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Q9UK33

- ZN580_HUMAN

UniProt

Q9UK33 - ZN580_HUMAN

Protein

Zinc finger protein 580

Gene

ZNF580

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Involved in the regulation of endothelial cell proliferation and migration. Mediates H2O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri92 – 11423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri120 – 14223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri150 – 17223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to hydrogen peroxide Source: UniProtKB
    2. chemotaxis Source: UniProtKB-KW
    3. inflammatory response Source: UniProtKB-KW
    4. positive regulation of endothelial cell migration Source: UniProtKB
    5. positive regulation of endothelial cell proliferation Source: UniProtKB
    6. positive regulation of gene expression Source: UniProtKB
    7. positive regulation of interleukin-8 production Source: UniProtKB
    8. positive regulation of leukocyte chemotaxis Source: UniProtKB
    9. regulation of transcription, DNA-templated Source: UniProtKB-KW
    10. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Chemotaxis, Inflammatory response, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 580
    Alternative name(s):
    LDL-induced EC protein
    Gene namesi
    Name:ZNF580
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:29473. ZNF580.

    Subcellular locationi

    Nucleus 2 Publications
    Note: Colocalized with SMAD2 in the nucleus.

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134867016.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 172172Zinc finger protein 580PRO_0000047671Add
    BLAST

    Proteomic databases

    MaxQBiQ9UK33.
    PaxDbiQ9UK33.
    PRIDEiQ9UK33.

    PTM databases

    PhosphoSiteiQ9UK33.

    Expressioni

    Tissue specificityi

    Expressed in endothelial cells.1 Publication

    Inductioni

    Up-regulated in presence of reactive oxygen species (ROS), like H2O2, through the NF-kappaB signaling pathway. Up-regulated by sphingosine-1-phosphate (SP1) through the p38 MAPK signaling pathway (at protein level).2 Publications

    Gene expression databases

    ArrayExpressiQ9UK33.
    BgeeiQ9UK33.
    CleanExiHS_ZNF580.
    GenevestigatoriQ9UK33.

    Organism-specific databases

    HPAiHPA054058.

    Interactioni

    Subunit structurei

    Interacts with SMAD2.1 Publication

    Protein-protein interaction databases

    BioGridi119340. 6 interactions.
    IntActiQ9UK33. 4 interactions.
    MINTiMINT-1469367.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UK33.
    SMRiQ9UK33. Positions 90-172.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi5 – 8884Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri92 – 11423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri120 – 14223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri150 – 17223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG312510.
    HOGENOMiHOG000059663.
    HOVERGENiHBG079385.
    InParanoidiQ9UK33.
    OMAiECGRIFA.
    PhylomeDBiQ9UK33.
    TreeFamiTF338348.

    Family and domain databases

    Gene3Di3.30.160.60. 2 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UK33-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLLPPRPPH PRSSSPEAMD PPPPKAPPFP KAEGPSSTPS SAAGPRPPRL    50
    GRHLLIDANG VPYTYTVQLE EEPRGPPQRE APPGEPGPRK GYSCPECARV 100
    FASPLRLQSH RVSHSDLKPF TCGACGKAFK RSSHLSRHRA THRARAGPPH 150
    TCPLCPRRFQ DAAELAQHVR LH 172
    Length:172
    Mass (Da):18,756
    Last modified:May 1, 2000 - v1
    Checksum:i55A89DD94E0440A8
    GO

    Sequence cautioni

    The sequence CAB94389.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF184939 mRNA. Translation: AAD56549.1.
    AL359054 mRNA. Translation: CAB94389.1. Different initiation.
    AK314888 mRNA. Translation: BAG37402.1.
    BC017698 mRNA. Translation: AAH17698.1.
    CCDSiCCDS12931.1.
    RefSeqiNP_001156895.1. NM_001163423.1.
    NP_057286.1. NM_016202.2.
    NP_996998.1. NM_207115.1.
    XP_005259025.1. XM_005258968.1.
    XP_006723299.1. XM_006723236.1.
    UniGeneiHs.631551.

    Genome annotation databases

    EnsembliENST00000325333; ENSP00000320050; ENSG00000213015.
    ENST00000543039; ENSP00000443957; ENSG00000213015.
    ENST00000545125; ENSP00000446126; ENSG00000213015.
    GeneIDi51157.
    KEGGihsa:51157.
    UCSCiuc002qlo.3. human.

    Polymorphism databases

    DMDMi55976777.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF184939 mRNA. Translation: AAD56549.1 .
    AL359054 mRNA. Translation: CAB94389.1 . Different initiation.
    AK314888 mRNA. Translation: BAG37402.1 .
    BC017698 mRNA. Translation: AAH17698.1 .
    CCDSi CCDS12931.1.
    RefSeqi NP_001156895.1. NM_001163423.1.
    NP_057286.1. NM_016202.2.
    NP_996998.1. NM_207115.1.
    XP_005259025.1. XM_005258968.1.
    XP_006723299.1. XM_006723236.1.
    UniGenei Hs.631551.

    3D structure databases

    ProteinModelPortali Q9UK33.
    SMRi Q9UK33. Positions 90-172.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119340. 6 interactions.
    IntActi Q9UK33. 4 interactions.
    MINTi MINT-1469367.

    PTM databases

    PhosphoSitei Q9UK33.

    Polymorphism databases

    DMDMi 55976777.

    Proteomic databases

    MaxQBi Q9UK33.
    PaxDbi Q9UK33.
    PRIDEi Q9UK33.

    Protocols and materials databases

    DNASUi 51157.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000325333 ; ENSP00000320050 ; ENSG00000213015 .
    ENST00000543039 ; ENSP00000443957 ; ENSG00000213015 .
    ENST00000545125 ; ENSP00000446126 ; ENSG00000213015 .
    GeneIDi 51157.
    KEGGi hsa:51157.
    UCSCi uc002qlo.3. human.

    Organism-specific databases

    CTDi 51157.
    GeneCardsi GC19P056152.
    HGNCi HGNC:29473. ZNF580.
    HPAi HPA054058.
    neXtProti NX_Q9UK33.
    PharmGKBi PA134867016.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG312510.
    HOGENOMi HOG000059663.
    HOVERGENi HBG079385.
    InParanoidi Q9UK33.
    OMAi ECGRIFA.
    PhylomeDBi Q9UK33.
    TreeFami TF338348.

    Miscellaneous databases

    GenomeRNAii 51157.
    NextBioi 54067.
    PROi Q9UK33.

    Gene expression databases

    ArrayExpressi Q9UK33.
    Bgeei Q9UK33.
    CleanExi HS_ZNF580.
    Genevestigatori Q9UK33.

    Family and domain databases

    Gene3Di 3.30.160.60. 2 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene associated with LDL stimulation in vascular endothelial cells."
      Zhang W.C., Zhang K.M., Chen B.S.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Vascular endothelial cell.
    2. The European IMAGE consortium
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2 production via transcription factor ZNF580: novel insights into angiogenesis."
      Sun H.Y., Wei S.P., Xu R.C., Xu P.X., Zhang W.C.
      Biochem. Biophys. Res. Commun. 395:361-366(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION BY SPHINGOSINE-1-PHOSPHATE.
    7. "ZNF580, a novel C2H2 zinc-finger transcription factor, interacts with the TGF-beta signal molecule Smad2."
      Luo Y., Hu W., Xu R., Hou B., Zhang L., Zhang W.
      Cell Biol. Int. 35:1153-1157(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SMAD2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    8. "ROS-induced ZNF580 expression: a key role for H2O2/NF-kappaB signaling pathway in vascular endothelial inflammation."
      DangLi R., HeKong W., JiQin L., MingHua Z., WenCheng Z.
      Mol. Cell. Biochem. 359:183-191(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION BY REACTIVE OXYGEN SPECIES.

    Entry informationi

    Entry nameiZN580_HUMAN
    AccessioniPrimary (citable) accession number: Q9UK33
    Secondary accession number(s): B2RC05, Q9NPP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3