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Q9UKB3 (DJC12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 16, 2012. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DnaJ homolog subfamily C member 12
Alternative name(s):
J domain-containing protein 1
Gene names
Name:DNAJC12
Synonyms:JDP1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Expressed at high levels in brain, heart, and testis, and at reduced levels in kidney and stomach.

Sequence similarities

Contains 1 J domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Molecular functionChaperone
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processprotein folding

Inferred from electronic annotation. Source: InterPro

   Molecular functionheat shock protein binding

Inferred from electronic annotation. Source: InterPro

unfolded protein binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform a (identifier: Q9UKB3-1)

Also known as: JDP1a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: Q9UKB3-2)

Also known as: JDP1b;

The sequence of this isoform differs from the canonical sequence as follows:
     100-107: SMHWVVRG → VGFSLGAT
     108-198: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198DnaJ homolog subfamily C member 12
PRO_0000071066

Regions

Domain14 – 7966J

Natural variations

Alternative sequence100 – 1078SMHWVVRG → VGFSLGAT in isoform B.
VSP_001295
Alternative sequence108 – 19891Missing in isoform B.
VSP_001296
Natural variant1241M → I.
Corresponds to variant rs35690028 [ dbSNP | Ensembl ].
VAR_048913
Natural variant1291C → W.
Corresponds to variant rs36099123 [ dbSNP | Ensembl ].
VAR_048914

Secondary structure

1 ............. 198
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform a (JDP1a) [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 03429472C61413EB

FASTA19823,415
        10         20         30         40         50         60 
MDAILNYRSE DTEDYYTLLG CDELSSVEQI LAEFKVRALE CHPDKHPENP KAVETFQKLQ 

        70         80         90        100        110        120 
KAKEILTNEE SRARYDHWRR SQMSMPFQQW EALNDSVKTS MHWVVRGKKD LMLEESDKTH 

       130        140        150        160        170        180 
TTKMENEECN EQRERKKEEL ASTAEKTEQK EPKPLEKSVS PQNSDSSGFA DVNGWHLRFR 

       190 
WSKDAPSELL RKFRNYEI

« Hide

Isoform B (JDP1b) [UniParc].

Checksum: EA285E75AE30CE11
Show »

FASTA10712,456

References

« Hide 'large scale' references
[1]"Characterization of JDP genes, an evolutionarily conserved J domain-only protein family, from human and moths."
Lee J., Hahn Y., Yun J.H., Mita K., Chung J.H.
Biochim. Biophys. Acta 1491:355-363(2000) [PubMed: 10760603] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed: 15164054] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
Tissue: Lung.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Solution structure of J-domain from human DnaJ subfamily C member 12."
RIKEN structural genomics initiative (RSGI)
Submitted (NOV-2005) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 1-100.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF176012 mRNA. Translation: AAD52650.1.
AF176013 mRNA. Translation: AAD52651.1.
AL133551 Genomic DNA. Translation: CAC04172.1.
AL133551 Genomic DNA. Translation: CAI16033.1.
CH471083 Genomic DNA. Translation: EAW54257.1.
BC017018 mRNA. Translation: AAH17018.1.
IPIIPI00029149.
IPI00220169.
RefSeqNP_068572.1. NM_021800.2.
NP_957714.1. NM_201262.1.
UniGeneHs.260720.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2CTQNMR-A1-99[»]
ProteinModelPortalQ9UKB3.
SMRQ9UKB3. Positions 1-100.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9UKB3. 1 interaction.
STRINGQ9UKB3.

PTM databases

PhosphoSiteQ9UKB3.

Polymorphism databases

DMDM28201819.

Proteomic databases

PRIDEQ9UKB3.

Protocols and materials databases

DNASU56521.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000225171; ENSP00000225171; ENSG00000108176.
GeneID56521.
KEGGhsa:56521.
UCSCuc001jnb.3. human.
uc001jnc.3. human.

Organism-specific databases

CTD56521.
GeneCardsGC10M069556.
H-InvDBHIX0008866.
HGNCHGNC:28908. DNAJC12.
HPAHPA036289.
MIM606060. gene.
neXtProtNX_Q9UKB3.
PharmGKBPA134931354.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2214.
GeneTreeENSGT00550000074688.
HOGENOMHOG000017161.
HOVERGENHBG051379.
InParanoidQ9UKB3.
KOK09532.
OMARGKKDLM.
OrthoDBEOG4J6RS7.
PhylomeDBQ9UKB3.

Gene expression databases

ArrayExpressQ5JVQ1.
BgeeQ9UKB3.
CleanExHS_DNAJC12.
GenevestigatorQ9UKB3.
GermOnlineENSG00000108176. Homo sapiens.

Family and domain databases

Gene3DG3DSA:1.10.287.110. DnaJ_N. 1 hit.
InterProIPR001623. DnaJ_N.
IPR003095. Hsp_DnaJ.
[Graphical view]
PfamPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSPR00625. JDOMAIN.
SMARTSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMSSF46565. DnaJ_N. 1 hit.
PROSITEPS00636. DNAJ_1. False negative.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9UKB3.
NextBio62025.
SOURCESearch...

Entry information

Entry nameDJC12_HUMAN
AccessionPrimary (citable) accession number: Q9UKB3
Secondary accession number(s): Q5JVQ1, Q9UKB2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: May 1, 2000
Last modified: May 16, 2012
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents