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Protein

Glucocorticoid modulatory element-binding protein 2

Gene

GMEB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi110ZincBy similarity1
Binding sitei136DNABy similarity1
Binding sitei140DNABy similarity1
Binding sitei143DNABy similarity1
Binding sitei154DNABy similarity1
Metal bindingi167ZincBy similarity1
Metal bindingi171ZincBy similarity1
Metal bindingi175ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription by RNA polymerase II Source: GO_Central
  • transcription by RNA polymerase II Source: ProtInc

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Glucocorticoid modulatory element-binding protein 2
Short name:
GMEB-2
Alternative name(s):
DNA-binding protein p79PIF
Parvovirus initiation factor p79
Short name:
PIF p79
Gene namesi
Name:GMEB2
Synonyms:KIAA1269
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101216.10
HGNCiHGNC:4371 GMEB2
MIMi607451 gene
neXtProtiNX_Q9UKD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101216
PharmGKBiPA28756

Polymorphism and mutation databases

BioMutaiGMEB2
DMDMi22001626

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000740921 – 530Glucocorticoid modulatory element-binding protein 2Add BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki155Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki155Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei373PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UKD1
MaxQBiQ9UKD1
PaxDbiQ9UKD1
PeptideAtlasiQ9UKD1
PRIDEiQ9UKD1

PTM databases

iPTMnetiQ9UKD1
PhosphoSitePlusiQ9UKD1

Expressioni

Tissue specificityi

Expressed in peripheral blood lymphocytes and fetal liver. Expressed preferentially in reproductive and/or developmentally important cells, such as testis, placenta, bone marrow and fetal tissues.

Gene expression databases

BgeeiENSG00000101216
CleanExiHS_GMEB2
ExpressionAtlasiQ9UKD1 baseline and differential
GenevisibleiQ9UKD1 HS

Organism-specific databases

HPAiHPA009706
HPA067455

Interactioni

Subunit structurei

Homodimer, and heterodimer of GMEB1 and GMEB2. GMEB1 and GMEB2 form the parvovirus initiator complex (PIF). Interacts with the glucocorticoid receptor (NR3C1). May interact with CREB-binding protein (CBP).

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi117605, 14 interactors
IntActiQ9UKD1, 16 interactors
STRINGi9606.ENSP00000266068

Structurei

3D structure databases

ProteinModelPortaliQ9UKD1
SMRiQ9UKD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 163SANDPROSITE-ProRule annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili304 – 348Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi57 – 64Poly-Ala8

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4333 Eukaryota
ENOG410ZMTP LUCA
GeneTreeiENSGT00410000025596
HOVERGENiHBG051742
InParanoidiQ9UKD1
OMAiALEQQCD
OrthoDBiEOG091G07Q9
PhylomeDBiQ9UKD1
TreeFamiTF317090

Family and domain databases

Gene3Di3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR024830 GMEB1/2
IPR010919 SAND-like_dom_sf
IPR000770 SAND_dom
PANTHERiPTHR10417 PTHR10417, 1 hit
PfamiView protein in Pfam
PF01342 SAND, 1 hit
SMARTiView protein in SMART
SM00258 SAND, 1 hit
SUPFAMiSSF63763 SSF63763, 1 hit
PROSITEiView protein in PROSITE
PS50864 SAND, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UKD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPDVSVHM EEVVVVTTPD TAVDGSGVEG VKTVLVTTNL APHGGDLTED
60 70 80 90 100
NMETENAAAA AAAAFTASSQ LKEAVLVKMA EEGENLEAEI VYPITCGDSR
110 120 130 140 150
ANLIWRKFVC PGINVKCVQY DEHVISPKEF VHLAGKSTLK DWKRAIRMNG
160 170 180 190 200
IMLRKIMDSG ELDFYQHDKV CSNTCRSTKI DLSGARVSLS SPTSAEYIPL
210 220 230 240 250
TPAAADVNGS PATITIETCE DPGDWTAAIG DDTFTFWRGL KDAGLLDEVI
260 270 280 290 300
QEFHQELVET MRGLQQRVQD PPLQLRDAVL LNNIVQNFGM LDLVKKVLAS
310 320 330 340 350
HKCQMDRSRE QYARDLAALE QQCDEHRRRA KELKHKSQHL SNVLMTLTPV
360 370 380 390 400
SLPPPVKRPR LARATSGPAA MASQVLTQSA QLALGPGVPV PQLTSVPLGK
410 420 430 440 450
VVSTLPSTVL GKGSLQAPPA SSPASPLLGG YTVLASSGST YPSTVEIHPD
460 470 480 490 500
ASSLTVLSTA AVQDGSTVFK VVSPLQLLTL PGLGPTLQNV AQASPGSSTI
510 520 530
VTVPAGAAPG PEEHTATIEV AAMAEDHERK
Length:530
Mass (Da):56,421
Last modified:May 1, 2000 - v1
Checksum:iD2EEF49FD8206854
GO

Sequence cautioni

The sequence BAA86583 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24 – 44DGSGV…LAPHG → CPAGCALRDPDSILSSLHFT R (PubMed:17974005).CuratedAdd BLAST21
Sequence conflicti77 – 78Missing (PubMed:17974005).Curated2
Sequence conflicti381 – 382QL → PV in BAA86583 (PubMed:10574462).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173867 mRNA Translation: AAD51351.1
AB033095 mRNA Translation: BAA86583.1 Different initiation.
AL121907 Genomic DNA No translation available.
AL353715 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75253.1
CH471077 Genomic DNA Translation: EAW75254.1
BC036305 mRNA Translation: AAH36305.1
AL133646 mRNA Translation: CAB63765.1
CCDSiCCDS13528.1
RefSeqiNP_036516.1, NM_012384.4
XP_005260259.1, XM_005260202.4
UniGeneiHs.473286

Genome annotation databases

EnsembliENST00000266068; ENSP00000266068; ENSG00000101216
ENST00000370077; ENSP00000359094; ENSG00000101216
GeneIDi26205
KEGGihsa:26205
UCSCiuc002yfp.1 human

Similar proteinsi

Entry informationi

Entry nameiGMEB2_HUMAN
AccessioniPrimary (citable) accession number: Q9UKD1
Secondary accession number(s): E1P5J3
, Q5TDS0, Q9H431, Q9H4X7, Q9H4X8, Q9UF78, Q9ULF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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