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Protein

Inhibitor of growth protein 1

Gene

ING1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei355Histone H3K4me3Combined sources1 Publication1
Metal bindingi356Zinc 1Combined sources1 Publication1
Metal bindingi358Zinc 1Combined sources1 Publication1
Binding sitei366Histone H3K4me3Combined sources1 Publication1
Metal bindingi369Zinc 2Combined sources1 Publication1
Binding sitei370Histone H3K4me3Combined sources1 Publication1
Metal bindingi374Zinc 2Combined sources1 Publication1
Binding sitei378Histone H3K4me3Combined sources1 Publication1
Metal bindingi380Zinc 1; via pros nitrogenCombined sources1 Publication1
Metal bindingi383Zinc 1Combined sources1 Publication1
Metal bindingi396Zinc 2Combined sources1 Publication1
Metal bindingi399Zinc 2Combined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri353 – 402PHD-typePROSITE-ProRule annotationAdd BLAST50

GO - Molecular functioni

  • methylated histone binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • chromatin organization Source: InterPro
  • negative regulation of cell growth Source: UniProtKB
  • negative regulation of cell proliferation Source: ProtInc
  • regulation of cell death Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of growth protein 1
Gene namesi
Name:ING1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:6062. ING1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Squamous cell carcinoma of the head and neck (HNSCC)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.
See also OMIM:275355
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017420335A → D in HNSCC. 1 Publication1
Natural variantiVAR_017421358C → S in HNSCC. 1 Publication1
Natural variantiVAR_017422359N → S in HNSCC. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi378W → A: Unable to stimulate DNA repair after UV irradiation or promote DNA-damage-induced apoptosis. 1 Publication1

Keywords - Diseasei

Disease mutation, Tumor suppressor

Organism-specific databases

DisGeNETi3621.
MalaCardsiING1.
MIMi275355. phenotype.
OpenTargetsiENSG00000153487.
Orphaneti67037. Squamous cell carcinoma of head and neck.
PharmGKBiPA29872.

Polymorphism and mutation databases

BioMutaiING1.
DMDMi212276438.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126611 – 422Inhibitor of growth protein 1Add BLAST422

Proteomic databases

EPDiQ9UK53.
PaxDbiQ9UK53.
PeptideAtlasiQ9UK53.
PRIDEiQ9UK53.

PTM databases

iPTMnetiQ9UK53.
PhosphoSitePlusiQ9UK53.

Expressioni

Tissue specificityi

Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.1 Publication

Gene expression databases

BgeeiENSG00000153487.
ExpressionAtlasiQ9UK53. baseline and differential.
GenevisibleiQ9UK53. HS.

Organism-specific databases

HPAiCAB016136.
CAB017773.
HPA052591.

Interactioni

Subunit structurei

Interacts with H3K4me3 and to a lesser extent with H3K4me2. Interacts with TP53. Isoform 2 interacts with RSL1D1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NQO1P155593EBI-399198,EBI-3989435

GO - Molecular functioni

  • methylated histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109833. 55 interactors.
DIPiDIP-24256N.
DIP-24257N.
DIP-24258N.
IntActiQ9UK53. 18 interactors.
STRINGi9606.ENSP00000364929.

Structurei

Secondary structure

1422
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni356 – 359Combined sources4
Beta strandi364 – 368Combined sources5
Beta strandi378 – 380Combined sources3
Helixi382 – 384Combined sources3
Helixi397 – 400Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QICX-ray2.10A345-404[»]
ProteinModelPortaliQ9UK53.
SMRiQ9UK53.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UK53.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni405 – 422PBRBy similarityAdd BLAST18

Domaini

The PHD-type zinc finger mediates the binding to H3K4me3.1 Publication
The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns5P).By similarity

Sequence similaritiesi

Belongs to the ING family.Curated
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri353 – 402PHD-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1973. Eukaryota.
COG5034. LUCA.
GeneTreeiENSGT00550000074538.
HOGENOMiHOG000239724.
HOVERGENiHBG006607.
InParanoidiQ9UK53.
KOiK19197.
OMAiIDAKCVH.
PhylomeDBiQ9UK53.
TreeFamiTF352014.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR028643. ING1.
IPR028651. ING_fam.
IPR024610. ING_N_histone_binding.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10333. PTHR10333. 1 hit.
PTHR10333:SF38. PTHR10333:SF38. 1 hit.
PfamiPF12998. ING. 1 hit.
[Graphical view]
SMARTiSM01408. ING. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UK53-1) [UniParc]FASTAAdd to basket
Also known as: p47ING1a, ING1-ALT2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFVECPYHS PAERLVAEAD EGGPSAITGM GLCFRCLLFS FSGRSGVEGG
60 70 80 90 100
RVDLNVFGSL GLQPWIGSSR CWGGPCSSAL RCGWFSSWPP PSKSAIPIGG
110 120 130 140 150
GSRGAGRVSR WPPPHWLEAW RVSPLPLSPL SPATFGRGFI AVAVIPGLWA
160 170 180 190 200
RGRGCSSDRL PRPAGPARRQ FQAASLLTRG WGRAWPWKQI LKELDECYER
210 220 230 240 250
FSRETDGAQK RRMLHCVQRA LIRSQELGDE KIQIVSQMVE LVENRTRQVD
260 270 280 290 300
SHVELFEAQQ ELGDTAGNSG KAGADRPKGE AAAQADKPNS KRSRRQRNNE
310 320 330 340 350
NRENASSNHD HDDGASGTPK EKKAKTSKKK KRSKAKAERE ASPADLPIDP
360 370 380 390 400
NEPTYCLCNQ VSYGEMIGCD NDECPIEWFH FSCVGLNHKP KGKWYCPKCR
410 420
GENEKTMDKA LEKSKKERAY NR
Length:422
Mass (Da):46,738
Last modified:November 4, 2008 - v2
Checksum:i03D6AEEAA6E39090
GO
Isoform 2 (identifier: Q9UK53-2) [UniParc]FASTAAdd to basket
Also known as: p33ING1b, Variant A

The sequence of this isoform differs from the canonical sequence as follows:
     1-189: MSFVECPYHS...GWGRAWPWKQ → MLSPANGEQL...MREIDAKYQE

Show »
Length:279
Mass (Da):31,864
Checksum:i6DA3F3F892B35810
GO
Isoform 3 (identifier: Q9UK53-3) [UniParc]FASTAAdd to basket
Also known as: p24ING1c, ING1-ALT1, Variant B

The sequence of this isoform differs from the canonical sequence as follows:
     1-212: Missing.

Show »
Length:210
Mass (Da):23,671
Checksum:i98961A2886E319FC
GO
Isoform 4 (identifier: Q9UK53-4) [UniParc]FASTAAdd to basket
Also known as: Variant C

The sequence of this isoform differs from the canonical sequence as follows:
     1-189: MSFVECPYHS...GWGRAWPWKQ → ME

Show »
Length:235
Mass (Da):26,757
Checksum:i0422C638B9AB741C
GO
Isoform 5 (identifier: Q9UK53-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-189: MSFVECPYHS...GWGRAWPWKQ → MSFVECPYHSPAERLVAEADEGGPSAITE

Show »
Length:262
Mass (Da):29,572
Checksum:i7C1A910F8B850C59
GO

Sequence cautioni

The sequence AAB60879 differs from that shown. Reason: Frameshift at position 149.Curated
The sequence AAG02579 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti266A → V in AAC00501 (PubMed:8944021).Curated1
Sequence conflicti266A → V in AAB60879 (PubMed:8944021).Curated1
Sequence conflicti266A → V (PubMed:10626813).Curated1
Sequence conflicti266A → V (PubMed:10807544).Curated1
Sequence conflicti272A → V in AAC00501 (PubMed:8944021).Curated1
Sequence conflicti272A → V in AAB60879 (PubMed:8944021).Curated1
Sequence conflicti272A → V (PubMed:10626813).Curated1
Sequence conflicti272A → V (PubMed:10807544).Curated1
Sequence conflicti278K → N in AAC00501 (PubMed:8944021).Curated1
Sequence conflicti278K → N in AAB60879 (PubMed:8944021).Curated1
Sequence conflicti278K → N (PubMed:10626813).Curated1
Sequence conflicti278K → N (PubMed:10807544).Curated1
Sequence conflicti280E → D in AAC00501 (PubMed:8944021).Curated1
Sequence conflicti280E → D in AAB60879 (PubMed:8944021).Curated1
Sequence conflicti280E → D (PubMed:10626813).Curated1
Sequence conflicti280E → D (PubMed:10807544).Curated1
Sequence conflicti282A → V in AAC00501 (PubMed:8944021).Curated1
Sequence conflicti282A → V in AAB60879 (PubMed:8944021).Curated1
Sequence conflicti282A → V (PubMed:10626813).Curated1
Sequence conflicti282A → V (PubMed:10807544).Curated1
Sequence conflicti285A → S in AAC00501 (PubMed:8944021).Curated1
Sequence conflicti285A → S in AAB60879 (PubMed:8944021).Curated1
Sequence conflicti285A → S (PubMed:10626813).Curated1
Sequence conflicti285A → S (PubMed:10807544).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047097125L → R.3 PublicationsCorresponds to variant rs7338333dbSNPEnsembl.1
Natural variantiVAR_017420335A → D in HNSCC. 1 Publication1
Natural variantiVAR_017421358C → S in HNSCC. 1 Publication1
Natural variantiVAR_017422359N → S in HNSCC. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0091291 – 212Missing in isoform 3. 2 PublicationsAdd BLAST212
Alternative sequenceiVSP_0091261 – 189MSFVE…WPWKQ → MLSPANGEQLHLVNYVEDYL DSIESLPFDLQRNVSLMREI DAKYQE in isoform 2. 5 PublicationsAdd BLAST189
Alternative sequenceiVSP_0091271 – 189MSFVE…WPWKQ → ME in isoform 4. 2 PublicationsAdd BLAST189
Alternative sequenceiVSP_0091281 – 189MSFVE…WPWKQ → MSFVECPYHSPAERLVAEAD EGGPSAITE in isoform 5. CuratedAdd BLAST189

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181849 mRNA. Translation: AAF07920.1.
AF181850 mRNA. Translation: AAF07921.1.
AF001954 mRNA. Translation: AAB60879.1. Frameshift.
AF044076 mRNA. Translation: AAC00501.1.
AF149721 mRNA. Translation: AAF37421.1.
AF149722 mRNA. Translation: AAF37422.1.
AF149723 mRNA. Translation: AAF37423.1.
AF167551, AF167550 Genomic DNA. Translation: AAG02578.1.
AF167551, AF167549 Genomic DNA. Translation: AAG02579.1. Sequence problems.
AB037387 Genomic DNA. Translation: BAB08101.1.
AB037387 Genomic DNA. Translation: BAB08102.1.
AB037387 Genomic DNA. Translation: BAB08103.1.
AB037594 mRNA. Translation: BAB20992.2.
AB031269 mRNA. Translation: BAA83496.1.
AB024401 mRNA. Translation: BAA82886.1.
AB024402 mRNA. Translation: BAA82887.1.
AB024403 Genomic DNA. Translation: BAA82888.1.
AB024404 Genomic DNA. Translation: BAA82889.1.
AB024404 Genomic DNA. Translation: BAA83462.1.
AB024405 Genomic DNA. Translation: BAA82890.1.
AJ310392 mRNA. Translation: CAC38067.1.
AF078835 mRNA. Translation: AAG12174.1.
AF078837, AF078836 Genomic DNA. Translation: AAG12175.1.
AK302353 mRNA. Translation: BAG63679.1.
AL157820 Genomic DNA. Translation: CAI16972.1.
AL157820 Genomic DNA. Translation: CAI16973.1.
AL157820 Genomic DNA. Translation: CAI16974.1.
AL157820 Genomic DNA. Translation: CAI16975.1.
CH471085 Genomic DNA. Translation: EAX09127.1.
CH471085 Genomic DNA. Translation: EAX09130.1.
BC093942 mRNA. Translation: AAH93942.1.
BC093944 mRNA. Translation: AAH93944.1.
CCDSiCCDS9515.1. [Q9UK53-4]
CCDS9516.1. [Q9UK53-2]
CCDS9517.1. [Q9UK53-1]
CCDS9518.1. [Q9UK53-3]
RefSeqiNP_001254657.1. NM_001267728.1. [Q9UK53-5]
NP_005528.4. NM_005537.5.
NP_937860.1. NM_198217.2. [Q9UK53-4]
NP_937861.1. NM_198218.2. [Q9UK53-3]
NP_937862.1. NM_198219.2. [Q9UK53-2]
UniGeneiHs.46700.
Hs.508725.

Genome annotation databases

EnsembliENST00000333219; ENSP00000328436; ENSG00000153487. [Q9UK53-2]
ENST00000338450; ENSP00000345202; ENSG00000153487. [Q9UK53-4]
ENST00000375775; ENSP00000364930; ENSG00000153487. [Q9UK53-3]
GeneIDi3621.
KEGGihsa:3621.
UCSCiuc001vrf.5. human. [Q9UK53-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181849 mRNA. Translation: AAF07920.1.
AF181850 mRNA. Translation: AAF07921.1.
AF001954 mRNA. Translation: AAB60879.1. Frameshift.
AF044076 mRNA. Translation: AAC00501.1.
AF149721 mRNA. Translation: AAF37421.1.
AF149722 mRNA. Translation: AAF37422.1.
AF149723 mRNA. Translation: AAF37423.1.
AF167551, AF167550 Genomic DNA. Translation: AAG02578.1.
AF167551, AF167549 Genomic DNA. Translation: AAG02579.1. Sequence problems.
AB037387 Genomic DNA. Translation: BAB08101.1.
AB037387 Genomic DNA. Translation: BAB08102.1.
AB037387 Genomic DNA. Translation: BAB08103.1.
AB037594 mRNA. Translation: BAB20992.2.
AB031269 mRNA. Translation: BAA83496.1.
AB024401 mRNA. Translation: BAA82886.1.
AB024402 mRNA. Translation: BAA82887.1.
AB024403 Genomic DNA. Translation: BAA82888.1.
AB024404 Genomic DNA. Translation: BAA82889.1.
AB024404 Genomic DNA. Translation: BAA83462.1.
AB024405 Genomic DNA. Translation: BAA82890.1.
AJ310392 mRNA. Translation: CAC38067.1.
AF078835 mRNA. Translation: AAG12174.1.
AF078837, AF078836 Genomic DNA. Translation: AAG12175.1.
AK302353 mRNA. Translation: BAG63679.1.
AL157820 Genomic DNA. Translation: CAI16972.1.
AL157820 Genomic DNA. Translation: CAI16973.1.
AL157820 Genomic DNA. Translation: CAI16974.1.
AL157820 Genomic DNA. Translation: CAI16975.1.
CH471085 Genomic DNA. Translation: EAX09127.1.
CH471085 Genomic DNA. Translation: EAX09130.1.
BC093942 mRNA. Translation: AAH93942.1.
BC093944 mRNA. Translation: AAH93944.1.
CCDSiCCDS9515.1. [Q9UK53-4]
CCDS9516.1. [Q9UK53-2]
CCDS9517.1. [Q9UK53-1]
CCDS9518.1. [Q9UK53-3]
RefSeqiNP_001254657.1. NM_001267728.1. [Q9UK53-5]
NP_005528.4. NM_005537.5.
NP_937860.1. NM_198217.2. [Q9UK53-4]
NP_937861.1. NM_198218.2. [Q9UK53-3]
NP_937862.1. NM_198219.2. [Q9UK53-2]
UniGeneiHs.46700.
Hs.508725.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QICX-ray2.10A345-404[»]
ProteinModelPortaliQ9UK53.
SMRiQ9UK53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109833. 55 interactors.
DIPiDIP-24256N.
DIP-24257N.
DIP-24258N.
IntActiQ9UK53. 18 interactors.
STRINGi9606.ENSP00000364929.

PTM databases

iPTMnetiQ9UK53.
PhosphoSitePlusiQ9UK53.

Polymorphism and mutation databases

BioMutaiING1.
DMDMi212276438.

Proteomic databases

EPDiQ9UK53.
PaxDbiQ9UK53.
PeptideAtlasiQ9UK53.
PRIDEiQ9UK53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333219; ENSP00000328436; ENSG00000153487. [Q9UK53-2]
ENST00000338450; ENSP00000345202; ENSG00000153487. [Q9UK53-4]
ENST00000375775; ENSP00000364930; ENSG00000153487. [Q9UK53-3]
GeneIDi3621.
KEGGihsa:3621.
UCSCiuc001vrf.5. human. [Q9UK53-1]

Organism-specific databases

CTDi3621.
DisGeNETi3621.
GeneCardsiING1.
H-InvDBHIX0056146.
HGNCiHGNC:6062. ING1.
HPAiCAB016136.
CAB017773.
HPA052591.
MalaCardsiING1.
MIMi275355. phenotype.
601566. gene.
neXtProtiNX_Q9UK53.
OpenTargetsiENSG00000153487.
Orphaneti67037. Squamous cell carcinoma of head and neck.
PharmGKBiPA29872.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1973. Eukaryota.
COG5034. LUCA.
GeneTreeiENSGT00550000074538.
HOGENOMiHOG000239724.
HOVERGENiHBG006607.
InParanoidiQ9UK53.
KOiK19197.
OMAiIDAKCVH.
PhylomeDBiQ9UK53.
TreeFamiTF352014.

Miscellaneous databases

ChiTaRSiING1. human.
EvolutionaryTraceiQ9UK53.
GeneWikiiING1.
GenomeRNAii3621.
PROiQ9UK53.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153487.
ExpressionAtlasiQ9UK53. baseline and differential.
GenevisibleiQ9UK53. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR028643. ING1.
IPR028651. ING_fam.
IPR024610. ING_N_histone_binding.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10333. PTHR10333. 1 hit.
PTHR10333:SF38. PTHR10333:SF38. 1 hit.
PfamiPF12998. ING. 1 hit.
[Graphical view]
SMARTiSM01408. ING. 1 hit.
SM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiING1_HUMAN
AccessioniPrimary (citable) accession number: Q9UK53
Secondary accession number(s): O00532
, O43658, Q53ZR3, Q5T9G8, Q5T9G9, Q5T9H0, Q5T9H1, Q9H007, Q9HD98, Q9HD99, Q9NS83, Q9P0U6, Q9UBC6, Q9UIJ1, Q9UIJ2, Q9UIJ3, Q9UIJ4, Q9UK52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 4, 2008
Last modified: November 30, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.