Q9UK96 (FBX10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
F-box only protein 10

Gene names

Name:	FBXO10
Synonyms:	FBX10

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	956 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex By similarity.
Subunit structure	Directly interacts with SKP1 and CUL1 By similarity.
Sequence similarities	Contains 1 F-box domain. Contains 17 PbH1 repeats.
Sequence caution	The sequence AAF03705.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAF03705.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part. The sequence AAF04519.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAI16152.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Coding sequence diversity	Polymorphism
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	ubiquitin ligase complex Non-traceable author statement Ref.5Ref.4. Source: UniProtKB
Molecular_function	ubiquitin-protein ligase activity Non-traceable author statement Ref.5Ref.4. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 956	956	F-box only protein 10		PRO_0000119889
Regions
	Domain	1 – 48	48	F-box
	Repeat	198 – 217	20	PbH1 1
	Repeat	238 – 260	23	PbH1 2
	Repeat	427 – 448	22	PbH1 3
	Repeat	449 – 470	22	PbH1 4
	Repeat	471 – 493	23	PbH1 5
	Repeat	494 – 516	23	PbH1 6
	Repeat	538 – 560	23	PbH1 7
	Repeat	561 – 583	23	PbH1 8
	Repeat	584 – 606	23	PbH1 9
	Repeat	607 – 629	23	PbH1 10
	Repeat	630 – 652	23	PbH1 11
	Repeat	653 – 675	23	PbH1 12
	Repeat	717 – 739	23	PbH1 13
	Repeat	740 – 762	23	PbH1 14
	Repeat	764 – 786	23	PbH1 15
	Repeat	787 – 809	23	PbH1 16
	Repeat	832 – 854	23	PbH1 17
Natural variations
	Natural variant	212	1	H → N. Corresponds to variant rs7044561 [ dbSNP | Ensembl ].		VAR_055801

Sequences

	Sequence		Length	Mass (Da)
	Q9UK96 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 3F9BDEBE0139B16F	FASTA	956	105,195
	10 20 30 40 50 60 MEAGGLPLEL WRMILAYLHL PDLGRCSLVC RAWYELILSL DSTRWRQLCL GCTECRHPNW 70 80 90 100 110 120 PNQPDVEPES WREAFKQHYL ASKTWTKNAL DLESSICFSL FRRRRERRTL SVGPGREFDS 130 140 150 160 170 180 LGSALAMASL YDRIVLFPGV YEEQGEIILK VPVEIVGQGK LGEVALLASI DQHCSTTRLC 190 200 210 220 230 240 NLVFTPAWFS PIMYKTTSGH VQFDNCNFEN GHIQVHGPGT CQVKFCTFKN THIFLHNVPL 250 260 270 280 290 300 CVLENCEFVG SENNSVTVEG HPSADKNWAY KYLLGLIKSS PTFLPTEDSD FLMSLDLESR 310 320 330 340 350 360 DQAWSPKTCD IVIEGSQSPT SPASSSPKPG SKAGSQEAEV GSDGERVAQT PDSSDGGLSP 370 380 390 400 410 420 SGEDEDEDQL MYRLSYQVQG PRPVLGGSFL GPPLPGASIQ LPSCLVLNSL QQELQKDKEA 430 440 450 460 470 480 MALANSVQGC LIRKCLFRDG KGGVFVCSHG RAKMEGNIFR NLTYAVRCIH NSKIIMLRND 490 500 510 520 530 540 IYRCRASGIF LRLEGGGLIA GNNIYHNAEA GVDIRKKSNP LILCNQIHHG LRSGIVVLGN 550 560 570 580 590 600 GKGIIRNNQI FSNKEAGIYI LYHGNPVVSG NHIFKGRAAG IAVNENGKGL ITENVIRENQ 610 620 630 640 650 660 WGGVDIRRGG IPVLRSNLIC FGYSDGVVVG DEGKGLIEGN TIYANKGCGV WMMSSSLPHV 670 680 690 700 710 720 TSNHVSYNGL YGVAVFSQKD GSSELPRGHR AQENFSEDGD AILWETELEK EDDPLRRPIT 730 740 750 760 770 780 IALVESNSIN HNGASGLYVQ SSEALHVITN VIHANGDRGI TVAQSSQPTR VANNSISCNR 790 800 810 820 830 840 QSGVKVEAQC KVELRGNGIY DNRGHGIITK GDSTIVIEND IIGNRGSGLQ LLPRSDTKVI 850 860 870 880 890 900 KNRIHSFRAY GIAVRGRAKA LVQENIIFQG KTSKTIFQQI SNNRECIMQN NKFLVFKKKS 910 920 930 940 950 DTWRLVNPPA RPHLENSLRR PSAAHNGQKV TAMATRITAR VEGGYHSNRS VFCTIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"A family of mammalian F-box proteins." Winston J.T., Koepp D.M., Zhu C., Elledge S.J., Harper J.W. Curr. Biol. 9:1180-1182(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-521.
[5]	"Identification of a family of human F-box proteins." Cenciarelli C., Chiaur D.S., Guardavaccaro D., Parks W., Vidal M., Pagano M. Curr. Biol. 9:1177-1179(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-162.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL513165 Genomic DNA. Translation: CAI16152.1. Sequence problems. CH471071 Genomic DNA. Translation: EAW58274.1. CH471071 Genomic DNA. Translation: EAW58275.1. BC125125 mRNA. Translation: AAI25126.1. BC140785 mRNA. Translation: AAI40786.1. BC171785 mRNA. Translation: AAI71785.1. AF176705 mRNA. Translation: AAF03705.1. Sequence problems. AF174598 mRNA. Translation: AAF04519.1. Different initiation.
IPI	IPI00552091.
RefSeq	NP_036298.2. NM_012166.2.
UniGene	Hs.709527.
3D structure databases
ProteinModelPortal	Q9UK96.
SMR	Q9UK96. Positions 720-845.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UK96. 1 interaction.
STRING	9606.ENSP00000403802.
PTM databases
PhosphoSite	Q9UK96.
Polymorphism databases
DMDM	296439345.
Proteomic databases
PaxDb	Q9UK96.
PRIDE	Q9UK96.
Protocols and materials databases
DNASU	26267.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000432825; ENSP00000403802; ENSG00000147912.
GeneID	26267.
KEGG	hsa:26267.
UCSC	uc004aab.3. human.
Organism-specific databases
CTD	26267.
GeneCards	GC09M037510.
HGNC	HGNC:13589. FBXO10.
HPA	HPA002863.
MIM	609092. gene.
neXtProt	NX_Q9UK96.
PharmGKB	PA28030.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG292700.
HOGENOM	HOG000112542.
HOVERGEN	HBG080399.
InParanoid	Q9UK96.
KO	K10296.
OMA	LPRSDTK.
OrthoDB	EOG4MPHPD.
Gene expression databases
ArrayExpress	Q9UK96.
Bgee	Q9UK96.
CleanEx	HS_FBXO10.
Genevestigator	Q9UK96.
GermOnline	ENSG00000147912. Homo sapiens.
Family and domain databases
Gene3D	2.160.20.10. 3 hits.
InterPro	IPR006633. Carb-bd_sugar_hydrolysis-dom. IPR001810. F-box_dom_cyclin-like. IPR007742. NosD_dom. IPR022441. Para_beta_helix_rpt-2. IPR006626. PbH1. IPR012334. Pectin_lyas_fold. IPR011050. Pectin_lyase_fold/virulence. [Graphical view]
Pfam	PF00646. F-box. 1 hit. PF05048. NosD. 1 hit. [Graphical view]
SMART	SM00722. CASH. 3 hits. SM00256. FBOX. 1 hit. SM00710. PbH1. 18 hits. [Graphical view]
SUPFAM	SSF81383. F-box_dom_Skp2-like. 1 hit. SSF51126. Pectin_lyas_like. 4 hits.
TIGRFAMs	TIGR03804. para_beta_helix. 1 hit.
PROSITE	PS50181. FBOX. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FBXO10. human.
GenomeRNAi	26267.
NextBio	48541.
SOURCE	Search...

Entry information

Entry name

FBX10_HUMAN

Accession

Primary (citable) accession number: Q9UK96
Secondary accession number(s): Q08AL3, Q5JRT8, Q9UKC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 104 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.