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Q9UKC9

- FBXL2_HUMAN

UniProt

Q9UKC9 - FBXL2_HUMAN

Protein

F-box/LRR-repeat protein 2

Gene

FBXL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 3 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin By similarity. Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G0, also antagonized by calmodulin. Binds to hepatitis C virus non-structural protein 5A (NS5A) in a reaction crucial for hepatitis C virus RNA replication.By similarity3 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. ubiquitin-protein transferase activity Source: ProtInc

    GO - Biological processi

    1. cellular protein modification process Source: ProtInc
    2. protein monoubiquitination Source: Ensembl
    3. proteolysis Source: ProtInc
    4. ubiquitin-dependent protein catabolic process Source: Ensembl
    5. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Ubl conjugation pathway

    Keywords - Ligandi

    Calcium, Calmodulin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box/LRR-repeat protein 2
    Alternative name(s):
    F-box and leucine-rich repeat protein 2
    F-box protein FBL2/FBL3
    Gene namesi
    Name:FBXL2
    Synonyms:FBL2, FBL3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:13598. FBXL2.

    Subcellular locationi

    Membrane 1 Publication; Lipid-anchor 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: ProtInc
    2. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi420 – 4201C → S: Loss of geranylgeranylation and association to membranes. 1 Publication

    Organism-specific databases

    PharmGKBiPA28021.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 423423F-box/LRR-repeat protein 2PRO_0000119840Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi420 – 4201S-geranylgeranyl cysteine1 Publication

    Keywords - PTMi

    Lipoprotein, Prenylation

    Proteomic databases

    MaxQBiQ9UKC9.
    PaxDbiQ9UKC9.
    PRIDEiQ9UKC9.

    Expressioni

    Tissue specificityi

    Expressed in brain, heart, kidney, liver, lung, pancreas and placenta.1 Publication

    Gene expression databases

    ArrayExpressiQ9UKC9.
    BgeeiQ9UKC9.
    CleanExiHS_FBXL2.
    GenevestigatoriQ9UKC9.

    Organism-specific databases

    HPAiHPA003240.

    Interactioni

    Subunit structurei

    Interacts with SKP1. Interacts with PCYT1A. Part of a SCF (SKP1-cullin-F-box) protein ligase complex By similarity. Interacts (via CAAX motif) with hepatitis C virus non-structural protein 5A (NS5A). May also interact, but less efficiently, with hepatitis C virus non-structural protein 5B (NS5B). Interacts with CCND2 and CCND3.By similarity4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HSP90AB1P082382EBI-724253,EBI-352572

    Protein-protein interaction databases

    BioGridi117355. 14 interactions.
    IntActiQ9UKC9. 7 interactions.
    MINTiMINT-1390736.
    STRINGi9606.ENSP00000417601.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UKC9.
    SMRiQ9UKC9. Positions 15-394.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 5547F-boxPROSITE-ProRule annotationAdd
    BLAST
    Repeati61 – 8727LRR 1Add
    BLAST
    Repeati88 – 11326LRR 2Add
    BLAST
    Repeati114 – 13926LRR 3Add
    BLAST
    Repeati140 – 16526LRR 4Add
    BLAST
    Repeati166 – 19126LRR 5Add
    BLAST
    Repeati192 – 21726LRR 6Add
    BLAST
    Repeati218 – 24326LRR 7Add
    BLAST
    Repeati244 – 26926LRR 8Add
    BLAST
    Repeati270 – 29526LRR 9Add
    BLAST
    Repeati296 – 32126LRR 10Add
    BLAST
    Repeati322 – 35029LRR 11Add
    BLAST
    Repeati351 – 37525LRR 12Add
    BLAST
    Repeati376 – 40126LRR 13Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni80 – 9011Interaction with CalmodulinBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi420 – 4234CAAX motif

    Sequence similaritiesi

    Contains 1 F-box domain.PROSITE-ProRule annotation
    Contains 13 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG300245.
    HOGENOMiHOG000230659.
    HOVERGENiHBG051586.
    InParanoidiQ9UKC9.
    KOiK10268.
    OMAiCVAITNS.
    OrthoDBiEOG7CVPXM.
    PhylomeDBiQ9UKC9.
    TreeFamiTF313434.

