Q9UKA9 (PTBP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Polypyrimidine tract-binding protein 2

Alternative name(s):
Neural polypyrimidine tract-binding protein
Neurally-enriched homolog of PTB
PTB-like protein

Gene names

Name:	PTBP2
Synonyms:	NPTB, PTB, PTBLP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	531 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. Beside its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA. Ref.1 Ref.6
Subunit structure	Monomer. Interacts with NOVA1; the interaction is direct. Interacts with NOVA2; the interaction is direct By similarity. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Part of a ternary complex containing KHSRP and HNRPH1. Ref.1 Ref.7
Subcellular location	Nucleus By similarity.
Tissue specificity	Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non-neuronal tissues. Ref.1 Ref.3
Sequence similarities	Contains 4 RRM (RNA recognition motif) domains.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	RNA-binding
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	mRNA splice site selection Inferred from electronic annotation. Source: Compara negative regulation of RNA splicing Inferred from direct assay PubMed 18335065. Source: UniProtKB regulation of neural precursor cell proliferation Inferred from electronic annotation. Source: Compara
Cellular_component	spliceosomal complex Inferred from electronic annotation. Source: Compara
Molecular_function	mRNA binding Inferred from electronic annotation. Source: Compara nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UKA9-1)

Also known as: nPTB1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UKA9-2)

Also known as: nPTB2; PTBPLP-L;

The sequence of this isoform differs from the canonical sequence as follows:
     489-489: Q → QR

Isoform 3 (identifier: Q9UKA9-3)

Also known as: nPTB3; PTBPLP-L';

The sequence of this isoform differs from the canonical sequence as follows:
     302-302: A → GLPVAA
     489-489: Q → QR

Isoform 4 (identifier: Q9UKA9-4)

Also known as: nPTB4;

The sequence of this isoform differs from the canonical sequence as follows:
     302-302: A → GLPVAA

Isoform 5 (identifier: Q9UKA9-5)

Also known as: nPTB5; nPTB7; PTBPLP-S;

The sequence of this isoform differs from the canonical sequence as follows:
     349-356: MVTPQSLF → VFMEMCSV
     357-531: Missing.

Isoform 6 (identifier: Q9UKA9-6)

Also known as: nPTB6; nPTB8; PTBPLP-S';

The sequence of this isoform differs from the canonical sequence as follows:
     302-302: A → GLPVAA
     349-356: MVTPQSLF → VFMEMCSV
     357-531: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 531

531

Polypyrimidine tract-binding protein 2

PRO_0000232928

Regions

Domain

59 – 133

75

RRM 1

Domain

181 – 257

77

RRM 2

Domain

338 – 412

75

RRM 3

Domain

455 – 529

75

RRM 4

Compositional bias

315 – 324

10

Poly-Ala

Amino acid modifications

Modified residue

27

1

Phosphoserine By similarity

Modified residue

308

1

Phosphoserine Ref.8

Natural variations

Alternative sequence

302

1

A → GLPVAA in isoform 3, isoform 4 and isoform 6.

VSP_018015

Alternative sequence

349 – 356

8

MVTPQSLF → VFMEMCSV in isoform 5 and isoform 6.

VSP_018016

Alternative sequence

357 – 531

175

Missing in isoform 5 and isoform 6.

VSP_018017

Alternative sequence

489

1

Q → QR in isoform 2 and isoform 3.

VSP_018018

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

531

Helix Strand Turn

Details...

Beta strand

59 – 65

7

Helix

72 – 77

6

Turn

78 – 82

5

Beta strand

85 – 91

7

Turn

92 – 95

4

Beta strand

96 – 103

8

Helix

104 – 116

13

Beta strand

127 – 130

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (nPTB1) [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 57ADA23F422AE02A	FASTA	531	57,491
	10 20 30 40 50 60 MDGIVTEVAV GVKRGSDELL SGSVLSSPNS NMSSMVVTAN GNDSKKFKGE DKMDGAPSRV 70 80 90 100 110 120 LHIRKLPGEV TETEVIALGL PFGKVTNILM LKGKNQAFLE LATEEAAITM VNYYSAVTPH 130 140 150 160 170 180 LRNQPIYIQY SNHKELKTDN TLNQRAQAVL QAVTAVQTAN TPLSGTTVSE SAVTPAQSPV 190 200 210 220 230 240 LRIIIDNMYY PVTLDVLHQI FSKFGAVLKI ITFTKNNQFQ ALLQYGDPVN AQQAKLALDG 250 260 270 280 290 300 QNIYNACCTL RIDFSKLVNL NVKYNNDKSR DYTRPDLPSG DGQPALDPAI AAAFAKETSL 310 320 330 340 350 360 LAVPGALSPL AIPNAAAAAA AAAAGRVGMP GVSAGGNTVL LVSNLNEEMV TPQSLFTLFG 370 380 390 400 410 420 VYGDVQRVKI LYNKKDSALI QMADGNQSQL AMNHLNGQKM YGKIIRVTLS KHQTVQLPRE 430 440 450 460 470 480 GLDDQGLTKD FGNSPLHRFK KPGSKNFQNI FPPSATLHLS NIPPSVAEED LRTLFANTGG 490 500 510 520 530 TVKAFKFFQD HKMALLQMAT VEEAIQALID LHNYNLGENH HLRVSFSKST I
	Isoform 2 (nPTB2) (PTBPLP-L) [UniParc]. Checksum: A77702A0B7A84298	FASTA	532	57,647
	10 20 30 40 50 60 MDGIVTEVAV GVKRGSDELL SGSVLSSPNS NMSSMVVTAN GNDSKKFKGE DKMDGAPSRV 70 80 90 100 110 120 LHIRKLPGEV TETEVIALGL PFGKVTNILM LKGKNQAFLE LATEEAAITM VNYYSAVTPH 130 140 150 160 170 180 LRNQPIYIQY SNHKELKTDN TLNQRAQAVL QAVTAVQTAN TPLSGTTVSE SAVTPAQSPV 190 200 210 220 230 240 LRIIIDNMYY PVTLDVLHQI FSKFGAVLKI ITFTKNNQFQ ALLQYGDPVN AQQAKLALDG 250 260 270 280 290 300 QNIYNACCTL RIDFSKLVNL NVKYNNDKSR DYTRPDLPSG DGQPALDPAI AAAFAKETSL 310 320 330 340 350 360 LAVPGALSPL AIPNAAAAAA AAAAGRVGMP GVSAGGNTVL LVSNLNEEMV TPQSLFTLFG 370 380 390 400 410 420 VYGDVQRVKI LYNKKDSALI QMADGNQSQL AMNHLNGQKM YGKIIRVTLS KHQTVQLPRE 430 440 450 460 470 480 GLDDQGLTKD FGNSPLHRFK KPGSKNFQNI FPPSATLHLS NIPPSVAEED LRTLFANTGG 490 500 510 520 530 TVKAFKFFQR DHKMALLQMA TVEEAIQALI DLHNYNLGEN HHLRVSFSKS TI
	Isoform 3 (nPTB3) (PTBPLP-L') [UniParc]. Checksum: 35F5BFD2614647B3	FASTA	537	58,084
	10 20 30 40 50 60 MDGIVTEVAV GVKRGSDELL SGSVLSSPNS NMSSMVVTAN GNDSKKFKGE DKMDGAPSRV 70 80 90 100 110 120 LHIRKLPGEV TETEVIALGL PFGKVTNILM LKGKNQAFLE LATEEAAITM VNYYSAVTPH 130 140 150 160 170 180 LRNQPIYIQY SNHKELKTDN TLNQRAQAVL QAVTAVQTAN TPLSGTTVSE SAVTPAQSPV 190 200 210 220 230 240 LRIIIDNMYY PVTLDVLHQI FSKFGAVLKI ITFTKNNQFQ ALLQYGDPVN AQQAKLALDG 250 260 270 280 290 300 QNIYNACCTL RIDFSKLVNL NVKYNNDKSR DYTRPDLPSG DGQPALDPAI AAAFAKETSL 310 320 330 340 350 360 LGLPVAAVPG ALSPLAIPNA AAAAAAAAAG RVGMPGVSAG GNTVLLVSNL NEEMVTPQSL 370 380 390 400 410 420 FTLFGVYGDV QRVKILYNKK DSALIQMADG NQSQLAMNHL NGQKMYGKII RVTLSKHQTV 430 440 450 460 470 480 QLPREGLDDQ GLTKDFGNSP LHRFKKPGSK NFQNIFPPSA TLHLSNIPPS VAEEDLRTLF 490 500 510 520 530 ANTGGTVKAF KFFQRDHKMA LLQMATVEEA IQALIDLHNY NLGENHHLRV SFSKSTI
	Isoform 4 (nPTB4) [UniParc]. Checksum: 9510D0E9AC2FCBD6	FASTA	536	57,928
	10 20 30 40 50 60 MDGIVTEVAV GVKRGSDELL SGSVLSSPNS NMSSMVVTAN GNDSKKFKGE DKMDGAPSRV 70 80 90 100 110 120 LHIRKLPGEV TETEVIALGL PFGKVTNILM LKGKNQAFLE LATEEAAITM VNYYSAVTPH 130 140 150 160 170 180 LRNQPIYIQY SNHKELKTDN TLNQRAQAVL QAVTAVQTAN TPLSGTTVSE SAVTPAQSPV 190 200 210 220 230 240 LRIIIDNMYY PVTLDVLHQI FSKFGAVLKI ITFTKNNQFQ ALLQYGDPVN AQQAKLALDG 250 260 270 280 290 300 QNIYNACCTL RIDFSKLVNL NVKYNNDKSR DYTRPDLPSG DGQPALDPAI AAAFAKETSL 310 320 330 340 350 360 LGLPVAAVPG ALSPLAIPNA AAAAAAAAAG RVGMPGVSAG GNTVLLVSNL NEEMVTPQSL 370 380 390 400 410 420 FTLFGVYGDV QRVKILYNKK DSALIQMADG NQSQLAMNHL NGQKMYGKII RVTLSKHQTV 430 440 450 460 470 480 QLPREGLDDQ GLTKDFGNSP LHRFKKPGSK NFQNIFPPSA TLHLSNIPPS VAEEDLRTLF 490 500 510 520 530 ANTGGTVKAF KFFQDHKMAL LQMATVEEAI QALIDLHNYN LGENHHLRVS FSKSTI
