Q9UK33 (ZN580_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 580

Alternative name(s):
LDL-induced EC protein

Gene names

Name:

ZNF580

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Contains 3 C2H2-type zinc fingers.
Sequence caution	The sequence CAB94389.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 172	172	Zinc finger protein 580		PRO_0000047671
Regions
	Zinc finger	92 – 114	23	C2H2-type 1
	Zinc finger	120 – 142	23	C2H2-type 2
	Zinc finger	150 – 172	23	C2H2-type 3
	Compositional bias	5 – 88	84	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	Q9UK33 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 55A89DD94E0440A8	FASTA	172	18,756
	10 20 30 40 50 60 MLLLPPRPPH PRSSSPEAMD PPPPKAPPFP KAEGPSSTPS SAAGPRPPRL GRHLLIDANG 70 80 90 100 110 120 VPYTYTVQLE EEPRGPPQRE APPGEPGPRK GYSCPECARV FASPLRLQSH RVSHSDLKPF 130 140 150 160 170 TCGACGKAFK RSSHLSRHRA THRARAGPPH TCPLCPRRFQ DAAELAQHVR LH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel gene associated with LDL stimulation in vascular endothelial cells." Zhang W.C., Zhang K.M., Chen B.S. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Vascular endothelial cell.
[2]	The European IMAGE consortium Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF184939 mRNA. Translation: AAD56549.1. AL359054 mRNA. Translation: CAB94389.1. Different initiation. AK314888 mRNA. Translation: BAG37402.1. BC017698 mRNA. Translation: AAH17698.1.
IPI	IPI00478837.
RefSeq	NP_001156895.1. NM_001163423.1. NP_057286.1. NM_016202.2. NP_996998.1. NM_207115.1.
UniGene	Hs.631551.
3D structure databases
ProteinModelPortal	Q9UK33.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UK33. 2 interactions.
MINT	MINT-1469367.
PTM databases
PhosphoSite	Q9UK33.
Polymorphism databases
DMDM	55976777.
Proteomic databases
PaxDb	Q9UK33.
PRIDE	Q9UK33.
Protocols and materials databases
DNASU	51157.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000325333; ENSP00000320050; ENSG00000213015. ENST00000543039; ENSP00000443957; ENSG00000213015. ENST00000545125; ENSP00000446126; ENSG00000213015.
GeneID	51157.
KEGG	hsa:51157.
UCSC	uc002qlo.3. human.
Organism-specific databases
CTD	51157.
GeneCards	GC19P056152.
HGNC	HGNC:29473. ZNF580.
HPA	HPA054058.
neXtProt	NX_Q9UK33.
PharmGKB	PA134867016.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG312510.
HOGENOM	HOG000059663.
HOVERGEN	HBG079385.
InParanoid	Q9UK33.
OMA	FPKTEGP.
OrthoDB	EOG4BZN3V.
Gene expression databases
Bgee	Q9UK33.
CleanEx	HS_ZNF580.
Genevestigator	Q9UK33.
GermOnline	ENSG00000171425. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 2 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF00096. zf-C2H2. 2 hits. [Graphical view]
SMART	SM00355. ZnF_C2H2. 3 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	51157.
NextBio	54067.

Entry information

Entry name

ZN580_HUMAN

Accession

Primary (citable) accession number: Q9UK33
Secondary accession number(s): B2RC05, Q9NPP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.