Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9UKD2

- MRT4_HUMAN

UniProt

Q9UKD2 - MRT4_HUMAN

Protein

mRNA turnover protein 4 homolog

Gene

MRTO4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (16 Aug 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in mRNA turnover and ribosome assembly.By similarity

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. ribosome biogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Ribosome biogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    mRNA turnover protein 4 homolog
    Gene namesi
    Name:MRTO4
    Synonyms:C1orf33, MRT4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:18477. MRTO4.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. nuclear membrane Source: HPA
    2. nucleolus Source: HPA
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162396216.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 239239mRNA turnover protein 4 homologPRO_0000154816Add
    BLAST

    Proteomic databases

    MaxQBiQ9UKD2.
    PaxDbiQ9UKD2.
    PeptideAtlasiQ9UKD2.
    PRIDEiQ9UKD2.

    2D gel databases

    SWISS-2DPAGEQ9UKD2.

    PTM databases

    PhosphoSiteiQ9UKD2.

    Expressioni

    Gene expression databases

    BgeeiQ9UKD2.
    CleanExiHS_MRTO4.
    GenevestigatoriQ9UKD2.

    Organism-specific databases

    HPAiHPA026438.
    HPA026446.

    Interactioni

    Protein-protein interaction databases

    BioGridi119337. 27 interactions.
    IntActiQ9UKD2. 5 interactions.
    MINTiMINT-4727757.
    STRINGi9606.ENSP00000364320.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UKD2.
    SMRiQ9UKD2. Positions 5-218.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L10P family.Curated

    Phylogenomic databases

    eggNOGiCOG0244.
    HOGENOMiHOG000177263.
    HOVERGENiHBG052510.
    InParanoidiQ9UKD2.
    KOiK14815.
    OMAiDCMTISE.
    OrthoDBiEOG70GMGM.
    PhylomeDBiQ9UKD2.
    TreeFamiTF300111.

    Family and domain databases

    InterProiIPR001790. Ribosomal_L10/acidic_P0.
    [Graphical view]
    PfamiPF00466. Ribosomal_L10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UKD2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKSKRDKKV SLTKTAKKGL ELKQNLIEEL RKCVDTYKYL FIFSVANMRN    50
    SKLKDIRNAW KHSRMFFGKN KVMMVALGRS PSDEYKDNLH QVSKRLRGEV 100
    GLLFTNRTKE EVNEWFTKYT EMDYARAGNK AAFTVSLDPG PLEQFPHSME 150
    PQLRQLGLPT ALKRGVVTLL SDYEVCKEGD VLTPEQARVL KLFGYEMAEF 200
    KVTIKYMWDS QSGRFQQMGD DLPESASEST EESDSEDDD 239
    Length:239
    Mass (Da):27,560
    Last modified:August 16, 2004 - v2
    Checksum:iF1BFF6E566FF942F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti95 – 951R → T in AAD52608. 1 PublicationCurated
    Sequence conflicti235 – 2351S → L in BAB55205. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF173378 mRNA. Translation: AAD52608.1.
    AY303790 mRNA. Translation: AAP68821.1.
    AK024227 mRNA. Translation: BAG51275.1.
    AK027569 mRNA. Translation: BAB55205.1.
    AL035413 Genomic DNA. Translation: CAI22233.1.
    CH471134 Genomic DNA. Translation: EAW94873.1.
    BC003013 mRNA. Translation: AAH03013.1.
    BC006504 mRNA. Translation: AAH06504.1.
    CCDSiCCDS191.1.
    RefSeqiNP_057267.2. NM_016183.3.
    UniGeneiHs.463797.

    Genome annotation databases

    EnsembliENST00000330263; ENSP00000364320; ENSG00000053372.
    GeneIDi51154.
    KEGGihsa:51154.
    UCSCiuc001bbs.3. human.

    Polymorphism databases

    DMDMi51316541.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF173378 mRNA. Translation: AAD52608.1 .
    AY303790 mRNA. Translation: AAP68821.1 .
    AK024227 mRNA. Translation: BAG51275.1 .
    AK027569 mRNA. Translation: BAB55205.1 .
    AL035413 Genomic DNA. Translation: CAI22233.1 .
    CH471134 Genomic DNA. Translation: EAW94873.1 .
    BC003013 mRNA. Translation: AAH03013.1 .
    BC006504 mRNA. Translation: AAH06504.1 .
    CCDSi CCDS191.1.
    RefSeqi NP_057267.2. NM_016183.3.
    UniGenei Hs.463797.

    3D structure databases

    ProteinModelPortali Q9UKD2.
    SMRi Q9UKD2. Positions 5-218.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119337. 27 interactions.
    IntActi Q9UKD2. 5 interactions.
    MINTi MINT-4727757.
    STRINGi 9606.ENSP00000364320.

    PTM databases

    PhosphoSitei Q9UKD2.

    Polymorphism databases

    DMDMi 51316541.

    2D gel databases

    SWISS-2DPAGE Q9UKD2.

    Proteomic databases

    MaxQBi Q9UKD2.
    PaxDbi Q9UKD2.
    PeptideAtlasi Q9UKD2.
    PRIDEi Q9UKD2.

    Protocols and materials databases

    DNASUi 51154.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000330263 ; ENSP00000364320 ; ENSG00000053372 .
    GeneIDi 51154.
    KEGGi hsa:51154.
    UCSCi uc001bbs.3. human.

    Organism-specific databases

    CTDi 51154.
    GeneCardsi GC01P019578.
    HGNCi HGNC:18477. MRTO4.
    HPAi HPA026438.
    HPA026446.
    neXtProti NX_Q9UKD2.
    PharmGKBi PA162396216.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0244.
    HOGENOMi HOG000177263.
    HOVERGENi HBG052510.
    InParanoidi Q9UKD2.
    KOi K14815.
    OMAi DCMTISE.
    OrthoDBi EOG70GMGM.
    PhylomeDBi Q9UKD2.
    TreeFami TF300111.

    Miscellaneous databases

    ChiTaRSi MRTO4. human.
    GenomeRNAii 51154.
    NextBioi 54049.
    PROi Q9UKD2.

    Gene expression databases

    Bgeei Q9UKD2.
    CleanExi HS_MRTO4.
    Genevestigatori Q9UKD2.

    Family and domain databases

    InterProi IPR001790. Ribosomal_L10/acidic_P0.
    [Graphical view ]
    Pfami PF00466. Ribosomal_L10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Ge H.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Zou S.W., Miao S.Y., Zhang X.D., Qiao Y., Wang L.F.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMRT4_HUMAN
    AccessioniPrimary (citable) accession number: Q9UKD2
    Secondary accession number(s): B3KNB3
    , Q5TG55, Q96SS6, Q9BPV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3