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Protein

DnaJ homolog subfamily C member 12

Gene

DNAJC12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108176-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 12
Alternative name(s):
J domain-containing protein 1
Gene namesi
Name:DNAJC12
Synonyms:JDP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:28908. DNAJC12.

Pathology & Biotechi

Organism-specific databases

DisGeNETi56521.
OpenTargetsiENSG00000108176.
PharmGKBiPA134931354.

Polymorphism and mutation databases

BioMutaiDNAJC12.
DMDMi28201819.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710661 – 198DnaJ homolog subfamily C member 12Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei166PhosphoserineBy similarity1
Modified residuei182PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UKB3.
PaxDbiQ9UKB3.
PeptideAtlasiQ9UKB3.
PRIDEiQ9UKB3.

PTM databases

iPTMnetiQ9UKB3.
PhosphoSitePlusiQ9UKB3.

Expressioni

Tissue specificityi

Expressed at high levels in brain, heart, and testis, and at reduced levels in kidney and stomach.

Gene expression databases

BgeeiENSG00000108176.
CleanExiHS_DNAJC12.
ExpressionAtlasiQ9UKB3. baseline and differential.
GenevisibleiQ9UKB3. HS.

Organism-specific databases

HPAiHPA036289.

Interactioni

Protein-protein interaction databases

BioGridi121150. 16 interactors.
IntActiQ9UKB3. 1 interactor.
STRINGi9606.ENSP00000225171.

Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 18Combined sources4
Helixi27 – 39Combined sources13
Turni43 – 45Combined sources3
Helixi52 – 67Combined sources16
Helixi69 – 81Combined sources13
Helixi87 – 95Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CTQNMR-A1-99[»]
ProteinModelPortaliQ9UKB3.
SMRiQ9UKB3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UKB3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 79JPROSITE-ProRule annotationAdd BLAST66

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0691. Eukaryota.
COG2214. LUCA.
GeneTreeiENSGT00550000074688.
HOGENOMiHOG000017161.
HOVERGENiHBG051379.
InParanoidiQ9UKB3.
KOiK09532.
PhylomeDBiQ9UKB3.
TreeFamiTF105171.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q9UKB3-1) [UniParc]FASTAAdd to basket
Also known as: JDP1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDAILNYRSE DTEDYYTLLG CDELSSVEQI LAEFKVRALE CHPDKHPENP
60 70 80 90 100
KAVETFQKLQ KAKEILTNEE SRARYDHWRR SQMSMPFQQW EALNDSVKTS
110 120 130 140 150
MHWVVRGKKD LMLEESDKTH TTKMENEECN EQRERKKEEL ASTAEKTEQK
160 170 180 190
EPKPLEKSVS PQNSDSSGFA DVNGWHLRFR WSKDAPSELL RKFRNYEI
Length:198
Mass (Da):23,415
Last modified:May 1, 2000 - v1
Checksum:i03429472C61413EB
GO
Isoform B (identifier: Q9UKB3-2) [UniParc]FASTAAdd to basket
Also known as: JDP1b

The sequence of this isoform differs from the canonical sequence as follows:
     100-107: SMHWVVRG → VGFSLGAT
     108-198: Missing.

Show »
Length:107
Mass (Da):12,456
Checksum:iEA285E75AE30CE11
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048913124M → I.Corresponds to variant rs35690028dbSNPEnsembl.1
Natural variantiVAR_048914129C → W.Corresponds to variant rs36099123dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001295100 – 107SMHWVVRG → VGFSLGAT in isoform B. 1 Publication8
Alternative sequenceiVSP_001296108 – 198Missing in isoform B. 1 PublicationAdd BLAST91

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176012 mRNA. Translation: AAD52650.1.
AF176013 mRNA. Translation: AAD52651.1.
AL133551 Genomic DNA. Translation: CAC04172.1.
AL133551 Genomic DNA. Translation: CAI16033.1.
CH471083 Genomic DNA. Translation: EAW54257.1.
BC017018 mRNA. Translation: AAH17018.1.
CCDSiCCDS7271.1. [Q9UKB3-1]
CCDS7272.1. [Q9UKB3-2]
RefSeqiNP_068572.1. NM_021800.2. [Q9UKB3-1]
NP_957714.1. NM_201262.1. [Q9UKB3-2]
UniGeneiHs.260720.

Genome annotation databases

EnsembliENST00000225171; ENSP00000225171; ENSG00000108176. [Q9UKB3-1]
ENST00000339758; ENSP00000343575; ENSG00000108176. [Q9UKB3-2]
GeneIDi56521.
KEGGihsa:56521.
UCSCiuc001jnb.4. human. [Q9UKB3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176012 mRNA. Translation: AAD52650.1.
AF176013 mRNA. Translation: AAD52651.1.
AL133551 Genomic DNA. Translation: CAC04172.1.
AL133551 Genomic DNA. Translation: CAI16033.1.
CH471083 Genomic DNA. Translation: EAW54257.1.
BC017018 mRNA. Translation: AAH17018.1.
CCDSiCCDS7271.1. [Q9UKB3-1]
CCDS7272.1. [Q9UKB3-2]
RefSeqiNP_068572.1. NM_021800.2. [Q9UKB3-1]
NP_957714.1. NM_201262.1. [Q9UKB3-2]
UniGeneiHs.260720.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CTQNMR-A1-99[»]
ProteinModelPortaliQ9UKB3.
SMRiQ9UKB3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121150. 16 interactors.
IntActiQ9UKB3. 1 interactor.
STRINGi9606.ENSP00000225171.

PTM databases

iPTMnetiQ9UKB3.
PhosphoSitePlusiQ9UKB3.

Polymorphism and mutation databases

BioMutaiDNAJC12.
DMDMi28201819.

Proteomic databases

EPDiQ9UKB3.
PaxDbiQ9UKB3.
PeptideAtlasiQ9UKB3.
PRIDEiQ9UKB3.

Protocols and materials databases

DNASUi56521.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225171; ENSP00000225171; ENSG00000108176. [Q9UKB3-1]
ENST00000339758; ENSP00000343575; ENSG00000108176. [Q9UKB3-2]
GeneIDi56521.
KEGGihsa:56521.
UCSCiuc001jnb.4. human. [Q9UKB3-1]

Organism-specific databases

CTDi56521.
DisGeNETi56521.
GeneCardsiDNAJC12.
HGNCiHGNC:28908. DNAJC12.
HPAiHPA036289.
MIMi606060. gene.
neXtProtiNX_Q9UKB3.
OpenTargetsiENSG00000108176.
PharmGKBiPA134931354.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0691. Eukaryota.
COG2214. LUCA.
GeneTreeiENSGT00550000074688.
HOGENOMiHOG000017161.
HOVERGENiHBG051379.
InParanoidiQ9UKB3.
KOiK09532.
PhylomeDBiQ9UKB3.
TreeFamiTF105171.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108176-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9UKB3.
GenomeRNAii56521.
PROiQ9UKB3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108176.
CleanExiHS_DNAJC12.
ExpressionAtlasiQ9UKB3. baseline and differential.
GenevisibleiQ9UKB3. HS.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDJC12_HUMAN
AccessioniPrimary (citable) accession number: Q9UKB3
Secondary accession number(s): Q5JVQ1, Q9UKB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.