Reviewed, UniProtKB/Swiss-Prot Q9UK85 (DKKL1_HUMAN)

Names and origin

Protein names

Recommended name:
    Dickkopf-like protein 1
Alternative name(s):
    Protein soggy-1
      Short name=SGY-1
    Cancer/testis antigen 34
      Short name=CT34

Gene names

Name:	DKKL1
Synonyms:	SGY1
ORF Names:	UNQ735/PRO1429

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Secreted.
Post-translational modification	N-glycosylated.
Sequence similarities	To the N-terminal section of DKK-3.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anatomical structure morphogenesis Ref.1 Traceable author statement. Source: ProtInc
Cellular component	extracellular space Ref.1 Traceable author statement. Source: ProtInc
Molecular function	protein binding Inferred from physical interaction. Source: IntAct signal transducer activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ABL1	P00519	1	EBI-1753048,EBI-375543
CRK	P46108	1	EBI-1753048,EBI-886
FYN	P06241	1	EBI-1753048,EBI-515315

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 242	212	Dickkopf-like protein 1		PRO_0000007228
Amino acid modifications
	Modified residue	223	1	Phosphoserine Ref.5
	Modified residue	226	1	Phosphoserine Ref.5
	Glycosylation	97	1	N-linked (GlcNAc...) Potential
	Glycosylation	112	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	24	1	L → R: dbSNP rs2303757.		VAR_053061
	Natural variant	29	1	A → T: dbSNP rs919364.		VAR_024432
	Natural variant	104	1	L → I: dbSNP rs35693137.		VAR_053062
	Natural variant	109	1	M → R: dbSNP rs2303759.		VAR_021967
	Natural variant	187	1	G → S: dbSNP rs1054770.		VAR_053063
	Natural variant	214	1	E → K: dbSNP rs2288481.		VAR_021968

Sequences

	Sequence		Length	Mass (Da)
	Q9UK85-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 8811A4460CB5389E	FASTA	242	27,007
	10 20 30 40 50 60 MGEASPPAPA RRHLLVLLLL LSTLVIPSAA APIHDADAQE SSLGLTGLQS LLQGFSRLFL 70 80 90 100 110 120 KGNLLRGIDS LFSAPMDFRG LPGNYHKEEN QEHQLGNNTL SSHLQIDKMT DNKTGEVLIS 130 140 150 160 170 180 ENVVASIQPA EGSFEGDLKV PRMEEKEALV PIQKATDSFH TELHPRVAFW IIKLPRRRSH 190 200 210 220 230 240 QDALEGGHWL SEKRHRLQAI RDGLRKGTHK DVLEEGTESS SHSRLSPRKT HLLYILRPSR QL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Functional and structural diversity of the human Dickkopf gene family." Krupnik V.E., Sharp J.D., Jiang C., Robison K., Chickering T.W., Amaravadi L., Brown D.E., Guyot D., Mays G., Leiby K., Chang B., Duong T., Goodearl A.D.J., Gearing D.P., Sokol S.Y., McCarthy S.A. Gene 238:301-313(1999) [PubMed: 10570958] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genomic organization of the human and mouse Soggy." Tate G. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[5]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223 AND SER-226, MASS SPECTROMETRY. Tissue: Epithelium.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF177398 mRNA. Translation: AAF02678.1. AB047818 Genomic DNA. Translation: BAB12400.1. AY358922 mRNA. Translation: AAQ89281.1. BC030581 mRNA. Translation: AAH30581.1.
IPI	IPI00007271.
RefSeq	NP_055234.1.
UniGene	Hs.515855
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UK85. 3 interactions.
STRING	Q9UK85.
Proteomic databases
PRIDE	Q9UK85.
Genome annotation databases
Ensembl	ENST00000221498; ENSP00000221498; ENSG00000104901; Homo sapiens. [Genome view]
GeneID	27120.
KEGG	hsa:27120.
UCSC	uc002pnk.1. human.
Organism-specific databases
CTD	27120.
GeneCards	GC19P054559.
HGNC	HGNC:16528. DKKL1.
HPA	CAB025410.
MIM	605418. gene.
PharmGKB	PA134974559.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12953.
HOGENOM	HBG126913.
HOVERGEN	Q9UK85.
InParanoid	Q9UK85.
OMA	MDFRGLP.
OrthoDB	EOG9PCDC5.
PhylomeDB	Q9UK85.
Gene expression databases
ArrayExpress	Q9UK85.
Bgee	Q9UK85.
CleanEx	HS_DKKL1.
Genevestigator	Q9UK85.
GermOnline	ENSG00000104901. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	49804.
SOURCE	Search...

Entry information

Entry name

DKKL1_HUMAN

Accession

Primary (citable) accession number: Q9UK85

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 1, 2000
Last modified:	January 19, 2010
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.