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Protein

Cyclin-L1

Gene

CCNL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036).4 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ9UK58.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-L1
Short name:
Cyclin-L
Gene namesi
Name:CCNL1
ORF Names:BM-001, UNQ530/PRO1073
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:20569. CCNL1.

Subcellular locationi

GO - Cellular componenti

  • cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
  • nuclear speck Source: UniProtKB-SubCell
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi57018.
OpenTargetsiENSG00000163660.
PharmGKBiPA134980948.

Polymorphism and mutation databases

BioMutaiCCNL1.
DMDMi74753368.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804801 – 526Cyclin-L1Add BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei325PhosphothreonineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei338PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1
Cross-linki362Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei374PhosphoserineCombined sources1
Modified residuei445PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UK58.
PaxDbiQ9UK58.
PeptideAtlasiQ9UK58.
PRIDEiQ9UK58.

PTM databases

iPTMnetiQ9UK58.
PhosphoSitePlusiQ9UK58.

Expressioni

Tissue specificityi

Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).4 Publications

Gene expression databases

BgeeiENSG00000163660.
CleanExiHS_CCNL1.
ExpressionAtlasiQ9UK58. baseline and differential.
GenevisibleiQ9UK58. HS.

Organism-specific databases

HPAiHPA034752.
HPA057911.

Interactioni

Subunit structurei

Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD) (By similarity). Interacts with CDK11A, CDK12 and CDK13 (PubMed:11980906, PubMed:18216018). Isoforms 1 and 2, but not isoform 3, interact with CDK11B. May form a ternary complex with CDK11B and casein kinase II (CKII) (PubMed:18216018). Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7 (PubMed:11980906, PubMed:18216018).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-2836773,EBI-743771
TFIP11Q9UBB93EBI-2836773,EBI-1105213

Protein-protein interaction databases

BioGridi121327. 8 interactors.
IntActiQ9UK58. 24 interactors.
MINTiMINT-4541433.
STRINGi9606.ENSP00000295926.

Structurei

3D structure databases

ProteinModelPortaliQ9UK58.
SMRiQ9UK58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni88 – 190Cyclin-like 1Add BLAST103
Regioni203 – 287Cyclin-like 2Add BLAST85
Regioni390 – 432RSAdd BLAST43

Domaini

Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions.1 Publication

Sequence similaritiesi

Belongs to the cyclin family. Cyclin L subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0835. Eukaryota.
COG5333. LUCA.
GeneTreeiENSGT00760000119191.
HOVERGENiHBG056044.
InParanoidiQ9UK58.
OMAiQEICLTT.
OrthoDBiEOG091G0BW9.
PhylomeDBiQ9UK58.
TreeFamiTF101011.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR015429. Cyclin_L/T.
IPR015431. Cyclin_L1_chr.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10026:SF64. PTHR10026:SF64. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF036580. Cyclin_L. 1 hit.
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Ccnl1 is an immediate-early gene with independently regulated isoforms.
Isoform 1 (identifier: Q9UK58-1) [UniParc]FASTAAdd to basket
Also known as: Cyclin L alpha, cyclin L1alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGPHSTAT AAAAASSAAP SAGGSSSGTT TTTTTTTGGI LIGDRLYSEV
60 70 80 90 100
SLTIDHSLIP EERLSPTPSM QDGLDLPSET DLRILGCELI QAAGILLRLP
110 120 130 140 150
QVAMATGQVL FHRFFYSKSF VKHSFEIVAM ACINLASKIE EAPRRIRDVI
160 170 180 190 200
NVFHHLRQLR GKRTPSPLIL DQNYINTKNQ VIKAERRVLK ELGFCVHVKH
210 220 230 240 250
PHKIIVMYLQ VLECERNQTL VQTAWNYMND SLRTNVFVRF QPETIACACI
260 270 280 290 300
YLAARALQIP LPTRPHWFLL FGTTEEEIQE ICIETLRLYT RKKPNYELLE
310 320 330 340 350
KEVEKRKVAL QEAKLKAKGL NPDGTPALST LGGFSPASKP SSPREVKAEE
360 370 380 390 400
KSPISINVKT VKKEPEDRQQ ASKSPYNGVR KDSKRSRNSR SASRSRSRTR
410 420 430 440 450
SRSRSHTPRR HYNNRRSRSG TYSSRSRSRS RSHSESPRRH HNHGSPHLKA
460 470 480 490 500
KHTRDDLKSS NRHGHKRKKS RSRSQSKSRD HSDAAKKHRH ERGHHRDRRE
510 520
RSRSFERSHK SKHHGGSRSG HGRHRR
Length:526
Mass (Da):59,634
Last modified:May 1, 2000 - v1
Checksum:i64C0CAEF54A3E9F9
GO
Isoform 2 (identifier: Q9UK58-4) [UniParc]FASTAAdd to basket
Also known as: Cyclin L beta, cyclin L1beta

The sequence of this isoform differs from the canonical sequence as follows:
     226-232: NYMNDSL → VVHDGKS
     233-526: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:232
Mass (Da):25,408
Checksum:iACD35FB41FF67306
GO
Isoform 3 (identifier: Q9UK58-5) [UniParc]FASTAAdd to basket
Also known as: Cyclin L gamma, cyclin L1gamma

The sequence of this isoform differs from the canonical sequence as follows:
     163-172: RTPSPLILDQ → SDQLHLPKPG
     173-526: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:172
Mass (Da):18,322
Checksum:i972B0E52D25720E1
GO
Isoform 4 (identifier: Q9UK58-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     411-428: HYNNRRSRSGTYSSRSRS → QDEVLLRCPGRSRTPGLK
     429-526: Missing.

Note: No experimental confirmation.
Show »
Length:428
Mass (Da):47,789
Checksum:iBBB4FEAE8731FAD0
GO

Sequence cautioni

The sequence AAF64257 differs from that shown. Probable cloning artifact.Curated
The sequence AAQ89026 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149V → L in AAH67812 (PubMed:15489334).Curated1
Sequence conflicti507 – 508RS → SP in AAF64257 (PubMed:11042152).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016120163 – 172RTPSPLILDQ → SDQLHLPKPG in isoform 3. 1 Publication10
Alternative sequenceiVSP_016121173 – 526Missing in isoform 3. 1 PublicationAdd BLAST354
Alternative sequenceiVSP_016122226 – 232NYMNDSL → VVHDGKS in isoform 2. 1 Publication7
Alternative sequenceiVSP_016123233 – 526Missing in isoform 2. 1 PublicationAdd BLAST294
Alternative sequenceiVSP_058299411 – 428HYNNR…SRSRS → QDEVLLRCPGRSRTPGLK in isoform 4. Add BLAST18
Alternative sequenceiVSP_058300429 – 526Missing in isoform 4. Add BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180920 mRNA. Translation: AAD53184.1.
AF367476 mRNA. Translation: AAM21204.1.
AF367477 mRNA. Translation: AAM21205.1.
AY034790 mRNA. Translation: AAK61551.1.
AK022974 mRNA. Translation: BAG51145.1.
AK122738 mRNA. No translation available.
AC104411 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78712.1.
BC007081 mRNA. Translation: AAH07081.1.
BC038394 mRNA. Translation: AAH38394.1.
BC067812 mRNA. Translation: AAH67812.1.
AF208843 mRNA. Translation: AAF64257.1. Sequence problems.
AY358663 mRNA. Translation: AAQ89026.1. Sequence problems.
CCDSiCCDS3178.1. [Q9UK58-1]
CCDS77847.1. [Q9UK58-6]
RefSeqiNP_001295114.1. NM_001308185.1. [Q9UK58-6]
NP_064703.1. NM_020307.3. [Q9UK58-1]
XP_016862381.1. XM_017006892.1.
XP_016862382.1. XM_017006893.1.
XP_016862383.1. XM_017006894.1.
XP_016862384.1. XM_017006895.1.
XP_016862385.1. XM_017006896.1.
UniGeneiHs.4859.

Genome annotation databases

EnsembliENST00000295925; ENSP00000295925; ENSG00000163660. [Q9UK58-5]
ENST00000295926; ENSP00000295926; ENSG00000163660. [Q9UK58-1]
ENST00000461804; ENSP00000420277; ENSG00000163660. [Q9UK58-6]
ENST00000465947; ENSP00000418094; ENSG00000163660. [Q9UK58-5]
ENST00000470121; ENSP00000417237; ENSG00000163660. [Q9UK58-4]
ENST00000475298; ENSP00000417343; ENSG00000163660. [Q9UK58-5]
ENST00000477127; ENSP00000418449; ENSG00000163660. [Q9UK58-5]
ENST00000631619; ENSP00000487951; ENSG00000163660. [Q9UK58-5]
GeneIDi57018.
KEGGihsa:57018.
UCSCiuc003fbd.2. human.
uc003fbf.4. human. [Q9UK58-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180920 mRNA. Translation: AAD53184.1.
AF367476 mRNA. Translation: AAM21204.1.
AF367477 mRNA. Translation: AAM21205.1.
AY034790 mRNA. Translation: AAK61551.1.
AK022974 mRNA. Translation: BAG51145.1.
AK122738 mRNA. No translation available.
AC104411 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78712.1.
BC007081 mRNA. Translation: AAH07081.1.
BC038394 mRNA. Translation: AAH38394.1.
BC067812 mRNA. Translation: AAH67812.1.
AF208843 mRNA. Translation: AAF64257.1. Sequence problems.
AY358663 mRNA. Translation: AAQ89026.1. Sequence problems.
CCDSiCCDS3178.1. [Q9UK58-1]
CCDS77847.1. [Q9UK58-6]
RefSeqiNP_001295114.1. NM_001308185.1. [Q9UK58-6]
NP_064703.1. NM_020307.3. [Q9UK58-1]
XP_016862381.1. XM_017006892.1.
XP_016862382.1. XM_017006893.1.
XP_016862383.1. XM_017006894.1.
XP_016862384.1. XM_017006895.1.
XP_016862385.1. XM_017006896.1.
UniGeneiHs.4859.

3D structure databases

ProteinModelPortaliQ9UK58.
SMRiQ9UK58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121327. 8 interactors.
IntActiQ9UK58. 24 interactors.
MINTiMINT-4541433.
STRINGi9606.ENSP00000295926.

PTM databases

iPTMnetiQ9UK58.
PhosphoSitePlusiQ9UK58.

Polymorphism and mutation databases

BioMutaiCCNL1.
DMDMi74753368.

Proteomic databases

EPDiQ9UK58.
PaxDbiQ9UK58.
PeptideAtlasiQ9UK58.
PRIDEiQ9UK58.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295925; ENSP00000295925; ENSG00000163660. [Q9UK58-5]
ENST00000295926; ENSP00000295926; ENSG00000163660. [Q9UK58-1]
ENST00000461804; ENSP00000420277; ENSG00000163660. [Q9UK58-6]
ENST00000465947; ENSP00000418094; ENSG00000163660. [Q9UK58-5]
ENST00000470121; ENSP00000417237; ENSG00000163660. [Q9UK58-4]
ENST00000475298; ENSP00000417343; ENSG00000163660. [Q9UK58-5]
ENST00000477127; ENSP00000418449; ENSG00000163660. [Q9UK58-5]
ENST00000631619; ENSP00000487951; ENSG00000163660. [Q9UK58-5]
GeneIDi57018.
KEGGihsa:57018.
UCSCiuc003fbd.2. human.
uc003fbf.4. human. [Q9UK58-1]

Organism-specific databases

CTDi57018.
DisGeNETi57018.
GeneCardsiCCNL1.
HGNCiHGNC:20569. CCNL1.
HPAiHPA034752.
HPA057911.
MIMi613384. gene.
neXtProtiNX_Q9UK58.
OpenTargetsiENSG00000163660.
PharmGKBiPA134980948.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0835. Eukaryota.
COG5333. LUCA.
GeneTreeiENSGT00760000119191.
HOVERGENiHBG056044.
InParanoidiQ9UK58.
OMAiQEICLTT.
OrthoDBiEOG091G0BW9.
PhylomeDBiQ9UK58.
TreeFamiTF101011.

Enzyme and pathway databases

SignaLinkiQ9UK58.

Miscellaneous databases

ChiTaRSiCCNL1. human.
GeneWikiiCCNL1.
GenomeRNAii57018.
PROiQ9UK58.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163660.
CleanExiHS_CCNL1.
ExpressionAtlasiQ9UK58. baseline and differential.
GenevisibleiQ9UK58. HS.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR015429. Cyclin_L/T.
IPR015431. Cyclin_L1_chr.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10026:SF64. PTHR10026:SF64. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF036580. Cyclin_L. 1 hit.
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCCNL1_HUMAN
AccessioniPrimary (citable) accession number: Q9UK58
Secondary accession number(s): B3KMY3
, C9JPL0, Q6NVY9, Q6UWS7, Q8NI48, Q96QT0, Q9NZF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

CCNL1 is amplified in several HNSCC. May play a critical role in the formation of loco-regional metastases and an unfavorable clinical outcome of HNSCC.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.