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Protein

mRNA turnover protein 4 homolog

Gene

MRTO4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.1 Publication

GO - Molecular functioni

  • large ribosomal subunit rRNA binding Source: GO_Central
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA turnover protein 4 homologBy similarity
Alternative name(s):
Ribosome assembly factor MRTO4By similarityCurated
Gene namesi
Name:MRTO4
Synonyms:C1orf33, MRT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18477. MRTO4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51154.
OpenTargetsiENSG00000053372.
PharmGKBiPA162396216.

Polymorphism and mutation databases

BioMutaiMRTO4.
DMDMi51316541.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001548161 – 239mRNA turnover protein 4 homologAdd BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei225PhosphoserineBy similarity1
Modified residuei229PhosphoserineBy similarity1
Modified residuei233PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UKD2.
MaxQBiQ9UKD2.
PaxDbiQ9UKD2.
PeptideAtlasiQ9UKD2.
PRIDEiQ9UKD2.

2D gel databases

SWISS-2DPAGEQ9UKD2.

PTM databases

iPTMnetiQ9UKD2.
PhosphoSitePlusiQ9UKD2.
SwissPalmiQ9UKD2.

Expressioni

Gene expression databases

BgeeiENSG00000053372.
CleanExiHS_MRTO4.
ExpressionAtlasiQ9UKD2. baseline and differential.
GenevisibleiQ9UKD2. HS.

Organism-specific databases

HPAiHPA026438.
HPA026446.

Interactioni

Subunit structurei

Associates with the pre-60S ribosomal particle.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2IPQ9NYB02EBI-1046493,EBI-750109

Protein-protein interaction databases

BioGridi119337. 62 interactors.
IntActiQ9UKD2. 13 interactors.
MINTiMINT-4727757.
STRINGi9606.ENSP00000364320.

Structurei

3D structure databases

ProteinModelPortaliQ9UKD2.
SMRiQ9UKD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L10P family.Curated

Phylogenomic databases

eggNOGiKOG0816. Eukaryota.
COG0244. LUCA.
GeneTreeiENSGT00390000006238.
HOGENOMiHOG000177263.
HOVERGENiHBG052510.
InParanoidiQ9UKD2.
KOiK14815.
OMAiIKCMWNS.
OrthoDBiEOG091G0MDD.
PhylomeDBiQ9UKD2.
TreeFamiTF300111.

Family and domain databases

CDDicd05796. Ribosomal_P0_like. 1 hit.
InterProiIPR033867. Mrt4.
IPR001790. Ribosomal_L10P.
[Graphical view]
PANTHERiPTHR21141:SF37. PTHR21141:SF37. 1 hit.
PfamiPF00466. Ribosomal_L10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UKD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKSKRDKKV SLTKTAKKGL ELKQNLIEEL RKCVDTYKYL FIFSVANMRN
60 70 80 90 100
SKLKDIRNAW KHSRMFFGKN KVMMVALGRS PSDEYKDNLH QVSKRLRGEV
110 120 130 140 150
GLLFTNRTKE EVNEWFTKYT EMDYARAGNK AAFTVSLDPG PLEQFPHSME
160 170 180 190 200
PQLRQLGLPT ALKRGVVTLL SDYEVCKEGD VLTPEQARVL KLFGYEMAEF
210 220 230
KVTIKYMWDS QSGRFQQMGD DLPESASEST EESDSEDDD
Length:239
Mass (Da):27,560
Last modified:August 16, 2004 - v2
Checksum:iF1BFF6E566FF942F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95R → T in AAD52608 (Ref. 1) Curated1
Sequence conflicti235S → L in BAB55205 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173378 mRNA. Translation: AAD52608.1.
AY303790 mRNA. Translation: AAP68821.1.
AK024227 mRNA. Translation: BAG51275.1.
AK027569 mRNA. Translation: BAB55205.1.
AL035413 Genomic DNA. Translation: CAI22233.1.
CH471134 Genomic DNA. Translation: EAW94873.1.
BC003013 mRNA. Translation: AAH03013.1.
BC006504 mRNA. Translation: AAH06504.1.
CCDSiCCDS191.1.
RefSeqiNP_057267.2. NM_016183.3.
UniGeneiHs.463797.

Genome annotation databases

EnsembliENST00000330263; ENSP00000364320; ENSG00000053372.
GeneIDi51154.
KEGGihsa:51154.
UCSCiuc001bbs.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173378 mRNA. Translation: AAD52608.1.
AY303790 mRNA. Translation: AAP68821.1.
AK024227 mRNA. Translation: BAG51275.1.
AK027569 mRNA. Translation: BAB55205.1.
AL035413 Genomic DNA. Translation: CAI22233.1.
CH471134 Genomic DNA. Translation: EAW94873.1.
BC003013 mRNA. Translation: AAH03013.1.
BC006504 mRNA. Translation: AAH06504.1.
CCDSiCCDS191.1.
RefSeqiNP_057267.2. NM_016183.3.
UniGeneiHs.463797.

3D structure databases

ProteinModelPortaliQ9UKD2.
SMRiQ9UKD2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119337. 62 interactors.
IntActiQ9UKD2. 13 interactors.
MINTiMINT-4727757.
STRINGi9606.ENSP00000364320.

PTM databases

iPTMnetiQ9UKD2.
PhosphoSitePlusiQ9UKD2.
SwissPalmiQ9UKD2.

Polymorphism and mutation databases

BioMutaiMRTO4.
DMDMi51316541.

2D gel databases

SWISS-2DPAGEQ9UKD2.

Proteomic databases

EPDiQ9UKD2.
MaxQBiQ9UKD2.
PaxDbiQ9UKD2.
PeptideAtlasiQ9UKD2.
PRIDEiQ9UKD2.

Protocols and materials databases

DNASUi51154.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330263; ENSP00000364320; ENSG00000053372.
GeneIDi51154.
KEGGihsa:51154.
UCSCiuc001bbs.4. human.

Organism-specific databases

CTDi51154.
DisGeNETi51154.
GeneCardsiMRTO4.
HGNCiHGNC:18477. MRTO4.
HPAiHPA026438.
HPA026446.
neXtProtiNX_Q9UKD2.
OpenTargetsiENSG00000053372.
PharmGKBiPA162396216.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0816. Eukaryota.
COG0244. LUCA.
GeneTreeiENSGT00390000006238.
HOGENOMiHOG000177263.
HOVERGENiHBG052510.
InParanoidiQ9UKD2.
KOiK14815.
OMAiIKCMWNS.
OrthoDBiEOG091G0MDD.
PhylomeDBiQ9UKD2.
TreeFamiTF300111.

Miscellaneous databases

ChiTaRSiMRTO4. human.
GenomeRNAii51154.
PROiQ9UKD2.

Gene expression databases

BgeeiENSG00000053372.
CleanExiHS_MRTO4.
ExpressionAtlasiQ9UKD2. baseline and differential.
GenevisibleiQ9UKD2. HS.

Family and domain databases

CDDicd05796. Ribosomal_P0_like. 1 hit.
InterProiIPR033867. Mrt4.
IPR001790. Ribosomal_L10P.
[Graphical view]
PANTHERiPTHR21141:SF37. PTHR21141:SF37. 1 hit.
PfamiPF00466. Ribosomal_L10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRT4_HUMAN
AccessioniPrimary (citable) accession number: Q9UKD2
Secondary accession number(s): B3KNB3
, Q5TG55, Q96SS6, Q9BPV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.