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Protein

TRAF2 and NCK-interacting protein kinase

Gene

TNIK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.6 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54ATPPROSITE-ProRule annotation1
Active sitei153Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 39ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB
  • receptor signaling protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • actin cytoskeleton reorganization Source: UniProtKB
  • activation of JNKK activity Source: UniProtKB
  • cytoskeleton organization Source: UniProtKB
  • intracellular signal transduction Source: UniProtKB
  • microvillus assembly Source: UniProtKB
  • positive regulation of protein phosphorylation Source: UniProtKB
  • protein autophosphorylation Source: UniProtKB
  • protein localization to plasma membrane Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • regulation of dendrite morphogenesis Source: UniProtKB
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Neurogenesis, Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS07972-MONOMER.
ReactomeiR-HSA-2559580. Oxidative Stress Induced Senescence.
SignaLinkiQ9UKE5.
SIGNORiQ9UKE5.

Names & Taxonomyi

Protein namesi
Recommended name:
TRAF2 and NCK-interacting protein kinase (EC:2.7.11.1)
Gene namesi
Name:TNIK
Synonyms:KIAA0551
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30765. TNIK.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytoskeleton Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • recycling endosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi54K → A: Kinase dead. Loss of autophosphorylation and loss of function in cytoskeleton regulation. 2 Publications1
Mutagenesisi152 – 153RD → AA: Loss of autophosphorylation. 1 Publication2
Mutagenesisi171 – 172DF → AA: Loss of autophosphorylation. 1 Publication2

Organism-specific databases

DisGeNETi23043.
OpenTargetsiENSG00000154310.
PharmGKBiPA134893180.

Chemistry databases

ChEMBLiCHEMBL4527.
GuidetoPHARMACOLOGYi2244.

Polymorphism and mutation databases

BioMutaiTNIK.
DMDMi29840818.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867611 – 1360TRAF2 and NCK-interacting protein kinaseAdd BLAST1360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei187PhosphothreonineBy similarity1
Modified residuei324PhosphoserineBy similarity1
Modified residuei326PhosphoserineCombined sources1
Modified residuei560PhosphoserineCombined sources1
Modified residuei570PhosphoserineCombined sources1
Modified residuei581PhosphothreonineBy similarity1
Modified residuei600PhosphoserineCombined sources1
Modified residuei608PhosphoserineCombined sources1
Modified residuei610PhosphoserineCombined sources1
Modified residuei640PhosphoserineCombined sources1
Modified residuei678PhosphoserineCombined sources1
Modified residuei680PhosphoserineCombined sources1
Modified residuei688PhosphoserineCombined sources1
Modified residuei701PhosphoserineCombined sources1
Modified residuei707PhosphoserineCombined sources1
Modified residuei720PhosphoserineCombined sources1
Modified residuei764PhosphoserineCombined sources1
Modified residuei766PhosphoserineCombined sources1
Modified residuei769PhosphoserineCombined sources1
Modified residuei959PhosphoserineCombined sources1

Post-translational modificationi

Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UKE5.
PaxDbiQ9UKE5.
PeptideAtlasiQ9UKE5.
PRIDEiQ9UKE5.

PTM databases

iPTMnetiQ9UKE5.
PhosphoSitePlusiQ9UKE5.

Miscellaneous databases

PMAP-CutDBQ9UKE5.

Expressioni

Tissue specificityi

Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.2 Publications

Gene expression databases

BgeeiENSG00000154310.
ExpressionAtlasiQ9UKE5. baseline and differential.
GenevisibleiQ9UKE5. HS.

Organism-specific databases

HPAiHPA012128.
HPA012297.

Interactioni

Subunit structurei

Interacts (via the CNH domain) with RAP2A (GTP-bound form preferentially); the interaction is direct and required for the activation of TNIK by RAP2A. Interacts with NEDD4; recruits RAP2A to NEDD4. Interacts with TRAF2 and NCK. Interacts with TCF7L2/TCF4 and CTNNB1; the interaction is direct. Interacts with TANC1.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CTNNB1P352223EBI-1051794,EBI-491549
Tanc1Q6F6B32EBI-1051794,EBI-2133582From a different organism.
TCF7L2Q9NQB03EBI-1051794,EBI-924724

Protein-protein interaction databases

BioGridi116682. 43 interactors.
DIPiDIP-37562N.
IntActiQ9UKE5. 23 interactors.
MINTiMINT-7242209.
STRINGi9606.ENSP00000399511.

Chemistry databases

BindingDBiQ9UKE5.

Structurei

Secondary structure

11360
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 17Combined sources3
Turni22 – 24Combined sources3
Beta strandi25 – 34Combined sources10
Beta strandi37 – 44Combined sources8
Turni45 – 47Combined sources3
Beta strandi50 – 58Combined sources9
Turni60 – 62Combined sources3
Helixi63 – 76Combined sources14
Beta strandi85 – 91Combined sources7
Beta strandi95 – 97Combined sources3
Beta strandi99 – 106Combined sources8
Helixi113 – 118Combined sources6
Helixi121 – 123Combined sources3
Helixi127 – 146Combined sources20
Helixi156 – 158Combined sources3
Beta strandi159 – 161Combined sources3
Beta strandi167 – 169Combined sources3
Turni173 – 175Combined sources3
Helixi192 – 194Combined sources3
Helixi197 – 199Combined sources3
Beta strandi203 – 207Combined sources5
Helixi212 – 228Combined sources17
Turni232 – 235Combined sources4
Helixi238 – 247Combined sources10
Helixi260 – 269Combined sources10
Helixi274 – 276Combined sources3
Helixi280 – 283Combined sources4
Helixi287 – 290Combined sources4
Helixi295 – 306Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X7FX-ray2.80A/B/C/D/E1-325[»]
5AX9X-ray2.40A/B/C11-314[»]
5CWZX-ray2.90A/B/C11-314[»]
5D7AX-ray2.90A/B/C11-314[»]
ProteinModelPortaliQ9UKE5.
SMRiQ9UKE5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UKE5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 289Protein kinasePROSITE-ProRule annotationAdd BLAST265
Domaini1047 – 1334CNHPROSITE-ProRule annotationAdd BLAST288

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni290 – 1047Mediates interaction with NEDD41 PublicationAdd BLAST758

Sequence similaritiesi

Contains 1 CNH domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0587. Eukaryota.
ENOG410XPHR. LUCA.
GeneTreeiENSGT00810000125351.
HOVERGENiHBG036506.
InParanoidiQ9UKE5.
KOiK08840.
OMAiTEQYNVG.
OrthoDBiEOG091G018A.
PhylomeDBiQ9UKE5.
TreeFamiTF105138.

Family and domain databases

InterProiIPR001180. CNH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00036. CNH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50219. CNH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UKE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL
60 70 80 90 100
AAIKVMDVTG DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKNPPGMDDQ
110 120 130 140 150
LWLVMEFCGA GSVTDLIKNT KGNTLKEEWI AYICREILRG LSHLHQHKVI
160 170 180 190 200
HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI
210 220 230 240 250
ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPA
260 270 280 290 300
PRLKSKKWSK KFQSFIESCL VKNHSQRPAT EQLMKHPFIR DQPNERQVRI
310 320 330 340 350
QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EENDSGEPSS ILNLPGESTL
360 370 380 390 400
RRDFLRLQLA NKERSEALRR QQLEQQQREN EEHKRQLLAE RQKRIEEQKE
410 420 430 440 450
QRRRLEEQQR REKELRKQQE REQRRHYEEQ MRREEERRRA EHEQEYIRRQ
460 470 480 490 500
LEEEQRQLEI LQQQLLHEQA LLLEYKRKQL EEQRQAERLQ RQLKQERDYL
510 520 530 540 550
VSLQHQRQEQ RPVEKKPLYH YKEGMSPSEK PAWAKEVEER SRLNRQSSPA
560 570 580 590 600
MPHKVANRIS DPNLPPRSES FSISGVQPAR TPPMLRPVDP QIPHLVAVKS
610 620 630 640 650
QGPALTASQS VHEQPTKGLS GFQEALNVTS HRVEMPRQNS DPTSENPPLP
660 670 680 690 700
TRIEKFDRSS WLRQEEDIPP KVPQRTTSIS PALARKNSPG NGSALGPRLG
710 720 730 740 750
SQPIRASNPD LRRTEPILES PLQRTSSGSS SSSSTPSSQP SSQGGSQPGS
760 770 780 790 800
QAGSSERTRV RANSKSEGSP VLPHEPAKVK PEESRDITRP SRPASYKKAI
810 820 830 840 850
DEDLTALAKE LRELRIEETN RPMKKVTDYS SSSEESESSE EEEEDGESET
860 870 880 890 900
HDGTVAVSDI PRLIPTGAPG SNEQYNVGMV GTHGLETSHA DSFSGSISRE
910 920 930 940 950
GTLMIRETSG EKKRSGHSDS NGFAGHINLP DLVQQSHSPA GTPTEGLGRV
960 970 980 990 1000
STHSQEMDSG TEYGMGSSTK ASFTPFVDPR VYQTSPTDED EEDEESSAAA
1010 1020 1030 1040 1050
LFTSELLRQE QAKLNEARKI SVVNVNPTNI RPHSDTPEIR KYKKRFNSEI
1060 1070 1080 1090 1100
LCAALWGVNL LVGTENGLML LDRSGQGKVY NLINRRRFQQ MDVLEGLNVL
1110 1120 1130 1140 1150
VTISGKKNKL RVYYLSWLRN RILHNDPEVE KKQGWITVGD LEGCIHYKVV
1160 1170 1180 1190 1200
KYERIKFLVI ALKNAVEIYA WAPKPYHKFM AFKSFADLQH KPLLVDLTVE
1210 1220 1230 1240 1250
EGQRLKVIFG SHTGFHVIDV DSGNSYDIYI PSHIQGNITP HAIVILPKTD
1260 1270 1280 1290 1300
GMEMLVCYED EGVYVNTYGR ITKDVVLQWG EMPTSVAYIH SNQIMGWGEK
1310 1320 1330 1340 1350
AIEIRSVETG HLDGVFMHKR AQRLKFLCER NDKVFFASVR SGGSSQVFFM
1360
TLNRNSMMNW
Length:1,360
Mass (Da):154,943
Last modified:May 1, 2000 - v1
Checksum:i3590BC2905A72C3D
GO
Isoform 2 (identifier: Q9UKE5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-473: Missing.

Show »
Length:1,331
Mass (Da):151,300
Checksum:i85378CBC98631411
GO
Isoform 3 (identifier: Q9UKE5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     537-591: Missing.

Show »
Length:1,305
Mass (Da):148,829
Checksum:i209230BB15712DFC
GO
Isoform 4 (identifier: Q9UKE5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     795-802: Missing.

Show »
Length:1,352
Mass (Da):154,008
Checksum:iF4708A71FF26C54F
GO
Isoform 5 (identifier: Q9UKE5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-473: Missing.
     537-591: Missing.

Show »
Length:1,276
Mass (Da):145,186
Checksum:i9B85E462E4FAE9F0
GO
Isoform 6 (identifier: Q9UKE5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-473: Missing.
     795-802: Missing.

Show »
Length:1,323
Mass (Da):150,365
Checksum:i93B2E73EF75034B9
GO
Isoform 7 (identifier: Q9UKE5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     537-591: Missing.
     795-802: Missing.

Show »
Length:1,297
Mass (Da):147,894
Checksum:iEED944B571948D3F
GO
Isoform 8 (identifier: Q9UKE5-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     445-473: Missing.
     537-591: Missing.
     795-802: Missing.

