Q9UKE5 (TNIK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
TRAF2 and NCK-interacting protein kinase
EC=2.7.11.1

Gene names

Name:	TNIK
Synonyms:	KIAA0551

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1360 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Ref.1 Ref.9 Ref.14 Ref.15 Ref.17 Ref.19
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. Ref.1
Subunit structure	Interacts (via the CNH domain) with RAP2A (GTP-bound form preferentially); the interaction is direct and required for the activation of TNIK by RAP2A. Interacts with NEDD4; recruits RAP2A to NEDD4. Interacts with TRAF2 and NCK. Interacts with TCF7L2/TCF4 and CTNNB1; the interaction is direct. Interacts with TANC1. Ref.1 Ref.9 Ref.10 Ref.15 Ref.17
Subcellular location	Nucleus. Cytoplasm. Recycling endosome. Cytoplasm › cytoskeleton. Note: Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression. Ref.9 Ref.14 Ref.15
Tissue specificity	Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues. Ref.1 Ref.15
Post-translational modification	Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction. Ref.1 Ref.9 Ref.15
Sequence similarities	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 CNH domain. Contains 1 protein kinase domain.
Sequence caution	The sequence BAA25477.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Neurogenesis Wnt signaling pathway
Cellular component	Cytoplasm Cytoskeleton Endosome Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW actin cytoskeleton reorganization Inferred from direct assay Ref.9. Source: UniProtKB activation of JNKK activity Inferred from direct assay Ref.9. Source: UniProtKB protein autophosphorylation Inferred from direct assay Ref.1Ref.9. Source: UniProtKB regulation of dendrite morphogenesis Inferred from direct assay Ref.17. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay Ref.9Ref.14. Source: UniProtKB cytoskeleton Inferred from direct assay Ref.9. Source: UniProtKB nucleus Inferred from direct assay Ref.15. Source: UniProtKB recycling endosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Non-traceable author statement. Source: UniProtKB protein serine/threonine kinase activity Inferred from direct assay Ref.1Ref.9. Source: UniProtKB small GTPase regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Tanc1	Q6F6B3	2	EBI-1051794,EBI-2133582	From a different organism.

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UKE5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UKE5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     445-473: Missing.

Isoform 3 (identifier: Q9UKE5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     537-591: Missing.

Isoform 4 (identifier: Q9UKE5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     795-802: Missing.

Isoform 5 (identifier: Q9UKE5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     445-473: Missing.
     537-591: Missing.

Isoform 6 (identifier: Q9UKE5-6)

The sequence of this isoform differs from the canonical sequence as follows:
     445-473: Missing.
     795-802: Missing.

Isoform 7 (identifier: Q9UKE5-7)

The sequence of this isoform differs from the canonical sequence as follows:
     537-591: Missing.
     795-802: Missing.

Isoform 8 (identifier: Q9UKE5-8)

The sequence of this isoform differs from the canonical sequence as follows:
     445-473: Missing.
     537-591: Missing.
     795-802: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1360

1360

TRAF2 and NCK-interacting protein kinase

PRO_0000086761

Regions

Domain

25 – 289

265

Protein kinase

Domain

1047 – 1334

288

CNH

Nucleotide binding

31 – 39

9

ATP By similarity UniProtKB O00506

Region

290 – 1047

758

Mediates interaction with NEDD4

Sites

Active site

153

1

Proton acceptor By similarity UniProtKB O00506

Binding site

54

1

ATP By similarity UniProtKB O00506

Amino acid modifications

Modified residue

326

1

Phosphoserine Ref.20

Modified residue

560

1

Phosphoserine Ref.16

Modified residue

640

1

Phosphoserine Ref.11 Ref.12 Ref.16 Ref.20

Modified residue

678

1

Phosphoserine Ref.13

Modified residue

680

1

Phosphoserine Ref.13

Modified residue

688

1

Phosphoserine Ref.12 Ref.16 Ref.20

Modified residue

707

1

Phosphoserine Ref.16

Modified residue

720

1

Phosphoserine Ref.12 Ref.16

Modified residue

766

1

Phosphoserine Ref.16

Modified residue

769

1

Phosphoserine Ref.8 Ref.11 Ref.12 Ref.16 Ref.20

Modified residue

987

1

Phosphothreonine By similarity

Natural variations

Alternative sequence

445 – 473

29

Missing in isoform 2, isoform 5, isoform 6 and isoform 8. Ref.1

VSP_004889

Alternative sequence

537 – 591

55

Missing in isoform 3, isoform 5, isoform 7 and isoform 8. Ref.1

VSP_004890

Alternative sequence

795 – 802

8

Missing in isoform 4, isoform 6, isoform 7 and isoform 8. Ref.1

VSP_004891

Natural variant

778

1

K → E. Ref.21
Corresponds to variant rs55778284 [ dbSNP | Ensembl ].

VAR_041231

Natural variant

910

1

G → E. Ref.21
Corresponds to variant rs35090763 [ dbSNP | Ensembl ].

VAR_041232

Natural variant

999

1

A → T. Ref.21
Corresponds to variant rs17857452 [ dbSNP | Ensembl ].

VAR_041233

Experimental info

Mutagenesis

54

1

K → A: Kinase dead. Loss of autophosphorylation and loss of function in cytoskeleton regulation. Ref.9 Ref.15

Mutagenesis

152 – 153

2

RD → AA: Loss of autophosphorylation.

Mutagenesis

171 – 172

2

DF → AA: Loss of autophosphorylation.

Secondary structure

1

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1360

Helix Strand Turn

Details...

Turn

22 – 24

3

Beta strand

25 – 34

10

Beta strand

37 – 44

8

Turn

45 – 47

3

Beta strand

50 – 57

8

Helix

64 – 76

13

Beta strand

85 – 91

7

Beta strand

100 – 106

7

Helix

113 – 119

7

Helix

121 – 123

3

Helix

127 – 146

20

Beta strand

158 – 161

4

Beta strand

167 – 169

3

Turn

173 – 175

3

Helix

192 – 194

3

Helix

197 – 200

4

Helix

214 – 228

15

Turn

232 – 235

4

Helix

238 – 247

10

Helix

260 – 269

10

Helix

274 – 276

3

Helix

280 – 284

5

Helix

287 – 290

4

Helix

295 – 311

17

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 3590BC2905A72C3D	FASTA	1,360	154,943
	10 20 30 40 50 60 MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL AAIKVMDVTG 70 80 90 100 110 120 DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKNPPGMDDQ LWLVMEFCGA GSVTDLIKNT 130 140 150 160 170 180 KGNTLKEEWI AYICREILRG LSHLHQHKVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 190 200 210 220 230 240 TVGRRNTFIG TPYWMAPEVI ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR 250 260 270 280 290 300 ALFLIPRNPA PRLKSKKWSK KFQSFIESCL VKNHSQRPAT EQLMKHPFIR DQPNERQVRI 310 320 330 340 350 360 QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EENDSGEPSS ILNLPGESTL RRDFLRLQLA 370 380 390 400 410 420 NKERSEALRR QQLEQQQREN EEHKRQLLAE RQKRIEEQKE QRRRLEEQQR REKELRKQQE 430 440 450 460 470 480 REQRRHYEEQ MRREEERRRA EHEQEYIRRQ LEEEQRQLEI LQQQLLHEQA LLLEYKRKQL 490 500 510 520 530 540 EEQRQAERLQ RQLKQERDYL VSLQHQRQEQ RPVEKKPLYH YKEGMSPSEK PAWAKEVEER 550 560 570 580 590 600 SRLNRQSSPA MPHKVANRIS DPNLPPRSES FSISGVQPAR TPPMLRPVDP QIPHLVAVKS 610 620 630 640 650 660 QGPALTASQS VHEQPTKGLS GFQEALNVTS HRVEMPRQNS DPTSENPPLP TRIEKFDRSS 670 680 690 700 710 720 WLRQEEDIPP KVPQRTTSIS PALARKNSPG NGSALGPRLG SQPIRASNPD LRRTEPILES 730 740 750 760 770 780 PLQRTSSGSS SSSSTPSSQP SSQGGSQPGS QAGSSERTRV RANSKSEGSP VLPHEPAKVK 790 800 810 820 830 840 PEESRDITRP SRPASYKKAI DEDLTALAKE LRELRIEETN RPMKKVTDYS SSSEESESSE 850 860 870 880 890 900 EEEEDGESET HDGTVAVSDI PRLIPTGAPG SNEQYNVGMV GTHGLETSHA DSFSGSISRE 910 920 930 940 950 960 GTLMIRETSG EKKRSGHSDS NGFAGHINLP DLVQQSHSPA GTPTEGLGRV STHSQEMDSG 970 980 990 1000 1010 1020 TEYGMGSSTK ASFTPFVDPR VYQTSPTDED EEDEESSAAA LFTSELLRQE QAKLNEARKI 1030 1040 1050 1060 1070 1080 SVVNVNPTNI RPHSDTPEIR KYKKRFNSEI LCAALWGVNL LVGTENGLML LDRSGQGKVY 1090 1100 1110 1120 1130 1140 NLINRRRFQQ MDVLEGLNVL VTISGKKNKL RVYYLSWLRN RILHNDPEVE KKQGWITVGD 1150 1160 1170 1180 1190 1200 LEGCIHYKVV KYERIKFLVI ALKNAVEIYA WAPKPYHKFM AFKSFADLQH KPLLVDLTVE 1210 1220 1230 1240 1250 1260 EGQRLKVIFG SHTGFHVIDV DSGNSYDIYI PSHIQGNITP HAIVILPKTD GMEMLVCYED 1270 1280 1290 1300 1310 1320 EGVYVNTYGR ITKDVVLQWG EMPTSVAYIH SNQIMGWGEK AIEIRSVETG HLDGVFMHKR 1330 1340 1350 1360 AQRLKFLCER NDKVFFASVR SGGSSQVFFM TLNRNSMMNW
	Isoform 2 [UniParc]. Checksum: 85378CBC98631411	FASTA	1,331	151,300
	10 20 30 40 50 60 MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL AAIKVMDVTG 70 80 90 100 110 120 DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKNPPGMDDQ LWLVMEFCGA GSVTDLIKNT 130 140 150 160 170 180 KGNTLKEEWI AYICREILRG LSHLHQHKVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 190 200 210 220 230 240 TVGRRNTFIG TPYWMAPEVI ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR 250 260 270 280 290 300 ALFLIPRNPA PRLKSKKWSK KFQSFIESCL VKNHSQRPAT EQLMKHPFIR DQPNERQVRI 310 320 330 340 350 360 QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EENDSGEPSS ILNLPGESTL RRDFLRLQLA 370 380 390 400 410 420 NKERSEALRR QQLEQQQREN EEHKRQLLAE