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Protein

Adherens junction-associated protein 1

Gene

AJAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in cell adhesion and cell migration.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:G66-30645-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Adherens junction-associated protein 1
Alternative name(s):
Membrane protein shrew-1
Gene namesi
Name:AJAP1
Synonyms:MOT8, SHREW1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30801. AJAP1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 282ExtracellularSequence analysisAdd BLAST282
Transmembranei283 – 303Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini304 – 411CytoplasmicSequence analysisAdd BLAST108

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi303L → A: Mistargeting to the apical membrane. 1 Publication1
Mutagenesisi350Y → A: Mistargeting to the apical membrane. 1 Publication1
Mutagenesisi368Y → A: Mistargeting to the apical membrane. 1 Publication1
Mutagenesisi380Y → A: Mistargeting to the apical membrane. 1 Publication1
Mutagenesisi396 – 397LI → HV: Mistargeting to the apical membrane. 1 Publication2
Mutagenesisi396L → A: Mistargeting to the apical membrane. 1 Publication1

Organism-specific databases

DisGeNETi55966.
OpenTargetsiENSG00000196581.
PharmGKBiPA142672629.

Polymorphism and mutation databases

BioMutaiAJAP1.
DMDMi74761984.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002848011 – 411Adherens junction-associated protein 1Add BLAST411

Post-translational modificationi

Thr-237 and Ser-239 may be phosphorylated; however as this position is probably extracellular, the in vivo relevance is not proven.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UKB5.
PaxDbiQ9UKB5.
PeptideAtlasiQ9UKB5.
PRIDEiQ9UKB5.

PTM databases

iPTMnetiQ9UKB5.
PhosphoSitePlusiQ9UKB5.

Expressioni

Tissue specificityi

Expressed in uterus and pancreas (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000196581.
CleanExiHS_AJAP1.
GenevisibleiQ9UKB5. HS.

Organism-specific databases

HPAiHPA012157.

Interactioni

Subunit structurei

Forms a complex with CDH1 and CTNNB1; interacts directly with CTNNB1. Interacts with AP1M2 and BSG/CD147.3 Publications

Protein-protein interaction databases

BioGridi121012. 3 interactors.
IntActiQ9UKB5. 2 interactors.
MINTiMINT-7969255.
STRINGi9606.ENSP00000367432.

Structurei

3D structure databases

ProteinModelPortaliQ9UKB5.
SMRiQ9UKB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni303 – 411Targeting signalsAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi175 – 237Thr-richAdd BLAST63

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHN1. Eukaryota.
ENOG410YW4K. LUCA.
GeneTreeiENSGT00510000048586.
HOGENOMiHOG000033873.
HOVERGENiHBG096853.
InParanoidiQ9UKB5.
OMAiESNTFPG.
OrthoDBiEOG091G0GGA.
PhylomeDBiQ9UKB5.
TreeFamiTF336539.

Family and domain databases

InterProiIPR029198. AJAP1_PANP_C.
[Graphical view]
PfamiPF15298. AJAP1_PANP_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UKB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWIQQLLGLS SMSIRWPGRP LGSHAWILIA MFQLAVDLPA CEALGPGPEF
60 70 80 90 100
WLLPRSPPRP PRLWSFRSGQ PARVPAPVWS PRPPRVERIH GQMQMPRARR
110 120 130 140 150
AHRPRDQAAA LVPKAGLAKP PAAAKSSPSL ASSSSSSSSA VAGGAPEQQA
160 170 180 190 200
LLRRGKRHLQ GDGLSSFDSR GSRPTTETEF IAWGPTGDEE ALESNTFPGV
210 220 230 240 250
YGPTTVSILQ TRKTTVAATT TTTTTATPMT LQTKGFTESL DPRRRIPGGV
260 270 280 290 300
STTEPSTSPS NNGEVTQPPR ILGEASGLAV HQIITITVSL IMVIAALITT
310 320 330 340 350
LVLKNCCAQS GNTRRNSHQR KTNQQEESCQ NLTDFPSARV PSSLDIFTAY
360 370 380 390 400
NETLQCSHEC VRASVPVYTD ETLHSTTGEY KSTFNGNRPS SSDRHLIPVA
410
FVSEKWFEIS C
Length:411
Mass (Da):44,536
Last modified:May 1, 2000 - v1
Checksum:i42C1C5F56B9FC975
GO

Sequence cautioni

The sequence CAB41245 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB41246 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031821263G → R.1 PublicationCorresponds to variant rs242056dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY282806 mRNA. Translation: AAP35025.1.
AF175409 mRNA. Translation: AAD53278.1.
AL391808, AL023586, Z98886 Genomic DNA. Translation: CAH72438.1.
AL023586, AL391808, Z98886 Genomic DNA. Translation: CAI20566.1.
Z98886, AL023586, AL391808 Genomic DNA. Translation: CAI22750.1.
AL049672 mRNA. Translation: CAB41245.1. Different initiation.
AL049673 mRNA. Translation: CAB41246.1. Different initiation.
CCDSiCCDS54.1.
RefSeqiNP_001035943.1. NM_001042478.1.
NP_061324.1. NM_018836.3.
XP_011540088.1. XM_011541786.2.
UniGeneiHs.12473.
Hs.25924.

Genome annotation databases

EnsembliENST00000378190; ENSP00000367432; ENSG00000196581.
ENST00000378191; ENSP00000367433; ENSG00000196581.
GeneIDi55966.
KEGGihsa:55966.
UCSCiuc001alm.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY282806 mRNA. Translation: AAP35025.1.
AF175409 mRNA. Translation: AAD53278.1.
AL391808, AL023586, Z98886 Genomic DNA. Translation: CAH72438.1.
AL023586, AL391808, Z98886 Genomic DNA. Translation: CAI20566.1.
Z98886, AL023586, AL391808 Genomic DNA. Translation: CAI22750.1.
AL049672 mRNA. Translation: CAB41245.1. Different initiation.
AL049673 mRNA. Translation: CAB41246.1. Different initiation.
CCDSiCCDS54.1.
RefSeqiNP_001035943.1. NM_001042478.1.
NP_061324.1. NM_018836.3.
XP_011540088.1. XM_011541786.2.
UniGeneiHs.12473.
Hs.25924.

3D structure databases

ProteinModelPortaliQ9UKB5.
SMRiQ9UKB5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121012. 3 interactors.
IntActiQ9UKB5. 2 interactors.
MINTiMINT-7969255.
STRINGi9606.ENSP00000367432.

PTM databases

iPTMnetiQ9UKB5.
PhosphoSitePlusiQ9UKB5.

Polymorphism and mutation databases

BioMutaiAJAP1.
DMDMi74761984.

Proteomic databases

MaxQBiQ9UKB5.
PaxDbiQ9UKB5.
PeptideAtlasiQ9UKB5.
PRIDEiQ9UKB5.

Protocols and materials databases

DNASUi55966.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378190; ENSP00000367432; ENSG00000196581.
ENST00000378191; ENSP00000367433; ENSG00000196581.
GeneIDi55966.
KEGGihsa:55966.
UCSCiuc001alm.2. human.

Organism-specific databases

CTDi55966.
DisGeNETi55966.
GeneCardsiAJAP1.
H-InvDBHIX0028526.
HGNCiHGNC:30801. AJAP1.
HPAiHPA012157.
MIMi610972. gene.
neXtProtiNX_Q9UKB5.
OpenTargetsiENSG00000196581.
PharmGKBiPA142672629.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHN1. Eukaryota.
ENOG410YW4K. LUCA.
GeneTreeiENSGT00510000048586.
HOGENOMiHOG000033873.
HOVERGENiHBG096853.
InParanoidiQ9UKB5.
OMAiESNTFPG.
OrthoDBiEOG091G0GGA.
PhylomeDBiQ9UKB5.
TreeFamiTF336539.

Enzyme and pathway databases

BioCyciZFISH:G66-30645-MONOMER.

Miscellaneous databases

GenomeRNAii55966.
PROiQ9UKB5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196581.
CleanExiHS_AJAP1.
GenevisibleiQ9UKB5. HS.

Family and domain databases

InterProiIPR029198. AJAP1_PANP_C.
[Graphical view]
PfamiPF15298. AJAP1_PANP_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAJAP1_HUMAN
AccessioniPrimary (citable) accession number: Q9UKB5
Secondary accession number(s): Q9Y229
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.