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Protein

Dickkopf-like protein 1

Gene

DKKL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility.By similarity

GO - Molecular functioni

  • signal transducer activity Source: ProtInc

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Dickkopf-like protein 1Curated
Alternative name(s):
Cancer/testis antigen 34
Short name:
CT34
Protein soggy-1
Short name:
SGY-11 Publication
Gene namesi
Name:DKKL1Imported
Synonyms:SGY1Imported
ORF Names:UNQ735/PRO1429
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104901.6.
HGNCiHGNC:16528. DKKL1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104901.
PharmGKBiPA134974559.

Polymorphism and mutation databases

BioMutaiDKKL1.
DMDMi13124528.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000000722831 – 242Dickkopf-like protein 1Add BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated during spermatogenesis. Not N-glycosylated in mature sperm.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UK85.
PeptideAtlasiQ9UK85.
PRIDEiQ9UK85.

PTM databases

iPTMnetiQ9UK85.
PhosphoSitePlusiQ9UK85.

Expressioni

Tissue specificityi

More highly expressed in adult testis than in fetal testis. Exclusively expressed in the testis (at protein level). Intense expression in stages II, III and IV of spermatogenesis, whereas expression is lower in stage I.1 Publication

Inductioni

Abnormal expression in testes of patients with male infertility.1 Publication

Gene expression databases

BgeeiENSG00000104901.
CleanExiHS_DKKL1.
ExpressionAtlasiQ9UK85. baseline and differential.
GenevisibleiQ9UK85. HS.

Organism-specific databases

HPAiCAB025410.
HPA047194.

Interactioni

Subunit structurei

Interacts with SLXL1; Co-localize in seminiferous tubules. Interacts with SLY.By similarity

Protein-protein interaction databases

BioGridi118011. 79 interactors.
IntActiQ9UK85. 6 interactors.
STRINGi9606.ENSP00000221498.

Structurei

3D structure databases

ProteinModelPortaliQ9UK85.
SMRiQ9UK85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Contains a N-terminal domain similar to that of the N-terminal section of DKK3.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX83. Eukaryota.
ENOG4111EFK. LUCA.
GeneTreeiENSGT00390000014026.
HOGENOMiHOG000112221.
HOVERGENiHBG051362.
InParanoidiQ9UK85.
OMAiHPRVAFW.
OrthoDBiEOG091G0BUI.
PhylomeDBiQ9UK85.
TreeFamiTF337340.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UK85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEASPPAPA RRHLLVLLLL LSTLVIPSAA APIHDADAQE SSLGLTGLQS
60 70 80 90 100
LLQGFSRLFL KGNLLRGIDS LFSAPMDFRG LPGNYHKEEN QEHQLGNNTL
110 120 130 140 150
SSHLQIDKMT DNKTGEVLIS ENVVASIQPA EGSFEGDLKV PRMEEKEALV
160 170 180 190 200
PIQKATDSFH TELHPRVAFW IIKLPRRRSH QDALEGGHWL SEKRHRLQAI
210 220 230 240
RDGLRKGTHK DVLEEGTESS SHSRLSPRKT HLLYILRPSR QL
Length:242
Mass (Da):27,007
Last modified:May 1, 2000 - v1
Checksum:i8811A4460CB5389E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05306124L → R. Corresponds to variant dbSNP:rs2303757Ensembl.1
Natural variantiVAR_02443229A → T. Corresponds to variant dbSNP:rs919364Ensembl.1
Natural variantiVAR_053062104L → I. Corresponds to variant dbSNP:rs35693137Ensembl.1
Natural variantiVAR_021967109M → R. Corresponds to variant dbSNP:rs2303759Ensembl.1
Natural variantiVAR_053063187G → S. Corresponds to variant dbSNP:rs1054770Ensembl.1
Natural variantiVAR_021968214E → K. Corresponds to variant dbSNP:rs2288481Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177398 mRNA. Translation: AAF02678.1.
AB047818 Genomic DNA. Translation: BAB12400.1.
AY358922 mRNA. Translation: AAQ89281.1.
BC030581 mRNA. Translation: AAH30581.1.
CCDSiCCDS12762.1.
RefSeqiNP_001184230.1. NM_001197301.1.
NP_001184231.1. NM_001197302.1.
NP_055234.1. NM_014419.3.
UniGeneiHs.515855.

Genome annotation databases

EnsembliENST00000221498; ENSP00000221498; ENSG00000104901.
GeneIDi27120.
KEGGihsa:27120.
UCSCiuc002pnk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDKKL1_HUMAN
AccessioniPrimary (citable) accession number: Q9UK85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot