Q9UK45 (LSM7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
U6 snRNA-associated Sm-like protein LSm7

Gene names

Name:

LSM7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	103 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds specifically to the 3'-terminal U-tract of U6 snRNA and is probably a component of the spliceosome.
Subunit structure	LSm subunits form a heteromer with a doughnut shape. Also interacts with TACC1. Ref.4
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the snRNP Sm proteins family.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus Spliceosome
Ligand	RNA-binding
Molecular function	Ribonucleoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Traceable author statement. Source: Reactome mRNA splicing, via spliceosome Non-traceable author statement. Source: UniProtKB
Cellular_component	cytosol Traceable author statement. Source: Reactome nucleus Non-traceable author statement. Source: UniProtKB spliceosomal complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	U6 snRNA binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LSM2	Q9Y333	4	EBI-348372,EBI-347416
LSM3	P62310	3	EBI-348372,EBI-348239
LSM4	Q9Y4Z0	5	EBI-348372,EBI-372521
LSM5	Q9Y4Y9	4	EBI-348372,EBI-373007
LSM6	P62312	3	EBI-348372,EBI-373310
TACC1	O75410-1	4	EBI-348372,EBI-624252
TACC1	O75410-6	2	EBI-348372,EBI-624278

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 103	103	U6 snRNA-associated Sm-like protein LSm7		PRO_0000125579

Sequences

	Sequence		Length	Mass (Da)
	Q9UK45 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 7429DC0FB365C9C8	FASTA	103	11,602
	10 20 30 40 50 60 MADKEKKKKE SILDLSKYID KTIRVKFQGG REASGILKGF DPLLNLVLDG TIEYMRDPDD 70 80 90 100 QYKLTEDTRQ LGLVVCRGTS VVLICPQDGM EAIPNPFIQQ QDA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro." Achsel T., Brahms H., Kastner B., Bachi A., Wilm M., Luehrmann R. EMBO J. 18:5789-5802(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell.
[4]	"Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators." Conte N., Charafe-Jauffret E., Delaval B., Adelaide J., Ginestier C., Geneix J., Isnardon D., Jacquemier J., Birnbaum D. Oncogene 21:5619-5630(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TACC1.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF182293 mRNA. Translation: AAD56231.1. AC005258 Genomic DNA. Translation: AAG45442.1. BC018621 mRNA. Translation: AAH18621.1.
IPI	IPI00007163.
RefSeq	NP_057283.1. NM_016199.2.
UniGene	Hs.512610.
3D structure databases
ProteinModelPortal	Q9UK45.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-31129N.
IntAct	Q9UK45. 20 interactions.
MINT	MINT-1036641.
STRING	9606.ENSP00000252622.
PTM databases
PhosphoSite	Q9UK45.
Polymorphism databases
DMDM	10720075.
Proteomic databases
PaxDb	Q9UK45.
PRIDE	Q9UK45.
Protocols and materials databases
DNASU	51690.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000252622; ENSP00000252622; ENSG00000130332.
GeneID	51690.
KEGG	hsa:51690.
UCSC	uc002lvp.4. human.
Organism-specific databases
CTD	51690.
GeneCards	GC19M002321.
HGNC	HGNC:20470. LSM7.
HPA	HPA041850.
MIM	607287. gene.
neXtProt	NX_Q9UK45.
PharmGKB	PA134888612.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG276686.
HOGENOM	HOG000223548.
HOVERGEN	HBG000513.
KO	K12626.
OMA	VLDNTVE.
OrthoDB	EOG4GB77F.
Enzyme and pathway databases
Reactome	REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
Bgee	Q9UK45.
CleanEx	HS_LSM7.
Genevestigator	Q9UK45.
GermOnline	ENSG00000130332. Homo sapiens.
Family and domain databases
InterPro	IPR010920. LSM_dom. IPR001163. Ribonucl_LSM. IPR006649. Ribonucl_LSM_euk/arc. IPR017132. U6_snRNA_Lsm7. [Graphical view]
Pfam	PF01423. LSM. 1 hit. [Graphical view]
PIRSF	PIRSF037188. U6_snRNA_Lsm7. 1 hit.
SMART	SM00651. Sm. 1 hit. [Graphical view]
SUPFAM	SSF50182. Sm_like_riboprot. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	51690.
NextBio	55694.
SOURCE	Search...

Entry information

Entry name

LSM7_HUMAN

Accession

Primary (citable) accession number: Q9UK45

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.