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Q9UK96 (FBX10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-box only protein 10
Gene names
Name:FBXO10
Synonyms:FBX10, PRMT11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length956 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. Ref.6

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Component of the SCF(FBXO10) complex consisting of CUL1, SKP1 and FBXO10. Interacts with BCL2. Ref.6

Subcellular location

Cytoplasm Ref.6.

Involvement in disease

Defects in FBXO10 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of BCL2, an oncoprotein that has a critical role in lymphomas (Ref.6).

Sequence similarities

Contains 1 F-box domain.

Contains 17 PbH1 repeats.

Sequence caution

The sequence AAF03705.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence AAF03705.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part.

The sequence AAF04519.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence CAI16152.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 956956F-box only protein 10
PRO_0000119889

Regions

Domain1 – 4848F-box
Repeat198 – 21720PbH1 1
Repeat238 – 26023PbH1 2
Repeat427 – 44822PbH1 3
Repeat449 – 47022PbH1 4
Repeat471 – 49323PbH1 5
Repeat494 – 51623PbH1 6
Repeat538 – 56023PbH1 7
Repeat561 – 58323PbH1 8
Repeat584 – 60623PbH1 9
Repeat607 – 62923PbH1 10
Repeat630 – 65223PbH1 11
Repeat653 – 67523PbH1 12
Repeat717 – 73923PbH1 13
Repeat740 – 76223PbH1 14
Repeat764 – 78623PbH1 15
Repeat787 – 80923PbH1 16
Repeat832 – 85423PbH1 17

Natural variations

Natural variant441R → H Found in a patient with lymphoma; inhibits binding with SKP1. Ref.6
VAR_070692
Natural variant2121H → N Found in a patient with lymphomain. Ref.6
Corresponds to variant rs7044561 [ dbSNP | Ensembl ].
VAR_055801
Natural variant7621V → C Requires 2 nucleotide substitutions;found in a patient with lymphoma; partial loss of function in controlling the stability of BCL2. Ref.6
VAR_070693
Natural variant8251R → W Found in a patient with lymphoma; partial loss of function in controlling the stability of BCL2. Ref.6
VAR_070694

Sequences

Sequence LengthMass (Da)Tools
Q9UK96 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 3F9BDEBE0139B16F

FASTA956105,195
        10         20         30         40         50         60 
MEAGGLPLEL WRMILAYLHL PDLGRCSLVC RAWYELILSL DSTRWRQLCL GCTECRHPNW 

        70         80         90        100        110        120 
PNQPDVEPES WREAFKQHYL ASKTWTKNAL DLESSICFSL FRRRRERRTL SVGPGREFDS 

       130        140        150        160        170        180 
LGSALAMASL YDRIVLFPGV YEEQGEIILK VPVEIVGQGK LGEVALLASI DQHCSTTRLC 

       190        200        210        220        230        240 
NLVFTPAWFS PIMYKTTSGH VQFDNCNFEN GHIQVHGPGT CQVKFCTFKN THIFLHNVPL 

       250        260        270        280        290        300 
CVLENCEFVG SENNSVTVEG HPSADKNWAY KYLLGLIKSS PTFLPTEDSD FLMSLDLESR 

       310        320        330        340        350        360 
DQAWSPKTCD IVIEGSQSPT SPASSSPKPG SKAGSQEAEV GSDGERVAQT PDSSDGGLSP 

       370        380        390        400        410        420 
SGEDEDEDQL MYRLSYQVQG PRPVLGGSFL GPPLPGASIQ LPSCLVLNSL QQELQKDKEA 

       430        440        450        460        470        480 
MALANSVQGC LIRKCLFRDG KGGVFVCSHG RAKMEGNIFR NLTYAVRCIH NSKIIMLRND 

       490        500        510        520        530        540 
IYRCRASGIF LRLEGGGLIA GNNIYHNAEA GVDIRKKSNP LILCNQIHHG LRSGIVVLGN 

       550        560        570        580        590        600 
GKGIIRNNQI FSNKEAGIYI LYHGNPVVSG NHIFKGRAAG IAVNENGKGL ITENVIRENQ 

       610        620        630        640        650        660 
WGGVDIRRGG IPVLRSNLIC FGYSDGVVVG DEGKGLIEGN TIYANKGCGV WMMSSSLPHV 

       670        680        690        700        710        720 
TSNHVSYNGL YGVAVFSQKD GSSELPRGHR AQENFSEDGD AILWETELEK EDDPLRRPIT 

       730        740        750        760        770        780 
IALVESNSIN HNGASGLYVQ SSEALHVITN VIHANGDRGI TVAQSSQPTR VANNSISCNR 

       790        800        810        820        830        840 
QSGVKVEAQC KVELRGNGIY DNRGHGIITK GDSTIVIEND IIGNRGSGLQ LLPRSDTKVI 

       850        860        870        880        890        900 
KNRIHSFRAY GIAVRGRAKA LVQENIIFQG KTSKTIFQQI SNNRECIMQN NKFLVFKKKS 

       910        920        930        940        950 
DTWRLVNPPA RPHLENSLRR PSAAHNGQKV TAMATRITAR VEGGYHSNRS VFCTIL 

« Hide

References

« Hide 'large scale' references
[1]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"A family of mammalian F-box proteins."
Winston J.T., Koepp D.M., Zhu C., Elledge S.J., Harper J.W.
Curr. Biol. 9:1180-1182(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-521.
[5]"Identification of a family of human F-box proteins."
Cenciarelli C., Chiaur D.S., Guardavaccaro D., Parks W., Vidal M., Pagano M.
Curr. Biol. 9:1177-1179(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-162.
[6]"Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma."
Chiorazzi M., Rui L., Yang Y., Ceribelli M., Tishbi N., Maurer C.W., Ranuncolo S.M., Zhao H., Xu W., Chan W.C., Jaffe E.S., Gascoyne R.D., Campo E., Rosenwald A., Ott G., Delabie J., Rimsza L.M., Shaham S., Staudt L.M.
Proc. Natl. Acad. Sci. U.S.A. 110:3943-3948(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH BCL2, FUNCTION IN UBIQUITINATION OF BCL2, SUBCELLULAR LOCATION, IDENTIFICATION IN THE SCF(FBXO10) COMPLEX, VARIANTS HIS-44; ASN-212; CYS-762 AND TRP-825, CHARACTERIZATION OF VARIANTS HIS-44; CYS-762 AND TRP-825.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL513165 Genomic DNA. Translation: CAI16152.1. Sequence problems.
CH471071 Genomic DNA. Translation: EAW58274.1.
CH471071 Genomic DNA. Translation: EAW58275.1.
BC125125 mRNA. Translation: AAI25126.1.
BC140785 mRNA. Translation: AAI40786.1.
BC171785 mRNA. Translation: AAI71785.1.
AF176705 mRNA. Translation: AAF03705.1. Sequence problems.
AF174598 mRNA. Translation: AAF04519.1. Different initiation.
RefSeqNP_036298.2. NM_012166.2.
UniGeneHs.709527.

3D structure databases

ProteinModelPortalQ9UK96.
SMRQ9UK96. Positions 3-117, 127-160, 429-643, 720-845.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117651. 3 interactions.
IntActQ9UK96. 1 interaction.
STRING9606.ENSP00000403802.

PTM databases

PhosphoSiteQ9UK96.

Polymorphism databases

DMDM296439345.

Proteomic databases

PaxDbQ9UK96.
PRIDEQ9UK96.

Protocols and materials databases

DNASU26267.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000432825; ENSP00000403802; ENSG00000147912.
GeneID26267.
KEGGhsa:26267.
UCSCuc004aab.3. human.

Organism-specific databases

CTD26267.
GeneCardsGC09M037510.
HGNCHGNC:13589. FBXO10.
HPAHPA002863.
MIM609092. gene.
neXtProtNX_Q9UK96.
PharmGKBPA28030.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG292700.
HOGENOMHOG000112542.
HOVERGENHBG080399.
InParanoidQ9UK96.
KOK10296.
OMANHNGASG.
OrthoDBEOG71ZP0Z.
PhylomeDBQ9UK96.
TreeFamTF313602.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

ArrayExpressQ9UK96.
BgeeQ9UK96.
CleanExHS_FBXO10.
GenevestigatorQ9UK96.

Family and domain databases

Gene3D2.160.20.10. 3 hits.
InterProIPR006633. Carb-bd_sugar_hydrolysis-dom.
IPR001810. F-box_dom.
IPR007742. NosD_dom.
IPR022441. Para_beta_helix_rpt-2.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
PfamPF00646. F-box. 1 hit.
PF05048. NosD. 1 hit.
[Graphical view]
SMARTSM00722. CASH. 3 hits.
SM00256. FBOX. 1 hit.
SM00710. PbH1. 18 hits.
[Graphical view]
SUPFAMSSF51126. SSF51126. 4 hits.
SSF81383. SSF81383. 1 hit.
TIGRFAMsTIGR03804. para_beta_helix. 1 hit.
PROSITEPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFBXO10. human.
GenomeRNAi26267.
NextBio48541.
PROQ9UK96.
SOURCESearch...

Entry information

Entry nameFBX10_HUMAN
AccessionPrimary (citable) accession number: Q9UK96
Secondary accession number(s): Q08AL3, Q5JRT8, Q9UKC3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM