Reviewed, UniProtKB/Swiss-Prot Q9UKB3 (DJC12_HUMAN)

Names and origin

Protein names

Recommended name:
    DnaJ homolog subfamily C member 12
Alternative name(s):
    J domain-containing protein 1

Gene names

Name:	DNAJC12
Synonyms:	JDP1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Tissue specificity	Expressed at high levels in brain, heart, and testis, and at reduced levels in kidney and stomach.
Sequence similarities	Contains 1 J domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Chaperone
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Molecular function	heat shock protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform a (identifier: Q9UKB3-1)

Also known as: JDP1a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q9UKB3-2)

Also known as: JDP1b;

The sequence of this isoform differs from the canonical sequence as follows:
     100-107: SMHWVVRG → VGFSLGAT
     108-198: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 198

198

DnaJ homolog subfamily C member 12

PRO_0000071066

Regions

Domain

14 – 79

66

J

Natural variations

Alternative sequence

100 – 107

8

SMHWVVRG → VGFSLGAT in isoform B.

VSP_001295

Alternative sequence

108 – 198

91

Missing in isoform B.

VSP_001296

Natural variant

124

1

M → I: dbSNP rs35690028.

VAR_048913

Natural variant

129

1

C → W: dbSNP rs36099123.

VAR_048914

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

198

Helix Strand Turn

Details...

Helix

15 – 18

4

Helix

27 – 39

13

Turn

43 – 45

3

Helix

52 – 67

16

Helix

69 – 81

13

Helix

87 – 95

9

Sequences

	Sequence		Length	Mass (Da)
	Isoform a (JDP1a) [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 03429472C61413EB	FASTA	198	23,415
	10 20 30 40 50 60 MDAILNYRSE DTEDYYTLLG CDELSSVEQI LAEFKVRALE CHPDKHPENP KAVETFQKLQ 70 80 90 100 110 120 KAKEILTNEE SRARYDHWRR SQMSMPFQQW EALNDSVKTS MHWVVRGKKD LMLEESDKTH 130 140 150 160 170 180 TTKMENEECN EQRERKKEEL ASTAEKTEQK EPKPLEKSVS PQNSDSSGFA DVNGWHLRFR 190 WSKDAPSELL RKFRNYEI
	Isoform B (JDP1b). Checksum: EA285E75AE30CE11	FASTA	107	12,456
	10 20 30 40 50 60 MDAILNYRSE DTEDYYTLLG CDELSSVEQI LAEFKVRALE CHPDKHPENP KAVETFQKLQ 70 80 90 100 KAKEILTNEE SRARYDHWRR SQMSMPFQQW EALNDSVKTV GFSLGAT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of JDP genes, an evolutionarily conserved J domain-only protein family, from human and moths." Lee J., Hahn Y., Yun J.H., Mita K., Chung J.H. Biochim. Biophys. Acta 1491:355-363(2000) [PubMed: 10760603] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). Tissue: Lung.
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[5]	"Solution structure of J-domain from human DnaJ subfamily C member 12." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 1-100.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF176012 mRNA. Translation: AAD52650.1.
AF176013 mRNA. Translation: AAD52651.1.
AL133551 Genomic DNA. Translation: CAC04172.1.
BC017018 mRNA. Translation: AAH17018.1.

IPI

IPI00029149.
IPI00220169.

RefSeq

NP_068572.1.
NP_957714.1.

UniGene

Hs.260720

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CTQ	NMR	-	A	1-99	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

Q9UKB3.

PTM databases

PhosphoSite

Q9UKB3.

Proteomic databases

PRIDE

Q9UKB3.

Genome annotation databases

Ensembl

ENST00000225171; ENSP00000225171; ENSG00000108176; Homo sapiens. [Genome view]
ENST00000339758; ENSP00000343575; ENSG00000108176; Homo sapiens. [Genome view]

GeneID

56521.

KEGG

hsa:56521.

UCSC

uc001jnb.1. human.
uc001jnc.1. human.

Organism-specific databases

CTD

56521.

GeneCards

GC10M069226.

H-InvDB

HIX0008866.

HGNC

HGNC:28908. DNAJC12.

MIM

606060. gene.

PharmGKB

PA134931354.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q9UKB3.

HOVERGEN

Q9UKB3.

OMA

RGKKDLM.

Gene expression databases

ArrayExpress

Q9UKB3.

Bgee

Q9UKB3.

CleanEx

HS_DNAJC12.

Genevestigator

Q9UKB3.

GermOnline

ENSG00000108176. Homo sapiens.

Family and domain databases

InterPro

IPR001623. DnaJ_N.
IPR018253. Heat_shock_DnaJ_CS.
IPR015609. Hsp40/DnaJ_Rel.
[Graphical view]

Gene3D

G3DSA:1.10.287.110. DnaJ_N. 1 hit.

PANTHER

PTHR11821. Hsp40/DnaJ_Rel. 1 hit.

Pfam

PF00226. DnaJ. 1 hit.
[Graphical view]

SMART

SM00271. DnaJ. 1 hit.
[Graphical view]

PROSITE

PS00636. DNAJ_1. False negative.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

62025.

SOURCE

Search...

Entry information

Entry name

DJC12_HUMAN

Accession

Primary (citable) accession number: Q9UKB3
Secondary accession number(s): Q9UKB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
Last sequence update:	May 1, 2000
Last modified:	November 3, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.