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Q9UKA8

- RCAN3_HUMAN

UniProt

Q9UKA8 - RCAN3_HUMAN

Protein

Calcipressin-3

Gene

RCAN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: ProtInc
    2. troponin I binding Source: UniProtKB

    GO - Biological processi

    1. anatomical structure morphogenesis Source: ProtInc
    2. calcium-mediated signaling Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcipressin-3
    Alternative name(s):
    Down syndrome candidate region 1-like protein 2
    Myocyte-enriched calcineurin-interacting protein 3
    Short name:
    MCIP3
    Regulator of calcineurin 3
    Gene namesi
    Name:RCAN3
    Synonyms:DSCR1L2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:3042. RCAN3.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162400972.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 241241Calcipressin-3PRO_0000211420Add
    BLAST

    Proteomic databases

    MaxQBiQ9UKA8.
    PaxDbiQ9UKA8.
    PRIDEiQ9UKA8.

    PTM databases

    PhosphoSiteiQ9UKA8.

    Expressioni

    Tissue specificityi

    Highest expression in heart, skeletal muscle kidney, liver and peripheral blood leukocytes. Lower expression in all other tissues.

    Gene expression databases

    ArrayExpressiQ9UKA8.
    BgeeiQ9UKA8.
    CleanExiHS_RCAN3.
    GenevestigatoriQ9UKA8.

    Organism-specific databases

    HPAiHPA034533.

    Interactioni

    Protein-protein interaction databases

    BioGridi116297. 2 interactions.
    IntActiQ9UKA8. 1 interaction.
    STRINGi9606.ENSP00000363516.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UKA8.
    SMRiQ9UKA8. Positions 47-143.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RCAN family.Curated

    Phylogenomic databases

    eggNOGiNOG321341.
    HOGENOMiHOG000254788.
    HOVERGENiHBG018932.
    InParanoidiQ9UKA8.
    KOiK17905.
    OMAiYFAQVQV.
    OrthoDBiEOG715Q51.
    PhylomeDBiQ9UKA8.
    TreeFamiTF313579.

    Family and domain databases

    InterProiIPR006931. Calcipressin.
    [Graphical view]
    PANTHERiPTHR10300. PTHR10300. 1 hit.
    PfamiPF04847. Calcipressin. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UKA8-1) [UniParc]FASTAAdd to Basket

    Also known as: RCAN3-1a,2,3,4,5

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLRDTMKSWN DSQSDLCSTD QEEEEEMIFG ENEDDLDEMM DLSDLPTSLF    50
    ACSVHEAVFE AREQKERFEA LFTIYDDQVT FQLFKSFRRV RINFSKPEAA 100
    ARARIELHET DFNGQKLKLY FAQVQMSGEV RDKSYLLPPQ PVKQFLISPP 150
    ASPPVGWKQS EDAMPVINYD LLCAVSKLGP GEKYELHAGT ESTPSVVVHV 200
    CESETEEEEE TKNPKQKIAQ TRRPDPPTAA LNEPQTFDCA L 241
    Length:241
    Mass (Da):27,492
    Last modified:May 1, 2000 - v1
    Checksum:i91AB619F5E443FBD
    GO
    Isoform 2 (identifier: Q9UKA8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         124-133: Missing.

    Show »
    Length:231
    Mass (Da):26,361
    Checksum:i346DE2B3E62C9A66
    GO
    Isoform 3 (identifier: Q9UKA8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         124-173: VQMSGEVRDK...MPVINYDLLC → ERNMNFTREQ...RGAPTLRPQR
         174-241: Missing.

    Show »
    Length:173
    Mass (Da):20,747
    Checksum:i323CC883395F2C63
    GO
    Isoform 4 (identifier: Q9UKA8-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         68-115: FEALFTIYDD...ELHETDFNGQ → NMNFTREQSR...RGAPTLRPQR
         116-241: Missing.

    Show »
    Length:115
    Mass (Da):13,764
    Checksum:i09FA31CAE7A64D21
    GO
    Isoform 5 (identifier: Q9UKA8-5) [UniParc]FASTAAdd to Basket

    Also known as: RCAN3-2,4,5, RCAN3-1c,2,4,5

    The sequence of this isoform differs from the canonical sequence as follows:
         66-123: Missing.

    Show »
    Length:183
    Mass (Da):20,508
    Checksum:i9F5DDAECF807B489
    GO
    Isoform 6 (identifier: Q9UKA8-6) [UniParc]FASTAAdd to Basket

    Also known as: RCAN3-1,3,4,5, RCAN3-1a,3,4,5, RCAN3-1c,3,4,5

    The sequence of this isoform differs from the canonical sequence as follows:
         1-125: Missing.

    Show »
    Length:116
    Mass (Da):12,745
    Checksum:iE2D8F424C595539D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Isoform 4 (identifier: Q9UKA8-4)
    Sequence conflicti106 – 1061R → Q in AAW83514. (PubMed:16516408)Curated
    Isoform 3 (identifier: Q9UKA8-3)
    Sequence conflicti164 – 1641R → Q in ABO46010. (PubMed:16516408)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti236 – 2361T → N.
    Corresponds to variant rs16829813 [ dbSNP | Ensembl ].
    VAR_033727

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 125125Missing in isoform 6. 1 PublicationVSP_054855Add
    BLAST
    Alternative sequencei66 – 12358Missing in isoform 5. 2 PublicationsVSP_047510Add
    BLAST
    Alternative sequencei68 – 11548FEALF…DFNGQ → NMNFTREQSRHPAWWFMSVK VKLKRKKRQKTPNRKLPRRG APTLRPQR in isoform 4. 1 PublicationVSP_045968Add
    BLAST
    Alternative sequencei116 – 241126Missing in isoform 4. 1 PublicationVSP_045969Add
    BLAST
    Alternative sequencei124 – 17350VQMSG…YDLLC → ERNMNFTREQSRHPAWWFMS VKVKLKRKKRQKTPNRKLPR RGAPTLRPQR in isoform 3. 1 PublicationVSP_045970Add
    BLAST
    Alternative sequencei124 – 13310Missing in isoform 2. 1 PublicationVSP_001319
    Alternative sequencei174 – 24168Missing in isoform 3. 1 PublicationVSP_045971Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF176116 mRNA. Translation: AAF01684.1.
    AF176117 mRNA. Translation: AAF01685.1.
    AY906854 mRNA. Translation: AAW83514.1.
    EF467309 mRNA. Translation: ABO46010.1.
    EF431960 mRNA. Translation: ABO27184.1.
    EF529733 mRNA. Translation: ABP88933.1.
    JN228252 mRNA. Translation: AEL88283.1.
    JN203053 mRNA. Translation: AEL12453.1.
    HQ287726 mRNA. Translation: ADO15700.1.
    HQ317421 mRNA. Translation: ADR51177.1.
    HQ317422 mRNA. Translation: ADR51178.1.
    HQ317423 mRNA. Translation: ADR51179.1.
    HQ317426 mRNA. Translation: ADR51182.1.
    HQ317427 mRNA. Translation: ADR51183.1.
    HQ317445 mRNA. Translation: ADR02808.1.
    HQ317446 mRNA. Translation: ADR02809.1.
    AL034582 Genomic DNA. Translation: CAI21916.1.
    CH471134 Genomic DNA. Translation: EAW95133.1.
    BC035854 mRNA. Translation: AAH35854.1.
    CCDSiCCDS254.1. [Q9UKA8-1]
    CCDS57979.1. [Q9UKA8-2]
    CCDS57980.1. [Q9UKA8-3]
    CCDS57981.1. [Q9UKA8-5]
    CCDS57982.1. [Q9UKA8-4]
    RefSeqiNP_001238906.1. NM_001251977.1. [Q9UKA8-1]
    NP_001238907.1. NM_001251978.1. [Q9UKA8-1]
    NP_001238908.1. NM_001251979.1. [Q9UKA8-1]
    NP_001238909.1. NM_001251980.1. [Q9UKA8-2]
    NP_001238910.1. NM_001251981.1. [Q9UKA8-5]
    NP_001238911.1. NM_001251982.1. [Q9UKA8-3]
    NP_001238912.1. NM_001251983.1. [Q9UKA8-6]
    NP_001238913.1. NM_001251984.1. [Q9UKA8-6]
    NP_001238914.1. NM_001251985.1. [Q9UKA8-4]
    NP_038469.1. NM_013441.3. [Q9UKA8-1]
    UniGeneiHs.656799.
    Hs.737226.

    Genome annotation databases

    EnsembliENST00000374393; ENSP00000363514; ENSG00000117602. [Q9UKA8-4]
    ENST00000374395; ENSP00000363516; ENSG00000117602. [Q9UKA8-1]
    ENST00000412742; ENSP00000391912; ENSG00000117602. [Q9UKA8-3]
    ENST00000436717; ENSP00000414447; ENSG00000117602. [Q9UKA8-2]
    ENST00000538532; ENSP00000445401; ENSG00000117602. [Q9UKA8-5]
    GeneIDi11123.
    KEGGihsa:11123.
    UCSCiuc001bjj.3. human. [Q9UKA8-1]
    uc009vrd.3. human. [Q9UKA8-2]

    Polymorphism databases

    DMDMi15213951.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF176116 mRNA. Translation: AAF01684.1 .
    AF176117 mRNA. Translation: AAF01685.1 .
    AY906854 mRNA. Translation: AAW83514.1 .
    EF467309 mRNA. Translation: ABO46010.1 .
    EF431960 mRNA. Translation: ABO27184.1 .
    EF529733 mRNA. Translation: ABP88933.1 .
    JN228252 mRNA. Translation: AEL88283.1 .
    JN203053 mRNA. Translation: AEL12453.1 .
    HQ287726 mRNA. Translation: ADO15700.1 .
    HQ317421 mRNA. Translation: ADR51177.1 .
    HQ317422 mRNA. Translation: ADR51178.1 .
    HQ317423 mRNA. Translation: ADR51179.1 .
    HQ317426 mRNA. Translation: ADR51182.1 .
    HQ317427 mRNA. Translation: ADR51183.1 .
    HQ317445 mRNA. Translation: ADR02808.1 .
    HQ317446 mRNA. Translation: ADR02809.1 .
    AL034582 Genomic DNA. Translation: CAI21916.1 .
    CH471134 Genomic DNA. Translation: EAW95133.1 .
    BC035854 mRNA. Translation: AAH35854.1 .
    CCDSi CCDS254.1. [Q9UKA8-1 ]
    CCDS57979.1. [Q9UKA8-2 ]
    CCDS57980.1. [Q9UKA8-3 ]
    CCDS57981.1. [Q9UKA8-5 ]
    CCDS57982.1. [Q9UKA8-4 ]
    RefSeqi NP_001238906.1. NM_001251977.1. [Q9UKA8-1 ]
    NP_001238907.1. NM_001251978.1. [Q9UKA8-1 ]
    NP_001238908.1. NM_001251979.1. [Q9UKA8-1 ]
    NP_001238909.1. NM_001251980.1. [Q9UKA8-2 ]
    NP_001238910.1. NM_001251981.1. [Q9UKA8-5 ]
    NP_001238911.1. NM_001251982.1. [Q9UKA8-3 ]
    NP_001238912.1. NM_001251983.1. [Q9UKA8-6 ]
    NP_001238913.1. NM_001251984.1. [Q9UKA8-6 ]
    NP_001238914.1. NM_001251985.1. [Q9UKA8-4 ]
    NP_038469.1. NM_013441.3. [Q9UKA8-1 ]
    UniGenei Hs.656799.
    Hs.737226.

    3D structure databases

    ProteinModelPortali Q9UKA8.
    SMRi Q9UKA8. Positions 47-143.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116297. 2 interactions.
    IntActi Q9UKA8. 1 interaction.
    STRINGi 9606.ENSP00000363516.

    PTM databases

    PhosphoSitei Q9UKA8.

    Polymorphism databases

    DMDMi 15213951.

    Proteomic databases

    MaxQBi Q9UKA8.
    PaxDbi Q9UKA8.
    PRIDEi Q9UKA8.

    Protocols and materials databases

    DNASUi 11123.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374393 ; ENSP00000363514 ; ENSG00000117602 . [Q9UKA8-4 ]
    ENST00000374395 ; ENSP00000363516 ; ENSG00000117602 . [Q9UKA8-1 ]
    ENST00000412742 ; ENSP00000391912 ; ENSG00000117602 . [Q9UKA8-3 ]
    ENST00000436717 ; ENSP00000414447 ; ENSG00000117602 . [Q9UKA8-2 ]
    ENST00000538532 ; ENSP00000445401 ; ENSG00000117602 . [Q9UKA8-5 ]
    GeneIDi 11123.
    KEGGi hsa:11123.
    UCSCi uc001bjj.3. human. [Q9UKA8-1 ]
    uc009vrd.3. human. [Q9UKA8-2 ]

    Organism-specific databases

    CTDi 11123.
    GeneCardsi GC01P024829.
    HGNCi HGNC:3042. RCAN3.
    HPAi HPA034533.
    MIMi 605860. gene.
    neXtProti NX_Q9UKA8.
    PharmGKBi PA162400972.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG321341.
    HOGENOMi HOG000254788.
    HOVERGENi HBG018932.
    InParanoidi Q9UKA8.
    KOi K17905.
    OMAi YFAQVQV.
    OrthoDBi EOG715Q51.
    PhylomeDBi Q9UKA8.
    TreeFami TF313579.

    Miscellaneous databases

    GeneWikii RCAN3.
    GenomeRNAii 11123.
    NextBioi 35497679.
    PROi Q9UKA8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UKA8.
    Bgeei Q9UKA8.
    CleanExi HS_RCAN3.
    Genevestigatori Q9UKA8.

    Family and domain databases

    InterProi IPR006931. Calcipressin.
    [Graphical view ]
    PANTHERi PTHR10300. PTHR10300. 1 hit.
    Pfami PF04847. Calcipressin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new gene family including DSCR1 (Down syndrome candidate region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)."
      Strippoli P., Lenzi L., Petrini M., Carinci P., Zannotti M.
      Genomics 64:252-263(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Peripheral blood and Placenta.
    2. "Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3)."
      Canaider S., Facchin F., Griffoni C., Casadei R., Vitale L., Lenzi L., Frabetti F., D'Addabbo P., Carinci P., Zannotti M., Strippoli P.
      Gene 372:128-136(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
      Tissue: Heart.
    3. "Identification and analysis of human RCAN3 (DSCR1L2) mRNA and protein isoforms."
      Facchin F., Canaider S., Vitale L., Frabetti F., Griffoni C., Lenzi L., Casadei R., Strippoli P.
      Gene 407:159-168(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), ALTERNATIVE SPLICING.
      Tissue: Skeletal muscle.
    4. "Complexity of bidirectional transcription and alternative splicing at human RCAN3 locus."
      Facchin F., Vitale L., Bianconi E., Piva F., Frabetti F., Strippoli P., Casadei R., Pelleri M.C., Piovesan A., Canaider S.
      PLoS ONE 6:E24508-E24508(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 5 AND 6), ALTERNATIVE SPLICING.
      Tissue: Lung, Prostate and Testis.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiRCAN3_HUMAN
    AccessioniPrimary (citable) accession number: Q9UKA8
    Secondary accession number(s): A4GU14
    , A4LA69, E3VWE2, E5L4P0, E5L4P7, E7ENV1, E7EWD8, G1FI66, G1FLF0, Q5ECL3, Q5TGC6, Q9NUC8, Q9UKA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3