Q9UKA2 (FBXL4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
F-box/LRR-repeat protein 4

Alternative name(s):
F-box and leucine-rich repeat protein 4
F-box protein FBL4/FBL5

Gene names

Name:	FBXL4
Synonyms:	FBL4, FBL5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	621 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Part of a SCF (SKP1-cullin-F-box) protein ligase complex By similarity.
Subcellular location	Cytoplasm. Nucleus Ref.1.
Tissue specificity	Expressed in heart, kidney, liver, lung, pancreas, and placenta, but not in skeletal muscle. Ref.1
Sequence similarities	Contains 1 F-box domain. Contains 9 LRR (leucine-rich) repeats.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cytoplasm Nucleus
Domain	Leucine-rich repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ubiquitin-dependent protein catabolic process Traceable author statement Ref.2. Source: ProtInc
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay. Source: HPA ubiquitin ligase complex Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 621	621	F-box/LRR-repeat protein 4		PRO_0000119844
Regions
	Domain	277 – 332	56	F-box
	Repeat	376 – 397	22	LRR 1
	Repeat	402 – 421	20	LRR 2
	Repeat	427 – 448	22	LRR 3
	Repeat	452 – 474	23	LRR 4
	Repeat	480 – 501	22	LRR 5
	Repeat	504 – 524	21	LRR 6
	Repeat	532 – 558	27	LRR 7
	Repeat	559 – 583	25	LRR 8
	Repeat	584 – 609	26	LRR 9
Experimental info
	Sequence conflict	5	1	F → Y in AAF03699. Ref.1
	Sequence conflict	42	1	S → G in AAF09247. Ref.3
	Sequence conflict	122	1	Q → K in AAF03699. Ref.1
	Sequence conflict	126	1	Y → I in AAF03699. Ref.1
	Sequence conflict	219	1	E → G in AAF03699. Ref.1
	Sequence conflict	232	1	P → A in AAF03699. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9UKA2 [UniParc]. Last modified May 27, 2002. Version 2. Checksum: D8FD51A5C4F922D3	FASTA	621	70,097
	10 20 30 40 50 60 MSPVFPMLTV LTMFYYICLR RRARTATRGE MMNTHRAIES NSQTSPLNAE VVQYAKEVVD 70 80 90 100 110 120 FSSHYGSENS MSYTMWNLAG VPNVFPSSGD FTQTAVFRTY GTWWDQCPSA SLPFKRTPPN 130 140 150 160 170 180 FQSQDYVELT FEQQVYPTAV HVLETYHPGA VIRILACSAN PYSPNPPAEV RWEILWSERP 190 200 210 220 230 240 TKVNASQARQ FKPCIKQINF PTNLIRLEVN SSLLEYYTEL DAVVLHGVKD KPVLSLKTSL 250 260 270 280 290 300 IDMNDIEDDA YAEKDGCGMD SLNKKFSSAV LGEGPNNGYF DKLPYELIQL ILNHLTLPDL 310 320 330 340 350 360 CRLAQTCKLL SQHCCDPLQY IHLNLQPYWA KLDDTSLEFL QSRCTLVQWL NLSWTGNRGF 370 380 390 400 410 420 ISVAGFSRFL KVCGSELVRL ELSCSHFLNE TCLEVISEMC PNLQALNLSS CDKLPPQAFN 430 440 450 460 470 480 HIAKLCSLKR LVLYRTKVEQ TALLSILNFC SELQHLSLGS CVMIEDYDVI ASMIGAKCKK 490 500 510 520 530 540 LRTLDLWRCK NITENGIAEL ASGCPLLEEL DLGWCPTLQS STGCFTRLAH QLPNLQKLFL 550 560 570 580 590 600 TANRSVCDTD IDELACNCTR LQQLDILGTR MVSPASLRKL LESCKDLSLL DVSFCSQIDN 610 620 RAVLELNASF PKVFIKKSFT Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A family of mammalian F-box proteins." Winston J.T., Koepp D.M., Zhu C., Elledge S.J., Harper J.W. Curr. Biol. 9:1180-1182(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[2]	"Identification of a family of human F-box proteins." Cenciarelli C., Chiaur D.S., Guardavaccaro D., Parks W., Vidal M., Pagano M. Curr. Biol. 9:1177-1179(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"cDNA cloning and expression analysis of new members of the mammalian F-box protein family." Ilyin G.P., Rialland M., Pigeon C., Guguen-Guillouzo C. Genomics 67:40-47(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye and PNS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF176699 mRNA. Translation: AAF03699.1. AF174590 mRNA. Translation: AAF04511.1. AF199355 mRNA. Translation: AAF09247.1. AL022395 Genomic DNA. Translation: CAB37981.1. CH471051 Genomic DNA. Translation: EAW48489.1. CH471051 Genomic DNA. Translation: EAW48490.1. BC055010 mRNA. Translation: AAH55010.1. BC091484 mRNA. Translation: AAH91484.1.
IPI	IPI00145799.
RefSeq	NP_036292.2. NM_012160.3.
UniGene	Hs.536850.
3D structure databases
ProteinModelPortal	Q9UKA2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UKA2. 1 interaction.
STRING	9606.ENSP00000229971.
PTM databases
PhosphoSite	Q9UKA2.
Polymorphism databases
DMDM	21263631.
Proteomic databases
PaxDb	Q9UKA2.
PRIDE	Q9UKA2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000229971; ENSP00000229971; ENSG00000112234. ENST00000369244; ENSP00000358247; ENSG00000112234.
GeneID	26235.
KEGG	hsa:26235.
UCSC	uc003ppf.1. human.
Organism-specific databases
CTD	26235.
GeneCards	GC06M099367.
HGNC	HGNC:13601. FBXL4.
HPA	CAB033362. HPA029140.
MIM	605654. gene.
neXtProt	NX_Q9UKA2.
PharmGKB	PA28024.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG287004.
HOGENOM	HOG000006948.
HOVERGEN	HBG051588.
InParanoid	Q9UKA2.
KO	K10270.
OMA	EVISEMC.
OrthoDB	EOG4XSKPD.
PhylomeDB	Q9UKA2.
Gene expression databases
Bgee	Q9UKA2.
CleanEx	HS_FBXL4.
Genevestigator	Q9UKA2.
GermOnline	ENSG00000112234. Homo sapiens.
Family and domain databases
InterPro	IPR001810. F-box_dom_cyclin-like. IPR006553. Leu-rich_rpt_Cys-con_subtyp. [Graphical view]
Pfam	PF00646. F-box. 1 hit. [Graphical view]
SMART	SM00256. FBOX. 1 hit. SM00367. LRR_CC. 1 hit. [Graphical view]
SUPFAM	SSF81383. F-box_dom_Skp2-like. 1 hit.
PROSITE	PS50181. FBOX. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FBXL4. human.
GenomeRNAi	26235.
NextBio	48423.
SOURCE	Search...

Entry information

Entry name

FBXL4_HUMAN

Accession

Primary (citable) accession number: Q9UKA2
Secondary accession number(s): E1P530 , O95919, Q5BJH0, Q9UJU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	May 27, 2002
Last modified:	May 1, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.