434 AND LYS-503.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-31 AND ILE-205.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF171929 mRNA. Translation: AAF03777.1. AF171930 mRNA. Translation: AAF03778.1. AF171931 mRNA. Translation: AAF03779.1. AF134708 mRNA. Translation: AAF22163.1. AK292410 mRNA. Translation: BAF85099.1. AC105914 Genomic DNA. Translation: AAY41055.1. CH471056 Genomic DNA. Translation: EAX04727.1. CH471056 Genomic DNA. Translation: EAX04728.1.
IPI	IPI00029112. IPI00029113. IPI00289829.
RefSeq	NP_001124175.1. NM_001130703.1. NP_001124176.1. NM_001130704.1. NP_001124177.1. NM_001130705.1. NP_055084.3. NM_014269.4.
UniGene	Hs.126838.
3D structure databases
ProteinModelPortal	Q9UKF5.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-252736.
STRING	9606.ENSP00000352177.
Protein family/group databases
MEROPS	M12.981.
PTM databases
PhosphoSite	Q9UKF5.
Polymorphism databases
DMDM	145559438.
Proteomic databases
PaxDb	Q9UKF5.
PRIDE	Q9UKF5.
Protocols and materials databases
DNASU	11086.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359240; ENSP00000352177; ENSG00000168594. ENST00000404450; ENSP00000384229; ENSG00000168594. ENST00000445694; ENSP00000414544; ENSG00000168594. ENST00000514159; ENSP00000423517; ENSG00000168594.
GeneID	11086.
KEGG	hsa:11086.
UCSC	uc003iuc.3. human.
Organism-specific databases
CTD	11086.
GeneCards	GC04P175751.
HGNC	HGNC:207. ADAM29.
HPA	HPA014159.
MIM	604778. gene.
neXtProt	NX_Q9UKF5.
PharmGKB	PA24524.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG297875.
HOGENOM	HOG000230883.
HOVERGEN	HBG006978.
InParanoid	Q9UKF5.
KO	K16069.
OMA	SCAIVTF.
OrthoDB	EOG4XWFX8.
PhylomeDB	Q9UKF5.
Gene expression databases
ArrayExpress	Q9UKF5.
Bgee	Q9UKF5.
CleanEx	HS_ADAM29.
Genevestigator	Q9UKF5.
GermOnline	ENSG00000168594. Homo sapiens.
Family and domain databases
Gene3D	3.40.390.10. 1 hit. 4.10.70.10. 1 hit.
InterPro	IPR006586. ADAM_Cys-rich. IPR001762. Blood-coag_inhib_Disintegrin. IPR018358. Disintegrin_CS. IPR024079. MetalloPept_cat_dom. IPR001590. Peptidase_M12B. IPR002870. Peptidase_M12B_N. [Graphical view]
Pfam	PF08516. ADAM_CR. 1 hit. PF00200. Disintegrin. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit. [Graphical view]
PRINTS	PR00289. DISINTEGRIN.
SMART	SM00608. ACR. 1 hit. SM00050. DISIN. 1 hit. [Graphical view]
SUPFAM	SSF57552. Disintegrin. 1 hit.
PROSITE	PS50215. ADAM_MEPRO. 1 hit. PS00427. DISINTEGRIN_1. 1 hit. PS50214. DISINTEGRIN_2. 1 hit. PS00022. EGF_1. False negative. PS01186. EGF_2. False negative. PS50026. EGF_3. False negative. PS00142. ZINC_PROTEASE. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ADAM29. human.
GenomeRNAi	11086.
NextBio	42152.
SOURCE	Search...

Entry information

Entry name

ADA29_HUMAN

Accession

Primary (citable) accession number: Q9UKF5
Secondary accession number(s): Q4W5F3 , Q9UHP1, Q9UKF3, Q9UKF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	April 17, 2007
Last modified:	May 1, 2013
This is version 121 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.