Show »
Length:1,268
Mass (Da):144,251
Checksum:i55AD5F59B7A08A2A
GO

Sequence cautioni

The sequence BAA25477 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041231778K → E.1 PublicationCorresponds to variant rs55778284dbSNPEnsembl.1
Natural variantiVAR_041232910G → E.1 PublicationCorresponds to variant rs35090763dbSNPEnsembl.1
Natural variantiVAR_041233999A → T.1 PublicationCorresponds to variant rs17857452dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004889445 – 473Missing in isoform 2, isoform 5, isoform 6 and isoform 8. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_004890537 – 591Missing in isoform 3, isoform 5, isoform 7 and isoform 8. 2 PublicationsAdd BLAST55
Alternative sequenceiVSP_004891795 – 802Missing in isoform 4, isoform 6, isoform 7 and isoform 8. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172264 mRNA. Translation: AAF03782.1.
AF172268 mRNA. Translation: AAF03786.1.
AF172267 mRNA. Translation: AAF03785.1.
AF172266 mRNA. Translation: AAF03784.1.
AF172265 mRNA. Translation: AAF03783.1.
AF172270 mRNA. Translation: AAF03788.1.
AF172271 mRNA. Translation: AAF03789.1.
AF172269 mRNA. Translation: AAF03787.1.
AB011123 mRNA. Translation: BAA25477.2. Different initiation.
AK291056 mRNA. Translation: BAF83745.1.
AC026315 Genomic DNA. No translation available.
AC078793 Genomic DNA. No translation available.
AC092919 Genomic DNA. No translation available.
AC137517 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78484.1.
CH471052 Genomic DNA. Translation: EAW78489.1.
CH471052 Genomic DNA. Translation: EAW78492.1.
CH471052 Genomic DNA. Translation: EAW78493.1.
BC019081 mRNA. Translation: AAH19081.2.
BC150256 mRNA. Translation: AAI50257.1.
CCDSiCCDS46956.1. [Q9UKE5-1]
CCDS54673.1. [Q9UKE5-8]
CCDS54674.1. [Q9UKE5-5]
CCDS54675.1. [Q9UKE5-6]
CCDS54676.1. [Q9UKE5-2]
CCDS54677.1. [Q9UKE5-7]
CCDS54678.1. [Q9UKE5-3]
CCDS54679.1. [Q9UKE5-4]
RefSeqiNP_001155032.1. NM_001161560.2. [Q9UKE5-4]
NP_001155033.1. NM_001161561.2. [Q9UKE5-2]
NP_001155034.1. NM_001161562.2. [Q9UKE5-6]
NP_001155035.1. NM_001161563.2. [Q9UKE5-3]
NP_001155036.1. NM_001161564.2. [Q9UKE5-7]
NP_001155037.1. NM_001161565.2. [Q9UKE5-5]
NP_001155038.1. NM_001161566.2. [Q9UKE5-8]
NP_055843.1. NM_015028.3. [Q9UKE5-1]
UniGeneiHs.34024.
Hs.723245.

Genome annotation databases

EnsembliENST00000284483; ENSP00000284483; ENSG00000154310. [Q9UKE5-4]
ENST00000341852; ENSP00000345352; ENSG00000154310. [Q9UKE5-5]
ENST00000357327; ENSP00000349880; ENSG00000154310. [Q9UKE5-2]
ENST00000436636; ENSP00000399511; ENSG00000154310. [Q9UKE5-1]
ENST00000460047; ENSP00000418916; ENSG00000154310. [Q9UKE5-7]
ENST00000470834; ENSP00000419990; ENSG00000154310. [Q9UKE5-6]
ENST00000475336; ENSP00000418156; ENSG00000154310. [Q9UKE5-8]
ENST00000488470; ENSP00000418378; ENSG00000154310. [Q9UKE5-3]
GeneIDi23043.
KEGGihsa:23043.
UCSCiuc003fhh.3. human. [Q9UKE5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172264 mRNA. Translation: AAF03782.1.
AF172268 mRNA. Translation: AAF03786.1.
AF172267 mRNA. Translation: AAF03785.1.
AF172266 mRNA. Translation: AAF03784.1.
AF172265 mRNA. Translation: AAF03783.1.
AF172270 mRNA. Translation: AAF03788.1.
AF172271 mRNA. Translation: AAF03789.1.
AF172269 mRNA. Translation: AAF03787.1.
AB011123 mRNA. Translation: BAA25477.2. Different initiation.
AK291056 mRNA. Translation: BAF83745.1.
AC026315 Genomic DNA. No translation available.
AC078793 Genomic DNA. No translation available.
AC092919 Genomic DNA. No translation available.
AC137517 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78484.1.
CH471052 Genomic DNA. Translation: EAW78489.1.
CH471052 Genomic DNA. Translation: EAW78492.1.
CH471052 Genomic DNA. Translation: EAW78493.1.
BC019081 mRNA. Translation: AAH19081.2.
BC150256 mRNA. Translation: AAI50257.1.
CCDSiCCDS46956.1. [Q9UKE5-1]
CCDS54673.1. [Q9UKE5-8]
CCDS54674.1. [Q9UKE5-5]
CCDS54675.1. [Q9UKE5-6]
CCDS54676.1. [Q9UKE5-2]
CCDS54677.1. [Q9UKE5-7]
CCDS54678.1. [Q9UKE5-3]
CCDS54679.1. [Q9UKE5-4]
RefSeqiNP_001155032.1. NM_001161560.2. [Q9UKE5-4]
NP_001155033.1. NM_001161561.2. [Q9UKE5-2]
NP_001155034.1. NM_001161562.2. [Q9UKE5-6]
NP_001155035.1. NM_001161563.2. [Q9UKE5-3]
NP_001155036.1. NM_001161564.2. [Q9UKE5-7]
NP_001155037.1. NM_001161565.2. [Q9UKE5-5]
NP_001155038.1. NM_001161566.2. [Q9UKE5-8]
NP_055843.1. NM_015028.3. [Q9UKE5-1]
UniGeneiHs.34024.
Hs.723245.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X7FX-ray2.80A/B/C/D/E1-325[»]
5AX9X-ray2.40A/B/C11-314[»]
5CWZX-ray2.90A/B/C11-314[»]
5D7AX-ray2.90A/B/C11-314[»]
ProteinModelPortaliQ9UKE5.
SMRiQ9UKE5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116682. 43 interactors.
DIPiDIP-37562N.
IntActiQ9UKE5. 23 interactors.
MINTiMINT-7242209.
STRINGi9606.ENSP00000399511.

Chemistry databases

BindingDBiQ9UKE5.
ChEMBLiCHEMBL4527.
GuidetoPHARMACOLOGYi2244.

PTM databases

iPTMnetiQ9UKE5.
PhosphoSitePlusiQ9UKE5.

Polymorphism and mutation databases

BioMutaiTNIK.
DMDMi29840818.

Proteomic databases

EPDiQ9UKE5.
PaxDbiQ9UKE5.
PeptideAtlasiQ9UKE5.
PRIDEiQ9UKE5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284483; ENSP00000284483; ENSG00000154310. [Q9UKE5-4]
ENST00000341852; ENSP00000345352; ENSG00000154310. [Q9UKE5-5]
ENST00000357327; ENSP00000349880; ENSG00000154310. [Q9UKE5-2]
ENST00000436636; ENSP00000399511; ENSG00000154310. [Q9UKE5-1]
ENST00000460047; ENSP00000418916; ENSG00000154310. [Q9UKE5-7]
ENST00000470834; ENSP00000419990; ENSG00000154310. [Q9UKE5-6]
ENST00000475336; ENSP00000418156; ENSG00000154310. [Q9UKE5-8]
ENST00000488470; ENSP00000418378; ENSG00000154310. [Q9UKE5-3]
GeneIDi23043.
KEGGihsa:23043.
UCSCiuc003fhh.3. human. [Q9UKE5-1]

Organism-specific databases

CTDi23043.
DisGeNETi23043.
GeneCardsiTNIK.
HGNCiHGNC:30765. TNIK.
HPAiHPA012128.
HPA012297.
MIMi610005. gene.
neXtProtiNX_Q9UKE5.
OpenTargetsiENSG00000154310.
PharmGKBiPA134893180.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0587. Eukaryota.
ENOG410XPHR. LUCA.
GeneTreeiENSGT00810000125351.
HOVERGENiHBG036506.
InParanoidiQ9UKE5.
KOiK08840.
OMAiTEQYNVG.
OrthoDBiEOG091G018A.
PhylomeDBiQ9UKE5.
TreeFamiTF105138.

Enzyme and pathway databases

BioCyciZFISH:HS07972-MONOMER.
ReactomeiR-HSA-2559580. Oxidative Stress Induced Senescence.
SignaLinkiQ9UKE5.
SIGNORiQ9UKE5.

Miscellaneous databases

ChiTaRSiTNIK. human.
EvolutionaryTraceiQ9UKE5.
GeneWikiiTNIK.
GenomeRNAii23043.
PMAP-CutDBQ9UKE5.
PROiQ9UKE5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154310.
ExpressionAtlasiQ9UKE5. baseline and differential.
GenevisibleiQ9UKE5. HS.

Family and domain databases

InterProiIPR001180. CNH_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00036. CNH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50219. CNH. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNIK_HUMAN
AccessioniPrimary (citable) accession number: Q9UKE5
Secondary accession number(s): A7E2A3
, A8K4U1, D3DNQ6, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 164 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.