ID   DJC12_HUMAN             Reviewed;         198 AA.
AC   Q9UKB3; Q5JVQ1; Q9UKB2;
DT   01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   24-NOV-2009, entry version 74.
DE   RecName: Full=DnaJ homolog subfamily C member 12;
DE   AltName: Full=J domain-containing protein 1;
GN   Name=DNAJC12; Synonyms=JDP1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
RX   MEDLINE=20225482; PubMed=10760603; DOI=10.1016/S0167-4781(00)00047-6;
RA   Lee J., Hahn Y., Yun J.H., Mita K., Chung J.H.;
RT   "Characterization of JDP genes, an evolutionarily conserved J domain-
RT   only protein family, from human and moths.";
RL   Biochim. Biophys. Acta 1491:355-363(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA   Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA   Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA   Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA   Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA   Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA   Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA   Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA   Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA   Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA   Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA   Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA   Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA   Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA   Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA   Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA   Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
RA   Colinge J., Superti-Furga G., Bennett K.L.;
RL   Submitted (OCT-2008) to UniProtKB.
RN   [6]
RP   STRUCTURE BY NMR OF 1-100.
RG   RIKEN structural genomics initiative (RSGI);
RT   "Solution structure of J-domain from human DnaJ subfamily C member
RT   12.";
RL   Submitted (NOV-2005) to the PDB data bank.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a; Synonyms=JDP1a;
CC         IsoId=Q9UKB3-1; Sequence=Displayed;
CC       Name=B; Synonyms=JDP1b;
CC         IsoId=Q9UKB3-2; Sequence=VSP_001295, VSP_001296;
CC   -!- TISSUE SPECIFICITY: Expressed at high levels in brain, heart, and
CC       testis, and at reduced levels in kidney and stomach.
CC   -!- SIMILARITY: Contains 1 J domain.
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DR   EMBL; AF176012; AAD52650.1; -; mRNA.
DR   EMBL; AF176013; AAD52651.1; -; mRNA.
DR   EMBL; AL133551; CAC04172.1; -; Genomic_DNA.
DR   EMBL; AL133551; CAI16033.1; -; Genomic_DNA.
DR   EMBL; CH471083; EAW54257.1; -; Genomic_DNA.
DR   EMBL; BC017018; AAH17018.1; -; mRNA.
DR   IPI; IPI00029149; -.
DR   IPI; IPI00220169; -.
DR   RefSeq; NP_068572.1; -.
DR   RefSeq; NP_957714.1; -.
DR   UniGene; Hs.260720; -.
DR   PDB; 2CTQ; NMR; -; A=1-99.
DR   PDBsum; 2CTQ; -.
DR   STRING; Q9UKB3; -.
DR   PhosphoSite; Q9UKB3; -.
DR   PRIDE; Q9UKB3; -.
DR   Ensembl; ENST00000225171; ENSP00000225171; ENSG00000108176; Homo sapiens.
DR   GeneID; 56521; -.
DR   KEGG; hsa:56521; -.
DR   UCSC; uc001jnb.1; human.
DR   UCSC; uc001jnc.1; human.
DR   CTD; 56521; -.
DR   GeneCards; GC10M069226; -.
DR   H-InvDB; HIX0008866; -.
DR   HGNC; HGNC:28908; DNAJC12.
DR   MIM; 606060; gene.
DR   PharmGKB; PA134931354; -.
DR   HOGENOM; Q9UKB3; -.
DR   HOVERGEN; Q9UKB3; -.
DR   OMA; RGKKDLM; -.
DR   OrthoDB; EOG9R52MZ; -.
DR   NextBio; 62025; -.
DR   ArrayExpress; Q9UKB3; -.
DR   Bgee; Q9UKB3; -.
DR   CleanEx; HS_DNAJC12; -.
DR   Genevestigator; Q9UKB3; -.
DR   GermOnline; ENSG00000108176; Homo sapiens.
DR   GO; GO:0031072; F:heat shock protein binding; IEA:InterPro.
DR   InterPro; IPR001623; DnaJ_N.
DR   InterPro; IPR015609; Hsp40/DnaJ_Rel.
DR   Gene3D; G3DSA:1.10.287.110; DnaJ_N; 1.
DR   PANTHER; PTHR11821; Hsp40/DnaJ_Rel; 1.
DR   Pfam; PF00226; DnaJ; 1.
DR   SMART; SM00271; DnaJ; 1.
DR   PROSITE; PS00636; DNAJ_1; FALSE_NEG.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Chaperone; Complete proteome;
KW   Polymorphism.
FT   CHAIN         1    198       DnaJ homolog subfamily C member 12.
FT                                /FTId=PRO_0000071066.
FT   DOMAIN       14     79       J.
FT   VAR_SEQ     100    107       SMHWVVRG -> VGFSLGAT (in isoform B).
FT                                /FTId=VSP_001295.
FT   VAR_SEQ     108    198       Missing (in isoform B).
FT                                /FTId=VSP_001296.
FT   VARIANT     124    124       M -> I (in dbSNP:rs35690028).
FT                                /FTId=VAR_048913.
FT   VARIANT     129    129       C -> W (in dbSNP:rs36099123).
FT                                /FTId=VAR_048914.
FT   HELIX        15     18
FT   HELIX        27     39
FT   TURN         43     45
FT   HELIX        52     67
FT   HELIX        69     81
FT   HELIX        87     95
SQ   SEQUENCE   198 AA;  23415 MW;  03429472C61413EB CRC64;
     MDAILNYRSE DTEDYYTLLG CDELSSVEQI LAEFKVRALE CHPDKHPENP KAVETFQKLQ
     KAKEILTNEE SRARYDHWRR SQMSMPFQQW EALNDSVKTS MHWVVRGKKD LMLEESDKTH
     TTKMENEECN EQRERKKEEL ASTAEKTEQK EPKPLEKSVS PQNSDSSGFA DVNGWHLRFR
     WSKDAPSELL RKFRNYEI
//