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Protein

Zinc finger protein 580

Gene

ZNF580

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of endothelial cell proliferation and migration. Mediates H2O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri92 – 11423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri120 – 14223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri150 – 17223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to hydrogen peroxide Source: UniProtKB
  2. chemotaxis Source: UniProtKB-KW
  3. inflammatory response Source: UniProtKB-KW
  4. positive regulation of endothelial cell migration Source: UniProtKB
  5. positive regulation of endothelial cell proliferation Source: UniProtKB
  6. positive regulation of gene expression Source: UniProtKB
  7. positive regulation of interleukin-8 production Source: UniProtKB
  8. positive regulation of leukocyte chemotaxis Source: UniProtKB
  9. regulation of transcription, DNA-templated Source: UniProtKB-KW
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Chemotaxis, Inflammatory response, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 580
Alternative name(s):
LDL-induced EC protein
Gene namesi
Name:ZNF580
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:29473. ZNF580.

Subcellular locationi

Nucleus 2 Publications
Note: Colocalized with SMAD2 in the nucleus.

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134867016.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Zinc finger protein 580PRO_0000047671Add
BLAST

Proteomic databases

MaxQBiQ9UK33.
PaxDbiQ9UK33.
PRIDEiQ9UK33.

PTM databases

PhosphoSiteiQ9UK33.

Expressioni

Tissue specificityi

Expressed in endothelial cells.1 Publication

Inductioni

Up-regulated in presence of reactive oxygen species (ROS), like H2O2, through the NF-kappaB signaling pathway. Up-regulated by sphingosine-1-phosphate (SP1) through the p38 MAPK signaling pathway (at protein level).2 Publications

Gene expression databases

BgeeiQ9UK33.
CleanExiHS_ZNF580.
ExpressionAtlasiQ9UK33. baseline and differential.
GenevestigatoriQ9UK33.

Organism-specific databases

HPAiHPA054058.

Interactioni

Subunit structurei

Interacts with SMAD2.1 Publication

Protein-protein interaction databases

BioGridi119340. 6 interactions.
IntActiQ9UK33. 4 interactions.
MINTiMINT-1469367.

Structurei

3D structure databases

ProteinModelPortaliQ9UK33.
SMRiQ9UK33. Positions 90-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 8884Pro-richAdd
BLAST

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri92 – 11423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri120 – 14223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri150 – 17223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG312510.
GeneTreeiENSGT00780000121994.
HOGENOMiHOG000059663.
HOVERGENiHBG079385.
InParanoidiQ9UK33.
OMAiECGRIFA.
PhylomeDBiQ9UK33.
TreeFamiTF338348.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UK33-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLLPPRPPH PRSSSPEAMD PPPPKAPPFP KAEGPSSTPS SAAGPRPPRL
60 70 80 90 100
GRHLLIDANG VPYTYTVQLE EEPRGPPQRE APPGEPGPRK GYSCPECARV
110 120 130 140 150
FASPLRLQSH RVSHSDLKPF TCGACGKAFK RSSHLSRHRA THRARAGPPH
160 170
TCPLCPRRFQ DAAELAQHVR LH
Length:172
Mass (Da):18,756
Last modified:May 1, 2000 - v1
Checksum:i55A89DD94E0440A8
GO

Sequence cautioni

The sequence CAB94389.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF184939 mRNA. Translation: AAD56549.1.
AL359054 mRNA. Translation: CAB94389.1. Different initiation.
AK314888 mRNA. Translation: BAG37402.1.
BC017698 mRNA. Translation: AAH17698.1.
CCDSiCCDS12931.1.
RefSeqiNP_001156895.1. NM_001163423.1.
NP_057286.1. NM_016202.2.
NP_996998.1. NM_207115.1.
XP_005259025.1. XM_005258968.1.
XP_006723299.1. XM_006723236.1.
UniGeneiHs.631551.

Genome annotation databases

EnsembliENST00000325333; ENSP00000320050; ENSG00000213015.
ENST00000543039; ENSP00000443957; ENSG00000213015.
ENST00000545125; ENSP00000446126; ENSG00000213015.
GeneIDi51157.
KEGGihsa:51157.
UCSCiuc002qlo.3. human.

Polymorphism databases

DMDMi55976777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF184939 mRNA. Translation: AAD56549.1.
AL359054 mRNA. Translation: CAB94389.1. Different initiation.
AK314888 mRNA. Translation: BAG37402.1.
BC017698 mRNA. Translation: AAH17698.1.
CCDSiCCDS12931.1.
RefSeqiNP_001156895.1. NM_001163423.1.
NP_057286.1. NM_016202.2.
NP_996998.1. NM_207115.1.
XP_005259025.1. XM_005258968.1.
XP_006723299.1. XM_006723236.1.
UniGeneiHs.631551.

3D structure databases

ProteinModelPortaliQ9UK33.
SMRiQ9UK33. Positions 90-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119340. 6 interactions.
IntActiQ9UK33. 4 interactions.
MINTiMINT-1469367.

PTM databases

PhosphoSiteiQ9UK33.

Polymorphism databases

DMDMi55976777.

Proteomic databases

MaxQBiQ9UK33.
PaxDbiQ9UK33.
PRIDEiQ9UK33.

Protocols and materials databases

DNASUi51157.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325333; ENSP00000320050; ENSG00000213015.
ENST00000543039; ENSP00000443957; ENSG00000213015.
ENST00000545125; ENSP00000446126; ENSG00000213015.
GeneIDi51157.
KEGGihsa:51157.
UCSCiuc002qlo.3. human.

Organism-specific databases

CTDi51157.
GeneCardsiGC19P056152.
HGNCiHGNC:29473. ZNF580.
HPAiHPA054058.
neXtProtiNX_Q9UK33.
PharmGKBiPA134867016.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG312510.
GeneTreeiENSGT00780000121994.
HOGENOMiHOG000059663.
HOVERGENiHBG079385.
InParanoidiQ9UK33.
OMAiECGRIFA.
PhylomeDBiQ9UK33.
TreeFamiTF338348.

Miscellaneous databases

GenomeRNAii51157.
NextBioi54067.
PROiQ9UK33.

Gene expression databases

BgeeiQ9UK33.
CleanExiHS_ZNF580.
ExpressionAtlasiQ9UK33. baseline and differential.
GenevestigatoriQ9UK33.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene associated with LDL stimulation in vascular endothelial cells."
    Zhang W.C., Zhang K.M., Chen B.S.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Vascular endothelial cell.
  2. The European IMAGE consortium
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2 production via transcription factor ZNF580: novel insights into angiogenesis."
    Sun H.Y., Wei S.P., Xu R.C., Xu P.X., Zhang W.C.
    Biochem. Biophys. Res. Commun. 395:361-366(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION BY SPHINGOSINE-1-PHOSPHATE.
  7. "ZNF580, a novel C2H2 zinc-finger transcription factor, interacts with the TGF-beta signal molecule Smad2."
    Luo Y., Hu W., Xu R., Hou B., Zhang L., Zhang W.
    Cell Biol. Int. 35:1153-1157(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SMAD2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  8. "ROS-induced ZNF580 expression: a key role for H2O2/NF-kappaB signaling pathway in vascular endothelial inflammation."
    DangLi R., HeKong W., JiQin L., MingHua Z., WenCheng Z.
    Mol. Cell. Biochem. 359:183-191(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION BY REACTIVE OXYGEN SPECIES.

Entry informationi

Entry nameiZN580_HUMAN
AccessioniPrimary (citable) accession number: Q9UK33
Secondary accession number(s): B2RC05, Q9NPP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 1, 2000
Last modified: February 4, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.