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Q9UKA8

- RCAN3_HUMAN

UniProt

Q9UKA8 - RCAN3_HUMAN

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Protein

Calcipressin-3

Gene
RCAN3, DSCR1L2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development By similarity.

GO - Molecular functioni

  1. RNA binding Source: ProtInc
  2. troponin I binding Source: UniProtKB

GO - Biological processi

  1. anatomical structure morphogenesis Source: ProtInc
  2. calcium-mediated signaling Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Calcipressin-3
Alternative name(s):
Down syndrome candidate region 1-like protein 2
Myocyte-enriched calcineurin-interacting protein 3
Short name:
MCIP3
Regulator of calcineurin 3
Gene namesi
Name:RCAN3
Synonyms:DSCR1L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:3042. RCAN3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400972.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Calcipressin-3PRO_0000211420Add
BLAST

Proteomic databases

MaxQBiQ9UKA8.
PaxDbiQ9UKA8.
PRIDEiQ9UKA8.

PTM databases

PhosphoSiteiQ9UKA8.

Expressioni

Tissue specificityi

Highest expression in heart, skeletal muscle kidney, liver and peripheral blood leukocytes. Lower expression in all other tissues.

Gene expression databases

ArrayExpressiQ9UKA8.
BgeeiQ9UKA8.
CleanExiHS_RCAN3.
GenevestigatoriQ9UKA8.

Organism-specific databases

HPAiHPA034533.

Interactioni

Protein-protein interaction databases

BioGridi116297. 2 interactions.
IntActiQ9UKA8. 1 interaction.
STRINGi9606.ENSP00000363516.

Structurei

3D structure databases

ProteinModelPortaliQ9UKA8.
SMRiQ9UKA8. Positions 47-143.

Family & Domainsi

Sequence similaritiesi

Belongs to the RCAN family.

Phylogenomic databases

eggNOGiNOG321341.
HOGENOMiHOG000254788.
HOVERGENiHBG018932.
InParanoidiQ9UKA8.
KOiK17905.
OMAiYFAQVQV.
OrthoDBiEOG715Q51.
PhylomeDBiQ9UKA8.
TreeFamiTF313579.

Family and domain databases

InterProiIPR006931. Calcipressin.
[Graphical view]
PANTHERiPTHR10300. PTHR10300. 1 hit.
PfamiPF04847. Calcipressin. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UKA8-1) [UniParc]FASTAAdd to Basket

Also known as: RCAN3-1a,2,3,4,5

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLRDTMKSWN DSQSDLCSTD QEEEEEMIFG ENEDDLDEMM DLSDLPTSLF    50
ACSVHEAVFE AREQKERFEA LFTIYDDQVT FQLFKSFRRV RINFSKPEAA 100
ARARIELHET DFNGQKLKLY FAQVQMSGEV RDKSYLLPPQ PVKQFLISPP 150
ASPPVGWKQS EDAMPVINYD LLCAVSKLGP GEKYELHAGT ESTPSVVVHV 200
CESETEEEEE TKNPKQKIAQ TRRPDPPTAA LNEPQTFDCA L 241
Length:241
Mass (Da):27,492
Last modified:May 1, 2000 - v1
Checksum:i91AB619F5E443FBD
GO
Isoform 2 (identifier: Q9UKA8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-133: Missing.

Show »
Length:231
Mass (Da):26,361
Checksum:i346DE2B3E62C9A66
GO
Isoform 3 (identifier: Q9UKA8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-173: VQMSGEVRDK...MPVINYDLLC → ERNMNFTREQ...RGAPTLRPQR
     174-241: Missing.

Show »
Length:173
Mass (Da):20,747
Checksum:i323CC883395F2C63
GO
Isoform 4 (identifier: Q9UKA8-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-115: FEALFTIYDD...ELHETDFNGQ → NMNFTREQSR...RGAPTLRPQR
     116-241: Missing.

Show »
Length:115
Mass (Da):13,764
Checksum:i09FA31CAE7A64D21
GO
Isoform 5 (identifier: Q9UKA8-5) [UniParc]FASTAAdd to Basket

Also known as: RCAN3-2,4,5, RCAN3-1c,2,4,5

The sequence of this isoform differs from the canonical sequence as follows:
     66-123: Missing.

Show »
Length:183
Mass (Da):20,508
Checksum:i9F5DDAECF807B489
GO
Isoform 6 (identifier: Q9UKA8-6) [UniParc]FASTAAdd to Basket

Also known as: RCAN3-1,3,4,5, RCAN3-1a,3,4,5, RCAN3-1c,3,4,5

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: Missing.

Show »
Length:116
Mass (Da):12,745
Checksum:iE2D8F424C595539D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti236 – 2361T → N.
Corresponds to variant rs16829813 [ dbSNP | Ensembl ].
VAR_033727

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 125125Missing in isoform 6. VSP_054855Add
BLAST
Alternative sequencei66 – 12358Missing in isoform 5. VSP_047510Add
BLAST
Alternative sequencei68 – 11548FEALF…DFNGQ → NMNFTREQSRHPAWWFMSVK VKLKRKKRQKTPNRKLPRRG APTLRPQR in isoform 4. VSP_045968Add
BLAST
Alternative sequencei116 – 241126Missing in isoform 4. VSP_045969Add
BLAST
Alternative sequencei124 – 17350VQMSG…YDLLC → ERNMNFTREQSRHPAWWFMS VKVKLKRKKRQKTPNRKLPR RGAPTLRPQR in isoform 3. VSP_045970Add
BLAST
Alternative sequencei124 – 13310Missing in isoform 2. VSP_001319
Alternative sequencei174 – 24168Missing in isoform 3. VSP_045971Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 4 (identifier: Q9UKA8-4)
Sequence conflicti106 – 1061R → Q in AAW83514. 1 Publication
Isoform 3 (identifier: Q9UKA8-3)
Sequence conflicti164 – 1641R → Q in ABO46010. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF176116 mRNA. Translation: AAF01684.1.
AF176117 mRNA. Translation: AAF01685.1.
AY906854 mRNA. Translation: AAW83514.1.
EF467309 mRNA. Translation: ABO46010.1.
EF431960 mRNA. Translation: ABO27184.1.
EF529733 mRNA. Translation: ABP88933.1.
JN228252 mRNA. Translation: AEL88283.1.
JN203053 mRNA. Translation: AEL12453.1.
HQ287726 mRNA. Translation: ADO15700.1.
HQ317421 mRNA. Translation: ADR51177.1.
HQ317422 mRNA. Translation: ADR51178.1.
HQ317423 mRNA. Translation: ADR51179.1.
HQ317426 mRNA. Translation: ADR51182.1.
HQ317427 mRNA. Translation: ADR51183.1.
HQ317445 mRNA. Translation: ADR02808.1.
HQ317446 mRNA. Translation: ADR02809.1.
AL034582 Genomic DNA. Translation: CAI21916.1.
CH471134 Genomic DNA. Translation: EAW95133.1.
BC035854 mRNA. Translation: AAH35854.1.
CCDSiCCDS254.1. [Q9UKA8-1]
CCDS57979.1. [Q9UKA8-2]
CCDS57980.1. [Q9UKA8-3]
CCDS57981.1. [Q9UKA8-5]
CCDS57982.1. [Q9UKA8-4]
RefSeqiNP_001238906.1. NM_001251977.1. [Q9UKA8-1]
NP_001238907.1. NM_001251978.1. [Q9UKA8-1]
NP_001238908.1. NM_001251979.1. [Q9UKA8-1]
NP_001238909.1. NM_001251980.1. [Q9UKA8-2]
NP_001238910.1. NM_001251981.1. [Q9UKA8-5]
NP_001238911.1. NM_001251982.1. [Q9UKA8-3]
NP_001238912.1. NM_001251983.1. [Q9UKA8-6]
NP_001238913.1. NM_001251984.1. [Q9UKA8-6]
NP_001238914.1. NM_001251985.1. [Q9UKA8-4]
NP_038469.1. NM_013441.3. [Q9UKA8-1]
UniGeneiHs.656799.
Hs.737226.

Genome annotation databases

EnsembliENST00000374393; ENSP00000363514; ENSG00000117602. [Q9UKA8-4]
ENST00000374395; ENSP00000363516; ENSG00000117602. [Q9UKA8-1]
ENST00000412742; ENSP00000391912; ENSG00000117602. [Q9UKA8-3]
ENST00000436717; ENSP00000414447; ENSG00000117602. [Q9UKA8-2]
ENST00000538532; ENSP00000445401; ENSG00000117602. [Q9UKA8-5]
GeneIDi11123.
KEGGihsa:11123.
UCSCiuc001bjj.3. human. [Q9UKA8-1]
uc009vrd.3. human. [Q9UKA8-2]

Polymorphism databases

DMDMi15213951.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF176116 mRNA. Translation: AAF01684.1 .
AF176117 mRNA. Translation: AAF01685.1 .
AY906854 mRNA. Translation: AAW83514.1 .
EF467309 mRNA. Translation: ABO46010.1 .
EF431960 mRNA. Translation: ABO27184.1 .
EF529733 mRNA. Translation: ABP88933.1 .
JN228252 mRNA. Translation: AEL88283.1 .
JN203053 mRNA. Translation: AEL12453.1 .
HQ287726 mRNA. Translation: ADO15700.1 .
HQ317421 mRNA. Translation: ADR51177.1 .
HQ317422 mRNA. Translation: ADR51178.1 .
HQ317423 mRNA. Translation: ADR51179.1 .
HQ317426 mRNA. Translation: ADR51182.1 .
HQ317427 mRNA. Translation: ADR51183.1 .
HQ317445 mRNA. Translation: ADR02808.1 .
HQ317446 mRNA. Translation: ADR02809.1 .
AL034582 Genomic DNA. Translation: CAI21916.1 .
CH471134 Genomic DNA. Translation: EAW95133.1 .
BC035854 mRNA. Translation: AAH35854.1 .
CCDSi CCDS254.1. [Q9UKA8-1 ]
CCDS57979.1. [Q9UKA8-2 ]
CCDS57980.1. [Q9UKA8-3 ]
CCDS57981.1. [Q9UKA8-5 ]
CCDS57982.1. [Q9UKA8-4 ]
RefSeqi NP_001238906.1. NM_001251977.1. [Q9UKA8-1 ]
NP_001238907.1. NM_001251978.1. [Q9UKA8-1 ]
NP_001238908.1. NM_001251979.1. [Q9UKA8-1 ]
NP_001238909.1. NM_001251980.1. [Q9UKA8-2 ]
NP_001238910.1. NM_001251981.1. [Q9UKA8-5 ]
NP_001238911.1. NM_001251982.1. [Q9UKA8-3 ]
NP_001238912.1. NM_001251983.1. [Q9UKA8-6 ]
NP_001238913.1. NM_001251984.1. [Q9UKA8-6 ]
NP_001238914.1. NM_001251985.1. [Q9UKA8-4 ]
NP_038469.1. NM_013441.3. [Q9UKA8-1 ]
UniGenei Hs.656799.
Hs.737226.

3D structure databases

ProteinModelPortali Q9UKA8.
SMRi Q9UKA8. Positions 47-143.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116297. 2 interactions.
IntActi Q9UKA8. 1 interaction.
STRINGi 9606.ENSP00000363516.

PTM databases

PhosphoSitei Q9UKA8.

Polymorphism databases

DMDMi 15213951.

Proteomic databases

MaxQBi Q9UKA8.
PaxDbi Q9UKA8.
PRIDEi Q9UKA8.

Protocols and materials databases

DNASUi 11123.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374393 ; ENSP00000363514 ; ENSG00000117602 . [Q9UKA8-4 ]
ENST00000374395 ; ENSP00000363516 ; ENSG00000117602 . [Q9UKA8-1 ]
ENST00000412742 ; ENSP00000391912 ; ENSG00000117602 . [Q9UKA8-3 ]
ENST00000436717 ; ENSP00000414447 ; ENSG00000117602 . [Q9UKA8-2 ]
ENST00000538532 ; ENSP00000445401 ; ENSG00000117602 . [Q9UKA8-5 ]
GeneIDi 11123.
KEGGi hsa:11123.
UCSCi uc001bjj.3. human. [Q9UKA8-1 ]
uc009vrd.3. human. [Q9UKA8-2 ]

Organism-specific databases

CTDi 11123.
GeneCardsi GC01P024829.
HGNCi HGNC:3042. RCAN3.
HPAi HPA034533.
MIMi 605860. gene.
neXtProti NX_Q9UKA8.
PharmGKBi PA162400972.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG321341.
HOGENOMi HOG000254788.
HOVERGENi HBG018932.
InParanoidi Q9UKA8.
KOi K17905.
OMAi YFAQVQV.
OrthoDBi EOG715Q51.
PhylomeDBi Q9UKA8.
TreeFami TF313579.

Miscellaneous databases

GeneWikii RCAN3.
GenomeRNAii 11123.
NextBioi 35497679.
PROi Q9UKA8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UKA8.
Bgeei Q9UKA8.
CleanExi HS_RCAN3.
Genevestigatori Q9UKA8.

Family and domain databases

InterProi IPR006931. Calcipressin.
[Graphical view ]
PANTHERi PTHR10300. PTHR10300. 1 hit.
Pfami PF04847. Calcipressin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new gene family including DSCR1 (Down syndrome candidate region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)."
    Strippoli P., Lenzi L., Petrini M., Carinci P., Zannotti M.
    Genomics 64:252-263(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Peripheral blood and Placenta.
  2. "Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3)."
    Canaider S., Facchin F., Griffoni C., Casadei R., Vitale L., Lenzi L., Frabetti F., D'Addabbo P., Carinci P., Zannotti M., Strippoli P.
    Gene 372:128-136(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
    Tissue: Heart.
  3. "Identification and analysis of human RCAN3 (DSCR1L2) mRNA and protein isoforms."
    Facchin F., Canaider S., Vitale L., Frabetti F., Griffoni C., Lenzi L., Casadei R., Strippoli P.
    Gene 407:159-168(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), ALTERNATIVE SPLICING.
    Tissue: Skeletal muscle.
  4. "Complexity of bidirectional transcription and alternative splicing at human RCAN3 locus."
    Facchin F., Vitale L., Bianconi E., Piva F., Frabetti F., Strippoli P., Casadei R., Pelleri M.C., Piovesan A., Canaider S.
    PLoS ONE 6:E24508-E24508(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 5 AND 6), ALTERNATIVE SPLICING.
    Tissue: Lung, Prostate and Testis.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiRCAN3_HUMAN
AccessioniPrimary (citable) accession number: Q9UKA8
Secondary accession number(s): A4GU14
, A4LA69, E3VWE2, E5L4P0, E5L4P7, E7ENV1, E7EWD8, G1FI66, G1FLF0, Q5ECL3, Q5TGC6, Q9NUC8, Q9UKA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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