RQKRIEEQKE QRRRLEEQQR REKELRKQQE 430 440 450 460 470 480 REQRRHYEEQ MRREEERRRA EHEQEYKRKQ LEEQRQAERL QRQLKQERDY LVSLQHQRQE 490 500 510 520 530 540 QRPVEKKPLY HYKEGMSPSE KPAWAKEVEE RSRLNRQSSP AMPHKVANRI SDPNLPPRSE 550 560 570 580 590 600 SFSISGVQPA RTPPMLRPVD PQIPHLVAVK SQGPALTASQ SVHEQPTKGL SGFQEALNVT 610 620 630 640 650 660 SHRVEMPRQN SDPTSENPPL PTRIEKFDRS SWLRQEEDIP PKVPQRTTSI SPALARKNSP 670 680 690 700 710 720 GNGSALGPRL GSQPIRASNP DLRRTEPILE SPLQRTSSGS SSSSSTPSSQ PSSQGGSQPG 730 740 750 760 770 780 SQAGSSERTR VRANSKSEGS PVLPHEPAKV KPEESRDITR PSRPASYKKA IDEDLTALAK 790 800 810 820 830 840 ELRELRIEET NRPMKKVTDY SSSSEESESS EEEEEDGESE THDGTVAVSD IPRLIPTGAP 850 860 870 880 890 900 GSNEQYNVGM VGTHGLETSH ADSFSGSISR EGTLMIRETS GEKKRSGHSD SNGFAGHINL 910 920 930 940 950 960 PDLVQQSHSP AGTPTEGLGR VSTHSQEMDS GTEYGMGSST KASFTPFVDP RVYQTSPTDE 970 980 990 1000 1010 1020 DEEDEESSAA ALFTSELLRQ EQAKLNEARK ISVVNVNPTN IRPHSDTPEI RKYKKRFNSE 1030 1040 1050 1060 1070 1080 ILCAALWGVN LLVGTENGLM LLDRSGQGKV YNLINRRRFQ QMDVLEGLNV LVTISGKKNK 1090 1100 1110 1120 1130 1140 LRVYYLSWLR NRILHNDPEV EKKQGWITVG DLEGCIHYKV VKYERIKFLV IALKNAVEIY 1150 1160 1170 1180 1190 1200 AWAPKPYHKF MAFKSFADLQ HKPLLVDLTV EEGQRLKVIF GSHTGFHVID VDSGNSYDIY 1210 1220 1230 1240 1250 1260 IPSHIQGNIT PHAIVILPKT DGMEMLVCYE DEGVYVNTYG RITKDVVLQW GEMPTSVAYI 1270 1280 1290 1300 1310 1320 HSNQIMGWGE KAIEIRSVET GHLDGVFMHK RAQRLKFLCE RNDKVFFASV RSGGSSQVFF 1330 MTLNRNSMMN W
	Isoform 3 [UniParc]. Checksum: 209230BB15712DFC	FASTA	1,305	148,829
	10 20 30 40 50 60 MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL AAIKVMDVTG 70 80 90 100 110 120 DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKNPPGMDDQ LWLVMEFCGA GSVTDLIKNT 130 140 150 160 170 180 KGNTLKEEWI AYICREILRG LSHLHQHKVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 190 200 210 220 230 240 TVGRRNTFIG TPYWMAPEVI ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR 250 260 270 280 290 300 ALFLIPRNPA PRLKSKKWSK KFQSFIESCL VKNHSQRPAT EQLMKHPFIR DQPNERQVRI 310 320 330 340 350 360 QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EENDSGEPSS ILNLPGESTL RRDFLRLQLA 370 380 390 400 410 420 NKERSEALRR QQLEQQQREN EEHKRQLLAE RQKRIEEQKE QRRRLEEQQR REKELRKQQE 430 440 450 460 470 480 REQRRHYEEQ MRREEERRRA EHEQEYIRRQ LEEEQRQLEI LQQQLLHEQA LLLEYKRKQL 490 500 510 520 530 540 EEQRQAERLQ RQLKQERDYL VSLQHQRQEQ RPVEKKPLYH YKEGMSPSEK PAWAKEIPHL 550 560 570 580 590 600 VAVKSQGPAL TASQSVHEQP TKGLSGFQEA LNVTSHRVEM PRQNSDPTSE NPPLPTRIEK 610 620 630 640 650 660 FDRSSWLRQE EDIPPKVPQR TTSISPALAR KNSPGNGSAL GPRLGSQPIR ASNPDLRRTE 670 680 690 700 710 720 PILESPLQRT SSGSSSSSST PSSQPSSQGG SQPGSQAGSS ERTRVRANSK SEGSPVLPHE 730 740 750 760 770 780 PAKVKPEESR DITRPSRPAS YKKAIDEDLT ALAKELRELR IEETNRPMKK VTDYSSSSEE 790 800 810 820 830 840 SESSEEEEED GESETHDGTV AVSDIPRLIP TGAPGSNEQY NVGMVGTHGL ETSHADSFSG 850 860 870 880 890 900 SISREGTLMI RETSGEKKRS GHSDSNGFAG HINLPDLVQQ SHSPAGTPTE GLGRVSTHSQ 910 920 930 940 950 960 EMDSGTEYGM GSSTKASFTP FVDPRVYQTS PTDEDEEDEE SSAAALFTSE LLRQEQAKLN 970 980 990 1000 1010 1020 EARKISVVNV NPTNIRPHSD TPEIRKYKKR FNSEILCAAL WGVNLLVGTE NGLMLLDRSG 1030 1040 1050 1060 1070 1080 QGKVYNLINR RRFQQMDVLE GLNVLVTISG KKNKLRVYYL SWLRNRILHN DPEVEKKQGW 1090 1100 1110 1120 1130 1140 ITVGDLEGCI HYKVVKYERI KFLVIALKNA VEIYAWAPKP YHKFMAFKSF ADLQHKPLLV 1150 1160 1170 1180 1190 1200 DLTVEEGQRL KVIFGSHTGF HVIDVDSGNS YDIYIPSHIQ GNITPHAIVI LPKTDGMEML 1210 1220 1230 1240 1250 1260 VCYEDEGVYV NTYGRITKDV VLQWGEMPTS VAYIHSNQIM GWGEKAIEIR SVETGHLDGV 1270 1280 1290 1300 FMHKRAQRLK FLCERNDKVF FASVRSGGSS QVFFMTLNRN SMMNW
	Isoform 4 [UniParc]. Checksum: F4708A71FF26C54F	FASTA	1,352	154,008
