Q9UKA8 (RCAN3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calcipressin-3

Alternative name(s):
Down syndrome candidate region 1-like protein 2
Myocyte-enriched calcineurin-interacting protein 3
Short name=MCIP3
Regulator of calcineurin 3

Gene names

Name:	RCAN3
Synonyms:	DSCR1L2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development By similarity.
Tissue specificity	Highest expression in heart, skeletal muscle kidney, liver and peripheral blood leukocytes. Lower expression in all other tissues.
Sequence similarities	Belongs to the RCAN family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anatomical structure morphogenesis Traceable author statement Ref.1. Source: ProtInc calcium-mediated signaling Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA binding Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UKA8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UKA8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     124-133: Missing.

Isoform 3 (identifier: Q9UKA8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     124-173: VQMSGEVRDK...MPVINYDLLC → ERNMNFTREQ...RGAPTLRPQR
     174-241: Missing.

Isoform 4 (identifier: Q9UKA8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     68-115: FEALFTIYDD...ELHETDFNGQ → NMNFTREQSR...RGAPTLRPQR
     116-241: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	Calcipressin-3		PRO_0000211420
Amino acid modifications
	Modified residue	120	1	Phosphotyrosine By similarity
Natural variations
	Alternative sequence	68 – 115	48	FEALF…DFNGQ → NMNFTREQSRHPAWWFMSVK VKLKRKKRQKTPNRKLPRRG APTLRPQR in isoform 4.		VSP_045968
	Alternative sequence	116 – 241	126	Missing in isoform 4.		VSP_045969
	Alternative sequence	124 – 173	50	VQMSG…YDLLC → ERNMNFTREQSRHPAWWFMS VKVKLKRKKRQKTPNRKLPR RGAPTLRPQR in isoform 3.		VSP_045970
	Alternative sequence	124 – 133	10	Missing in isoform 2.		VSP_001319
	Alternative sequence	174 – 241	68	Missing in isoform 3.		VSP_045971
	Natural variant	236	1	T → N. Corresponds to variant rs16829813 [ dbSNP | Ensembl ].		VAR_033727
Experimental info
Isoform 3:
	Sequence conflict	164	1	R → Q in ABO46010. Ref.2
Isoform 4:
	Sequence conflict	106	1	R → Q in AAW83514. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 91AB619F5E443FBD	FASTA	241	27,492
	10 20 30 40 50 60 MLRDTMKSWN DSQSDLCSTD QEEEEEMIFG ENEDDLDEMM DLSDLPTSLF ACSVHEAVFE 70 80 90 100 110 120 AREQKERFEA LFTIYDDQVT FQLFKSFRRV RINFSKPEAA ARARIELHET DFNGQKLKLY 130 140 150 160 170 180 FAQVQMSGEV RDKSYLLPPQ PVKQFLISPP ASPPVGWKQS EDAMPVINYD LLCAVSKLGP 190 200 210 220 230 240 GEKYELHAGT ESTPSVVVHV CESETEEEEE TKNPKQKIAQ TRRPDPPTAA LNEPQTFDCA L
	Isoform 2 [UniParc]. Checksum: 346DE2B3E62C9A66	FASTA	231	26,361
	10 20 30 40 50 60 MLRDTMKSWN DSQSDLCSTD QEEEEEMIFG ENEDDLDEMM DLSDLPTSLF ACSVHEAVFE 70 80 90 100 110 120 AREQKERFEA LFTIYDDQVT FQLFKSFRRV RINFSKPEAA ARARIELHET DFNGQKLKLY 130 140 150 160 170 180 FAQSYLLPPQ PVKQFLISPP ASPPVGWKQS EDAMPVINYD LLCAVSKLGP GEKYELHAGT 190 200 210 220 230 ESTPSVVVHV CESETEEEEE TKNPKQKIAQ TRRPDPPTAA LNEPQTFDCA L
	Isoform 3 [UniParc]. Checksum: 323CC883395F2C63	FASTA	173	20,747
	10 20 30 40 50 60 MLRDTMKSWN DSQSDLCSTD QEEEEEMIFG ENEDDLDEMM DLSDLPTSLF ACSVHEAVFE 70 80 90 100 110 120 AREQKERFEA LFTIYDDQVT FQLFKSFRRV RINFSKPEAA ARARIELHET DFNGQKLKLY 130 140 150 160 170 FAQERNMNFT REQSRHPAWW FMSVKVKLKR KKRQKTPNRK LPRRGAPTLR PQR
	Isoform 4 [UniParc]. Checksum: 09FA31CAE7A64D21	FASTA	115	13,764
	10 20 30 40 50 60 MLRDTMKSWN DSQSDLCSTD QEEEEEMIFG ENEDDLDEMM DLSDLPTSLF ACSVHEAVFE 70 80 90 100 110 AREQKERNMN FTREQSRHPA WWFMSVKVKL KRKKRQKTPN RKLPRRGAPT LRPQR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new gene family including DSCR1 (Down syndrome candidate region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)." Strippoli P., Lenzi L., Petrini M., Carinci P., Zannotti M. Genomics 64:252-263(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Peripheral blood and Placenta.
[2]	"Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3)." Canaider S., Facchin F., Griffoni C., Casadei R., Vitale L., Lenzi L., Frabetti F., D'Addabbo P., Carinci P., Zannotti M., Strippoli P. Gene 372:128-136(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4). Tissue: Heart.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF176116 mRNA. Translation: AAF01684.1. AF176117 mRNA. Translation: AAF01685.1. AY906854 mRNA. Translation: AAW83514.1. EF467309 mRNA. Translation: ABO46010.1. AL034582 Genomic DNA. Translation: CAI21916.1. BC035854 mRNA. Translation: AAH35854.1.
IPI	IPI00007419. IPI00217723. IPI00845485. IPI00854752.
RefSeq	NP_001238906.1. NM_001251977.1. NP_001238907.1. NM_001251978.1. NP_001238908.1. NM_001251979.1. NP_001238909.1. NM_001251980.1. NP_001238910.1. NM_001251981.1. NP_001238911.1. NM_001251982.1. NP_001238912.1. NM_001251983.1. NP_001238914.1. NM_001251985.1. NP_038469.1. NM_013441.3.
UniGene	Hs.656799. Hs.737226.
3D structure databases
ProteinModelPortal	Q9UKA8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000363516.
PTM databases
PhosphoSite	Q9UKA8.
Polymorphism databases
DMDM	15213951.
Proteomic databases
PaxDb	Q9UKA8.
PRIDE	Q9UKA8.
Protocols and materials databases
DNASU	11123.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000374393; ENSP00000363514; ENSG00000117602. ENST00000374395; ENSP00000363516; ENSG00000117602. ENST00000412742; ENSP00000391912; ENSG00000117602. ENST00000436717; ENSP00000414447; ENSG00000117602.
GeneID	11123.
KEGG	hsa:11123.
UCSC	uc001bjj.3. human. uc009vrd.3. human.
Organism-specific databases
CTD	11123.
GeneCards	GC01P024829.
HGNC	HGNC:3042. RCAN3.
HPA	HPA034533.
MIM	605860. gene.
neXtProt	NX_Q9UKA8.
PharmGKB	PA162400972.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG321341.
HOGENOM	HOG000254788.
HOVERGEN	HBG018932.
InParanoid	Q9UKA8.
OMA	YFAQVQV.
OrthoDB	EOG4G7C02.
PhylomeDB	Q9UKA8.
Gene expression databases
ArrayExpress	Q9UKA8.
Bgee	Q9UKA8.
CleanEx	HS_RCAN3.
Genevestigator	Q9UKA8.
GermOnline	ENSG00000117602. Homo sapiens.
Family and domain databases
InterPro	IPR006931. Calcipressin. [Graphical view]
PANTHER	PTHR10300. PTHR10300. 1 hit.
Pfam	PF04847. Calcipressin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	11123.
NextBio	42276.
SOURCE	Search...

Entry information

Entry name

RCAN3_HUMAN

Accession

Primary (citable) accession number: Q9UKA8
Secondary accession number(s): A4LA69 , E7ENV1, E7EWD8, Q5ECL3, Q5TGC6, Q9NUC8, Q9UKA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.