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Q9UKA4 (AKA11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
A-kinase anchor protein 11

Short name=AKAP-11
Alternative name(s):
A-kinase anchor protein 220 kDa
Short name=AKAP 220
Short name=hAKAP220
Protein kinase A-anchoring protein 11
Short name=PRKA11
Gene names
Name:AKAP11
Synonyms:AKAP220, KIAA0629
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1901 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to type II regulatory subunits of protein kinase A and anchors/targets them.

Subcellular location

Cytoplasm. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Note: Cytoplasmic in premeiotic pachytene spermatocytes and in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was found in elongating spermatocytes and mature sperm.

Tissue specificity

Expressed in heart, brain, lung, liver, kidney, testis and ovary. Weakly expressed in skeletal muscle, pancreas and spleen.

Domain

RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

Sequence similarities

Belongs to the AKAP110 family.

Sequence caution

The sequence BAA92117.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   Coding sequence diversityPolymorphism
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processintracellular signal transduction

Traceable author statement PubMed 10209101. Source: ProtInc

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

microtubule organizing center

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein kinase A binding

Traceable author statement PubMed 10209101. Source: ProtInc

protein phosphatase 1 binding

Traceable author statement PubMed 10209101. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 19011901A-kinase anchor protein 11
PRO_0000064517

Regions

Region1650 – 166314PKA-RII subunit binding domain
Compositional bias238 – 31578Ser-rich
Compositional bias1705 – 176763Ser-rich

Amino acid modifications

Modified residue181Phosphoserine Ref.10 Ref.11
Modified residue4221Phosphoserine Ref.8
Modified residue4331Phosphoserine Ref.8 Ref.10
Modified residue4481Phosphoserine Ref.8 Ref.9
Modified residue11001Phosphothreonine Ref.8 Ref.9 Ref.10
Modified residue12421Phosphoserine Ref.10
Modified residue13371Phosphoserine Ref.8

Natural variations

Natural variant7211S → C.
Corresponds to variant rs2236364 [ dbSNP | Ensembl ].
VAR_020131
Natural variant10701H → R.
Corresponds to variant rs17063163 [ dbSNP | Ensembl ].
VAR_048207
Natural variant14101L → F.
Corresponds to variant rs17063167 [ dbSNP | Ensembl ].
VAR_048208

Experimental info

Sequence conflict13031K → R in BAA92117. Ref.5
Sequence conflict1444 – 146926LDPYR…ITKDA → CGPSVELSPWKWQTRCGREG NSWKRE in BAA92117. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q9UKA4 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 0893316C46A75672

FASTA1,901210,512
        10         20         30         40         50         60 
MATFRNNHMK TKASVRKSFS EDVFQSVKSL LQSQKELCSV TAEDCLQQDE HANLTEVTFL 

        70         80         90        100        110        120 
GFNEETDAAH IQDLAAVSLE LPDILNSLHF CSLNENEIIC MKNINKPLDI SSDPLNQSHP 

       130        140        150        160        170        180 
SGMLCVMRVS PTSPRLRIDF IFSLLSKYAT GIRYTLDTFL HQKHQLETTD EDDDDTNQSV 

       190        200        210        220        230        240 
SSIEDDFVTA FEHLEEEETS KPYNDGMNIT VLRSQCDAAS QTVTGHHLET HDLKILISSG 

       250        260        270        280        290        300 
QQKSLAKPST SSVNVLGHKE LPSVKTSVTT SISEPWTQRS FYRSSNASDK DSDLQKTFFS 

       310        320        330        340        350        360 
SSPAYSSESE CSSPSPVIFL DEEGYQKSLK AKLELPKIPV MKDDIEDSDS EVSEFFDSFD 

       370        380        390        400        410        420 
QFDELEQTLE TCLFNKDPVI GKSSQRKGHK HGKSCMNPQK FKFDRPALPA NVRKPTPRKP 

       430        440        450        460        470        480 
ESPYGNLCDA PDSPRPVKAS REDSGLFSPI RSSAFSPLGG CTPAECFCQT DIGGDRIHEN 

       490        500        510        520        530        540 
HDSVYYTYED YAKSISCEVL GSVLRTHHTN TLSNINSIKH GENKTVTFKH GNLDQKNKSK 

       550        560        570        580        590        600 
NKSLMIKDSI QKFAADLVEK SFGSAFKDLQ KGVSSCTNAL YHLAIKLTSS VLQMAFDELR 

       610        620        630        640        650        660 
RQRAFSLKER AISGLANFLV SEALSNALKD LQYVKKQIFT NTVARFAADL AEELVFEGIM 

       670        680        690        700        710        720 
EVCQFSYPQT PASPQCGSFD FEDKVVKLYA KDLSESVIQE AFIELSQVDV TFTTKAAVSV 

       730        740        750        760        770        780 
STDNIKYVSA ESVVPSTQAV TFSPSFHNQA IMVTKPVQEY KKEYTVQQAL FCTSGIVTSI 

       790        800        810        820        830        840 
PVPLAGSALL PYHISSTACQ AKAHLSSDDS NSNGDSAQVH IATKNREEKA ACLRNICLPS 

       850        860        870        880        890        900 
EHNPGNQNDF KPTNDDIEMQ SSSKLPNDPA IISNFSAAVV HTIVNETLES MTSLEVTKMV 

       910        920        930        940        950        960 
DERTDYLTKS LKEKTPPFSH CDQAVLQCSE ASSNKDMFAD RLSKSIIKHS IDKSKSVIPN 

       970        980        990       1000       1010       1020 
IDKNAVYKES LPVSGEESQL TPEKSPKFPD SQNQLTHCSL SAAKDCVPEC KVSMVHGSSL 

      1030       1040       1050       1060       1070       1080 
ETLPSCPAVT GQKSDLKESA KDQPLKKHNL NSTSLEALSF GQENPFPHSH TFSSTALTCV 

      1090       1100       1110       1120       1130       1140 
DGLHVEDKQK VRDRNVIPDT PPSTPLVPSR ASSEWDIKKL TKKLKGELAK EFAPATPPST 

      1150       1160       1170       1180       1190       1200 
PHNSSVGSLS ENEQNTIEKE EFMLKLMRSL SEEVESSESG ELPEVDVKSE HSGKKVQFAE 

      1210       1220       1230       1240       1250       1260 
ALATHILSLA TEMAASHLDN KIIQEPKVKN PCLNVQSQRS VSPTFLNPSD ENLKTLCNFA 

      1270       1280       1290       1300       1310       1320 
GDLAAEVITE AEKIAKVRNC MLFKQKKNSC YADGDEDYKV EEKLDIEAVV HPREVDPFIL 

      1330       1340       1350       1360       1370       1380 
SLPPSSCMSG LMYKYPSCES VTDEYAGHLI QILKQEGGNS ELIMDQYANR LAYRSVKSGL 

      1390       1400       1410       1420       1430       1440 
QEAAKTTKVQ CNSRMFPVPS SQVKTNKELL MFSNKEHHQE ADKKRQSKRN EGYFCKNQTC 

      1450       1460       1470       1480       1490       1500 
ERTLDPYRNE VSQLYSFSTS LVHSITKDAK EELTASLVGL PKSLTDSCLF EKSGYEEDNE 

      1510       1520       1530       1540       1550       1560 
CHVTPELPKS LQPSSQNHRF YHSTGSLNGY GCGDNVVQAV EQYAKKVVDD TLELTLGSTV 

      1570       1580       1590       1600       1610       1620 
FRVSETTKSA DRVTYAEKLS PLTGQACRYC DLKELHNCTG NSSQHFFRQG SLASSKPASN 

      1630       1640       1650       1660       1670       1680 
PKFSSRYQKS RIFHLSVPQI HVNLDKKAVL AEKIVAEAIE KAERELSSTS LAADSGIGQE 

      1690       1700       1710       1720       1730       1740 
GASFAESLAT ETMTAAVTNV GHAVSSSKEI EDFQSTESVS SQQMNLSIGD DSTGSWSNLS 

      1750       1760       1770       1780       1790       1800 
FEDEHQDESS SFHHLSESNG NSSSWSSLGL EGDLYEDNLS FPTSDSDGPD DKDEEHEDEV 

      1810       1820       1830       1840       1850       1860 
EGLGQDGKTL LITNIDMEPC TVDPQLRIIL QWLIASEAEV AELYFHDSAN KEFMLLSKQL 

      1870       1880       1890       1900 
QEKGWKVGDL LQAVLQYYEV MEKASSEERC KSLFDWLLEN A 

« Hide

References

« Hide 'large scale' references
[1]"Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis."
Reinton N., Collas P., Haugen T.B., Skalhegg B.S., Hansson V., Jahnsen T., Tasken K.
Dev. Biol. 223:194-204(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 630-1901.
Tissue: Brain.
[4]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1121-1469.
Tissue: Placenta.
[6]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-422; SER-433; SER-448; THR-1100 AND SER-1337, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-448 AND THR-1100, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-433; THR-1100 AND SER-1242, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[11]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF176555 mRNA. Translation: AAF07045.1.
AL136527 Genomic DNA. Translation: CAB89419.1.
AB014529 mRNA. Translation: BAA31604.2.
AK002166 mRNA. Translation: BAA92117.1. Different initiation.
CCDSCCDS9383.1.
PIRT00384.
RefSeqNP_057332.1. NM_016248.3.
UniGeneHs.105105.

3D structure databases

ProteinModelPortalQ9UKA4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116384. 15 interactions.
IntActQ9UKA4. 6 interactions.
STRING9606.ENSP00000025301.

PTM databases

PhosphoSiteQ9UKA4.

Polymorphism databases

DMDM13431310.

Proteomic databases

MaxQBQ9UKA4.
PaxDbQ9UKA4.
PRIDEQ9UKA4.

Protocols and materials databases

DNASU11215.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000025301; ENSP00000025301; ENSG00000023516.
GeneID11215.
KEGGhsa:11215.
UCSCuc001uys.2. human.

Organism-specific databases

CTD11215.
GeneCardsGC13P042846.
HGNCHGNC:369. AKAP11.
HPAHPA039089.
MIM604696. gene.
neXtProtNX_Q9UKA4.
PharmGKBPA24663.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG28523.
HOGENOMHOG000033874.
HOVERGENHBG050470.
InParanoidQ9UKA4.
KOK16527.
OMASVFQMAF.
OrthoDBEOG73Z2SC.
PhylomeDBQ9UKA4.
TreeFamTF343800.

Gene expression databases

ArrayExpressQ9UKA4.
BgeeQ9UKA4.
CleanExHS_AKAP11.
GenevestigatorQ9UKA4.

Family and domain databases

InterProIPR008382. SPHK1-interactor_AKAP_110.
[Graphical view]
PANTHERPTHR10226. PTHR10226. 1 hit.
ProtoNetSearch...

Other

ChiTaRSAKAP11. human.
GeneWikiAKAP11.
GenomeRNAi11215.
NextBio42687.
PROQ9UKA4.
SOURCESearch...

Entry information

Entry nameAKA11_HUMAN
AccessionPrimary (citable) accession number: Q9UKA4
Secondary accession number(s): O75124, Q9NUK7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM