Reviewed, UniProtKB/Swiss-Prot Q9UK97 (FBX9_HUMAN)

Names and origin

Protein names

Recommended name:
    F-box only protein 9
Alternative name(s):
    Cross-immune reaction antigen 1
    Renal carcinoma antigen NY-REN-57

Gene names

Name:	FBXO9
Synonyms:	FBX9, VCIA1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	447 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex By similarity.
Subunit structure	Directly interacts with SKP1A and CUL1 By similarity.
Sequence similarities	Contains 1 F-box domain. Contains 1 TPR repeat.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Coding sequence diversity	Alternative splicing
Domain	TPR repeat
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW protein ubiquitination Ref.1 Ref.7 Non-traceable author statement. Source: UniProtKB
Cellular component	ubiquitin ligase complex Ref.1 Ref.7 Non-traceable author statement. Source: UniProtKB
Molecular function	ubiquitin-protein ligase activity Ref.1 Ref.7 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UK97-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UK97-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MPDIIWVFPPQ → M

Isoform 3 (identifier: Q9UK97-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 447	447	F-box only protein 9		PRO_0000119886
Regions
	Repeat	94 – 127	34	TPR
	Domain	185 – 236	52	F-box
Natural variations
	Alternative sequence	1 – 44	44	Missing in isoform 3.		VSP_012980
	Alternative sequence	1 – 11	11	MPDIIWVFPPQ → M in isoform 2.		VSP_012979

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 2A88163DAB898D69	FASTA	447	52,329
	10 20 30 40 50 60 MPDIIWVFPP QAEAEEDCHS DTVRADDDEE NESPAETDLQ AQLQMFRAQW MFELAPGVSS 70 80 90 100 110 120 SNLENRPCRA ARGSLQKTSA DTKGKQEQAK EEKARELFLK AVEEEQNGAL YEAIKFYRRA 130 140 150 160 170 180 MQLVPDIEFK ITYTRSPDGD GVGNSYIEDN DDDSKMADLL SYFQQQLTFQ ESVLKLCQPE 190 200 210 220 230 240 LESSQIHISV LPMEVLMYIF RWVVSSDLDL RSLEQLSLVC RGFYICARDP EIWRLACLKV 250 260 270 280 290 300 WGRSCIKLVP YTSWREMFLE RPRVRFDGVY ISKTTYIRQG EQSLDGFYRA WHQVEYYRYI 310 320 330 340 350 360 RFFPDGHVMM LTTPEEPQSI VPRLRTRNTR TDAILLGHYR LSQDTDNQTK VFAVITKKKE 370 380 390 400 410 420 EKPLDYKYRY FRRVPVQEAD QSFHVGLQLC SSGHQRFNKL IWIHHSCHIT YKSTGETAVS 430 440 AFEIDKMYTP LFFARVRSYT AFSERPL
	Isoform 2. Checksum: AF7DCF6AD4F4035E	FASTA	437	51,136
	10 20 30 40 50 60 MAEAEEDCHS DTVRADDDEE NESPAETDLQ AQLQMFRAQW MFELAPGVSS SNLENRPCRA 70 80 90 100 110 120 ARGSLQKTSA DTKGKQEQAK EEKARELFLK AVEEEQNGAL YEAIKFYRRA MQLVPDIEFK 130 140 150 160 170 180 ITYTRSPDGD GVGNSYIEDN DDDSKMADLL SYFQQQLTFQ ESVLKLCQPE LESSQIHISV 190 200 210 220 230 240 LPMEVLMYIF RWVVSSDLDL RSLEQLSLVC RGFYICARDP EIWRLACLKV WGRSCIKLVP 250 260 270 280 290 300 YTSWREMFLE RPRVRFDGVY ISKTTYIRQG EQSLDGFYRA WHQVEYYRYI RFFPDGHVMM 310 320 330 340 350 360 LTTPEEPQSI VPRLRTRNTR TDAILLGHYR LSQDTDNQTK VFAVITKKKE EKPLDYKYRY 370 380 390 400 410 420 FRRVPVQEAD QSFHVGLQLC SSGHQRFNKL IWIHHSCHIT YKSTGETAVS AFEIDKMYTP 430 LFFARVRSYT AFSERPL
	Isoform 3. Checksum: 1AAA1F46C31315BB	FASTA	403	47,361
	10 20 30 40 50 60 MFRAQWMFEL APGVSSSNLE NRPCRAARGS LQKTSADTKG KQEQAKEEKA RELFLKAVEE 70 80 90 100 110 120 EQNGALYEAI KFYRRAMQLV PDIEFKITYT RSPDGDGVGN SYIEDNDDDS KMADLLSYFQ 130 140 150 160 170 180 QQLTFQESVL KLCQPELESS QIHISVLPME VLMYIFRWVV SSDLDLRSLE QLSLVCRGFY 190 200 210 220 230 240 ICARDPEIWR LACLKVWGRS CIKLVPYTSW REMFLERPRV RFDGVYISKT TYIRQGEQSL 250 260 270 280 290 300 DGFYRAWHQV EYYRYIRFFP DGHVMMLTTP EEPQSIVPRL RTRNTRTDAI LLGHYRLSQD 310 320 330 340 350 360 TDNQTKVFAV ITKKKEEKPL DYKYRYFRRV PVQEADQSFH VGLQLCSSGH QRFNKLIWIH 370 380 390 400 HSCHITYKST GETAVSAFEI DKMYTPLFFA RVRSYTAFSE RPL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A family of mammalian F-box proteins." Winston J.T., Koepp D.M., Zhu C., Elledge S.J., Harper J.W. Curr. Biol. 9:1180-1182(1999) [PubMed: 10531037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
[2]	The German cDNA consortium Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[3]	"Identification of angiogenesis related genes by xenogeneic antibody screening." Deng H.-X., Wei Y.-Q., Zhao X., Yang J.-L., Yang H.-S., Tian L., Wang R. Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2). Tissue: Endothelial cell.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Embryo.
[5]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Skin.
[7]	"Identification of a family of human F-box proteins." Cenciarelli C., Chiaur D.S., Guardavaccaro D., Parks W., Vidal M., Pagano M. Curr. Biol. 9:1177-1179(1999) [PubMed: 10531035] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 121-447.
[8]	"Antigens recognized by autologous antibody in patients with renal-cell carcinoma." Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H., Jongeneel C.V., Gure A.O., Jaeger D., Jaeger E., Knuth A., Chen Y.-T., Old L.J. Int. J. Cancer 83:456-464(1999) [PubMed: 10508479] [Abstract] Cited for: IDENTIFICATION AS A RENAL CANCER ANTIGEN. Tissue: Renal cell carcinoma.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF176704 mRNA. Translation: AAF03704.1. AL137520 mRNA. Translation: CAB70786.2. AY858798 mRNA. Translation: AAW51115.1. AK021559 mRNA. Translation: BAG51038.1. AL031178 Genomic DNA. Translation: CAI20262.1. AL031178 Genomic DNA. Translation: CAI20263.1. BC000650 mRNA. Translation: AAH00650.2. AF174597 mRNA. Translation: AAF04518.1.
IPI	IPI00296788. IPI00470655. IPI00470662.
PIR	T46366.
RefSeq	NP_036479.1. NP_258441.1. NP_258442.2.
UniGene	Hs.216653
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UK97.
PTM databases
PhosphoSite	Q9UK97.
Proteomic databases
PRIDE	Q9UK97.
Genome annotation databases
Ensembl	ENST00000244426; ENSP00000244426; ENSG00000112146; Homo sapiens. [Genome view] ENST00000323557; ENSP00000326968; ENSG00000112146; Homo sapiens. [Genome view] ENST00000370939; ENSP00000359977; ENSG00000112146; Homo sapiens. [Genome view]
GeneID	26268.
KEGG	hsa:26268.
Organism-specific databases
CTD	26268.
GeneCards	GC06P053037.
H-InvDB	HIX0005961.
HGNC	HGNC:13588. FBXO9.
MIM	609091. gene.
PharmGKB	PA28049.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9UK97.
OMA	KLVWIHH.
Gene expression databases
ArrayExpress	Q9UK97.
Bgee	Q9UK97.
CleanEx	HS_FBXO9.
Genevestigator	Q9UK97.
GermOnline	ENSG00000112146. Homo sapiens.
Family and domain databases
InterPro	IPR001810. F-box. [Graphical view]
Pfam	PF00646. F-box. 1 hit. [Graphical view]
PROSITE	PS50181. FBOX. 1 hit. PS50005. TPR. False negative. PS50293. TPR_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	48545.
SOURCE	Search...

Entry information

Entry name

FBX9_HUMAN

Accession

Primary (citable) accession number: Q9UK97
Secondary accession number(s): A6NFW3 , B3KMM6, O75986, Q6PKH7, Q9NT57, Q9Y593

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 1, 2000
Last modified:	November 3, 2009
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.