Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q9UKB1 (FBW1B_HUMAN)

Last modified January 19, 2010. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    F-box/WD repeat-containing protein 11
Alternative name(s):
    F-box/WD repeat-containing protein 1B
    F-box and WD repeats protein beta-TrCP2
    Homologous to Slimb protein
      Short name=HOS
Gene names
Name: FBXW11
Synonyms: BTRCP2, FBW1B, FBXW1B, KIAA0696
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length542 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Function

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of NFKBIA, the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. Ref.7 Ref.8 Ref.9

Subunit structure

Self-associates. Component of the SCF(FBXW11) complex formed of CUL1, SKP1A, RBX1 and a FBXW11 dimer. Interacts with BTRC. Interacts with phosphorylated ubiquitination substrates CTNNB1, NFKBIA, IFNAR1; the interaction requires the phosphorylation of the two serine residues in the destruction motif D-S-G-X(2,3)-S. Ref.7 Ref.8 Ref.9

Subcellular location

Cytoplasm Potential.

Sequence similarities

Contains 1 F-box domain.

Contains 7 WD repeats.

Hide | Top

Binary interactions

With

Entry

#Exp.

IntAct

Notes

RPRMQ9NS641EBI-355189,EBI-1052363
WEE1P302911EBI-355189,EBI-914695

Hide | Top

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform C (identifier: Q9UKB1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform A (identifier: Q9UKB1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     16-49: Missing.
Isoform B (identifier: Q9UKB1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     16-48: CSVPRSLWLGCANLVESMCALSCLQSMPSVRCL → NTSVMEDQNEDESPKKNTLW

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 542542F-box/WD repeat-containing protein 11
PRO_0000050981

Regions

Domain129 – 16739F-box
Repeat238 – 27538WD 1
Repeat278 – 31538WD 2
Repeat318 – 35538WD 3
Repeat361 – 39838WD 4
Repeat401 – 44040WD 5
Repeat442 – 47837WD 6
Repeat490 – 52738WD 7

Natural variations

Alternative sequence16 – 4934Missing in isoform A.
VSP_006765
Alternative sequence16 – 4833CSVPR…SVRCL → NTSVMEDQNEDESPKKNTLW in isoform B.
VSP_006766

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Isoform C [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 7CD40087EFAA5C8A

FASTA54262,091
        10         20         30         40         50         60 
MEPDSVIEDK TIELMCSVPR SLWLGCANLV ESMCALSCLQ SMPSVRCLQI SNGTSSVIVS 

        70         80         90        100        110        120 
RKRPSEGNYQ KEKDLCIKYF DQWSESDQVE FVEHLISRMC HYQHGHINSY LKPMLQRDFI 

       130        140        150        160        170        180 
TALPEQGLDH IAENILSYLD ARSLCAAELV CKEWQRVISE GMLWKKLIER MVRTDPLWKG 

       190        200        210        220        230        240 
LSERRGWDQY LFKNRPTDGP PNSFYRSLYP KIIQDIETIE SNWRCGRHNL QRIQCRSENS 

       250        260        270        280        290        300 
KGVYCLQYDD EKIISGLRDN SIKIWDKTSL ECLKVLTGHT GSVLCLQYDE RVIVTGSSDS 

       310        320        330        340        350        360 
TVRVWDVNTG EVLNTLIHHN EAVLHLRFSN GLMVTCSKDR SIAVWDMASA TDITLRRVLV 

       370        380        390        400        410        420 
GHRAAVNVVD FDDKYIVSAS GDRTIKVWST STCEFVRTLN GHKRGIACLQ YRDRLVVSGS 

       430        440        450        460        470        480 
SDNTIRLWDI ECGACLRVLE GHEELVRCIR FDNKRIVSGA YDGKIKVWDL QAALDPRAPA 

       490        500        510        520        530        540 
STLCLRTLVE HSGRVFRLQF DEFQIISSSH DDTILIWDFL NVPPSAQNET RSPSRTYTYI 


SR

« Hide

Isoform A.

Checksum: 05C691DB32A91B50
Show »

FASTA50858,422
Isoform B.

Checksum: 53D181B789313D0E
Show »

