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Protein

mRNA turnover protein 4 homolog

Gene

MRTO4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA turnover protein 4 homologBy similarity
Alternative name(s):
Ribosome assembly factor MRTO4By similarityCurated
Gene namesi
Name:MRTO4
Synonyms:C1orf33, MRT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000053372.4
HGNCiHGNC:18477 MRTO4
neXtProtiNX_Q9UKD2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51154
OpenTargetsiENSG00000053372
PharmGKBiPA162396216

Polymorphism and mutation databases

BioMutaiMRTO4
DMDMi51316541

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001548161 – 239mRNA turnover protein 4 homologAdd BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei225PhosphoserineBy similarity1
Modified residuei229PhosphoserineBy similarity1
Modified residuei233PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UKD2
MaxQBiQ9UKD2
PaxDbiQ9UKD2
PeptideAtlasiQ9UKD2
PRIDEiQ9UKD2

2D gel databases

SWISS-2DPAGEiQ9UKD2

PTM databases

iPTMnetiQ9UKD2
PhosphoSitePlusiQ9UKD2
SwissPalmiQ9UKD2

Expressioni

Gene expression databases

BgeeiENSG00000053372
CleanExiHS_MRTO4
ExpressionAtlasiQ9UKD2 baseline and differential
GenevisibleiQ9UKD2 HS

Organism-specific databases

HPAiHPA026446

Interactioni

Subunit structurei

Associates with the pre-60S ribosomal particle.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2IPQ9NYB02EBI-1046493,EBI-750109

Protein-protein interaction databases

BioGridi11933767 interactors.
IntActiQ9UKD2 14 interactors.
STRINGi9606.ENSP00000364320

Structurei

3D structure databases

ProteinModelPortaliQ9UKD2
SMRiQ9UKD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0816 Eukaryota
COG0244 LUCA
GeneTreeiENSGT00390000006238
HOGENOMiHOG000177263
HOVERGENiHBG052510
InParanoidiQ9UKD2
KOiK14815
OMAiYWAVEYA
OrthoDBiEOG091G0MDD
PhylomeDBiQ9UKD2
TreeFamiTF300111

Family and domain databases

CDDicd05796 Ribosomal_P0_like, 1 hit
InterProiView protein in InterPro
IPR033867 Mrt4
IPR001790 Ribosomal_L10P
PfamiView protein in Pfam
PF00466 Ribosomal_L10, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UKD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKSKRDKKV SLTKTAKKGL ELKQNLIEEL RKCVDTYKYL FIFSVANMRN
60 70 80 90 100
SKLKDIRNAW KHSRMFFGKN KVMMVALGRS PSDEYKDNLH QVSKRLRGEV
110 120 130 140 150
GLLFTNRTKE EVNEWFTKYT EMDYARAGNK AAFTVSLDPG PLEQFPHSME
160 170 180 190 200
PQLRQLGLPT ALKRGVVTLL SDYEVCKEGD VLTPEQARVL KLFGYEMAEF
210 220 230
KVTIKYMWDS QSGRFQQMGD DLPESASEST EESDSEDDD
Length:239
Mass (Da):27,560
Last modified:August 16, 2004 - v2
Checksum:iF1BFF6E566FF942F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95R → T in AAD52608 (Ref. 1) Curated1
Sequence conflicti235S → L in BAB55205 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173378 mRNA Translation: AAD52608.1
AY303790 mRNA Translation: AAP68821.1
AK024227 mRNA Translation: BAG51275.1
AK027569 mRNA Translation: BAB55205.1
AL035413 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW94873.1
BC003013 mRNA Translation: AAH03013.1
BC006504 mRNA Translation: AAH06504.1
CCDSiCCDS191.1
RefSeqiNP_057267.2, NM_016183.3
UniGeneiHs.463797

Genome annotation databases

EnsembliENST00000330263; ENSP00000364320; ENSG00000053372
GeneIDi51154
KEGGihsa:51154
UCSCiuc001bbs.4 human

Similar proteinsi

Entry informationi

Entry nameiMRT4_HUMAN
AccessioniPrimary (citable) accession number: Q9UKD2
Secondary accession number(s): B3KNB3
, Q5TG55, Q96SS6, Q9BPV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: March 28, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome