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Protein

Dickkopf-like protein 1

Gene

DKKL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • signal transducer activity Source: ProtInc

GO - Biological processi

  • anatomical structure morphogenesis Source: ProtInc
  • mitophagy in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
  • positive regulation of defense response to virus by host Source: ParkinsonsUK-UCL
  • positive regulation of fat cell differentiation Source: Ensembl
  • xenophagy Source: ParkinsonsUK-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Dickkopf-like protein 1
Alternative name(s):
Cancer/testis antigen 34
Short name:
CT34
Protein soggy-1
Short name:
SGY-1
Gene namesi
Name:DKKL1
Synonyms:SGY1
ORF Names:UNQ735/PRO1429
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16528. DKKL1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134974559.

Polymorphism and mutation databases

BioMutaiDKKL1.
DMDMi13124528.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 242212Dickkopf-like protein 1PRO_0000007228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence analysis
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UK85.
PeptideAtlasiQ9UK85.
PRIDEiQ9UK85.

PTM databases

iPTMnetiQ9UK85.
PhosphoSiteiQ9UK85.

Expressioni

Gene expression databases

BgeeiENSG00000104901.
CleanExiHS_DKKL1.
ExpressionAtlasiQ9UK85. baseline and differential.
GenevisibleiQ9UK85. HS.

Organism-specific databases

HPAiCAB025410.
HPA047194.

Interactioni

Protein-protein interaction databases

BioGridi118011. 76 interactions.
IntActiQ9UK85. 6 interactions.
STRINGi9606.ENSP00000221498.

Structurei

3D structure databases

ProteinModelPortaliQ9UK85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Contains a N-terminal domain similar to that of the N-terminal section of DKK3.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX83. Eukaryota.
ENOG4111EFK. LUCA.
GeneTreeiENSGT00390000014026.
HOGENOMiHOG000112221.
HOVERGENiHBG051362.
InParanoidiQ9UK85.
OMAiHPRVAFW.
OrthoDBiEOG091G0BUI.
PhylomeDBiQ9UK85.
TreeFamiTF337340.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UK85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEASPPAPA RRHLLVLLLL LSTLVIPSAA APIHDADAQE SSLGLTGLQS
60 70 80 90 100
LLQGFSRLFL KGNLLRGIDS LFSAPMDFRG LPGNYHKEEN QEHQLGNNTL
110 120 130 140 150
SSHLQIDKMT DNKTGEVLIS ENVVASIQPA EGSFEGDLKV PRMEEKEALV
160 170 180 190 200
PIQKATDSFH TELHPRVAFW IIKLPRRRSH QDALEGGHWL SEKRHRLQAI
210 220 230 240
RDGLRKGTHK DVLEEGTESS SHSRLSPRKT HLLYILRPSR QL
Length:242
Mass (Da):27,007
Last modified:May 1, 2000 - v1
Checksum:i8811A4460CB5389E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241L → R.
Corresponds to variant rs2303757 [ dbSNP | Ensembl ].
VAR_053061
Natural varianti29 – 291A → T.
Corresponds to variant rs919364 [ dbSNP | Ensembl ].
VAR_024432
Natural varianti104 – 1041L → I.
Corresponds to variant rs35693137 [ dbSNP | Ensembl ].
VAR_053062
Natural varianti109 – 1091M → R.
Corresponds to variant rs2303759 [ dbSNP | Ensembl ].
VAR_021967
Natural varianti187 – 1871G → S.
Corresponds to variant rs1054770 [ dbSNP | Ensembl ].
VAR_053063
Natural varianti214 – 2141E → K.
Corresponds to variant rs2288481 [ dbSNP | Ensembl ].
VAR_021968

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177398 mRNA. Translation: AAF02678.1.
AB047818 Genomic DNA. Translation: BAB12400.1.
AY358922 mRNA. Translation: AAQ89281.1.
BC030581 mRNA. Translation: AAH30581.1.
CCDSiCCDS12762.1.
RefSeqiNP_001184230.1. NM_001197301.1.
NP_001184231.1. NM_001197302.1.
NP_055234.1. NM_014419.3.
UniGeneiHs.515855.

Genome annotation databases

EnsembliENST00000221498; ENSP00000221498; ENSG00000104901.
GeneIDi27120.
KEGGihsa:27120.
UCSCiuc002pnk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177398 mRNA. Translation: AAF02678.1.
AB047818 Genomic DNA. Translation: BAB12400.1.
AY358922 mRNA. Translation: AAQ89281.1.
BC030581 mRNA. Translation: AAH30581.1.
CCDSiCCDS12762.1.
RefSeqiNP_001184230.1. NM_001197301.1.
NP_001184231.1. NM_001197302.1.
NP_055234.1. NM_014419.3.
UniGeneiHs.515855.

3D structure databases

ProteinModelPortaliQ9UK85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118011. 76 interactions.
IntActiQ9UK85. 6 interactions.
STRINGi9606.ENSP00000221498.

PTM databases

iPTMnetiQ9UK85.
PhosphoSiteiQ9UK85.

Polymorphism and mutation databases

BioMutaiDKKL1.
DMDMi13124528.

Proteomic databases

PaxDbiQ9UK85.
PeptideAtlasiQ9UK85.
PRIDEiQ9UK85.

Protocols and materials databases

DNASUi27120.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221498; ENSP00000221498; ENSG00000104901.
GeneIDi27120.
KEGGihsa:27120.
UCSCiuc002pnk.4. human.

Organism-specific databases

CTDi27120.
GeneCardsiDKKL1.
HGNCiHGNC:16528. DKKL1.
HPAiCAB025410.
HPA047194.
MIMi605418. gene.
neXtProtiNX_Q9UK85.
PharmGKBiPA134974559.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX83. Eukaryota.
ENOG4111EFK. LUCA.
GeneTreeiENSGT00390000014026.
HOGENOMiHOG000112221.
HOVERGENiHBG051362.
InParanoidiQ9UK85.
OMAiHPRVAFW.
OrthoDBiEOG091G0BUI.
PhylomeDBiQ9UK85.
TreeFamiTF337340.

Miscellaneous databases

GenomeRNAii27120.
PROiQ9UK85.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104901.
CleanExiHS_DKKL1.
ExpressionAtlasiQ9UK85. baseline and differential.
GenevisibleiQ9UK85. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiDKKL1_HUMAN
AccessioniPrimary (citable) accession number: Q9UK85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.