FASTA52960,898

Hide | Top

References

« Hide 'large scale' references
[1]"Identification of a family of human F-box proteins."
Cenciarelli C., Chiaur D.S., Guardavaccaro D., Parks W., Vidal M., Pagano M.
Curr. Biol. 9:1177-1179(1999) [PubMed: 10531035] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Molecular cloning and genomic structure of the betaTRCP2 gene on chromosome 5q35.1."
Koike J., Sagara N., Kirikoshi H., Takagi A., Miwa T., Hirai M., Katoh M.
Biochem. Biophys. Res. Commun. 269:103-109(2000) [PubMed: 10694485] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
Tissue: Fetal lung.
[3]"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:169-176(1998) [PubMed: 9734811] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
Tissue: Hippocampus.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
Tissue: Lymph.
[6]"IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2."
Suzuki H., Chiba T., Kobayashi M., Takeuchi M., Suzuki T., Ichiyama A., Ikenoue T., Omata M., Furuichi K., Tanaka K.
Biochem. Biophys. Res. Commun. 256:127-132(1999) [PubMed: 10066435] [Abstract]
Cited for: IDENTIFICATION IN THE SCF(FBXW11) COMPLEX.
[7]"HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin."
Fuchs S.Y., Chen A., Xiong Y., Pan Z.Q., Ronai Z.
Oncogene 18:2039-2046(1999) [PubMed: 10321728] [Abstract]
Cited for: INTERACTION WITH NFKBIA AND CTNNB1, FUNCTION IN UBIQUITINATION OF NFKBIA AND CTNNB1.
[8]"Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination."
Suzuki H., Chiba T., Suzuki T., Fujita T., Ikenoue T., Omata M., Furuichi K., Shikama H., Tanaka K.
J. Biol. Chem. 275:2877-2884(2000) [PubMed: 10644755] [Abstract]
Cited for: SELF-ASSOCIATION, INTERACTION WITH BTRC AND NFKBIA, FUNCTION IN UBIQUITINATION OF NFKBIA.
[9]"SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor."
Kumar K.G., Tang W., Ravindranath A.K., Clark W.A., Croze E., Fuchs S.Y.
EMBO J. 22:5480-5490(2003) [PubMed: 14532120] [Abstract]
Cited for: INTERACTION WITH PHOSPHORYLATED IFNAR1, FUNCTION IN IFNAR1 UBIQUITINATION.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF176022 mRNA. Translation: AAF04528.1.
AB033279 mRNA. Translation: BAA92329.1.
AB033280 mRNA. Translation: BAA92330.1.
AB033281 mRNA. Translation: BAA92331.1.
AB014596 mRNA. Translation: BAA31671.1. Different initiation.
AK314999 mRNA. Translation: BAG37495.1.
BC026213 mRNA. Translation: AAH26213.1.
IPIIPI00301283.
IPI00306671.
IPI00328796.
RefSeqNP_036432.2.
NP_387448.2.
NP_387449.2.
UniGeneHs.484138

3D structure databases

SMRQ9UKB1. Positions 67-116, 114-518.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-27593N.
IntActQ9UKB1. 10 interactions.
STRINGQ9UKB1.

PTM databases

PhosphoSiteQ9UKB1.

Proteomic databases

PRIDEQ9UKB1.

Genome annotation databases

EnsemblENST00000265094; ENSP00000265094; ENSG00000072803; Homo sapiens. [Genome view]
GeneID23291.
KEGGhsa:23291.
UCSCuc003mbl.1. human.
uc003mbm.1. human.
uc003mbn.1. human.

Organism-specific databases

CTD23291.
GeneCardsGC05M171221.
H-InvDBHIX0005413.
HGNCHGNC:13607. FBXW11.
MIM605651. gene.
PharmGKBPA28050.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG05164.
HOGENOMHBG379811.
HOVERGENQ9UKB1.
InParanoidQ9UKB1.
OMAMEPEMED.
OrthoDBEOG94TRVB.
PhylomeDBQ9UKB1.

Enzyme and pathway databases

Pathway_Interaction_DBnfkappabalternativepathway. Alternative NF-kappaB pathway.
nfkappabatypicalpathway. Atypical NF-kappaB pathway.
nfkappabcanonicalpathway. Canonical NF-kappaB pathway.
wnt_canonical_pathway. Canonical Wnt signaling pathway.
hedgehog_glipathway. Hedgehog signaling events mediated by Gli proteins.
ps1pathway. Presenilin action in Notch and Wnt signaling.
hdac_classi_pathway. Signaling events mediated by HDAC Class I.

Gene expression databases

ArrayExpressQ9UKB1.
BgeeQ9UKB1.
CleanExHS_FBXW11.
GenevestigatorQ9UKB1.
GermOnlineENSG00000072803. Homo sapiens.

Family and domain databases

InterProIPR001810. F-box.
IPR020472. G-protein_beta_WD-40_rep_reg.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR011046. WD40_repeat-like_dom.
IPR019782. WD40_repeat_2.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR019781. WD40_repeat_sg.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
PfamPF00646. F-box. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSPR00320. GPROTEINBRPT.
SMARTSM00256. FBOX. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
PROSITEPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio45108.
SOURCESearch...

Hide | Top

Entry information

Entry nameFBW1B_HUMAN
AccessionPrimary (citable) accession number: Q9UKB1
Secondary accession number(s): B2RC98 expand/collapse secondary AC list , Q9P2S8, Q9P2S9, Q9Y4C6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: January 19, 2010
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Hide | Top

Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents