Reviewed, UniProtKB/Swiss-Prot Q9UK45 (LSM7_HUMAN)

Names and origin

Protein names

Recommended name:
    U6 snRNA-associated Sm-like protein LSm7

Gene names

Name:

LSM7

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	103 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds specifically to the 3'-terminal U-tract of U6 snRNA.
Subunit structure	LSm subunits form a heteromer with a donut shape. Also interacts with TACC1. Ref.4
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the snRNP Sm proteins family.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus
Ligand	RNA-binding
Molecular function	Ribonucleoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	nuclear mRNA splicing, via spliceosome Non-traceable author statement. Source: UniProtKB
Cellular component	nucleus Non-traceable author statement. Source: UniProtKB ribonucleoprotein complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	U6 snRNA binding Ref.1 Non-traceable author statement. Source: UniProtKB protein binding Ref.4 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
EXOSC8	Q96B26	1	EBI-348372,EBI-371922
LSM2	Q9Y333	3	EBI-348372,EBI-347416
LSM3	P62310	2	EBI-348372,EBI-348239
LSM4	Q9Y4Z0	2	EBI-348372,EBI-372521
LSM5	Q9Y4Y9	2	EBI-348372,EBI-373007
LSM6	P62312	2	EBI-348372,EBI-373310
LSM8	O95777	1	EBI-348372,EBI-347779
MYH13	Q9UKX3	1	EBI-348372,EBI-373433
NPY1R	P25929	1	EBI-348372,EBI-372227
RAB7L1	O14966	1	EBI-348372,EBI-372165
SNRPD3	P62318	1	EBI-348372,EBI-372789
TACC1	O75410-1	3	EBI-348372,EBI-624252
TACC1	O75410-6	1	EBI-348372,EBI-624278

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 103	103	U6 snRNA-associated Sm-like protein LSm7		PRO_0000125579

Sequences

	Sequence		Length	Mass (Da)
	Q9UK45-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 7429DC0FB365C9C8	FASTA	103	11,602
	10 20 30 40 50 60 MADKEKKKKE SILDLSKYID KTIRVKFQGG REASGILKGF DPLLNLVLDG TIEYMRDPDD 70 80 90 100 QYKLTEDTRQ LGLVVCRGTS VVLICPQDGM EAIPNPFIQQ QDA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro." Achsel T., Brahms H., Kastner B., Bachi A., Wilm M., Luehrmann R. EMBO J. 18:5789-5802(1999) [PubMed: 10523320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell.
[4]	"Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators." Conte N., Charafe-Jauffret E., Delaval B., Adelaide J., Ginestier C., Geneix J., Isnardon D., Jacquemier J., Birnbaum D. Oncogene 21:5619-5630(2002) [PubMed: 12165861] [Abstract] Cited for: INTERACTION WITH TACC1.
[5]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF182293 mRNA. Translation: AAD56231.1. AC005258 Genomic DNA. Translation: AAG45442.1. BC018621 mRNA. Translation: AAH18621.1.
IPI	IPI00007163.
RefSeq	NP_057283.1.
UniGene	Hs.512610
3D structure databases
HSSP	HSSP built from PDB template 1LJO based on UniProtKB O29885.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UK45. 14 interactions.
Proteomic databases
PRIDE	Q9UK45.
Genome annotation databases
GeneID	51690.
KEGG	hsa:51690.
Organism-specific databases
GeneCards	GC19M002272.
H-InvDB	HIX0014615.
HGNC	HGNC:20470. LSM7.
MIM	607287. gene.
PharmGKB	PA134888612.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9UK45.
HOVERGEN	Q9UK45.
Gene expression databases
CleanEx	HS_LSM7.
GermOnline	ENSG00000130332. Homo sapiens.
Family and domain databases
InterPro	IPR006649. Euk_arc_LSM_core. IPR001163. LSM_snRNP_core. IPR017132. U6_snRNA_Lsm7. [Graphical view]
Pfam	PF01423. LSM. 1 hit. [Graphical view]
PIRSF	PIRSF037188. U6_snRNA_Lsm7. 1 hit.
ProDom	PD020287. snRNP. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00651. Sm. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	55694.
SOURCE	Search...

Entry information

Entry name

LSM7_HUMAN

Accession

Primary (citable) accession number: Q9UK45

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)