SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9UK96

- FBX10_HUMAN

UniProt

Q9UK96 - FBX10_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

F-box only protein 10

Gene
FBXO10, FBX10, PRMT11
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.1 Publication

Pathwayi

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. protein ubiquitination Source: UniProtKB
  3. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: UniProtKB
  4. regulation of apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 10
Gene namesi
Name:FBXO10
Synonyms:FBX10, PRMT11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:13589. FBXO10.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Defects in FBXO10 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of BCL2, an oncoprotein that has a critical role in lymphomas (1 Publication).

Organism-specific databases

PharmGKBiPA28030.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 956956F-box only protein 10PRO_0000119889Add
BLAST

Proteomic databases

PaxDbiQ9UK96.
PRIDEiQ9UK96.

PTM databases

PhosphoSiteiQ9UK96.

Expressioni

Gene expression databases

ArrayExpressiQ9UK96.
BgeeiQ9UK96.
CleanExiHS_FBXO10.
GenevestigatoriQ9UK96.

Organism-specific databases

HPAiHPA002863.

Interactioni

Subunit structurei

Component of the SCF(FBXO10) complex consisting of CUL1, SKP1 and FBXO10. Interacts with BCL2.1 Publication

Protein-protein interaction databases

BioGridi117651. 3 interactions.
IntActiQ9UK96. 1 interaction.
STRINGi9606.ENSP00000403802.

Structurei

3D structure databases

ProteinModelPortaliQ9UK96.
SMRiQ9UK96. Positions 519-676, 720-845.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 4848F-boxAdd
BLAST
Repeati198 – 21720PbH1 1Add
BLAST
Repeati238 – 26023PbH1 2Add
BLAST
Repeati427 – 44822PbH1 3Add
BLAST
Repeati449 – 47022PbH1 4Add
BLAST
Repeati471 – 49323PbH1 5Add
BLAST
Repeati494 – 51623PbH1 6Add
BLAST
Repeati538 – 56023PbH1 7Add
BLAST
Repeati561 – 58323PbH1 8Add
BLAST
Repeati584 – 60623PbH1 9Add
BLAST
Repeati607 – 62923PbH1 10Add
BLAST
Repeati630 – 65223PbH1 11Add
BLAST
Repeati653 – 67523PbH1 12Add
BLAST
Repeati717 – 73923PbH1 13Add
BLAST
Repeati740 – 76223PbH1 14Add
BLAST
Repeati764 – 78623PbH1 15Add
BLAST
Repeati787 – 80923PbH1 16Add
BLAST
Repeati832 – 85423PbH1 17Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.
Contains 17 PbH1 repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG292700.
HOGENOMiHOG000112542.
HOVERGENiHBG080399.
InParanoidiQ9UK96.
KOiK10296.
OMAiNHNGASG.
OrthoDBiEOG71ZP0Z.
PhylomeDBiQ9UK96.
TreeFamiTF313602.

Family and domain databases

Gene3Di2.160.20.10. 3 hits.
InterProiIPR006633. Carb-bd_sugar_hydrolysis-dom.
IPR001810. F-box_dom.
IPR007742. NosD_dom.
IPR022441. Para_beta_helix_rpt-2.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF05048. NosD. 1 hit.
[Graphical view]
SMARTiSM00722. CASH. 3 hits.
SM00256. FBOX. 1 hit.
SM00710. PbH1. 18 hits.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 4 hits.
SSF81383. SSF81383. 1 hit.
TIGRFAMsiTIGR03804. para_beta_helix. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UK96-1 [UniParc]FASTAAdd to Basket

« Hide

MEAGGLPLEL WRMILAYLHL PDLGRCSLVC RAWYELILSL DSTRWRQLCL    50
GCTECRHPNW PNQPDVEPES WREAFKQHYL ASKTWTKNAL DLESSICFSL 100
FRRRRERRTL SVGPGREFDS LGSALAMASL YDRIVLFPGV YEEQGEIILK 150
VPVEIVGQGK LGEVALLASI DQHCSTTRLC NLVFTPAWFS PIMYKTTSGH 200
VQFDNCNFEN GHIQVHGPGT CQVKFCTFKN THIFLHNVPL CVLENCEFVG 250
SENNSVTVEG HPSADKNWAY KYLLGLIKSS PTFLPTEDSD FLMSLDLESR 300
DQAWSPKTCD IVIEGSQSPT SPASSSPKPG SKAGSQEAEV GSDGERVAQT 350
PDSSDGGLSP SGEDEDEDQL MYRLSYQVQG PRPVLGGSFL GPPLPGASIQ 400
LPSCLVLNSL QQELQKDKEA MALANSVQGC LIRKCLFRDG KGGVFVCSHG 450
RAKMEGNIFR NLTYAVRCIH NSKIIMLRND IYRCRASGIF LRLEGGGLIA 500
GNNIYHNAEA GVDIRKKSNP LILCNQIHHG LRSGIVVLGN GKGIIRNNQI 550
FSNKEAGIYI LYHGNPVVSG NHIFKGRAAG IAVNENGKGL ITENVIRENQ 600
WGGVDIRRGG IPVLRSNLIC FGYSDGVVVG DEGKGLIEGN TIYANKGCGV 650
WMMSSSLPHV TSNHVSYNGL YGVAVFSQKD GSSELPRGHR AQENFSEDGD 700
AILWETELEK EDDPLRRPIT IALVESNSIN HNGASGLYVQ SSEALHVITN 750
VIHANGDRGI TVAQSSQPTR VANNSISCNR QSGVKVEAQC KVELRGNGIY 800
DNRGHGIITK GDSTIVIEND IIGNRGSGLQ LLPRSDTKVI KNRIHSFRAY 850
GIAVRGRAKA LVQENIIFQG KTSKTIFQQI SNNRECIMQN NKFLVFKKKS 900
DTWRLVNPPA RPHLENSLRR PSAAHNGQKV TAMATRITAR VEGGYHSNRS 950
VFCTIL 956
Length:956
Mass (Da):105,195
Last modified:May 18, 2010 - v3
Checksum:i3F9BDEBE0139B16F
GO

Sequence cautioni

The sequence AAF03705.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the C-terminal part.
The sequence AAF03705.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AAF04519.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence CAI16152.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441R → H Found in a patient with lymphoma; inhibits interaction with SKP1. 1 Publication
VAR_070692
Natural varianti212 – 2121H → N Found in a patient with lymphoma. 1 Publication
Corresponds to variant rs7044561 [ dbSNP | Ensembl ].
VAR_055801
Natural varianti762 – 7621V → C Requires 2 nucleotide substitutions; found in a patient with lymphoma; partial loss of function in controlling the stability of BCL2. 1 Publication
VAR_070693
Natural varianti825 – 8251R → W Found in a patient with lymphoma; partial loss of function in controlling the stability of BCL2. 1 Publication
VAR_070694

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513165 Genomic DNA. Translation: CAI16152.1. Sequence problems.
CH471071 Genomic DNA. Translation: EAW58274.1.
CH471071 Genomic DNA. Translation: EAW58275.1.
BC125125 mRNA. Translation: AAI25126.1.
BC140785 mRNA. Translation: AAI40786.1.
BC171785 mRNA. Translation: AAI71785.1.
AF176705 mRNA. Translation: AAF03705.1. Sequence problems.
AF174598 mRNA. Translation: AAF04519.1. Different initiation.
CCDSiCCDS47966.1.
RefSeqiNP_036298.2. NM_012166.2.
UniGeneiHs.709527.

Genome annotation databases

EnsembliENST00000432825; ENSP00000403802; ENSG00000147912.
GeneIDi26267.
KEGGihsa:26267.
UCSCiuc004aab.3. human.

Polymorphism databases

DMDMi296439345.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513165 Genomic DNA. Translation: CAI16152.1 . Sequence problems.
CH471071 Genomic DNA. Translation: EAW58274.1 .
CH471071 Genomic DNA. Translation: EAW58275.1 .
BC125125 mRNA. Translation: AAI25126.1 .
BC140785 mRNA. Translation: AAI40786.1 .
BC171785 mRNA. Translation: AAI71785.1 .
AF176705 mRNA. Translation: AAF03705.1 . Sequence problems.
AF174598 mRNA. Translation: AAF04519.1 . Different initiation.
CCDSi CCDS47966.1.
RefSeqi NP_036298.2. NM_012166.2.
UniGenei Hs.709527.

3D structure databases

ProteinModelPortali Q9UK96.
SMRi Q9UK96. Positions 519-676, 720-845.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117651. 3 interactions.
IntActi Q9UK96. 1 interaction.
STRINGi 9606.ENSP00000403802.

PTM databases

PhosphoSitei Q9UK96.

Polymorphism databases

DMDMi 296439345.

Proteomic databases

PaxDbi Q9UK96.
PRIDEi Q9UK96.

Protocols and materials databases

DNASUi 26267.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000432825 ; ENSP00000403802 ; ENSG00000147912 .
GeneIDi 26267.
KEGGi hsa:26267.
UCSCi uc004aab.3. human.

Organism-specific databases

CTDi 26267.
GeneCardsi GC09M037510.
HGNCi HGNC:13589. FBXO10.
HPAi HPA002863.
MIMi 609092. gene.
neXtProti NX_Q9UK96.
PharmGKBi PA28030.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG292700.
HOGENOMi HOG000112542.
HOVERGENi HBG080399.
InParanoidi Q9UK96.
KOi K10296.
OMAi NHNGASG.
OrthoDBi EOG71ZP0Z.
PhylomeDBi Q9UK96.
TreeFami TF313602.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

ChiTaRSi FBXO10. human.
GenomeRNAii 26267.
NextBioi 48541.
PROi Q9UK96.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UK96.
Bgeei Q9UK96.
CleanExi HS_FBXO10.
Genevestigatori Q9UK96.

Family and domain databases

Gene3Di 2.160.20.10. 3 hits.
InterProi IPR006633. Carb-bd_sugar_hydrolysis-dom.
IPR001810. F-box_dom.
IPR007742. NosD_dom.
IPR022441. Para_beta_helix_rpt-2.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view ]
Pfami PF00646. F-box. 1 hit.
PF05048. NosD. 1 hit.
[Graphical view ]
SMARTi SM00722. CASH. 3 hits.
SM00256. FBOX. 1 hit.
SM00710. PbH1. 18 hits.
[Graphical view ]
SUPFAMi SSF51126. SSF51126. 4 hits.
SSF81383. SSF81383. 1 hit.
TIGRFAMsi TIGR03804. para_beta_helix. 1 hit.
PROSITEi PS50181. FBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-521.
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-162.
  6. Cited for: FUNCTION IN UBIQUITINATION OF BCL2, INTERACTION WITH BCL2, SUBCELLULAR LOCATION, IDENTIFICATION IN THE SCF(FBXO10) COMPLEX, VARIANTS HIS-44; ASN-212; CYS-762 AND TRP-825, CHARACTERIZATION OF VARIANTS HIS-44; CYS-762 AND TRP-825.

Entry informationi

Entry nameiFBX10_HUMAN
AccessioniPrimary (citable) accession number: Q9UK96
Secondary accession number(s): Q08AL3, Q5JRT8, Q9UKC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi