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Protein

F-box only protein 10

Gene

FBXO10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.1 Publication

Caution

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • post-translational protein modification Source: Reactome
  • protein polyubiquitination Source: Reactome
  • protein ubiquitination Source: UniProtKB
  • regulation of apoptotic process Source: UniProtKB
  • ubiquitin-dependent protein catabolic process Source: UniProtKB

Keywordsi

Biological processApoptosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 10
Gene namesi
Name:FBXO10
Synonyms:FBX10, PRMT11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000147912.12
HGNCiHGNC:13589 FBXO10
MIMi609092 gene
neXtProtiNX_Q9UK96

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Defects in FBXO10 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of BCL2, an oncoprotein that has a critical role in lymphomas.1 Publication

Organism-specific databases

DisGeNETi26267
OpenTargetsiENSG00000147912
PharmGKBiPA28030

Polymorphism and mutation databases

BioMutaiFBXO10
DMDMi296439345

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198891 – 956F-box only protein 10Add BLAST956

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei321PhosphoserineBy similarity1
Modified residuei326PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UK96
PaxDbiQ9UK96
PeptideAtlasiQ9UK96
PRIDEiQ9UK96

PTM databases

iPTMnetiQ9UK96
PhosphoSitePlusiQ9UK96

Expressioni

Gene expression databases

BgeeiENSG00000147912
CleanExiHS_FBXO10
ExpressionAtlasiQ9UK96 baseline and differential
GenevisibleiQ9UK96 HS

Organism-specific databases

HPAiHPA002863
HPA072721

Interactioni

Subunit structurei

Component of the SCF(FBXO10) complex consisting of CUL1, SKP1 and FBXO10 (PubMed:23431138). Interacts with BCL2 (PubMed:23431138). Interacts with PRDM1 (PubMed:24613396).2 Publications

Protein-protein interaction databases

BioGridi11765131 interactors.
IntActiQ9UK96 2 interactors.
STRINGi9606.ENSP00000403802

Structurei

3D structure databases

ProteinModelPortaliQ9UK96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 48F-boxPROSITE-ProRule annotationAdd BLAST48
Repeati198 – 217PbH1 1Add BLAST20
Repeati238 – 260PbH1 2Add BLAST23
Repeati427 – 448PbH1 3Add BLAST22
Repeati449 – 470PbH1 4Add BLAST22
Repeati471 – 493PbH1 5Add BLAST23
Repeati494 – 516PbH1 6Add BLAST23
Repeati538 – 560PbH1 7Add BLAST23
Repeati561 – 583PbH1 8Add BLAST23
Repeati584 – 606PbH1 9Add BLAST23
Repeati607 – 629PbH1 10Add BLAST23
Repeati630 – 652PbH1 11Add BLAST23
Repeati653 – 675PbH1 12Add BLAST23
Repeati717 – 739PbH1 13Add BLAST23
Repeati740 – 762PbH1 14Add BLAST23
Repeati764 – 786PbH1 15Add BLAST23
Repeati787 – 809PbH1 16Add BLAST23
Repeati832 – 854PbH1 17Add BLAST23

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IPED Eukaryota
ENOG410ZF90 LUCA
GeneTreeiENSGT00530000063425
HOGENOMiHOG000112542
HOVERGENiHBG080399
InParanoidiQ9UK96
KOiK10296
OMAiDVEPESW
OrthoDBiEOG091G0AXA
PhylomeDBiQ9UK96
TreeFamiTF313602

Family and domain databases

Gene3Di2.160.20.103 hits
InterProiView protein in InterPro
IPR006633 Carb-bd_sugar_hydrolysis-dom
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR007742 NosD_dom
IPR022441 Para_beta_helix_rpt-2
IPR006626 PbH1
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF05048 NosD, 1 hit
SMARTiView protein in SMART
SM00722 CASH, 3 hits
SM00256 FBOX, 1 hit
SM00710 PbH1, 18 hits
SUPFAMiSSF51126 SSF51126, 4 hits
SSF81383 SSF81383, 1 hit
TIGRFAMsiTIGR03804 para_beta_helix, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UK96-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAGGLPLEL WRMILAYLHL PDLGRCSLVC RAWYELILSL DSTRWRQLCL
60 70 80 90 100
GCTECRHPNW PNQPDVEPES WREAFKQHYL ASKTWTKNAL DLESSICFSL
110 120 130 140 150
FRRRRERRTL SVGPGREFDS LGSALAMASL YDRIVLFPGV YEEQGEIILK
160 170 180 190 200
VPVEIVGQGK LGEVALLASI DQHCSTTRLC NLVFTPAWFS PIMYKTTSGH
210 220 230 240 250
VQFDNCNFEN GHIQVHGPGT CQVKFCTFKN THIFLHNVPL CVLENCEFVG
260 270 280 290 300
SENNSVTVEG HPSADKNWAY KYLLGLIKSS PTFLPTEDSD FLMSLDLESR
310 320 330 340 350
DQAWSPKTCD IVIEGSQSPT SPASSSPKPG SKAGSQEAEV GSDGERVAQT
360 370 380 390 400
PDSSDGGLSP SGEDEDEDQL MYRLSYQVQG PRPVLGGSFL GPPLPGASIQ
410 420 430 440 450
LPSCLVLNSL QQELQKDKEA MALANSVQGC LIRKCLFRDG KGGVFVCSHG
460 470 480 490 500
RAKMEGNIFR NLTYAVRCIH NSKIIMLRND IYRCRASGIF LRLEGGGLIA
510 520 530 540 550
GNNIYHNAEA GVDIRKKSNP LILCNQIHHG LRSGIVVLGN GKGIIRNNQI
560 570 580 590 600
FSNKEAGIYI LYHGNPVVSG NHIFKGRAAG IAVNENGKGL ITENVIRENQ
610 620 630 640 650
WGGVDIRRGG IPVLRSNLIC FGYSDGVVVG DEGKGLIEGN TIYANKGCGV
660 670 680 690 700
WMMSSSLPHV TSNHVSYNGL YGVAVFSQKD GSSELPRGHR AQENFSEDGD
710 720 730 740 750
AILWETELEK EDDPLRRPIT IALVESNSIN HNGASGLYVQ SSEALHVITN
760 770 780 790 800
VIHANGDRGI TVAQSSQPTR VANNSISCNR QSGVKVEAQC KVELRGNGIY
810 820 830 840 850
DNRGHGIITK GDSTIVIEND IIGNRGSGLQ LLPRSDTKVI KNRIHSFRAY
860 870 880 890 900
GIAVRGRAKA LVQENIIFQG KTSKTIFQQI SNNRECIMQN NKFLVFKKKS
910 920 930 940 950
DTWRLVNPPA RPHLENSLRR PSAAHNGQKV TAMATRITAR VEGGYHSNRS

VFCTIL
Length:956
Mass (Da):105,195
Last modified:May 18, 2010 - v3
Checksum:i3F9BDEBE0139B16F
GO
Isoform 2 (identifier: Q9UK96-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-475: Missing.

Note: No experimental confirmation available.
Show »
Length:481
Mass (Da):52,572
Checksum:iCB0DE1CF022A7BD6
GO

Sequence cautioni

The sequence AAF03705 differs from that shown. Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated
The sequence AAF03705 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAF04519 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAI16152 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07069244R → H Found in a patient with lymphoma; inhibits interaction with SKP1. 1 PublicationCorresponds to variant dbSNP:rs780121584Ensembl.1
Natural variantiVAR_055801212H → N Found in a patient with lymphoma. 1 PublicationCorresponds to variant dbSNP:rs7044561Ensembl.1
Natural variantiVAR_070693762V → C Requires 2 nucleotide substitutions; found in a patient with lymphoma; partial loss of function in controlling the stability of BCL2. 1 Publication1
Natural variantiVAR_070694825R → W Found in a patient with lymphoma; partial loss of function in controlling the stability of BCL2. 1 PublicationCorresponds to variant dbSNP:rs573535073Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0563181 – 475Missing in isoform 2. 1 PublicationAdd BLAST475

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513165 Genomic DNA Translation: CAI16152.1 Sequence problems.
CH471071 Genomic DNA Translation: EAW58274.1
CH471071 Genomic DNA Translation: EAW58275.1
BC125124 mRNA Translation: AAI25125.1
BC125125 mRNA Translation: AAI25126.1
BC140785 mRNA Translation: AAI40786.1
BC171785 mRNA Translation: AAI71785.1
AF176705 mRNA Translation: AAF03705.1 Sequence problems.
AF174598 mRNA Translation: AAF04519.1 Different initiation.
CCDSiCCDS47966.1 [Q9UK96-1]
RefSeqiNP_036298.2, NM_012166.2 [Q9UK96-1]
XP_006716817.1, XM_006716754.3 [Q9UK96-2]
XP_016870108.1, XM_017014619.1 [Q9UK96-1]
UniGeneiHs.709527

Genome annotation databases

EnsembliENST00000432825; ENSP00000403802; ENSG00000147912 [Q9UK96-1]
GeneIDi26267
KEGGihsa:26267
UCSCiuc004aab.3 human [Q9UK96-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFBX10_HUMAN
AccessioniPrimary (citable) accession number: Q9UK96
Secondary accession number(s): Q08AL3
, Q08AL4, Q5JRT8, Q9UKC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 18, 2010
Last modified: April 25, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome