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Protein

Zinc finger protein 580

Gene

ZNF580

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of endothelial cell proliferation and migration. Mediates H2O2-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri120 – 142C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • cellular response to hydrogen peroxide Source: UniProtKB
  • chemotaxis Source: UniProtKB-KW
  • inflammatory response Source: UniProtKB-KW
  • positive regulation of endothelial cell migration Source: UniProtKB
  • positive regulation of endothelial cell proliferation Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of interleukin-8 production Source: UniProtKB
  • positive regulation of leukocyte chemotaxis Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processChemotaxis, Inflammatory response, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 580
Alternative name(s):
LDL-induced EC protein
Gene namesi
Name:ZNF580
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000213015.8.
HGNCiHGNC:29473. ZNF580.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000213015.
PharmGKBiPA134867016.

Polymorphism and mutation databases

BioMutaiZNF580.
DMDMi55976777.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476711 – 172Zinc finger protein 580Add BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki31Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9UK33.
MaxQBiQ9UK33.
PaxDbiQ9UK33.
PeptideAtlasiQ9UK33.
PRIDEiQ9UK33.

PTM databases

iPTMnetiQ9UK33.
PhosphoSitePlusiQ9UK33.

Expressioni

Tissue specificityi

Expressed in endothelial cells.1 Publication

Inductioni

Up-regulated in presence of reactive oxygen species (ROS), like H2O2, through the NF-kappaB signaling pathway. Up-regulated by sphingosine-1-phosphate (SP1) through the p38 MAPK signaling pathway (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000213015.
CleanExiHS_ZNF580.
ExpressionAtlasiQ9UK33. baseline and differential.
GenevisibleiQ9UK33. HS.

Organism-specific databases

HPAiHPA054058.

Interactioni

Subunit structurei

Interacts with SMAD2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
KHDRBS3O755254EBI-746277,EBI-722504

Protein-protein interaction databases

BioGridi119340. 7 interactors.
IntActiQ9UK33. 21 interactors.
MINTiMINT-1469367.
STRINGi9606.ENSP00000320050.

Structurei

3D structure databases

ProteinModelPortaliQ9UK33.
SMRiQ9UK33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 88Pro-richAdd BLAST84

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri120 – 142C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00900000141050.
HOGENOMiHOG000059663.
HOVERGENiHBG079385.
InParanoidiQ9UK33.
OMAiEVMDPPP.
OrthoDBiEOG091G0STS.
PhylomeDBiQ9UK33.
TreeFamiTF338348.

Family and domain databases

InterProiView protein in InterPro
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 3 hits.
SUPFAMiSSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9UK33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLPPRPPH PRSSSPEAMD PPPPKAPPFP KAEGPSSTPS SAAGPRPPRL
60 70 80 90 100
GRHLLIDANG VPYTYTVQLE EEPRGPPQRE APPGEPGPRK GYSCPECARV
110 120 130 140 150
FASPLRLQSH RVSHSDLKPF TCGACGKAFK RSSHLSRHRA THRARAGPPH
160 170
TCPLCPRRFQ DAAELAQHVR LH
Length:172
Mass (Da):18,756
Last modified:May 1, 2000 - v1
Checksum:i55A89DD94E0440A8
GO

Sequence cautioni

Q9UK33: The sequence CAB94389 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF184939 mRNA. Translation: AAD56549.1.
AL359054 mRNA. Translation: CAB94389.1. Different initiation.
AK314888 mRNA. Translation: BAG37402.1.
BC017698 mRNA. Translation: AAH17698.1.
CCDSiCCDS12931.1.
RefSeqiNP_001156895.1. NM_001163423.1.
NP_057286.1. NM_016202.2.
NP_996998.1. NM_207115.1.
UniGeneiHs.631551.

Genome annotation databases

EnsembliENST00000325333; ENSP00000320050; ENSG00000213015.
ENST00000543039; ENSP00000443957; ENSG00000213015.
ENST00000545125; ENSP00000446126; ENSG00000213015.
GeneIDi51157.
KEGGihsa:51157.
UCSCiuc002qlo.4. human.

Similar proteinsi

Entry informationi

Entry nameiZN580_HUMAN
AccessioniPrimary (citable) accession number: Q9UK33
Secondary accession number(s): B2RC05, Q9NPP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM