Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9UK96

- FBX10_HUMAN

UniProt

Q9UK96 - FBX10_HUMAN

Protein

F-box only protein 10

Gene

FBXO10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.1 Publication

    Pathwayi

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. ubiquitin-protein transferase activity Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. protein ubiquitination Source: UniProtKB
    3. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: UniProtKB
    4. regulation of apoptotic process Source: UniProtKB

    Keywords - Biological processi

    Apoptosis, Ubl conjugation pathway

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box only protein 10
    Gene namesi
    Name:FBXO10
    Synonyms:FBX10, PRMT11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:13589. FBXO10.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. ubiquitin ligase complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Involvement in diseasei

    Defects in FBXO10 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of BCL2, an oncoprotein that has a critical role in lymphomas.1 Publication

    Organism-specific databases

    PharmGKBiPA28030.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 956956F-box only protein 10PRO_0000119889Add
    BLAST

    Proteomic databases

    PaxDbiQ9UK96.
    PRIDEiQ9UK96.

    PTM databases

    PhosphoSiteiQ9UK96.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UK96.
    BgeeiQ9UK96.
    CleanExiHS_FBXO10.
    GenevestigatoriQ9UK96.

    Organism-specific databases

    HPAiHPA002863.

    Interactioni

    Subunit structurei

    Component of the SCF(FBXO10) complex consisting of CUL1, SKP1 and FBXO10. Interacts with BCL2.1 Publication

    Protein-protein interaction databases

    BioGridi117651. 3 interactions.
    IntActiQ9UK96. 1 interaction.
    STRINGi9606.ENSP00000403802.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UK96.
    SMRiQ9UK96. Positions 519-676, 720-845.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 4848F-boxPROSITE-ProRule annotationAdd
    BLAST
    Repeati198 – 21720PbH1 1Add
    BLAST
    Repeati238 – 26023PbH1 2Add
    BLAST
    Repeati427 – 44822PbH1 3Add
    BLAST
    Repeati449 – 47022PbH1 4Add
    BLAST
    Repeati471 – 49323PbH1 5Add
    BLAST
    Repeati494 – 51623PbH1 6Add
    BLAST
    Repeati538 – 56023PbH1 7Add
    BLAST
    Repeati561 – 58323PbH1 8Add
    BLAST
    Repeati584 – 60623PbH1 9Add
    BLAST
    Repeati607 – 62923PbH1 10Add
    BLAST
    Repeati630 – 65223PbH1 11Add
    BLAST
    Repeati653 – 67523PbH1 12Add
    BLAST
    Repeati717 – 73923PbH1 13Add
    BLAST
    Repeati740 – 76223PbH1 14Add
    BLAST
    Repeati764 – 78623PbH1 15Add
    BLAST
    Repeati787 – 80923PbH1 16Add
    BLAST
    Repeati832 – 85423PbH1 17Add
    BLAST

    Sequence similaritiesi

    Contains 1 F-box domain.PROSITE-ProRule annotation
    Contains 17 PbH1 repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG292700.
    HOGENOMiHOG000112542.
    HOVERGENiHBG080399.
    InParanoidiQ9UK96.
    KOiK10296.
    OMAiNHNGASG.
    OrthoDBiEOG71ZP0Z.
    PhylomeDBiQ9UK96.
    TreeFamiTF313602.

    Family and domain databases

    Gene3Di2.160.20.10. 3 hits.
    InterProiIPR006633. Carb-bd_sugar_hydrolysis-dom.
    IPR001810. F-box_dom.
    IPR007742. NosD_dom.
    IPR022441. Para_beta_helix_rpt-2.
    IPR006626. PbH1.
    IPR012334. Pectin_lyas_fold.
    IPR011050. Pectin_lyase_fold/virulence.
    [Graphical view]
    PfamiPF00646. F-box. 1 hit.
    PF05048. NosD. 1 hit.
    [Graphical view]
    SMARTiSM00722. CASH. 3 hits.
    SM00256. FBOX. 1 hit.
    SM00710. PbH1. 18 hits.
    [Graphical view]
    SUPFAMiSSF51126. SSF51126. 4 hits.
    SSF81383. SSF81383. 1 hit.
    TIGRFAMsiTIGR03804. para_beta_helix. 1 hit.
    PROSITEiPS50181. FBOX. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UK96-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEAGGLPLEL WRMILAYLHL PDLGRCSLVC RAWYELILSL DSTRWRQLCL    50
    GCTECRHPNW PNQPDVEPES WREAFKQHYL ASKTWTKNAL DLESSICFSL 100
    FRRRRERRTL SVGPGREFDS LGSALAMASL YDRIVLFPGV YEEQGEIILK 150
    VPVEIVGQGK LGEVALLASI DQHCSTTRLC NLVFTPAWFS PIMYKTTSGH 200
    VQFDNCNFEN GHIQVHGPGT CQVKFCTFKN THIFLHNVPL CVLENCEFVG 250
    SENNSVTVEG HPSADKNWAY KYLLGLIKSS PTFLPTEDSD FLMSLDLESR 300
    DQAWSPKTCD IVIEGSQSPT SPASSSPKPG SKAGSQEAEV GSDGERVAQT 350
    PDSSDGGLSP SGEDEDEDQL MYRLSYQVQG PRPVLGGSFL GPPLPGASIQ 400
    LPSCLVLNSL QQELQKDKEA MALANSVQGC LIRKCLFRDG KGGVFVCSHG 450
    RAKMEGNIFR NLTYAVRCIH NSKIIMLRND IYRCRASGIF LRLEGGGLIA 500
    GNNIYHNAEA GVDIRKKSNP LILCNQIHHG LRSGIVVLGN GKGIIRNNQI 550
    FSNKEAGIYI LYHGNPVVSG NHIFKGRAAG IAVNENGKGL ITENVIRENQ 600
    WGGVDIRRGG IPVLRSNLIC FGYSDGVVVG DEGKGLIEGN TIYANKGCGV 650
    WMMSSSLPHV TSNHVSYNGL YGVAVFSQKD GSSELPRGHR AQENFSEDGD 700
    AILWETELEK EDDPLRRPIT IALVESNSIN HNGASGLYVQ SSEALHVITN 750
    VIHANGDRGI TVAQSSQPTR VANNSISCNR QSGVKVEAQC KVELRGNGIY 800
    DNRGHGIITK GDSTIVIEND IIGNRGSGLQ LLPRSDTKVI KNRIHSFRAY 850
    GIAVRGRAKA LVQENIIFQG KTSKTIFQQI SNNRECIMQN NKFLVFKKKS 900
    DTWRLVNPPA RPHLENSLRR PSAAHNGQKV TAMATRITAR VEGGYHSNRS 950
    VFCTIL 956
    Length:956
    Mass (Da):105,195
    Last modified:May 18, 2010 - v3
    Checksum:i3F9BDEBE0139B16F
    GO
    Isoform 2 (identifier: Q9UK96-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-475: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:481
    Mass (Da):52,572
    Checksum:iCB0DE1CF022A7BD6
    GO

    Sequence cautioni

    The sequence AAF03705.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part.
    The sequence AAF03705.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAF04519.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAI16152.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti44 – 441R → H Found in a patient with lymphoma; inhibits interaction with SKP1. 1 Publication
    VAR_070692
    Natural varianti212 – 2121H → N Found in a patient with lymphoma. 1 Publication
    Corresponds to variant rs7044561 [ dbSNP | Ensembl ].
    VAR_055801
    Natural varianti762 – 7621V → C Requires 2 nucleotide substitutions; found in a patient with lymphoma; partial loss of function in controlling the stability of BCL2. 1 Publication
    VAR_070693
    Natural varianti825 – 8251R → W Found in a patient with lymphoma; partial loss of function in controlling the stability of BCL2. 1 Publication
    VAR_070694

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 475475Missing in isoform 2. 1 PublicationVSP_056318Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513165 Genomic DNA. Translation: CAI16152.1. Sequence problems.
    CH471071 Genomic DNA. Translation: EAW58274.1.
    CH471071 Genomic DNA. Translation: EAW58275.1.
    BC125124 mRNA. Translation: AAI25125.1.
    BC125125 mRNA. Translation: AAI25126.1.
    BC140785 mRNA. Translation: AAI40786.1.
    BC171785 mRNA. Translation: AAI71785.1.
    AF176705 mRNA. Translation: AAF03705.1. Sequence problems.
    AF174598 mRNA. Translation: AAF04519.1. Different initiation.
    CCDSiCCDS47966.1.
    RefSeqiNP_036298.2. NM_012166.2.
    XP_006716817.1. XM_006716754.1.
    UniGeneiHs.709527.

    Genome annotation databases

    EnsembliENST00000432825; ENSP00000403802; ENSG00000147912.
    ENST00000541829; ENSP00000441307; ENSG00000147912.
    GeneIDi26267.
    KEGGihsa:26267.
    UCSCiuc004aab.3. human.

    Polymorphism databases

    DMDMi296439345.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513165 Genomic DNA. Translation: CAI16152.1 . Sequence problems.
    CH471071 Genomic DNA. Translation: EAW58274.1 .
    CH471071 Genomic DNA. Translation: EAW58275.1 .
    BC125124 mRNA. Translation: AAI25125.1 .
    BC125125 mRNA. Translation: AAI25126.1 .
    BC140785 mRNA. Translation: AAI40786.1 .
    BC171785 mRNA. Translation: AAI71785.1 .
    AF176705 mRNA. Translation: AAF03705.1 . Sequence problems.
    AF174598 mRNA. Translation: AAF04519.1 . Different initiation.
    CCDSi CCDS47966.1.
    RefSeqi NP_036298.2. NM_012166.2.
    XP_006716817.1. XM_006716754.1.
    UniGenei Hs.709527.

    3D structure databases

    ProteinModelPortali Q9UK96.
    SMRi Q9UK96. Positions 519-676, 720-845.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117651. 3 interactions.
    IntActi Q9UK96. 1 interaction.
    STRINGi 9606.ENSP00000403802.

    PTM databases

    PhosphoSitei Q9UK96.

    Polymorphism databases

    DMDMi 296439345.

    Proteomic databases

    PaxDbi Q9UK96.
    PRIDEi Q9UK96.

    Protocols and materials databases

    DNASUi 26267.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000432825 ; ENSP00000403802 ; ENSG00000147912 .
    ENST00000541829 ; ENSP00000441307 ; ENSG00000147912 .
    GeneIDi 26267.
    KEGGi hsa:26267.
    UCSCi uc004aab.3. human.

    Organism-specific databases

    CTDi 26267.
    GeneCardsi GC09M037510.
    HGNCi HGNC:13589. FBXO10.
    HPAi HPA002863.
    MIMi 609092. gene.
    neXtProti NX_Q9UK96.
    PharmGKBi PA28030.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG292700.
    HOGENOMi HOG000112542.
    HOVERGENi HBG080399.
    InParanoidi Q9UK96.
    KOi K10296.
    OMAi NHNGASG.
    OrthoDBi EOG71ZP0Z.
    PhylomeDBi Q9UK96.
    TreeFami TF313602.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    ChiTaRSi FBXO10. human.
    GenomeRNAii 26267.
    NextBioi 48541.
    PROi Q9UK96.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UK96.
    Bgeei Q9UK96.
    CleanExi HS_FBXO10.
    Genevestigatori Q9UK96.

    Family and domain databases

    Gene3Di 2.160.20.10. 3 hits.
    InterProi IPR006633. Carb-bd_sugar_hydrolysis-dom.
    IPR001810. F-box_dom.
    IPR007742. NosD_dom.
    IPR022441. Para_beta_helix_rpt-2.
    IPR006626. PbH1.
    IPR012334. Pectin_lyas_fold.
    IPR011050. Pectin_lyase_fold/virulence.
    [Graphical view ]
    Pfami PF00646. F-box. 1 hit.
    PF05048. NosD. 1 hit.
    [Graphical view ]
    SMARTi SM00722. CASH. 3 hits.
    SM00256. FBOX. 1 hit.
    SM00710. PbH1. 18 hits.
    [Graphical view ]
    SUPFAMi SSF51126. SSF51126. 4 hits.
    SSF81383. SSF81383. 1 hit.
    TIGRFAMsi TIGR03804. para_beta_helix. 1 hit.
    PROSITEi PS50181. FBOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-521 (ISOFORM 1).
    5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-162 (ISOFORM 1).
    6. Cited for: FUNCTION IN UBIQUITINATION OF BCL2, INTERACTION WITH BCL2, SUBCELLULAR LOCATION, IDENTIFICATION IN THE SCF(FBXO10) COMPLEX, VARIANTS HIS-44; ASN-212; CYS-762 AND TRP-825, CHARACTERIZATION OF VARIANTS HIS-44; CYS-762 AND TRP-825.

    Entry informationi

    Entry nameiFBX10_HUMAN
    AccessioniPrimary (citable) accession number: Q9UK96
    Secondary accession number(s): Q08AL3
    , Q08AL4, Q5JRT8, Q9UKC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 116 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3