	10 20 30 40 50 60 MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL AAIKVMDVTG 70 80 90 100 110 120 DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKNPPGMDDQ LWLVMEFCGA GSVTDLIKNT 130 140 150 160 170 180 KGNTLKEEWI AYICREILRG LSHLHQHKVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 190 200 210 220 230 240 TVGRRNTFIG TPYWMAPEVI ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR 250 260 270 280 290 300 ALFLIPRNPA PRLKSKKWSK KFQSFIESCL VKNHSQRPAT EQLMKHPFIR DQPNERQVRI 310 320 330 340 350 360 QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EENDSGEPSS ILNLPGESTL RRDFLRLQLA 370 380 390 400 410 420 NKERSEALRR QQLEQQQREN EEHKRQLLAE RQKRIEEQKE QRRRLEEQQR REKELRKQQE 430 440 450 460 470 480 REQRRHYEEQ MRREEERRRA EHEQEYIRRQ LEEEQRQLEI LQQQLLHEQA LLLEYKRKQL 490 500 510 520 530 540 EEQRQAERLQ RQLKQERDYL VSLQHQRQEQ RPVEKKPLYH YKEGMSPSEK PAWAKEVEER 550 560 570 580 590 600 SRLNRQSSPA MPHKVANRIS DPNLPPRSES FSISGVQPAR TPPMLRPVDP QIPHLVAVKS 610 620 630 640 650 660 QGPALTASQS VHEQPTKGLS GFQEALNVTS HRVEMPRQNS DPTSENPPLP TRIEKFDRSS 670 680 690 700 710 720 WLRQEEDIPP KVPQRTTSIS PALARKNSPG NGSALGPRLG SQPIRASNPD LRRTEPILES 730 740 750 760 770 780 PLQRTSSGSS SSSSTPSSQP SSQGGSQPGS QAGSSERTRV RANSKSEGSP VLPHEPAKVK 790 800 810 820 830 840 PEESRDITRP SRPADLTALA KELRELRIEE TNRPMKKVTD YSSSSEESES SEEEEEDGES 850 860 870 880 890 900 ETHDGTVAVS DIPRLIPTGA PGSNEQYNVG MVGTHGLETS HADSFSGSIS REGTLMIRET 910 920 930 940 950 960 SGEKKRSGHS DSNGFAGHIN LPDLVQQSHS PAGTPTEGLG RVSTHSQEMD SGTEYGMGSS 970 980 990 1000 1010 1020 TKASFTPFVD PRVYQTSPTD EDEEDEESSA AALFTSELLR QEQAKLNEAR KISVVNVNPT 1030 1040 1050 1060 1070 1080 NIRPHSDTPE IRKYKKRFNS EILCAALWGV NLLVGTENGL MLLDRSGQGK VYNLINRRRF 1090 1100 1110 1120 1130 1140 QQMDVLEGLN VLVTISGKKN KLRVYYLSWL RNRILHNDPE VEKKQGWITV GDLEGCIHYK 1150 1160 1170 1180 1190 1200 VVKYERIKFL VIALKNAVEI YAWAPKPYHK FMAFKSFADL QHKPLLVDLT VEEGQRLKVI 1210 1220 1230 1240 1250 1260 FGSHTGFHVI DVDSGNSYDI YIPSHIQGNI TPHAIVILPK TDGMEMLVCY EDEGVYVNTY 1270 1280 1290 1300 1310 1320 GRITKDVVLQ WGEMPTSVAY IHSNQIMGWG EKAIEIRSVE TGHLDGVFMH KRAQRLKFLC 1330 1340 1350 ERNDKVFFAS VRSGGSSQVF FMTLNRNSMM NW
	Isoform 5 [UniParc]. Checksum: 9B85E462E4FAE9F0	FASTA	1,276	145,186
	10 20 30 40 50 60 MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL AAIKVMDVTG 70 80 90 100 110 120 DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKNPPGMDDQ LWLVMEFCGA GSVTDLIKNT 130 140 150 160 170 180 KGNTLKEEWI AYICREILRG LSHLHQHKVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 190 200 210 220 230 240 TVGRRNTFIG TPYWMAPEVI ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR 250 260 270 280 290 300 ALFLIPRNPA PRLKSKKWSK KFQSFIESCL VKNHSQRPAT EQLMKHPFIR DQPNERQVRI 310 320 330 340 350 360 QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EENDSGEPSS ILNLPGESTL RRDFLRLQLA 370 380 390 400 410 420 NKERSEALRR QQLEQQQREN EEHKRQLLAE RQKRIEEQKE QRRRLEEQQR REKELRKQQE 430 440 450 460 470 480 REQRRHYEEQ MRREEERRRA EHEQEYKRKQ LEEQRQAERL QRQLKQERDY LVSLQHQRQE 490 500 510 520 530 540 QRPVEKKPLY HYKEGMSPSE KPAWAKEIPH LVAVKSQGPA LTASQSVHEQ PTKGLSGFQE 550 560 570 580 590 600 ALNVTSHRVE MPRQNSDPTS ENPPLPTRIE KFDRSSWLRQ EEDIPPKVPQ RTTSISPALA 610 620 630 640 650 660 RKNSPGNGSA LGPRLGSQPI RASNPDLRRT EPILESPLQR TSSGSSSSSS TPSSQPSSQG 670 680 690 700 710 720 GSQPGSQAGS SERTRVRANS KSEGSPVLPH EPAKVKPEES RDITRPSRPA SYKKAIDEDL 730 740 750 760 770 780 TALAKELREL RIEETNRPMK KVTDYSSSSE ESESSEEEEE DGESETHDGT VAVSDIPRLI 790 800 810 820 830 840 PTGAPGSNEQ YNVGMVGTHG LETSHADSFS GSISREGTLM IRETSGEKKR SGHSDSNGFA 850 860 870 880 890 900 GHINLPDLVQ QSHSPAGTPT EGLGRVSTHS QEMDSGTEYG MGSSTKASFT PFVDPRVYQT 910 920 930 940 950 960 SPTDEDEEDE ESSAAALFTS ELLRQEQAKL NEARKISVVN VNPTNIRPHS DTPEIRKYKK 970 980 990 1000 1010 1020 RFNSEILCAA LWGVNLLVGT ENGLMLLDRS GQGKVYNLIN RRRFQQMDVL EGLNVLVTIS 1030 1040 1050 1060 1070 1080 GKKNKLRVYY LSWLRNRILH NDPEVEKKQG WITVGDLEGC IHYKVVKYER IKFLVIALKN 1090 1100 1110 1120 1130 1140 AVEIYAWAPK PYHKFMAFKS FADLQHKPLL VDLTVEEGQR LKVIFGSHTG FHVIDVDSGN 1150 1160 1170 1180 1190 1200 SYDIYIPSHI QGNITPHAIV ILPKTDGMEM LVCYEDEGVY VNTYGRITKD VVLQWGEMPT 1210 1220 1230 1240 1250 1260 SVAYIHSNQI MGWGEKAIEI RSVETGHLDG VFMHKRAQRL KFLCERNDKV FFASVRSGGS 1270 SQVFFMTLNR NSMMNW
	Isoform 6 [UniParc]. Checksum: 93B2E73EF75034B9	FASTA	1,323	150,365
	10 20 30 40 50 60 MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL AAIKVMDVTG 70 80 90 100 110 120 DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKNPPGMDDQ LWLVMEFCGA GSVTDLIKNT 130 140 150 160 170 180 KGNTLKEEWI AYICREILRG LSHLHQHKVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 190 200 210 220 230 240 TVGRRNTFIG TPYWMAPEVI ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR 250 260 270 280 290 300 ALFLIPRNPA PRLKSKKWSK KFQSFIESCL VKNHSQRPAT EQLMKHPFIR DQPNERQVRI 310 320 330 340 350 360 QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EENDSGEPSS ILNLPGESTL RRDFLRLQLA 370 380 390 400 410 420 NKERSEALRR QQLEQQQREN EEHKRQLLAE RQKRIEEQKE QRRRLEEQQR REKELRKQQE 430 440 450 460 470 480 REQRRHYEEQ MRREEERRRA EHEQEYKRKQ LEEQRQAERL QRQLKQERDY LVSLQHQRQE 490 500 510 520 530 540 QRPVEKKPLY HYKEGMSPSE KPAWAKEVEE RSRLNRQSSP AMPHKVANRI SDPNLPPRSE 550 560 570 580 590 600 SFSISGVQPA RTPPMLRPVD PQIPHLVAVK SQGPALTASQ SVHEQPTKGL SGFQEALNVT 610 620 630 640 650 660 SHRVEMPRQN SDPTSENPPL PTRIEKFDRS SWLRQEEDIP PKVPQRTTSI SPALARKNSP 670 680 690 700 710 720 GNGSALGPRL GSQPIRASNP DLRRTEPILE SPLQRTSSGS SSSSSTPSSQ PSSQGGSQPG 730 740 750 760 770 780 SQAGSSERTR VRANSKSEGS PVLPHEPAKV KPEESRDITR PSRPADLTAL AKELRELRIE 790 800 810 820 830 840 ETNRPMKKVT DYSSSSEESE SSEEEEEDGE SETHDGTVAV SDIPRLIPTG APGSNEQYNV 850 860 870 880 890 900 GMVGTHGLET SHADSFSGSI SREGTLMIRE TSGEKKRSGH SDSNGFAGHI NLPDLVQQSH 910 920 930 940 950 960 SPAGTPTEGL GRVSTHSQEM DSGTEYGMGS STKASFTPFV DPRVYQTSPT DEDEEDEESS 970 980 990 1000 1010 1020 AAALFTSELL RQEQAKLNEA RKISVVNVNP TNIRPHSDTP EIRKYKKRFN SEILCAALWG 1030 1040 1050 1060 1070 1080 VNLLVGTENG LMLLDRSGQG KVYNLINRRR FQQMDVLEGL NVLVTISGKK NKLRVYYLSW 1090 1100 1110 1120 1130 1140 LRNRILHNDP EVEKKQGWIT VGDLEGCIHY KVVKYERIKF LVIALKNAVE IYAWAPKPYH 1150 1160 1170 1180 1190 1200 KFMAFKSFAD LQHKPLLVDL TVEEGQRLKV IFGSHTGFHV IDVDSGNSYD IYIPSHIQGN 1210 1220 1230 1240 1250 1260 ITPHAIVILP KTDGMEMLVC YEDEGVYVNT YGRITKDVVL QWGEMPTSVA YIHSNQIMGW 1270 1280 1290 1300 1310 1320 GEKAIEIRSV ETGHLDGVFM HKRAQRLKFL CERNDKVFFA SVRSGGSSQV FFMTLNRNSM MNW
	Isoform 7 [UniParc]. Checksum: EED944B571948D3F	FASTA	1,297	147,894
	10 20 30 40 50 60 MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL AAIKVMDVTG 70 80 90 100 110 120 DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKNPPGMDDQ LWLVMEFCGA GSVTDLIKNT 130 140 150 160 170 180 KGNTLKEEWI AYICREILRG LSHLHQHKVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 190 200 210 220 230 240 TVGRRNTFIG TPYWMAPEVI ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR 250 260 270 280 290 300 ALFLIPRNPA PRLKSKKWSK KFQSFIESCL VKNHSQRPAT EQLMKHPFIR DQPNERQVRI 310 320 330 340 350 360 QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EENDSGEPSS ILNLPGESTL RRDFLRLQLA 370 380 390 400 410 420 NKERSEALRR QQLEQQQREN EEHKRQLLAE RQKRIEEQKE QRRRLEEQQR REKELRKQQE 430 440 450 460 470 480 REQRRHYEEQ MRREEERRRA EHEQEYIRRQ LEEEQRQLEI LQQQLLHEQA LLLEYKRKQL 490 500 510 520 530 540 EEQRQAERLQ RQLKQERDYL VSLQHQRQEQ RPVEKKPLYH YKEGMSPSEK PAWAKEIPHL 550 560 570 580 590 600 VAVKSQGPAL TASQSVHEQP TKGLSGFQEA LNVTSHRVEM PRQNSDPTSE NPPLPTRIEK 610 620 630 640 650 660 FDRSSWLRQE EDIPPKVPQR TTSISPALAR KNSPGNGSAL GPRLGSQPIR ASNPDLRRTE 670 680 690 700 710 720 PILESPLQRT SSGSSSSSST PSSQPSSQGG SQPGSQAGSS ERTRVRANSK SEGSPVLPHE 730 740 750 760 770 780 PAKVKPEESR DITRPSRPAD LTALAKELRE LRIEETNRPM KKVTDYSSSS EESESSEEEE 790 800 810 820 830 840 EDGESETHDG TVAVSDIPRL IPTGAPGSNE QYNVGMVGTH GLETSHADSF SGSISREGTL 850 860 870 880 890 900 MIRETSGEKK RSGHSDSNGF AGHINLPDLV QQSHSPAGTP TEGLGRVSTH SQEMDSGTEY 910 920 930 940 950 960 GMGSSTKASF TPFVDPRVYQ TSPTDEDEED EESSAAALFT SELLRQEQAK LNEARKISVV 970 980 990 1000 1010 1020 NVNPTNIRPH SDTPEIRKYK KRFNSEILCA ALWGVNLLVG TENGLMLLDR SGQGKVYNLI 1030 1040 1050 1060 1070 1080 NRRRFQQMDV LEGLNVLVTI SGKKNKLRVY YLSWLRNRIL HNDPEVEKKQ GWITVGDLEG 1090 1100 1110 1120 1130 1140 CIHYKVVKYE RIKFLVIALK NAVEIYAWAP KPYHKFMAFK SFADLQHKPL LVDLTVEEGQ 1150 1160 1170 1180 1190 1200 RLKVIFGSHT GFHVIDVDSG NSYDIYIPSH IQGNITPHAI VILPKTDGME MLVCYEDEGV 1210 1220 1230 1240 1250 1260 YVNTYGRITK DVVLQWGEMP TSVAYIHSNQ IMGWGEKAIE IRSVETGHLD GVFMHKRAQR 1270 1280 1290 LKFLCERNDK VFFASVRSGG SSQVFFMTLN RNSMMNW
	Isoform 8 [UniParc]. Checksum: 55AD5F59B7A08A2A	FASTA	1,268	144,251
	10 20 30 40 50 60 MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL AAIKVMDVTG 70 80 90 100 110 120 DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKNPPGMDDQ LWLVMEFCGA GSVTDLIKNT 130 140 150 160 170 180 KGNTLKEEWI AYICREILRG LSHLHQHKVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 190 200 210 220 230 240 TVGRRNTFIG TPYWMAPEVI ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR 250 260 270 280 290 300 ALFLIPRNPA PRLKSKKWSK KFQSFIESCL VKNHSQRPAT EQLMKHPFIR DQPNERQVRI 310 320 330 340 350 360 QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EENDSGEPSS ILNLPGESTL RRDFLRLQLA 370 380 390 400 410 420 NKERSEALRR QQLEQQQREN EEHKRQLLAE RQKRIEEQKE QRRRLEEQQR REKELRKQQE 430 440 450 460 470 480 REQRRHYEEQ MRREEERRRA EHEQEYKRKQ LEEQRQAERL QRQLKQERDY LVSLQHQRQE 490 500 510 520 530 540 QRPVEKKPLY HYKEGMSPSE KPAWAKEIPH LVAVKSQGPA LTASQSVHEQ PTKGLSGFQE 550 560 570 580 590 600 ALNVTSHRVE MPRQNSDPTS ENPPLPTRIE KFDRSSWLRQ EEDIPPKVPQ RTTSISPALA 610 620 630 640 650 660 RKNSPGNGSA LGPRLGSQPI RASNPDLRRT EPILESPLQR TSSGSSSSSS TPSSQPSSQG 670 680 690 700 710 720 GSQPGSQAGS SERTRVRANS KSEGSPVLPH EPAKVKPEES RDITRPSRPA DLTALAKELR 730 740 750 760 770 780 ELRIEETNRP MKKVTDYSSS SEESESSEEE EEDGESETHD GTVAVSDIPR LIPTGAPGSN 790 800 810 820 830 840 EQYNVGMVGT HGLETSHADS FSGSISREGT LMIRETSGEK KRSGHSDSNG FAGHINLPDL 850 860 870 880 890 900 VQQSHSPAGT PTEGLGRVST HSQEMDSGTE YGMGSSTKAS FTPFVDPRVY QTSPTDEDEE 910 920 930 940 950 960 DEESSAAALF TSELLRQEQA KLNEARKISV VNVNPTNIRP HSDTPEIRKY KKRFNSEILC 970 980 990 1000 1010 1020 AALWGVNLLV GTENGLMLLD RSGQGKVYNL INRRRFQQMD VLEGLNVLVT ISGKKNKLRV 1030 1040 1050 1060 1070 1080 YYLSWLRNRI LHNDPEVEKK QGWITVGDLE GCIHYKVVKY ERIKFLVIAL KNAVEIYAWA 1090 1100 1110 1120 1130 1140 PKPYHKFMAF KSFADLQHKP LLVDLTVEEG QRLKVIFGSH TGFHVIDVDS GNSYDIYIPS 1150 1160 1170 1180 1190 1200 HIQGNITPHA IVILPKTDGM EMLVCYEDEG VYVNTYGRIT KDVVLQWGEM PTSVAYIHSN 1210 1220 1230 1240 1250 1260 QIMGWGEKAI EIRSVETGHL DGVFMHKRAQ RLKFLCERND KVFFASVRSG GSSQVFFMTL NRNSMMNW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton." Fu C.A., Shen M., Huang B.C., Lasaga J., Payan D.G., Luo Y. J. Biol. Chem. 274:30729-30737(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7 AND 8), FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH TRAF2 AND NCK, AUTOPHOSPHORYLATION.
[2]	"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
[5]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[8]	"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry." Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C. Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-769, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[9]	"The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton." Taira K., Umikawa M., Takei K., Myagmar B.-E., Shinzato M., Machida N., Uezato H., Nonaka S., Kariya K. J. Biol. Chem. 279:49488-49496(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH RAP2A, SUBCELLULAR LOCATION, AUTOPHOSPHORYLATION, MUTAGENESIS OF LYS-54.
[10]	"MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1." Nonaka H., Takei K., Umikawa M., Oshiro M., Kuninaka K., Bayarjargal M., Asato T., Yamashiro Y., Uechi Y., Endo S., Suzuki T., Kariya K. Biochem. Biophys. Res. Commun. 377:573-578(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TANC1.
[11]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-640 AND SER-769, MASS SPECTROMETRY. Tissue: Platelet.
[12]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-640; SER-688; SER-720 AND SER-769, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-678 AND SER-680, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Rap2 function requires palmitoylation and recycling endosome localization." Uechi Y., Bayarjargal M., Umikawa M., Oshiro M., Takei K., Yamashiro Y., Asato T., Endo S., Misaki R., Taguchi T., Kariya K. Biochem. Biophys. Res. Commun. 378:732-737(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[15]	"The kinase TNIK is an essential activator of Wnt target genes." Mahmoudi T., Li V.S.W., Ng S.S., Taouatas N., Vries R.G.J., Mohammed S., Heck A.J., Clevers H. EMBO J. 28:3329-3340(2009) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, AUTOPHOSPHORYLATION, MUTAGENESIS OF LYS-54; 152-ARG-ASP-153 AND 171-ASP-PHE-172, INTERACTION WITH TCF7L2 AND CTNNB1, TISSUE SPECIFICITY, FUNCTION.
[16]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-560; SER-640; SER-688; SER-707; SER-720; SER-766 AND SER-769, MASS SPECTROMETRY.
[17]	"Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development." Kawabe H., Neeb A., Dimova K., Young S.M. Jr., Takeda M., Katsurabayashi S., Mitkovski M., Malakhova O.A., Zhang D.E., Umikawa M., Kariya K., Goebbels S., Nave K.A., Rosenmund C., Jahn O., Rhee J., Brose N. Neuron 65:358-372(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH NEDD4 AND RAP2A.
[18]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[19]	"Smad inhibition by the Ste20 kinase Misshapen." Kaneko S., Chen X., Lu P., Yao X., Wright T.G., Rajurkar M., Kariya K., Mao J., Ip Y.T., Xu L. Proc. Natl. Acad. Sci. U.S.A. 108:11127-11132(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[20]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-326; SER-640; SER-688 AND SER-769, MASS SPECTROMETRY.
[21]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-778; GLU-910 AND THR-999.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF172264 mRNA. Translation: AAF03782.1.
AF172268 mRNA. Translation: AAF03786.1.
AF172267 mRNA. Translation: AAF03785.1.
AF172266 mRNA. Translation: AAF03784.1.
AF172265 mRNA. Translation: AAF03783.1.
AF172270 mRNA. Translation: AAF03788.1.
AF172271 mRNA. Translation: AAF03789.1.
AF172269 mRNA. Translation: AAF03787.1.
AB011123 mRNA. Translation: BAA25477.2. Different initiation.
AK291056 mRNA. Translation: BAF83745.1.
AC026315 Genomic DNA. No translation available.
AC078793 Genomic DNA. No translation available.
AC092919 Genomic DNA. No translation available.
AC137517 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78484.1.
CH471052 Genomic DNA. Translation: EAW78489.1.
CH471052 Genomic DNA. Translation: EAW78492.1.
CH471052 Genomic DNA. Translation: EAW78493.1.
BC019081 mRNA. Translation: AAH19081.2.
BC150256 mRNA. Translation: AAI50257.1.

IPI

IPI00145805.
IPI00218901.
IPI00218902.
IPI00218904.
IPI00218906.
IPI00218907.
IPI00514275.
IPI00943704.

RefSeq

NP_001155032.1. NM_001161560.1.
NP_001155033.1. NM_001161561.1.
NP_001155034.1. NM_001161562.1.
NP_001155035.1. NM_001161563.1.
NP_001155036.1. NM_001161564.1.
NP_001155037.1. NM_001161565.1.
NP_001155038.1. NM_001161566.1.
NP_055843.1. NM_015028.2.

UniGene

Hs.34024.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2X7F	X-ray	2.80	A/B/C/D/E	1-325	[»]

ProteinModelPortal

Q9UKE5.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9UKE5. 18 interactions.

MINT

MINT-7242209.

PTM databases

PhosphoSite

Q9UKE5.

Polymorphism databases

DMDM

29840818.

Proteomic databases

PaxDb

Q9UKE5.

PRIDE

Q9UKE5.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000284483; ENSP00000284483; ENSG00000154310.
ENST00000341852; ENSP00000345352; ENSG00000154310.
ENST00000357327; ENSP00000349880; ENSG00000154310.
ENST00000436636; ENSP00000399511; ENSG00000154310.
ENST00000460047; ENSP00000418916; ENSG00000154310.
ENST00000470834; ENSP00000419990; ENSG00000154310.
ENST00000475336; ENSP00000418156; ENSG00000154310.
ENST00000488470; ENSP00000418378; ENSG00000154310.

GeneID

23043.

KEGG

hsa:23043.

UCSC

uc003fhh.2. human.
uc003fhi.2. human.
uc003fhj.2. human.
uc003fhk.2. human.
uc003fhl.2. human.
uc003fhm.2. human.
uc003fhn.2. human.
uc003fho.2. human.

Organism-specific databases

CTD

23043.

GeneCards

GC03M170779.

HGNC

HGNC:30765. TNIK.

HPA

HPA012128.
HPA012297.

MIM

610005. gene.

neXtProt

NX_Q9UKE5.

PharmGKB

PA134893180.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0515.

HOVERGEN

HBG036506.

InParanoid

Q9UKE5.

KO

K08840.

OMA

TALFTSE.

OrthoDB

EOG444KJG.

Enzyme and pathway databases

Pathway_Interaction_DB

tnfpathway. TNF receptor signaling pathway.

Gene expression databases

ArrayExpress

Q9UKE5.

Bgee

Q9UKE5.

Genevestigator

Q9UKE5.

GermOnline

ENSG00000154310. Homo sapiens.

Family and domain databases

InterPro

IPR001180. Citron.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]

Pfam

PF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]

SMART

SM00036. CNH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]

SUPFAM

SSF56112. Kinase_like. 1 hit.

PROSITE

PS50219. CNH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

Q9UKE5.

ChEMBL

CHEMBL4527.

EvolutionaryTrace

Q9UKE5.

GenomeRNAi

23043.

NextBio

44076.

PMAP-CutDB

Q9UKE5.

SOURCE

Search...

Entry information

Entry name

TNIK_HUMAN

Accession

Primary (citable) accession number: Q9UKE5
Secondary accession number(s): A7E2A3 , A8K4U1, D3DNQ6, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 28, 2003
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 125 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.