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Q9UKA8 (RCAN3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcipressin-3
Alternative name(s):
Down syndrome candidate region 1-like protein 2
Myocyte-enriched calcineurin-interacting protein 3
Short name=MCIP3
Regulator of calcineurin 3
Gene names
Name:RCAN3
Synonyms:DSCR1L2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development By similarity.

Tissue specificity

Highest expression in heart, skeletal muscle kidney, liver and peripheral blood leukocytes. Lower expression in all other tissues.

Sequence similarities

Belongs to the RCAN family.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UKA8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UKA8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     124-133: Missing.
Isoform 3 (identifier: Q9UKA8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     124-173: VQMSGEVRDK...MPVINYDLLC → ERNMNFTREQ...RGAPTLRPQR
     174-241: Missing.
Isoform 4 (identifier: Q9UKA8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     68-115: FEALFTIYDD...ELHETDFNGQ → NMNFTREQSR...RGAPTLRPQR
     116-241: Missing.
Isoform 5 (identifier: Q9UKA8-5)

Also known as: RCAN3-2,4,5;

The sequence of this isoform differs from the canonical sequence as follows:
     66-123: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 241241Calcipressin-3
PRO_0000211420

Natural variations

Alternative sequence66 – 12358Missing in isoform 5.
VSP_047510
Alternative sequence68 – 11548FEALF…DFNGQ → NMNFTREQSRHPAWWFMSVK VKLKRKKRQKTPNRKLPRRG APTLRPQR in isoform 4.
VSP_045968
Alternative sequence116 – 241126Missing in isoform 4.
VSP_045969
Alternative sequence124 – 17350VQMSG…YDLLC → ERNMNFTREQSRHPAWWFMS VKVKLKRKKRQKTPNRKLPR RGAPTLRPQR in isoform 3.
VSP_045970
Alternative sequence124 – 13310Missing in isoform 2.
VSP_001319
Alternative sequence174 – 24168Missing in isoform 3.
VSP_045971
Natural variant2361T → N.
Corresponds to variant rs16829813 [ dbSNP | Ensembl ].
VAR_033727

Experimental info

Isoform 3:
Sequence conflict1641R → Q in ABO46010. Ref.2
Isoform 4:
Sequence conflict1061R → Q in AAW83514. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 91AB619F5E443FBD

FASTA24127,492
        10         20         30         40         50         60 
MLRDTMKSWN DSQSDLCSTD QEEEEEMIFG ENEDDLDEMM DLSDLPTSLF ACSVHEAVFE 

        70         80         90        100        110        120 
AREQKERFEA LFTIYDDQVT FQLFKSFRRV RINFSKPEAA ARARIELHET DFNGQKLKLY 

       130        140        150        160        170        180 
FAQVQMSGEV RDKSYLLPPQ PVKQFLISPP ASPPVGWKQS EDAMPVINYD LLCAVSKLGP 

       190        200        210        220        230        240 
GEKYELHAGT ESTPSVVVHV CESETEEEEE TKNPKQKIAQ TRRPDPPTAA LNEPQTFDCA 


L 

« Hide

Isoform 2 [UniParc].

Checksum: 346DE2B3E62C9A66
Show »

FASTA23126,361
Isoform 3 [UniParc].

Checksum: 323CC883395F2C63
Show »

FASTA17320,747
Isoform 4 [UniParc].

Checksum: 09FA31CAE7A64D21
Show »

FASTA11513,764
Isoform 5 (RCAN3-2,4,5) [UniParc].

