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Protein

Jupiter microtubule associated homolog 1

Gene

JPT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation (PubMed:22155408).4 Publications

Names & Taxonomyi

Protein namesi
Recommended name:
Jupiter microtubule associated homolog 1Imported
Alternative name(s):
Androgen-regulated protein 2
Hematological and neurological expressed 1 protein
Cleaved into the following chain:
Gene namesi
Name:JPT1Imported
Synonyms:ARM2, HN11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000189159.15.
HGNCiHGNC:14569. JPT1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51155.
OpenTargetsiENSG00000189159.
PharmGKBiPA29347.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004244871 – 154Jupiter microtubule associated homolog 1Add BLAST154
Initiator methionineiRemoved; alternateCombined sources1 Publication
ChainiPRO_00000549182 – 154Jupiter microtubule associated homolog 1, N-terminally processedAdd BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonine; in Hematological and neurological expressed 1 protein, N-terminally processedCombined sources1 Publication1
Modified residuei28PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei54PhosphothreonineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei80PhosphoserineCombined sources1
Modified residuei87PhosphoserineCombined sources1 Publication1
Modified residuei88PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei148N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UK76.
PaxDbiQ9UK76.
PeptideAtlasiQ9UK76.
PRIDEiQ9UK76.
TopDownProteomicsiQ9UK76-1. [Q9UK76-1]
Q9UK76-2. [Q9UK76-2]
Q9UK76-3. [Q9UK76-3]

PTM databases

iPTMnetiQ9UK76.
PhosphoSitePlusiQ9UK76.

Expressioni

Tissue specificityi

Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta.1 Publication

Inductioni

Induced by EGF growth factor at mRNA and protein levels (PubMed:21323578). Induced by androgens (PubMed:22155408). Negatively regulated by the microRNA miR-132 (PubMed:25450365).3 Publications

Gene expression databases

BgeeiENSG00000189159.
CleanExiHS_HN1.
ExpressionAtlasiQ9UK76. baseline and differential.
GenevisibleiQ9UK76. HS.

Organism-specific databases

HPAiHPA059729.

Interactioni

Subunit structurei

Interacts with the complex composed, at least, of APC, CTNNB1 and GSK3B; the interaction takes place with the inactive form of GSK3B (phosphorylated at 'Ser-9').1 Publication

Protein-protein interaction databases

BioGridi119338. 16 interactors.
IntActiQ9UK76. 3 interactors.
MINTiMINT-1390948.
STRINGi9606.ENSP00000348316.

Structurei

3D structure databases

ProteinModelPortaliQ9UK76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the JUPITER family.Curated

Phylogenomic databases

eggNOGiENOG410J50B. Eukaryota.
ENOG410YZCR. LUCA.
GeneTreeiENSGT00390000000756.
HOGENOMiHOG000231170.
HOVERGENiHBG055006.
InParanoidiQ9UK76.
OMAiCELHNLS.
OrthoDBiEOG091G0NGB.
PhylomeDBiQ9UK76.
TreeFamiTF327169.

Family and domain databases

InterProiView protein in InterPro
IPR033335. JUPITER.
PANTHERiPTHR34930. PTHR34930. 1 hit.
PfamiView protein in Pfam
PF17054. JUPITER. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UK76-1) [UniParc]FASTAAdd to basket
Also known as: HN1A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTTTTFKGV DPNSRNSSRV LRPPGGGSNF SLGFDEPTEQ PVRKNKMASN
60 70 80 90 100
IFGTPEENQA SWAKSAGAKS SGGREDLESS GLQRRNSSEA SSGDFLDLKG
110 120 130 140 150
EGDIHENVDT DLPGSLGQSE EKPVPAAPVP SPVAPAPVPS RRNPPGGKSS

LVLG
Length:154
Mass (Da):16,015
Last modified:January 23, 2007 - v3
Checksum:i1B443E4C7A28F093
GO
Isoform 2 (identifier: Q9UK76-2) [UniParc]FASTAAdd to basket
Also known as: HN1B

The sequence of this isoform differs from the canonical sequence as follows:
     100-154: GEGDIHENVD...PGGKSSLVLG → KMWTQTCQAA...LTVHLLDLFH

Show »
Length:181
Mass (Da):19,916
Checksum:iFF644A114DE28850
GO
Isoform 3 (identifier: Q9UK76-3) [UniParc]FASTAAdd to basket
Also known as: HN1C

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Show »
Length:108
Mass (Da):11,023
Checksum:iC9E266E6180AB723
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85R → G in BAD97041 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0171321 – 46Missing in isoform 3. 2 PublicationsAdd BLAST46
Alternative sequenceiVSP_017133100 – 154GEGDI…SLVLG → KMWTQTCQAAWGRVKRSPCL LRLCPARWPRPQCHPEEIPL AASPASSWVSSDCPERCRSV CFLHACELHNLSLTVHLLDL FH in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086910 mRNA. Translation: AAP97140.1.
AY322169 mRNA. Translation: AAP83838.1.
AY322170 mRNA. Translation: AAP83839.1.
AF348672 Genomic DNA. Translation: AAL83903.1.
AF348672 Genomic DNA. Translation: AAP83962.1.
AF348672 Genomic DNA. Translation: AAP83963.1.
AF177862 mRNA. Translation: AAD53312.1.
AF266846 mRNA. Translation: AAQ14298.1.
AF266847 Genomic DNA. Translation: AAQ14299.1.
AK223321 mRNA. Translation: BAD97041.1.
AK312613 mRNA. Translation: BAG35500.1.
CH471099 Genomic DNA. Translation: EAW89244.1.
BC001420 mRNA. Translation: AAH01420.1.
BC039343 mRNA. Translation: AAH39343.1.
CCDSiCCDS32729.1. [Q9UK76-2]
CCDS45771.1. [Q9UK76-1]
CCDS45772.1. [Q9UK76-3]
RefSeqiNP_001002032.1. NM_001002032.2. [Q9UK76-2]
NP_001002033.1. NM_001002033.2. [Q9UK76-3]
NP_001275538.1. NM_001288609.1. [Q9UK76-3]
NP_001275539.1. NM_001288610.1. [Q9UK76-3]
NP_001275540.1. NM_001288611.1.
NP_057269.1. NM_016185.3. [Q9UK76-1]
UniGeneiHs.532803.

Genome annotation databases

EnsembliENST00000356033; ENSP00000348316; ENSG00000189159. [Q9UK76-2]
ENST00000409753; ENSP00000387059; ENSG00000189159. [Q9UK76-1]
ENST00000470924; ENSP00000462784; ENSG00000189159. [Q9UK76-3]
ENST00000476258; ENSP00000464266; ENSG00000189159. [Q9UK76-3]
ENST00000481647; ENSP00000462478; ENSG00000189159. [Q9UK76-3]
ENST00000482348; ENSP00000462834; ENSG00000189159. [Q9UK76-3]
GeneIDi51155.
KEGGihsa:51155.
UCSCiuc002jna.3. human. [Q9UK76-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiJUPI1_HUMAN
AccessioniPrimary (citable) accession number: Q9UK76
Secondary accession number(s): B2R6K3
, Q53FG7, Q7Z2D2, Q7Z2F0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families