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Q9UK53

- ING1_HUMAN

UniProt

Q9UK53 - ING1_HUMAN

Protein

Inhibitor of growth protein 1

Gene

ING1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (04 Nov 2008)
      Previous versions | rss
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    Functioni

    Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei355 – 3551Histone H3K4me3
    Binding sitei366 – 3661Histone H3K4me3
    Binding sitei370 – 3701Histone H3K4me3
    Binding sitei378 – 3781Histone H3K4me3

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri353 – 40250PHD-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. methylated histone binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. chromatin modification Source: InterPro
    3. negative regulation of cell growth Source: UniProtKB
    4. negative regulation of cell proliferation Source: ProtInc
    5. positive regulation of transcription, DNA-templated Source: Ensembl
    6. protein import into nucleus Source: Ensembl
    7. regulation of cell death Source: Ensembl

    Keywords - Biological processi

    Cell cycle

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inhibitor of growth protein 1
    Gene namesi
    Name:ING1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:6062. ING1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti335 – 3351A → D in HNSCC. 1 Publication
    VAR_017420
    Natural varianti358 – 3581C → S in HNSCC. 1 Publication
    VAR_017421
    Natural varianti359 – 3591N → S in HNSCC. 1 Publication
    VAR_017422

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi378 – 3781W → A: Unable to stimulate DNA repair after UV irradiation or promote DNA-damage-induced apoptosis. 1 Publication

    Keywords - Diseasei

    Disease mutation, Tumor suppressor

    Organism-specific databases

    MIMi275355. phenotype.
    Orphaneti67037. Squamous cell carcinoma of head and neck.
    PharmGKBiPA29872.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 422422Inhibitor of growth protein 1PRO_0000212661Add
    BLAST

    Proteomic databases

    MaxQBiQ9UK53.
    PaxDbiQ9UK53.
    PRIDEiQ9UK53.

    PTM databases

    PhosphoSiteiQ9UK53.

    Expressioni

    Tissue specificityi

    Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.1 Publication

    Gene expression databases

    BgeeiQ9UK53.
    GenevestigatoriQ9UK53.

    Organism-specific databases

    HPAiCAB016136.
    CAB017773.
    HPA052591.

    Interactioni

    Subunit structurei

    Interacts with H3K4me3 and to a lesser extent with H3K4me2. Interacts with TP53.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NQO1P155593EBI-399198,EBI-3989435

    Protein-protein interaction databases

    BioGridi109833. 51 interactions.
    DIPiDIP-24256N.
    DIP-24257N.
    DIP-24258N.
    IntActiQ9UK53. 13 interactions.

    Structurei

    Secondary structure

    1
    422
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni356 – 3594
    Beta strandi364 – 3685
    Beta strandi378 – 3803
    Helixi382 – 3843
    Helixi397 – 4004

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2QICX-ray2.10A345-404[»]
    ProteinModelPortaliQ9UK53.
    SMRiQ9UK53. Positions 352-402.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9UK53.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni405 – 42218PBRBy similarityAdd
    BLAST

    Domaini

    The PHD-type zinc finger mediates the binding to H3K4me3.1 Publication
    The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns5P).By similarity

    Sequence similaritiesi

    Belongs to the ING family.Curated
    Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri353 – 40250PHD-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5034.
    HOVERGENiHBG006607.
    InParanoidiQ9UK53.
    OMAiFETCQET.
    OrthoDBiEOG7RBZ9T.
    PhylomeDBiQ9UK53.
    TreeFamiTF352014.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR028643. ING1.
    IPR028651. ING_fam.
    IPR024610. ING_N.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PANTHERiPTHR10333. PTHR10333. 1 hit.
    PTHR10333:SF38. PTHR10333:SF38. 1 hit.
    PfamiPF12998. ING. 1 hit.
    PF00628. PHD. 1 hit.
    [Graphical view]
    SMARTiSM00249. PHD. 1 hit.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 1 hit.
    PROSITEiPS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UK53-1) [UniParc]FASTAAdd to Basket

    Also known as: p47ING1a, ING1-ALT2

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSFVECPYHS PAERLVAEAD EGGPSAITGM GLCFRCLLFS FSGRSGVEGG    50
    RVDLNVFGSL GLQPWIGSSR CWGGPCSSAL RCGWFSSWPP PSKSAIPIGG 100
    GSRGAGRVSR WPPPHWLEAW RVSPLPLSPL SPATFGRGFI AVAVIPGLWA 150
    RGRGCSSDRL PRPAGPARRQ FQAASLLTRG WGRAWPWKQI LKELDECYER 200
    FSRETDGAQK RRMLHCVQRA LIRSQELGDE KIQIVSQMVE LVENRTRQVD 250
    SHVELFEAQQ ELGDTAGNSG KAGADRPKGE AAAQADKPNS KRSRRQRNNE 300
    NRENASSNHD HDDGASGTPK EKKAKTSKKK KRSKAKAERE ASPADLPIDP 350
    NEPTYCLCNQ VSYGEMIGCD NDECPIEWFH FSCVGLNHKP KGKWYCPKCR 400
    GENEKTMDKA LEKSKKERAY NR 422
    Length:422
    Mass (Da):46,738
    Last modified:November 4, 2008 - v2
    Checksum:i03D6AEEAA6E39090
    GO
    Isoform 2 (identifier: Q9UK53-2) [UniParc]FASTAAdd to Basket

    Also known as: p33ING1b, Variant A

    The sequence of this isoform differs from the canonical sequence as follows:
         1-189: MSFVECPYHS...GWGRAWPWKQ → MLSPANGEQL...MREIDAKYQE

    Show »
    Length:279
    Mass (Da):31,864
    Checksum:i6DA3F3F892B35810
    GO
    Isoform 3 (identifier: Q9UK53-3) [UniParc]FASTAAdd to Basket

    Also known as: p24ING1c, ING1-ALT1, Variant B

    The sequence of this isoform differs from the canonical sequence as follows:
         1-212: Missing.

    Show »
    Length:210
    Mass (Da):23,671
    Checksum:i98961A2886E319FC
    GO
    Isoform 4 (identifier: Q9UK53-4) [UniParc]FASTAAdd to Basket

    Also known as: Variant C

    The sequence of this isoform differs from the canonical sequence as follows:
         1-189: MSFVECPYHS...GWGRAWPWKQ → ME

    Show »
    Length:235
    Mass (Da):26,757
    Checksum:i0422C638B9AB741C
    GO
    Isoform 5 (identifier: Q9UK53-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-189: MSFVECPYHS...GWGRAWPWKQ → MSFVECPYHSPAERLVAEADEGGPSAITE

    Show »
    Length:262
    Mass (Da):29,572
    Checksum:i7C1A910F8B850C59
    GO

    Sequence cautioni

    The sequence AAB60879.1 differs from that shown. Reason: Frameshift at position 149.
    The sequence AAG02579.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti266 – 2661A → V in AAC00501. (PubMed:8944021)Curated
    Sequence conflicti266 – 2661A → V in AAB60879. (PubMed:8944021)Curated
    Sequence conflicti266 – 2661A → V(PubMed:10626813)Curated
    Sequence conflicti266 – 2661A → V(PubMed:10807544)Curated
    Sequence conflicti272 – 2721A → V in AAC00501. (PubMed:8944021)Curated
    Sequence conflicti272 – 2721A → V in AAB60879. (PubMed:8944021)Curated
    Sequence conflicti272 – 2721A → V(PubMed:10626813)Curated
    Sequence conflicti272 – 2721A → V(PubMed:10807544)Curated
    Sequence conflicti278 – 2781K → N in AAC00501. (PubMed:8944021)Curated
    Sequence conflicti278 – 2781K → N in AAB60879. (PubMed:8944021)Curated
    Sequence conflicti278 – 2781K → N(PubMed:10626813)Curated
    Sequence conflicti278 – 2781K → N(PubMed:10807544)Curated
    Sequence conflicti280 – 2801E → D in AAC00501. (PubMed:8944021)Curated
    Sequence conflicti280 – 2801E → D in AAB60879. (PubMed:8944021)Curated
    Sequence conflicti280 – 2801E → D(PubMed:10626813)Curated
    Sequence conflicti280 – 2801E → D(PubMed:10807544)Curated
    Sequence conflicti282 – 2821A → V in AAC00501. (PubMed:8944021)Curated
    Sequence conflicti282 – 2821A → V in AAB60879. (PubMed:8944021)Curated
    Sequence conflicti282 – 2821A → V(PubMed:10626813)Curated
    Sequence conflicti282 – 2821A → V(PubMed:10807544)Curated
    Sequence conflicti285 – 2851A → S in AAC00501. (PubMed:8944021)Curated
    Sequence conflicti285 – 2851A → S in AAB60879. (PubMed:8944021)Curated
    Sequence conflicti285 – 2851A → S(PubMed:10626813)Curated
    Sequence conflicti285 – 2851A → S(PubMed:10807544)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti125 – 1251L → R.3 Publications
    Corresponds to variant rs7338333 [ dbSNP | Ensembl ].
    VAR_047097
    Natural varianti335 – 3351A → D in HNSCC. 1 Publication
    VAR_017420
    Natural varianti358 – 3581C → S in HNSCC. 1 Publication
    VAR_017421
    Natural varianti359 – 3591N → S in HNSCC. 1 Publication
    VAR_017422

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 212212Missing in isoform 3. 2 PublicationsVSP_009129Add
    BLAST
    Alternative sequencei1 – 189189MSFVE…WPWKQ → MLSPANGEQLHLVNYVEDYL DSIESLPFDLQRNVSLMREI DAKYQE in isoform 2. 5 PublicationsVSP_009126Add
    BLAST
    Alternative sequencei1 – 189189MSFVE…WPWKQ → ME in isoform 4. 2 PublicationsVSP_009127Add
    BLAST
    Alternative sequencei1 – 189189MSFVE…WPWKQ → MSFVECPYHSPAERLVAEAD EGGPSAITE in isoform 5. CuratedVSP_009128Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF181849 mRNA. Translation: AAF07920.1.
    AF181850 mRNA. Translation: AAF07921.1.
    AF001954 mRNA. Translation: AAB60879.1. Frameshift.
    AF044076 mRNA. Translation: AAC00501.1.
    AF149721 mRNA. Translation: AAF37421.1.
    AF149722 mRNA. Translation: AAF37422.1.
    AF149723 mRNA. Translation: AAF37423.1.
    AF167551, AF167550 Genomic DNA. Translation: AAG02578.1.
    AF167551, AF167549 Genomic DNA. Translation: AAG02579.1. Sequence problems.
    AB037387 Genomic DNA. Translation: BAB08101.1.
    AB037387 Genomic DNA. Translation: BAB08102.1.
    AB037387 Genomic DNA. Translation: BAB08103.1.
    AB037594 mRNA. Translation: BAB20992.2.
    AB031269 mRNA. Translation: BAA83496.1.
    AB024401 mRNA. Translation: BAA82886.1.
    AB024402 mRNA. Translation: BAA82887.1.
    AB024403 Genomic DNA. Translation: BAA82888.1.
    AB024404 Genomic DNA. Translation: BAA82889.1.
    AB024404 Genomic DNA. Translation: BAA83462.1.
    AB024405 Genomic DNA. Translation: BAA82890.1.
    AJ310392 mRNA. Translation: CAC38067.1.
    AF078835 mRNA. Translation: AAG12174.1.
    AF078837, AF078836 Genomic DNA. Translation: AAG12175.1.
    AK302353 mRNA. Translation: BAG63679.1.
    AL157820 Genomic DNA. Translation: CAI16972.1.
    AL157820 Genomic DNA. Translation: CAI16973.1.
    AL157820 Genomic DNA. Translation: CAI16974.1.
    AL157820 Genomic DNA. Translation: CAI16975.1.
    CH471085 Genomic DNA. Translation: EAX09127.1.
    CH471085 Genomic DNA. Translation: EAX09130.1.
    BC093942 mRNA. Translation: AAH93942.1.
    BC093944 mRNA. Translation: AAH93944.1.
    CCDSiCCDS9515.1. [Q9UK53-4]
    CCDS9516.1. [Q9UK53-2]
    CCDS9517.1. [Q9UK53-1]
    CCDS9518.1. [Q9UK53-3]
    RefSeqiNP_001254657.1. NM_001267728.1. [Q9UK53-5]
    NP_005528.4. NM_005537.5.
    NP_937860.1. NM_198217.2. [Q9UK53-4]
    NP_937861.1. NM_198218.2. [Q9UK53-3]
    NP_937862.1. NM_198219.2. [Q9UK53-2]
    UniGeneiHs.46700.
    Hs.508725.

    Genome annotation databases

    EnsembliENST00000333219; ENSP00000328436; ENSG00000153487. [Q9UK53-2]
    ENST00000338450; ENSP00000345202; ENSG00000153487. [Q9UK53-4]
    ENST00000375774; ENSP00000364929; ENSG00000153487. [Q9UK53-1]
    ENST00000375775; ENSP00000364930; ENSG00000153487. [Q9UK53-3]
    GeneIDi3621.
    KEGGihsa:3621.
    UCSCiuc001vrf.4. human. [Q9UK53-4]
    uc001vrg.3. human. [Q9UK53-3]
    uc001vrh.4. human. [Q9UK53-2]
    uc001vri.3. human. [Q9UK53-1]
    uc031qni.1. human. [Q9UK53-5]

