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Q9UK96

- FBX10_HUMAN

UniProt

Q9UK96 - FBX10_HUMAN

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Protein

F-box only protein 10

Gene

FBXO10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.1 Publication

Pathwayi

GO - Molecular functioni

  1. ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. protein ubiquitination Source: UniProtKB
  3. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: UniProtKB
  4. regulation of apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 10
Gene namesi
Name:FBXO10
Synonyms:FBX10, PRMT11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:13589. FBXO10.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Defects in FBXO10 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of BCL2, an oncoprotein that has a critical role in lymphomas.1 Publication

Organism-specific databases

PharmGKBiPA28030.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 956956F-box only protein 10PRO_0000119889Add
BLAST

Proteomic databases

PaxDbiQ9UK96.
PRIDEiQ9UK96.

PTM databases

PhosphoSiteiQ9UK96.

Expressioni

Gene expression databases

BgeeiQ9UK96.
CleanExiHS_FBXO10.
ExpressionAtlasiQ9UK96. baseline.
GenevestigatoriQ9UK96.

Organism-specific databases

HPAiHPA002863.

Interactioni

Subunit structurei

Component of the SCF(FBXO10) complex consisting of CUL1, SKP1 and FBXO10 (PubMed:23431138). Interacts with BCL2 (PubMed:23431138). Interacts with PRDM1 (PubMed:24613396).2 Publications

Protein-protein interaction databases

BioGridi117651. 5 interactions.
IntActiQ9UK96. 1 interaction.
STRINGi9606.ENSP00000403802.

Structurei

3D structure databases

ProteinModelPortaliQ9UK96.
SMRiQ9UK96. Positions 720-845.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 4848F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati198 – 21720PbH1 1Add
BLAST
Repeati238 – 26023PbH1 2Add
BLAST
Repeati427 – 44822PbH1 3Add
BLAST
Repeati449 – 47022PbH1 4Add
BLAST
Repeati471 – 49323PbH1 5Add
BLAST
Repeati494 – 51623PbH1 6Add
BLAST
Repeati538 – 56023PbH1 7Add
BLAST
Repeati561 – 58323PbH1 8Add
BLAST
Repeati584 – 60623PbH1 9Add
BLAST
Repeati607 – 62923PbH1 10Add
BLAST
Repeati630 – 65223PbH1 11Add
BLAST
Repeati653 – 67523PbH1 12Add
BLAST
Repeati717 – 73923PbH1 13Add
BLAST
Repeati740 – 76223PbH1 14Add
BLAST
Repeati764 – 78623PbH1 15Add
BLAST
Repeati787 – 80923PbH1 16Add
BLAST
Repeati832 – 85423PbH1 17Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 17 PbH1 repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG292700.
GeneTreeiENSGT00530000063425.
HOGENOMiHOG000112542.
HOVERGENiHBG080399.
InParanoidiQ9UK96.
KOiK10296.
OMAiNHNGASG.
OrthoDBiEOG71ZP0Z.
PhylomeDBiQ9UK96.
TreeFamiTF313602.

Family and domain databases

Gene3Di2.160.20.10. 2 hits.
InterProiIPR006633. Carb-bd_sugar_hydrolysis-dom.
IPR001810. F-box_dom.
IPR007742. NosD_dom.
IPR022441. Para_beta_helix_rpt-2.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF05048. NosD. 1 hit.
[Graphical view]
SMARTiSM00722. CASH. 3 hits.
SM00256. FBOX. 1 hit.
SM00710. PbH1. 13 hits.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 4 hits.
SSF81383. SSF81383. 1 hit.
TIGRFAMsiTIGR03804. para_beta_helix. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UK96-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAGGLPLEL WRMILAYLHL PDLGRCSLVC RAWYELILSL DSTRWRQLCL
60 70 80 90 100
GCTECRHPNW PNQPDVEPES WREAFKQHYL ASKTWTKNAL DLESSICFSL
110 120 130 140 150
FRRRRERRTL SVGPGREFDS LGSALAMASL YDRIVLFPGV YEEQGEIILK
160 170 180 190 200
VPVEIVGQGK LGEVALLASI DQHCSTTRLC NLVFTPAWFS PIMYKTTSGH
210 220 230 240 250
VQFDNCNFEN GHIQVHGPGT CQVKFCTFKN THIFLHNVPL CVLENCEFVG
260 270 280 290 300
SENNSVTVEG HPSADKNWAY KYLLGLIKSS PTFLPTEDSD FLMSLDLESR
310 320 330 340 350
DQAWSPKTCD IVIEGSQSPT SPASSSPKPG SKAGSQEAEV GSDGERVAQT
360 370 380 390 400
PDSSDGGLSP SGEDEDEDQL MYRLSYQVQG PRPVLGGSFL GPPLPGASIQ
410 420 430 440 450
LPSCLVLNSL QQELQKDKEA MALANSVQGC LIRKCLFRDG KGGVFVCSHG
460 470 480 490 500
RAKMEGNIFR NLTYAVRCIH NSKIIMLRND IYRCRASGIF LRLEGGGLIA
510 520 530 540 550
GNNIYHNAEA GVDIRKKSNP LILCNQIHHG LRSGIVVLGN GKGIIRNNQI
560 570 580 590 600
FSNKEAGIYI LYHGNPVVSG NHIFKGRAAG IAVNENGKGL ITENVIRENQ
610 620 630 640 650
WGGVDIRRGG IPVLRSNLIC FGYSDGVVVG DEGKGLIEGN TIYANKGCGV
660 670 680 690 700
WMMSSSLPHV TSNHVSYNGL YGVAVFSQKD GSSELPRGHR AQENFSEDGD
710 720 730 740 750
AILWETELEK EDDPLRRPIT IALVESNSIN HNGASGLYVQ SSEALHVITN
760 770 780 790 800
VIHANGDRGI TVAQSSQPTR VANNSISCNR QSGVKVEAQC KVELRGNGIY
810 820 830 840 850
DNRGHGIITK GDSTIVIEND IIGNRGSGLQ LLPRSDTKVI KNRIHSFRAY
860 870 880 890 900
GIAVRGRAKA LVQENIIFQG KTSKTIFQQI SNNRECIMQN NKFLVFKKKS
910 920 930 940 950
DTWRLVNPPA RPHLENSLRR PSAAHNGQKV TAMATRITAR VEGGYHSNRS

VFCTIL
Length:956
Mass (Da):105,195
Last modified:May 18, 2010 - v3
Checksum:i3F9BDEBE0139B16F
GO
Isoform 2 (identifier: Q9UK96-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-475: Missing.

Note: No experimental confirmation available.

Show »
Length:481
Mass (Da):52,572
Checksum:iCB0DE1CF022A7BD6
GO

Sequence cautioni

The sequence AAF03705.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part.
The sequence AAF03705.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AAF04519.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence CAI16152.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441R → H Found in a patient with lymphoma; inhibits interaction with SKP1. 1 Publication
VAR_070692
Natural varianti212 – 2121H → N Found in a patient with lymphoma. 1 Publication
Corresponds to variant rs7044561 [ dbSNP | Ensembl ].
VAR_055801
Natural varianti762 – 7621V → C Requires 2 nucleotide substitutions; found in a patient with lymphoma; partial loss of function in controlling the stability of BCL2. 1 Publication
VAR_070693
Natural varianti825 – 8251R → W Found in a patient with lymphoma; partial loss of function in controlling the stability of BCL2. 1 Publication
VAR_070694

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 475475Missing in isoform 2. 1 PublicationVSP_056318Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513165 Genomic DNA. Translation: CAI16152.1. Sequence problems.
CH471071 Genomic DNA. Translation: EAW58274.1.
CH471071 Genomic DNA. Translation: EAW58275.1.
BC125124 mRNA. Translation: AAI25125.1.
BC125125 mRNA. Translation: AAI25126.1.
BC140785 mRNA. Translation: AAI40786.1.
BC171785 mRNA. Translation: AAI71785.1.
AF176705 mRNA. Translation: AAF03705.1. Sequence problems.
AF174598 mRNA. Translation: AAF04519.1. Different initiation.
CCDSiCCDS47966.1. [Q9UK96-1]
RefSeqiNP_036298.2. NM_012166.2.
XP_006716817.1. XM_006716754.1.
UniGeneiHs.709527.

Genome annotation databases

EnsembliENST00000432825; ENSP00000403802; ENSG00000147912. [Q9UK96-1]
GeneIDi26267.
KEGGihsa:26267.
UCSCiuc004aab.3. human. [Q9UK96-1]

Polymorphism databases

DMDMi296439345.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513165 Genomic DNA. Translation: CAI16152.1 . Sequence problems.
CH471071 Genomic DNA. Translation: EAW58274.1 .
CH471071 Genomic DNA. Translation: EAW58275.1 .
BC125124 mRNA. Translation: AAI25125.1 .
BC125125 mRNA. Translation: AAI25126.1 .
BC140785 mRNA. Translation: AAI40786.1 .
BC171785 mRNA. Translation: AAI71785.1 .
AF176705 mRNA. Translation: AAF03705.1 . Sequence problems.
AF174598 mRNA. Translation: AAF04519.1 . Different initiation.
CCDSi CCDS47966.1. [Q9UK96-1 ]
RefSeqi NP_036298.2. NM_012166.2.
XP_006716817.1. XM_006716754.1.
UniGenei Hs.709527.

3D structure databases

ProteinModelPortali Q9UK96.
SMRi Q9UK96. Positions 720-845.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117651. 5 interactions.
IntActi Q9UK96. 1 interaction.
STRINGi 9606.ENSP00000403802.

PTM databases

PhosphoSitei Q9UK96.

Polymorphism databases

DMDMi 296439345.

Proteomic databases

PaxDbi Q9UK96.
PRIDEi Q9UK96.

Protocols and materials databases

DNASUi 26267.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000432825 ; ENSP00000403802 ; ENSG00000147912 . [Q9UK96-1 ]
GeneIDi 26267.
KEGGi hsa:26267.
UCSCi uc004aab.3. human. [Q9UK96-1 ]

Organism-specific databases

CTDi 26267.
GeneCardsi GC09M037510.
HGNCi HGNC:13589. FBXO10.
HPAi HPA002863.
MIMi 609092. gene.
neXtProti NX_Q9UK96.
PharmGKBi PA28030.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG292700.
GeneTreei ENSGT00530000063425.
HOGENOMi HOG000112542.
HOVERGENi HBG080399.
InParanoidi Q9UK96.
KOi K10296.
OMAi NHNGASG.
OrthoDBi EOG71ZP0Z.
PhylomeDBi Q9UK96.
TreeFami TF313602.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

ChiTaRSi FBXO10. human.
GenomeRNAii 26267.
NextBioi 48541.
PROi Q9UK96.
SOURCEi Search...

Gene expression databases

Bgeei Q9UK96.
CleanExi HS_FBXO10.
ExpressionAtlasi Q9UK96. baseline.
Genevestigatori Q9UK96.

Family and domain databases

Gene3Di 2.160.20.10. 2 hits.
InterProi IPR006633. Carb-bd_sugar_hydrolysis-dom.
IPR001810. F-box_dom.
IPR007742. NosD_dom.
IPR022441. Para_beta_helix_rpt-2.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view ]
Pfami PF00646. F-box. 1 hit.
PF05048. NosD. 1 hit.
[Graphical view ]
SMARTi SM00722. CASH. 3 hits.
SM00256. FBOX. 1 hit.
SM00710. PbH1. 13 hits.
[Graphical view ]
SUPFAMi SSF51126. SSF51126. 4 hits.
SSF81383. SSF81383. 1 hit.
TIGRFAMsi TIGR03804. para_beta_helix. 1 hit.
PROSITEi PS50181. FBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-521 (ISOFORM 1).
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-162 (ISOFORM 1).
  6. Cited for: FUNCTION IN UBIQUITINATION OF BCL2, INTERACTION WITH BCL2, SUBCELLULAR LOCATION, IDENTIFICATION IN THE SCF(FBXO10) COMPLEX, VARIANTS HIS-44; ASN-212; CYS-762 AND TRP-825, CHARACTERIZATION OF VARIANTS HIS-44; CYS-762 AND TRP-825.
  7. "DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation."
    Horn M., Geisen C., Cermak L., Becker B., Nakamura S., Klein C., Pagano M., Antebi A.
    Dev. Cell 28:697-710(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PRDM1.

Entry informationi

Entry nameiFBX10_HUMAN
AccessioniPrimary (citable) accession number: Q9UK96
Secondary accession number(s): Q08AL3
, Q08AL4, Q5JRT8, Q9UKC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3