	Isoform 5 (nPTB5) (nPTB7) (PTBPLP-S) [UniParc]. Checksum: C1D3D2E104207E27	FASTA	356	37,898
	10 20 30 40 50 60 MDGIVTEVAV GVKRGSDELL SGSVLSSPNS NMSSMVVTAN GNDSKKFKGE DKMDGAPSRV 70 80 90 100 110 120 LHIRKLPGEV TETEVIALGL PFGKVTNILM LKGKNQAFLE LATEEAAITM VNYYSAVTPH 130 140 150 160 170 180 LRNQPIYIQY SNHKELKTDN TLNQRAQAVL QAVTAVQTAN TPLSGTTVSE SAVTPAQSPV 190 200 210 220 230 240 LRIIIDNMYY PVTLDVLHQI FSKFGAVLKI ITFTKNNQFQ ALLQYGDPVN AQQAKLALDG 250 260 270 280 290 300 QNIYNACCTL RIDFSKLVNL NVKYNNDKSR DYTRPDLPSG DGQPALDPAI AAAFAKETSL 310 320 330 340 350 LAVPGALSPL AIPNAAAAAA AAAAGRVGMP GVSAGGNTVL LVSNLNEEVF MEMCSV
	Isoform 6 (nPTB6) (nPTB8) (PTBPLP-S') [UniParc]. Checksum: C47DB1BA2B404A03	FASTA	361	38,336
	10 20 30 40 50 60 MDGIVTEVAV GVKRGSDELL SGSVLSSPNS NMSSMVVTAN GNDSKKFKGE DKMDGAPSRV 70 80 90 100 110 120 LHIRKLPGEV TETEVIALGL PFGKVTNILM LKGKNQAFLE LATEEAAITM VNYYSAVTPH 130 140 150 160 170 180 LRNQPIYIQY SNHKELKTDN TLNQRAQAVL QAVTAVQTAN TPLSGTTVSE SAVTPAQSPV 190 200 210 220 230 240 LRIIIDNMYY PVTLDVLHQI FSKFGAVLKI ITFTKNNQFQ ALLQYGDPVN AQQAKLALDG 250 260 270 280 290 300 QNIYNACCTL RIDFSKLVNL NVKYNNDKSR DYTRPDLPSG DGQPALDPAI AAAFAKETSL 310 320 330 340 350 360 LGLPVAAVPG ALSPLAIPNA AAAAAAAAAG RVGMPGVSAG GNTVLLVSNL NEEVFMEMCS V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein." Markovtsov V., Nikolic J.M., Goldman J.A., Turck C.W., Chou M.-Y., Black D.L. Mol. Cell. Biol. 20:7463-7479(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 55-65; 210-215; 216-235; 370-374; 404-411; 431-440 AND 487-492, FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH HNRPH1 AND KHSRP. Tissue: Retinoblastoma.
[2]	"Molecular cloning and characterization of human PTB-like protein: a possible retinal autoantigen of cancer-associated retinopathy." Tateiwa H., Gotoh N., Ichikawa M., Kikuchi T., Yoshimura N. J. Neuroimmunol. 120:161-169(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 5), ALTERNATIVE SPLICING (ISOFORMS 3 AND 6). Tissue: Retina.
[3]	"Alternative splicing of brain-specific PTB defines a tissue-specific isoform pattern that predicts distinct functional roles." Rahman L., Bliskovski V., Reinhold W., Zajac-Kaye M. Genomics 80:245-249(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4), NUCLEOTIDE SEQUENCE [MRNA] OF 282-531 (ISOFORMS 5 AND 6), ALTERNATIVE SPLICING (ISOFORM 2), TISSUE SPECIFICITY. Tissue: Cervix carcinoma, Lung and Retinoblastoma.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Eye.
[6]	"The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr." Mitchell S.A., Spriggs K.A., Coldwell M.J., Jackson R.J., Willis A.E. Mol. Cell 11:757-771(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs." Weidensdorfer D., Stoehr N., Baude A., Lederer M., Koehn M., Schierhorn A., Buchmeier S., Wahle E., Huettelmaiery S. RNA 15:104-115(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN A MRNP COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[8]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-308, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]	"Solution structure of RNA-binding domain in PTB-like protein." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 51-138.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF176085 mRNA. Translation: AAF14284.1.
AB051232 mRNA. Translation: BAB71742.1.
AB051233 mRNA. Translation: BAB71743.1.
AF530580 mRNA. Translation: AAM94624.1.
AF530581 mRNA. Translation: AAM94625.1.
AF530582 mRNA. Translation: AAM94626.1.
AF530583 mRNA. Translation: AAM94627.1.
BK000526 mRNA. Translation: DAA00060.1.
AL357150 Genomic DNA. Translation: CAH70266.1.
AL357150 Genomic DNA. Translation: CAH70267.1.
AL357150 Genomic DNA. Translation: CAH70268.1.
AL357150 Genomic DNA. Translation: CAH70269.1.
BC016582 mRNA. Translation: AAH16582.1.

IPI

IPI00254162.
IPI00514064.
IPI00641664.
IPI00647067.
IPI00743676.
IPI00748295.

RefSeq

NP_067013.1. NM_021190.2.

UniGene

Hs.596061.
Hs.743449.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CQ1	NMR	-	A	51-138	[»]

ProteinModelPortal

Q9UKA9.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9UKA9. 6 interactions.

MINT

MINT-1483252.

STRING

9606.ENSP00000412788.

PTM databases

PhosphoSite

Q9UKA9.

Polymorphism databases

DMDM

74761983.

2D gel databases

REPRODUCTION-2DPAGE

IPI00647067.

Proteomic databases

PaxDb

Q9UKA9.

PRIDE

Q9UKA9.

Protocols and materials databases

DNASU

58155.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000236228; ENSP00000236228; ENSG00000117569.
ENST00000370197; ENSP00000359216; ENSG00000117569.
ENST00000370198; ENSP00000359217; ENSG00000117569.
ENST00000426398; ENSP00000412788; ENSG00000117569.

GeneID

58155.

KEGG

hsa:58155.

UCSC

uc001drn.2. human.
uc001dro.2. human.
uc001drq.3. human.
uc001drr.3. human.

Organism-specific databases

CTD

58155.

GeneCards

GC01P097187.

HGNC

HGNC:17662. PTBP2.

HPA

HPA047420.

MIM

608449. gene.

neXtProt

NX_Q9UKA9.

PharmGKB

PA33935.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG263741.

HOVERGEN

HBG069548.

KO

K14948.

OrthoDB

EOG473PSG.

Gene expression databases

ArrayExpress

Q9UKA9.

Bgee

Q9UKA9.

CleanEx

HS_PTBP2.

Genevestigator

Q9UKA9.

GermOnline

ENSG00000117569. Homo sapiens.

Family and domain databases

Gene3D

3.30.70.330. 4 hits.

InterPro

IPR006536. HnRNP-L_PTB.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]

SMART

SM00360. RRM. 4 hits.
[Graphical view]

TIGRFAMs

TIGR01649. hnRNP-L_PTB. 1 hit.

PROSITE

PS50102. RRM. 4 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

PTBP2. human.

EvolutionaryTrace

Q9UKA9.

GenomeRNAi

58155.

NextBio

64859.

SOURCE

Search...

Entry information

Entry name

PTBP2_HUMAN

Accession

Primary (citable) accession number: Q9UKA9
Secondary accession number(s): Q8N0Z1 , Q8N160, Q8NFB0, Q8NFB1, Q969N9, Q96Q76

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
Last sequence update:	May 1, 2000
Last modified:	May 29, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.