    Polymorphism databases

    DMDMi212276438.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF181849 mRNA. Translation: AAF07920.1 .
    AF181850 mRNA. Translation: AAF07921.1 .
    AF001954 mRNA. Translation: AAB60879.1 . Frameshift.
    AF044076 mRNA. Translation: AAC00501.1 .
    AF149721 mRNA. Translation: AAF37421.1 .
    AF149722 mRNA. Translation: AAF37422.1 .
    AF149723 mRNA. Translation: AAF37423.1 .
    AF167551 , AF167550 Genomic DNA. Translation: AAG02578.1 .
    AF167551 , AF167549 Genomic DNA. Translation: AAG02579.1 . Sequence problems.
    AB037387 Genomic DNA. Translation: BAB08101.1 .
    AB037387 Genomic DNA. Translation: BAB08102.1 .
    AB037387 Genomic DNA. Translation: BAB08103.1 .
    AB037594 mRNA. Translation: BAB20992.2 .
    AB031269 mRNA. Translation: BAA83496.1 .
    AB024401 mRNA. Translation: BAA82886.1 .
    AB024402 mRNA. Translation: BAA82887.1 .
    AB024403 Genomic DNA. Translation: BAA82888.1 .
    AB024404 Genomic DNA. Translation: BAA82889.1 .
    AB024404 Genomic DNA. Translation: BAA83462.1 .
    AB024405 Genomic DNA. Translation: BAA82890.1 .
    AJ310392 mRNA. Translation: CAC38067.1 .
    AF078835 mRNA. Translation: AAG12174.1 .
    AF078837 , AF078836 Genomic DNA. Translation: AAG12175.1 .
    AK302353 mRNA. Translation: BAG63679.1 .
    AL157820 Genomic DNA. Translation: CAI16972.1 .
    AL157820 Genomic DNA. Translation: CAI16973.1 .
    AL157820 Genomic DNA. Translation: CAI16974.1 .
    AL157820 Genomic DNA. Translation: CAI16975.1 .
    CH471085 Genomic DNA. Translation: EAX09127.1 .
    CH471085 Genomic DNA. Translation: EAX09130.1 .
    BC093942 mRNA. Translation: AAH93942.1 .
    BC093944 mRNA. Translation: AAH93944.1 .
    CCDSi CCDS9515.1. [Q9UK53-4 ]
    CCDS9516.1. [Q9UK53-2 ]
    CCDS9517.1. [Q9UK53-1 ]
    CCDS9518.1. [Q9UK53-3 ]
    RefSeqi NP_001254657.1. NM_001267728.1. [Q9UK53-5 ]
    NP_005528.4. NM_005537.5.
    NP_937860.1. NM_198217.2. [Q9UK53-4 ]
    NP_937861.1. NM_198218.2. [Q9UK53-3 ]
    NP_937862.1. NM_198219.2. [Q9UK53-2 ]
    UniGenei Hs.46700.
    Hs.508725.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2QIC X-ray 2.10 A 345-404 [» ]
    ProteinModelPortali Q9UK53.
    SMRi Q9UK53. Positions 352-402.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109833. 51 interactions.
    DIPi DIP-24256N.
    DIP-24257N.
    DIP-24258N.
    IntActi Q9UK53. 13 interactions.

    PTM databases

    PhosphoSitei Q9UK53.

    Polymorphism databases

    DMDMi 212276438.

    Proteomic databases

    MaxQBi Q9UK53.
    PaxDbi Q9UK53.
    PRIDEi Q9UK53.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333219 ; ENSP00000328436 ; ENSG00000153487 . [Q9UK53-2 ]
    ENST00000338450 ; ENSP00000345202 ; ENSG00000153487 . [Q9UK53-4 ]
    ENST00000375774 ; ENSP00000364929 ; ENSG00000153487 . [Q9UK53-1 ]
    ENST00000375775 ; ENSP00000364930 ; ENSG00000153487 . [Q9UK53-3 ]
    GeneIDi 3621.
    KEGGi hsa:3621.
    UCSCi uc001vrf.4. human. [Q9UK53-4 ]
    uc001vrg.3. human. [Q9UK53-3 ]
    uc001vrh.4. human. [Q9UK53-2 ]
    uc001vri.3. human. [Q9UK53-1 ]
    uc031qni.1. human. [Q9UK53-5 ]

    Organism-specific databases

    CTDi 3621.
    GeneCardsi GC13P111365.
    H-InvDB HIX0056146.
    HGNCi HGNC:6062. ING1.
    HPAi CAB016136.
    CAB017773.
    HPA052591.
    MIMi 275355. phenotype.
    601566. gene.
    neXtProti NX_Q9UK53.
    Orphaneti 67037. Squamous cell carcinoma of head and neck.
    PharmGKBi PA29872.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5034.
    HOVERGENi HBG006607.
    InParanoidi Q9UK53.
    OMAi FETCQET.
    OrthoDBi EOG7RBZ9T.
    PhylomeDBi Q9UK53.
    TreeFami TF352014.

    Miscellaneous databases

    ChiTaRSi ING1. human.
    EvolutionaryTracei Q9UK53.
    GeneWikii ING1.
    GenomeRNAii 3621.
    NextBioi 14163.
    PROi Q9UK53.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UK53.
    Genevestigatori Q9UK53.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR028643. ING1.
    IPR028651. ING_fam.
    IPR024610. ING_N.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    PANTHERi PTHR10333. PTHR10333. 1 hit.
    PTHR10333:SF38. PTHR10333:SF38. 1 hit.
    Pfami PF12998. ING. 1 hit.
    PF00628. PHD. 1 hit.
    [Graphical view ]
    SMARTi SM00249. PHD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 1 hit.
    PROSITEi PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation."
      Garkavtsev I.A., Kazarov A.R., Gudkov A.V., Riabowol K.
      Nat. Genet. 14:415-420(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-125.
    2. Erratum
      Garkavtsev I.A., Kazarov A.R., Gudkov A.V., Riabowol K.
      Nat. Genet. 23:373-373(1999)
    3. "Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene."
      Jaeger D., Stockert E., Scanlan M.J., Guere A.O., Jaeger E., Knuth A., Old L.J., Chen Y.-T.
      Cancer Res. 59:6197-6204(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), TISSUE SPECIFICITY.
      Tissue: Mammary cancer and Testis.
    4. "Genomic organization of the suppressor gene for tumor growth ING1."
      Baranova A.V., Ivanov D.V., Makeeva N.V., Corcoran M., Nikitin E.A., Borodina T.A., Poltaraus A.B., Glinshchikova O.A., Sudarikov A.B., Oscier D., Iankovskii N.K.
      Mol. Biol. (Mosk.) 34:263-269(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 2).
    5. "Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas."
      Gunduz M., Ouchida M., Fukushima K., Hanafusa H., Etani T., Nishioka S., Nishizaki K., Shimizu K.
      Cancer Res. 60:3143-3146(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2; 3 AND 5), VARIANTS HNSCC ARG-125; ASP-335; SER-358 AND SER-359.
    6. "p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1."
      Saito A., Furukawa T., Fukushige S., Koyama S., Hoshi M., Hayashi Y., Horii A.
      J. Hum. Genet. 45:177-181(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2 AND 3), VARIANT ARG-125.
    7. "Supplement: sequencing of ING1 tumour suppressor gene cDNAs generated from mRNA recovered from normal and neoplastic cell lines."
      Nouman G.S., Anderson J.J., Angus B., Lunec J.
      J. Pathol. 192:266-266(2000)
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
      Tissue: Brain.
    8. "DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53."
      Nagashima M., Shiseki M., Miura K., Hagiwara K., Linke S.P., Pedeux R., Wang X.W., Yokota J., Riabowol K., Harris C.C.
      Proc. Natl. Acad. Sci. U.S.A. 98:9671-9676(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2).
    9. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Testis.
    10. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    13. "The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control."
      Garkavtsev I.A., Grigorian I.A., Ossovskaya V.S., Chernov M.V., Chumakov P.M., Gudkov A.V.
      Nature 391:295-298(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TP53.
    14. Cited for: DOMAIN PHD-TYPE ZINC-FINGER, INTERACTION WITH HISTONES H3K4ME3 AND H3K4ME2.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor."
      Pena P.V., Hom R.A., Hung T., Lin H., Kuo A.J., Wong R.P., Subach O.M., Champagne K.S., Zhao R., Verkhusha V.V., Li G., Gozani O., Kutateladze T.G.
      J. Mol. Biol. 380:303-312(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 345-404 IN COMPLEX WITH H3K4ME3, MUTAGENESIS OF TRP-378.

    Entry informationi

    Entry nameiING1_HUMAN
    AccessioniPrimary (citable) accession number: Q9UK53
    Secondary accession number(s): O00532
    , O43658, Q53ZR3, Q5T9G8, Q5T9G9, Q5T9H0, Q5T9H1, Q9H007, Q9HD98, Q9HD99, Q9NS83, Q9P0U6, Q9UBC6, Q9UIJ1, Q9UIJ2, Q9UIJ3, Q9UIJ4, Q9UK52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: November 4, 2008
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3