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Protein

F-box only protein 10

Gene

FBXO10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • protein ubiquitination Source: UniProtKB
  • protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: UniProtKB
  • regulation of apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147912-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 10
Gene namesi
Name:FBXO10
Synonyms:FBX10, PRMT11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:13589. FBXO10.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Defects in FBXO10 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of BCL2, an oncoprotein that has a critical role in lymphomas.

Organism-specific databases

DisGeNETi26267.
OpenTargetsiENSG00000147912.
PharmGKBiPA28030.

Polymorphism and mutation databases

BioMutaiFBXO10.
DMDMi296439345.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198891 – 956F-box only protein 10Add BLAST956

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei321PhosphoserineBy similarity1
Modified residuei326PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UK96.
PaxDbiQ9UK96.
PeptideAtlasiQ9UK96.
PRIDEiQ9UK96.

PTM databases

iPTMnetiQ9UK96.
PhosphoSitePlusiQ9UK96.

Expressioni

Gene expression databases

BgeeiENSG00000147912.
CleanExiHS_FBXO10.
ExpressionAtlasiQ9UK96. baseline and differential.
GenevisibleiQ9UK96. HS.

Organism-specific databases

HPAiHPA002863.

Interactioni

Subunit structurei

Component of the SCF(FBXO10) complex consisting of CUL1, SKP1 and FBXO10 (PubMed:23431138). Interacts with BCL2 (PubMed:23431138). Interacts with PRDM1 (PubMed:24613396).2 Publications

Protein-protein interaction databases

BioGridi117651. 7 interactors.
IntActiQ9UK96. 2 interactors.
STRINGi9606.ENSP00000403802.

Structurei

3D structure databases

ProteinModelPortaliQ9UK96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 48F-boxPROSITE-ProRule annotationAdd BLAST48
Repeati198 – 217PbH1 1Add BLAST20
Repeati238 – 260PbH1 2Add BLAST23
Repeati427 – 448PbH1 3Add BLAST22
Repeati449 – 470PbH1 4Add BLAST22
Repeati471 – 493PbH1 5Add BLAST23
Repeati494 – 516PbH1 6Add BLAST23
Repeati538 – 560PbH1 7Add BLAST23
Repeati561 – 583PbH1 8Add BLAST23
Repeati584 – 606PbH1 9Add BLAST23
Repeati607 – 629PbH1 10Add BLAST23
Repeati630 – 652PbH1 11Add BLAST23
Repeati653 – 675PbH1 12Add BLAST23
Repeati717 – 739PbH1 13Add BLAST23
Repeati740 – 762PbH1 14Add BLAST23
Repeati764 – 786PbH1 15Add BLAST23
Repeati787 – 809PbH1 16Add BLAST23
Repeati832 – 854PbH1 17Add BLAST23

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 17 PbH1 repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IPED. Eukaryota.
ENOG410ZF90. LUCA.
GeneTreeiENSGT00530000063425.
HOGENOMiHOG000112542.
HOVERGENiHBG080399.
InParanoidiQ9UK96.
KOiK10296.
OMAiPRSDTKV.
OrthoDBiEOG091G0AXA.
PhylomeDBiQ9UK96.
TreeFamiTF313602.

Family and domain databases

Gene3Di2.160.20.10. 3 hits.
InterProiIPR006633. Carb-bd_sugar_hydrolysis-dom.
IPR001810. F-box_dom.
IPR007742. NosD_dom.
IPR022441. Para_beta_helix_rpt-2.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF05048. NosD. 1 hit.
[Graphical view]
SMARTiSM00722. CASH. 3 hits.
SM00256. FBOX. 1 hit.
SM00710. PbH1. 18 hits.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 4 hits.
SSF81383. SSF81383. 1 hit.
TIGRFAMsiTIGR03804. para_beta_helix. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UK96-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAGGLPLEL WRMILAYLHL PDLGRCSLVC RAWYELILSL DSTRWRQLCL
60 70 80 90 100
GCTECRHPNW PNQPDVEPES WREAFKQHYL ASKTWTKNAL DLESSICFSL
110 120 130 140 150
FRRRRERRTL SVGPGREFDS LGSALAMASL YDRIVLFPGV YEEQGEIILK
160 170 180 190 200
VPVEIVGQGK LGEVALLASI DQHCSTTRLC NLVFTPAWFS PIMYKTTSGH
210 220 230 240 250
VQFDNCNFEN GHIQVHGPGT CQVKFCTFKN THIFLHNVPL CVLENCEFVG
260 270 280 290 300
SENNSVTVEG HPSADKNWAY KYLLGLIKSS PTFLPTEDSD FLMSLDLESR
310 320 330 340 350
DQAWSPKTCD IVIEGSQSPT SPASSSPKPG SKAGSQEAEV GSDGERVAQT
360 370 380 390 400
PDSSDGGLSP SGEDEDEDQL MYRLSYQVQG PRPVLGGSFL GPPLPGASIQ
410 420 430 440 450
LPSCLVLNSL QQELQKDKEA MALANSVQGC LIRKCLFRDG KGGVFVCSHG
460 470 480 490 500
RAKMEGNIFR NLTYAVRCIH NSKIIMLRND IYRCRASGIF LRLEGGGLIA
510 520 530 540 550
GNNIYHNAEA GVDIRKKSNP LILCNQIHHG LRSGIVVLGN GKGIIRNNQI
560 570 580 590 600
FSNKEAGIYI LYHGNPVVSG NHIFKGRAAG IAVNENGKGL ITENVIRENQ
610 620 630 640 650
WGGVDIRRGG IPVLRSNLIC FGYSDGVVVG DEGKGLIEGN TIYANKGCGV
660 670 680 690 700
WMMSSSLPHV TSNHVSYNGL YGVAVFSQKD GSSELPRGHR AQENFSEDGD
710 720 730 740 750
AILWETELEK EDDPLRRPIT IALVESNSIN HNGASGLYVQ SSEALHVITN
760 770 780 790 800
VIHANGDRGI TVAQSSQPTR VANNSISCNR QSGVKVEAQC KVELRGNGIY
810 820 830 840 850
DNRGHGIITK GDSTIVIEND IIGNRGSGLQ LLPRSDTKVI KNRIHSFRAY
860 870 880 890 900
GIAVRGRAKA LVQENIIFQG KTSKTIFQQI SNNRECIMQN NKFLVFKKKS
910 920 930 940 950
DTWRLVNPPA RPHLENSLRR PSAAHNGQKV TAMATRITAR VEGGYHSNRS

VFCTIL
Length:956
Mass (Da):105,195
Last modified:May 18, 2010 - v3
Checksum:i3F9BDEBE0139B16F
GO
Isoform 2 (identifier: Q9UK96-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-475: Missing.

Note: No experimental confirmation available.
Show »
Length:481
Mass (Da):52,572
Checksum:iCB0DE1CF022A7BD6
GO

Sequence cautioni

The sequence AAF03705 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated
The sequence AAF03705 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAF04519 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAI16152 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07069244R → H Found in a patient with lymphoma; inhibits interaction with SKP1. 1 PublicationCorresponds to variant rs780121584dbSNPEnsembl.1
Natural variantiVAR_055801212H → N Found in a patient with lymphoma. 1 PublicationCorresponds to variant rs7044561dbSNPEnsembl.1
Natural variantiVAR_070693762V → C Requires 2 nucleotide substitutions; found in a patient with lymphoma; partial loss of function in controlling the stability of BCL2. 1 Publication1
Natural variantiVAR_070694825R → W Found in a patient with lymphoma; partial loss of function in controlling the stability of BCL2. 1 PublicationCorresponds to variant rs573535073dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0563181 – 475Missing in isoform 2. 1 PublicationAdd BLAST475

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513165 Genomic DNA. Translation: CAI16152.1. Sequence problems.
CH471071 Genomic DNA. Translation: EAW58274.1.
CH471071 Genomic DNA. Translation: EAW58275.1.
BC125124 mRNA. Translation: AAI25125.1.
BC125125 mRNA. Translation: AAI25126.1.
BC140785 mRNA. Translation: AAI40786.1.
BC171785 mRNA. Translation: AAI71785.1.
AF176705 mRNA. Translation: AAF03705.1. Sequence problems.
AF174598 mRNA. Translation: AAF04519.1. Different initiation.
CCDSiCCDS47966.1. [Q9UK96-1]
RefSeqiNP_036298.2. NM_012166.2. [Q9UK96-1]
XP_006716817.1. XM_006716754.3. [Q9UK96-2]
XP_016870108.1. XM_017014619.1. [Q9UK96-1]
UniGeneiHs.709527.

Genome annotation databases

EnsembliENST00000432825; ENSP00000403802; ENSG00000147912. [Q9UK96-1]
GeneIDi26267.
KEGGihsa:26267.
UCSCiuc004aab.3. human. [Q9UK96-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513165 Genomic DNA. Translation: CAI16152.1. Sequence problems.
CH471071 Genomic DNA. Translation: EAW58274.1.
CH471071 Genomic DNA. Translation: EAW58275.1.
BC125124 mRNA. Translation: AAI25125.1.
BC125125 mRNA. Translation: AAI25126.1.
BC140785 mRNA. Translation: AAI40786.1.
BC171785 mRNA. Translation: AAI71785.1.
AF176705 mRNA. Translation: AAF03705.1. Sequence problems.
AF174598 mRNA. Translation: AAF04519.1. Different initiation.
CCDSiCCDS47966.1. [Q9UK96-1]
RefSeqiNP_036298.2. NM_012166.2. [Q9UK96-1]
XP_006716817.1. XM_006716754.3. [Q9UK96-2]
XP_016870108.1. XM_017014619.1. [Q9UK96-1]
UniGeneiHs.709527.

3D structure databases

ProteinModelPortaliQ9UK96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117651. 7 interactors.
IntActiQ9UK96. 2 interactors.
STRINGi9606.ENSP00000403802.

PTM databases

iPTMnetiQ9UK96.
PhosphoSitePlusiQ9UK96.

Polymorphism and mutation databases

BioMutaiFBXO10.
DMDMi296439345.

Proteomic databases

EPDiQ9UK96.
PaxDbiQ9UK96.
PeptideAtlasiQ9UK96.
PRIDEiQ9UK96.

Protocols and materials databases

DNASUi26267.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000432825; ENSP00000403802; ENSG00000147912. [Q9UK96-1]
GeneIDi26267.
KEGGihsa:26267.
UCSCiuc004aab.3. human. [Q9UK96-1]

Organism-specific databases

CTDi26267.
DisGeNETi26267.
GeneCardsiFBXO10.
HGNCiHGNC:13589. FBXO10.
HPAiHPA002863.
MIMi609092. gene.
neXtProtiNX_Q9UK96.
OpenTargetsiENSG00000147912.
PharmGKBiPA28030.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPED. Eukaryota.
ENOG410ZF90. LUCA.
GeneTreeiENSGT00530000063425.
HOGENOMiHOG000112542.
HOVERGENiHBG080399.
InParanoidiQ9UK96.
KOiK10296.
OMAiPRSDTKV.
OrthoDBiEOG091G0AXA.
PhylomeDBiQ9UK96.
TreeFamiTF313602.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciZFISH:ENSG00000147912-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiFBXO10. human.
GenomeRNAii26267.
PROiQ9UK96.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147912.
CleanExiHS_FBXO10.
ExpressionAtlasiQ9UK96. baseline and differential.
GenevisibleiQ9UK96. HS.

Family and domain databases

Gene3Di2.160.20.10. 3 hits.
InterProiIPR006633. Carb-bd_sugar_hydrolysis-dom.
IPR001810. F-box_dom.
IPR007742. NosD_dom.
IPR022441. Para_beta_helix_rpt-2.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF05048. NosD. 1 hit.
[Graphical view]
SMARTiSM00722. CASH. 3 hits.
SM00256. FBOX. 1 hit.
SM00710. PbH1. 18 hits.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 4 hits.
SSF81383. SSF81383. 1 hit.
TIGRFAMsiTIGR03804. para_beta_helix. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX10_HUMAN
AccessioniPrimary (citable) accession number: Q9UK96
Secondary accession number(s): Q08AL3
, Q08AL4, Q5JRT8, Q9UKC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.