    Family and domain databases

    InterProiIPR001810. F-box_dom.
    IPR006553. Leu-rich_rpt_Cys-con_subtyp.
    [Graphical view]
    PfamiPF00646. F-box. 1 hit.
    [Graphical view]
    SMARTiSM00256. FBOX. 1 hit.
    SM00367. LRR_CC. 2 hits.
    [Graphical view]
    PROSITEiPS50181. FBOX. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UKC9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVFSNNDEGL INKKLPKELL LRIFSFLDIV TLCRCAQISK AWNILALDGS    50
    NWQRIDLFNF QTDVEGRVVE NISKRCGGFL RKLSLRGCIG VGDSSLKTFA 100
    QNCRNIEHLN LNGCTKITDS TCYSLSRFCS KLKHLDLTSC VSITNSSLKG 150
    ISEGCRNLEY LNLSWCDQIT KDGIEALVRG CRGLKALLLR GCTQLEDEAL 200
    KHIQNYCHEL VSLNLQSCSR ITDEGVVQIC RGCHRLQALC LSGCSNLTDA 250
    SLTALGLNCP RLQILEAARC SHLTDAGFTL LARNCHELEK MDLEECILIT 300
    DSTLIQLSIH CPKLQALSLS HCELITDDGI LHLSNSTCGH ERLRVLELDN 350
    CLLITDVALE HLENCRGLER LELYDCQQVT RAGIKRMRAQ LPHVKVHAYF 400
    APVTPPTAVA GSGQRLCRCC VIL 423
    Length:423
    Mass (Da):47,062
    Last modified:April 17, 2007 - v3
    Checksum:i61938E434618BA3D
    GO
    Isoform 2 (identifier: Q9UKC9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         132-199: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:355
    Mass (Da):39,613
    Checksum:iF1C3CDED0C7F0131
    GO

    Sequence cautioni

    The sequence AAF03128.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti62 – 621T → I in AAF04510. (PubMed:10531035)Curated
    Sequence conflicti62 – 621T → I in AAF03128. (PubMed:10531037)Curated
    Sequence conflicti62 – 621T → I in CAG33402. 1 PublicationCurated
    Sequence conflicti77 – 771G → V in AAF04510. (PubMed:10531035)Curated
    Sequence conflicti81 – 811R → K in BAA91691. (PubMed:14702039)Curated
    Sequence conflicti108 – 1081H → Q in BAG61062. (PubMed:14702039)Curated
    Sequence conflicti174 – 1741I → W in CAB43222. (PubMed:17974005)Curated
    Sequence conflicti320 – 3201S → P in CAB43222. (PubMed:17974005)Curated
    Sequence conflicti342 – 3421R → G in CAG33402. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti226 – 2261V → M in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036071

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei132 – 19968Missing in isoform 2. 1 PublicationVSP_044600Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF174589 mRNA. Translation: AAF04510.1.
    AF176518 mRNA. Translation: AAF03128.1. Different initiation.
    AF186273 mRNA. Translation: AAD56248.1.
    AK001438 mRNA. Translation: BAA91691.1.
    AK298967 mRNA. Translation: BAG61062.1.
    CR457121 mRNA. Translation: CAG33402.1.
    AC122176 Genomic DNA. No translation available.
    AC123900 Genomic DNA. No translation available.
    BC031556 mRNA. Translation: AAH31556.1.
    AL049953 mRNA. Translation: CAB43222.1.
    CCDSiCCDS2658.1. [Q9UKC9-1]
    CCDS54560.1. [Q9UKC9-2]
    PIRiT08680.
    RefSeqiNP_001165184.1. NM_001171713.1. [Q9UKC9-2]
    NP_036289.3. NM_012157.3. [Q9UKC9-1]
    UniGeneiHs.475872.

    Genome annotation databases

    EnsembliENST00000484457; ENSP00000417601; ENSG00000153558. [Q9UKC9-1]
    ENST00000507198; ENSP00000426163; ENSG00000153558. [Q9UKC9-2]
    ENST00000538892; ENSP00000441228; ENSG00000153558. [Q9UKC9-2]
    GeneIDi25827.
    KEGGihsa:25827.
    UCSCiuc003cfp.3. human. [Q9UKC9-1]
    uc021wuy.1. human.

    Polymorphism databases

    DMDMi145559475.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF174589 mRNA. Translation: AAF04510.1 .
    AF176518 mRNA. Translation: AAF03128.1 . Different initiation.
    AF186273 mRNA. Translation: AAD56248.1 .
    AK001438 mRNA. Translation: BAA91691.1 .
    AK298967 mRNA. Translation: BAG61062.1 .
    CR457121 mRNA. Translation: CAG33402.1 .
    AC122176 Genomic DNA. No translation available.
    AC123900 Genomic DNA. No translation available.
    BC031556 mRNA. Translation: AAH31556.1 .
    AL049953 mRNA. Translation: CAB43222.1 .
    CCDSi CCDS2658.1. [Q9UKC9-1 ]
    CCDS54560.1. [Q9UKC9-2 ]
    PIRi T08680.
    RefSeqi NP_001165184.1. NM_001171713.1. [Q9UKC9-2 ]
    NP_036289.3. NM_012157.3. [Q9UKC9-1 ]
    UniGenei Hs.475872.

    3D structure databases

    ProteinModelPortali Q9UKC9.
    SMRi Q9UKC9. Positions 15-394.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117355. 14 interactions.
    IntActi Q9UKC9. 7 interactions.
    MINTi MINT-1390736.
    STRINGi 9606.ENSP00000417601.

    Polymorphism databases

    DMDMi 145559475.

    Proteomic databases

    MaxQBi Q9UKC9.
    PaxDbi Q9UKC9.
    PRIDEi Q9UKC9.

    Protocols and materials databases

    DNASUi 25827.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000484457 ; ENSP00000417601 ; ENSG00000153558 . [Q9UKC9-1 ]
    ENST00000507198 ; ENSP00000426163 ; ENSG00000153558 . [Q9UKC9-2 ]
    ENST00000538892 ; ENSP00000441228 ; ENSG00000153558 . [Q9UKC9-2 ]
    GeneIDi 25827.
    KEGGi hsa:25827.
    UCSCi uc003cfp.3. human. [Q9UKC9-1 ]
    uc021wuy.1. human.

    Organism-specific databases

    CTDi 25827.
    GeneCardsi GC03P033293.
    HGNCi HGNC:13598. FBXL2.
    HPAi HPA003240.
    MIMi 605652. gene.
    neXtProti NX_Q9UKC9.
    PharmGKBi PA28021.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG300245.
    HOGENOMi HOG000230659.
    HOVERGENi HBG051586.
    InParanoidi Q9UKC9.
    KOi K10268.
    OMAi CVAITNS.
    OrthoDBi EOG7CVPXM.
    PhylomeDBi Q9UKC9.
    TreeFami TF313434.

    Miscellaneous databases

    ChiTaRSi FBXL2. human.
    GeneWikii FBXL2.
    GenomeRNAii 25827.
    NextBioi 47109.
    PROi Q9UKC9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UKC9.
    Bgeei Q9UKC9.
    CleanExi HS_FBXL2.
    Genevestigatori Q9UKC9.

    Family and domain databases

    InterProi IPR001810. F-box_dom.
    IPR006553. Leu-rich_rpt_Cys-con_subtyp.
    [Graphical view ]
    Pfami PF00646. F-box. 1 hit.
    [Graphical view ]
    SMARTi SM00256. FBOX. 1 hit.
    SM00367. LRR_CC. 2 hits.
    [Graphical view ]
    PROSITEi PS50181. FBOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH SKP1, TISSUE SPECIFICITY.
    3. "cDNA cloning and expression analysis of new members of the mammalian F-box protein family."
      Ilyin G.P., Rialland M., Pigeon C., Guguen-Guillouzo C.
      Genomics 67:40-47(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 174-423 (ISOFORM 1).
      Tissue: Brain.
    9. "Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication."
      Wang C., Gale M. Jr., Keller B.C., Huang H., Brown M.S., Goldstein J.L., Ye J.
      Mol. Cell 18:425-434(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH HEPATITIS C VIRUS NS5A, ISOPRENYLATION AT CYS-420, MUTAGENESIS OF CYS-420, SUBCELLULAR LOCATION.
    10. "F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation."
      Chen B.B., Glasser J.R., Coon T.A., Zou C., Miller H.L., Fenton M., McDyer J.F., Boyiadzis M., Mallampalli R.K.
      Blood 119:3132-3141(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CCND2.
    11. "F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest."
      Chen B.B., Glasser J.R., Coon T.A., Mallampalli R.K.
      Oncogene 31:2566-2579(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CCND3.
    12. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-226.

    Entry informationi

    Entry nameiFBXL2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UKC9
    Secondary accession number(s): B4DQV0
    , E9PD06, Q6IAN3, Q9NVQ8, Q9UK27, Q9UKA5, Q9Y3Y9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 21, 2003
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 119 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Deletion of the F-box domain creates a dominant-negative protein that inhibits replication of hepatitis C virus RNA when overexpressed in a hepatoma cell line; this inhibition could be overcome by NS5A coexpression.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3