Checksum: 9F5DDAECF807B489
Show »

FASTA18320,508

References

« Hide 'large scale' references
[1]"A new gene family including DSCR1 (Down syndrome candidate region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)."
Strippoli P., Lenzi L., Petrini M., Carinci P., Zannotti M.
Genomics 64:252-263(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Tissue: Peripheral blood and Placenta.
[2]"Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3)."
Canaider S., Facchin F., Griffoni C., Casadei R., Vitale L., Lenzi L., Frabetti F., D'Addabbo P., Carinci P., Zannotti M., Strippoli P.
Gene 372:128-136(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
Tissue: Heart.
[3]"Identification and analysis of human RCAN3 (DSCR1L2) mRNA and protein isoforms."
Facchin F., Canaider S., Vitale L., Frabetti F., Griffoni C., Lenzi L., Casadei R., Strippoli P.
Gene 407:159-168(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), ALTERNATIVE SPLICING.
Tissue: Skeletal muscle.
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF176116 mRNA. Translation: AAF01684.1.
AF176117 mRNA. Translation: AAF01685.1.
AY906854 mRNA. Translation: AAW83514.1.
EF467309 mRNA. Translation: ABO46010.1.
EF431960 mRNA. Translation: ABO27184.1.
EF529733 mRNA. Translation: ABP88933.1.
AL034582 Genomic DNA. Translation: CAI21916.1.
BC035854 mRNA. Translation: AAH35854.1.
RefSeqNP_001238906.1. NM_001251977.1.
NP_001238907.1. NM_001251978.1.
NP_001238908.1. NM_001251979.1.
NP_001238909.1. NM_001251980.1.
NP_001238910.1. NM_001251981.1.
NP_001238911.1. NM_001251982.1.
NP_001238912.1. NM_001251983.1.
NP_001238914.1. NM_001251985.1.
NP_038469.1. NM_013441.3.
UniGeneHs.656799.
Hs.737226.

3D structure databases

ProteinModelPortalQ9UKA8.
SMRQ9UKA8. Positions 47-143.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116297. 2 interactions.
STRING9606.ENSP00000363516.

PTM databases

PhosphoSiteQ9UKA8.

Polymorphism databases

DMDM15213951.

Proteomic databases

PaxDbQ9UKA8.
PRIDEQ9UKA8.

Protocols and materials databases

DNASU11123.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000374393; ENSP00000363514; ENSG00000117602. [Q9UKA8-4]
ENST00000374395; ENSP00000363516; ENSG00000117602. [Q9UKA8-1]
ENST00000412742; ENSP00000391912; ENSG00000117602. [Q9UKA8-3]
ENST00000436717; ENSP00000414447; ENSG00000117602. [Q9UKA8-2]
ENST00000538532; ENSP00000445401; ENSG00000117602. [Q9UKA8-5]
GeneID11123.
KEGGhsa:11123.
UCSCuc001bjj.3. human. [Q9UKA8-1]
uc009vrd.3. human. [Q9UKA8-2]

Organism-specific databases

CTD11123.
GeneCardsGC01P024829.
HGNCHGNC:3042. RCAN3.
HPAHPA034533.
MIM605860. gene.
neXtProtNX_Q9UKA8.
PharmGKBPA162400972.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG321341.
HOGENOMHOG000254788.
HOVERGENHBG018932.
InParanoidQ9UKA8.
KOK17905.
OMAYFAQVQV.
OrthoDBEOG715Q51.
PhylomeDBQ9UKA8.
TreeFamTF313579.

Gene expression databases

ArrayExpressQ9UKA8.
BgeeQ9UKA8.
CleanExHS_RCAN3.
GenevestigatorQ9UKA8.

Family and domain databases

InterProIPR006931. Calcipressin.
[Graphical view]
PANTHERPTHR10300. PTHR10300. 1 hit.
PfamPF04847. Calcipressin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiRCAN3.
GenomeRNAi11123.
NextBio42276.
PROQ9UKA8.
SOURCESearch...

Entry information

Entry nameRCAN3_HUMAN
AccessionPrimary (citable) accession number: Q9UKA8
Secondary accession number(s): A4GU14 expand/collapse secondary AC list , A4LA69, E7ENV1, E7EWD8, Q5ECL3, Q5TGC6, Q9NUC8, Q9UKA7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM