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Protein

Protein Z-dependent protease inhibitor

Gene

SERPINA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei261Essential for interaction with PROZBy similarity1
Sitei314Essential for interaction with PROZBy similarity1
Sitei408 – 409Reactive bondBy similarity2

GO - Molecular functioni

  • heparin binding Source: UniProtKB-KW
  • serine-type endopeptidase inhibitor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Photoprotein, Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Blood coagulation, Hemostasis, Luminescence

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140093-MONOMER.

Protein family/group databases

MEROPSiI04.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Z-dependent protease inhibitor
Short name:
PZ-dependent protease inhibitor
Short name:
PZI
Alternative name(s):
Serpin A10
Gene namesi
Name:SERPINA10
Synonyms:ZPI
ORF Names:UNQ707/PRO1358
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:15996. SERPINA10.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi408Y → A: Loss of inhibitory activity. 1 Publication1

Organism-specific databases

DisGeNETi51156.
MIMi605271. gene+phenotype.
OpenTargetsiENSG00000140093.
ENSG00000278767.
PharmGKBiPA38078.

Polymorphism and mutation databases

BioMutaiSERPINA10.
DMDMi12585541.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000003248222 – 444Protein Z-dependent protease inhibitorAdd BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...)1 Publication1
Modified residuei56Phosphoserine; by FAM20C1 Publication1
Glycosylationi180N-linked (GlcNAc...)1 Publication1
Glycosylationi197N-linked (GlcNAc...)1 Publication1
Glycosylationi295N-linked (GlcNAc...)2 Publications1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9UK55.
PeptideAtlasiQ9UK55.
PRIDEiQ9UK55.

PTM databases

iPTMnetiQ9UK55.
PhosphoSitePlusiQ9UK55.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiENSG00000140093.
CleanExiHS_SERPINA10.
ExpressionAtlasiQ9UK55. baseline and differential.
GenevisibleiQ9UK55. HS.

Organism-specific databases

HPAiHPA048739.

Interactioni

Subunit structurei

Interacts with PROZ.3 Publications

Protein-protein interaction databases

BioGridi119339. 6 interactors.
IntActiQ9UK55. 1 interactor.
STRINGi9606.ENSP00000261994.

Structurei

Secondary structure

1444
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi62 – 93Combined sources32
Beta strandi98 – 100Combined sources3
Helixi102 – 113Combined sources12
Helixi119 – 127Combined sources9
Helixi137 – 139Combined sources3
Helixi140 – 154Combined sources15
Helixi156 – 158Combined sources3
Beta strandi160 – 169Combined sources10
Helixi176 – 186Combined sources11
Beta strandi189 – 193Combined sources5
Beta strandi195 – 197Combined sources3
Helixi198 – 212Combined sources15
Turni213 – 215Combined sources3
Beta strandi216 – 218Combined sources3
Beta strandi228 – 244Combined sources17
Helixi248 – 250Combined sources3
Beta strandi252 – 261Combined sources10
Beta strandi263 – 280Combined sources18
Turni281 – 284Combined sources4
Beta strandi285 – 292Combined sources8
Beta strandi295 – 304Combined sources10
Beta strandi305 – 307Combined sources3
Helixi312 – 314Combined sources3
Helixi318 – 326Combined sources9
Beta strandi329 – 338Combined sources10
Beta strandi340 – 347Combined sources8
Helixi349 – 354Combined sources6
Helixi359 – 361Combined sources3
Turni368 – 370Combined sources3
Beta strandi371 – 373Combined sources3
Beta strandi378 – 390Combined sources13
Beta strandi392 – 406Combined sources15
Beta strandi413 – 415Combined sources3
Beta strandi420 – 426Combined sources7
Turni427 – 430Combined sources4
Beta strandi431 – 439Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F1SX-ray2.30A60-444[»]
3H5CX-ray3.26A22-444[»]
4AFXX-ray2.09A23-408[»]
B409-444[»]
4AJUX-ray2.65A23-408[»]
B409-444[»]
ProteinModelPortaliQ9UK55.
SMRiQ9UK55.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UK55.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni136 – 153Heparin-bindingAdd BLAST18

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG101138.
InParanoidiQ9UK55.
KOiK04525.
PhylomeDBiQ9UK55.
TreeFamiTF343094.

Family and domain databases

CDDicd02055. PZI. 1 hit.
InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
IPR033835. SERPINA10.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 2 hits.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UK55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVVPSLLLS VLLAQVWLVP GLAPSPQSPE TPAPQNQTSR VVQAPKEEEE
60 70 80 90 100
DEQEASEEKA SEEEKAWLMA SRQQLAKETS NFGFSLLRKI SMRHDGNMVF
110 120 130 140 150
SPFGMSLAMT GLMLGATGPT ETQIKRGLHL QALKPTKPGL LPSLFKGLRE
160 170 180 190 200
TLSRNLELGL TQGSFAFIHK DFDVKETFFN LSKRYFDTEC VPMNFRNASQ
210 220 230 240 250
AKRLMNHYIN KETRGKIPKL FDEINPETKL ILVDYILFKG KWLTPFDPVF
260 270 280 290 300
TEVDTFHLDK YKTIKVPMMY GAGKFASTFD KNFRCHVLKL PYQGNATMLV
310 320 330 340 350
VLMEKMGDHL ALEDYLTTDL VETWLRNMKT RNMEVFFPKF KLDQKYEMHE
360 370 380 390 400
LLRQMGIRRI FSPFADLSEL SATGRNLQVS RVLQRTVIEV DERGTEAVAG
410 420 430 440
ILSEITAYSM PPVIKVDRPF HFMIYEETSG MLLFLGRVVN PTLL
Length:444
Mass (Da):50,707
Last modified:May 1, 2000 - v1
Checksum:i06BD47C97BBDD700
GO

Sequence cautioni

The sequence CAD62339 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02032546K → R.2 PublicationsCorresponds to variant rs941590dbSNPEnsembl.1
Natural variantiVAR_02032661S → G.2 PublicationsCorresponds to variant rs941591dbSNPEnsembl.1
Natural variantiVAR_038833139G → R.1 PublicationCorresponds to variant rs56137907dbSNPEnsembl.1
Natural variantiVAR_051940158L → Q.Corresponds to variant rs2232699dbSNPEnsembl.1
Natural variantiVAR_020327161T → S.2 PublicationsCorresponds to variant rs2232700dbSNPEnsembl.1
Natural variantiVAR_051941196R → H.Corresponds to variant rs2232701dbSNPEnsembl.1
Natural variantiVAR_038834271G → S.1 PublicationCorresponds to variant rs2232708dbSNPEnsembl.1
Natural variantiVAR_038835384Q → P.1 Publication1
Natural variantiVAR_051942384Q → R.1 PublicationCorresponds to variant rs2232710dbSNPEnsembl.1
Natural variantiVAR_070192420F → L.1 PublicationCorresponds to variant rs546304706dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181467 mRNA. Translation: AAD53962.1.
AY358597 mRNA. Translation: AAQ88960.1.
BX248011 mRNA. Translation: CAD62339.1. Different initiation.
EF621762 Genomic DNA. Translation: ABR09269.1.
BC022261 mRNA. Translation: AAH22261.1.
CCDSiCCDS9923.1.
RefSeqiNP_001094077.1. NM_001100607.2.
NP_057270.1. NM_016186.2.
XP_005267790.1. XM_005267733.4.
UniGeneiHs.118620.

Genome annotation databases

EnsembliENST00000261994; ENSP00000261994; ENSG00000140093.
ENST00000393096; ENSP00000376809; ENSG00000140093.
ENST00000554173; ENSP00000450971; ENSG00000140093.
ENST00000614630; ENSP00000484632; ENSG00000278767.
GeneIDi51156.
KEGGihsa:51156.
UCSCiuc001ycu.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181467 mRNA. Translation: AAD53962.1.
AY358597 mRNA. Translation: AAQ88960.1.
BX248011 mRNA. Translation: CAD62339.1. Different initiation.
EF621762 Genomic DNA. Translation: ABR09269.1.
BC022261 mRNA. Translation: AAH22261.1.
CCDSiCCDS9923.1.
RefSeqiNP_001094077.1. NM_001100607.2.
NP_057270.1. NM_016186.2.
XP_005267790.1. XM_005267733.4.
UniGeneiHs.118620.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F1SX-ray2.30A60-444[»]
3H5CX-ray3.26A22-444[»]
4AFXX-ray2.09A23-408[»]
B409-444[»]
4AJUX-ray2.65A23-408[»]
B409-444[»]
ProteinModelPortaliQ9UK55.
SMRiQ9UK55.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119339. 6 interactors.
IntActiQ9UK55. 1 interactor.
STRINGi9606.ENSP00000261994.

Protein family/group databases

MEROPSiI04.005.

PTM databases

iPTMnetiQ9UK55.
PhosphoSitePlusiQ9UK55.

Polymorphism and mutation databases

BioMutaiSERPINA10.
DMDMi12585541.

Proteomic databases

PaxDbiQ9UK55.
PeptideAtlasiQ9UK55.
PRIDEiQ9UK55.

Protocols and materials databases

DNASUi51156.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261994; ENSP00000261994; ENSG00000140093.
ENST00000393096; ENSP00000376809; ENSG00000140093.
ENST00000554173; ENSP00000450971; ENSG00000140093.
ENST00000614630; ENSP00000484632; ENSG00000278767.
GeneIDi51156.
KEGGihsa:51156.
UCSCiuc001ycu.6. human.

Organism-specific databases

CTDi51156.
DisGeNETi51156.
GeneCardsiSERPINA10.
HGNCiHGNC:15996. SERPINA10.
HPAiHPA048739.
MIMi602455. gene.
605271. gene+phenotype.
neXtProtiNX_Q9UK55.
OpenTargetsiENSG00000140093.
ENSG00000278767.
PharmGKBiPA38078.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG101138.
InParanoidiQ9UK55.
KOiK04525.
PhylomeDBiQ9UK55.
TreeFamiTF343094.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140093-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9UK55.
GenomeRNAii51156.
PROiQ9UK55.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140093.
CleanExiHS_SERPINA10.
ExpressionAtlasiQ9UK55. baseline and differential.
GenevisibleiQ9UK55. HS.

Family and domain databases

CDDicd02055. PZI. 1 hit.
InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
IPR033835. SERPINA10.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 2 hits.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiZPI_HUMAN
AccessioniPrimary (citable) accession number: Q9UK55
Secondary accession number(s): A5Z2A5, Q6UWX9, Q86U20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Heparin acts as an important cofactor, producing 20 to 100-fold accelerations of SERPINA10 reactions with factor Xa and factor XIa.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.