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Q9UK33 (ZN580_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 580
Alternative name(s):
LDL-induced EC protein
Gene names
Name:ZNF580
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length172 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the regulation of endothelial cell proliferation and migration. Mediates H2O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation. Ref.6 Ref.8

Subunit structure

Interacts with SMAD2. Ref.7

Subcellular location

Nucleus. Note: Colocalized with SMAD2 in the nucleus. Ref.6 Ref.7

Tissue specificity

Expressed in endothelial cells. Ref.7

Induction

Up-regulated in presence of reactive oxygen species (ROS), like H2O2, through the NF-kappaB signaling pathway. Up-regulated by sphingosine-1-phosphate (SP1) through the p38 MAPK signaling pathway (at protein level). Ref.6 Ref.8

Sequence similarities

Contains 3 C2H2-type zinc fingers.

Sequence caution

The sequence CAB94389.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 172172Zinc finger protein 580
PRO_0000047671

Regions

Zinc finger92 – 11423C2H2-type 1
Zinc finger120 – 14223C2H2-type 2
Zinc finger150 – 17223C2H2-type 3
Compositional bias5 – 8884Pro-rich

Sequences

Sequence LengthMass (Da)Tools
Q9UK33 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 55A89DD94E0440A8

FASTA17218,756
        10         20         30         40         50         60 
MLLLPPRPPH PRSSSPEAMD PPPPKAPPFP KAEGPSSTPS SAAGPRPPRL GRHLLIDANG 

        70         80         90        100        110        120 
VPYTYTVQLE EEPRGPPQRE APPGEPGPRK GYSCPECARV FASPLRLQSH RVSHSDLKPF 

       130        140        150        160        170 
TCGACGKAFK RSSHLSRHRA THRARAGPPH TCPLCPRRFQ DAAELAQHVR LH 

« Hide

References

« Hide 'large scale' references
[1]"A novel gene associated with LDL stimulation in vascular endothelial cells."
Zhang W.C., Zhang K.M., Chen B.S.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Vascular endothelial cell.
[2]The European IMAGE consortium
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2 production via transcription factor ZNF580: novel insights into angiogenesis."
Sun H.Y., Wei S.P., Xu R.C., Xu P.X., Zhang W.C.
Biochem. Biophys. Res. Commun. 395:361-366(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION BY SPHINGOSINE-1-PHOSPHATE.
[7]"ZNF580, a novel C2H2 zinc-finger transcription factor, interacts with the TGF-beta signal molecule Smad2."
Luo Y., Hu W., Xu R., Hou B., Zhang L., Zhang W.
Cell Biol. Int. 35:1153-1157(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SMAD2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[8]"ROS-induced ZNF580 expression: a key role for H2O2/NF-kappaB signaling pathway in vascular endothelial inflammation."
DangLi R., HeKong W., JiQin L., MingHua Z., WenCheng Z.
Mol. Cell. Biochem. 359:183-191(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION BY REACTIVE OXYGEN SPECIES.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF184939 mRNA. Translation: AAD56549.1.
AL359054 mRNA. Translation: CAB94389.1. Different initiation.
AK314888 mRNA. Translation: BAG37402.1.
BC017698 mRNA. Translation: AAH17698.1.
RefSeqNP_001156895.1. NM_001163423.1.
NP_057286.1. NM_016202.2.
NP_996998.1. NM_207115.1.
XP_005259025.1. XM_005258968.1.
UniGeneHs.631551.

3D structure databases

ProteinModelPortalQ9UK33.
SMRQ9UK33. Positions 90-172.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119340. 6 interactions.
IntActQ9UK33. 4 interactions.
MINTMINT-1469367.

PTM databases

PhosphoSiteQ9UK33.

Polymorphism databases

DMDM55976777.

Proteomic databases

PaxDbQ9UK33.
PRIDEQ9UK33.

Protocols and materials databases

DNASU51157.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000325333; ENSP00000320050; ENSG00000213015.
ENST00000543039; ENSP00000443957; ENSG00000213015.
ENST00000545125; ENSP00000446126; ENSG00000213015.
GeneID51157.
KEGGhsa:51157.
UCSCuc002qlo.3. human.

Organism-specific databases

CTD51157.
GeneCardsGC19P056152.
HGNCHGNC:29473. ZNF580.
HPAHPA054058.
neXtProtNX_Q9UK33.
PharmGKBPA134867016.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG312510.
HOGENOMHOG000059663.
HOVERGENHBG079385.
InParanoidQ9UK33.
OMAECGRIFA.
PhylomeDBQ9UK33.
TreeFamTF338348.

Gene expression databases

ArrayExpressQ9UK33.
BgeeQ9UK33.
CleanExHS_ZNF580.
GenevestigatorQ9UK33.

Family and domain databases

Gene3D3.30.160.60. 2 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi51157.
NextBio54067.
PROQ9UK33.

Entry information

Entry nameZN580_HUMAN
AccessionPrimary (citable) accession number: Q9UK33
Secondary accession number(s): B2RC05, Q9NPP7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM