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Protein

Transmembrane protein 59-like

Gene

TMEM59L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 59-like
Alternative name(s):
Brain-specific membrane-anchored protein
Gene namesi
Name:TMEM59L
Synonyms:BSMAP, C19orf4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13237. TMEM59L.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei268 – 29023HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: ProtInc
  • membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406615.

Polymorphism and mutation databases

BioMutaiTMEM59L.
DMDMi18203502.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 342318Transmembrane protein 59-likePRO_0000003000Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9UK28.
PaxDbiQ9UK28.
PeptideAtlasiQ9UK28.
PRIDEiQ9UK28.

PTM databases

iPTMnetiQ9UK28.
PhosphoSiteiQ9UK28.

Expressioni

Tissue specificityi

Expressed preferentially at high level in the brain.

Gene expression databases

BgeeiENSG00000105696.
CleanExiHS_TMEM59L.
ExpressionAtlasiQ9UK28. baseline and differential.
GenevisibleiQ9UK28. HS.

Organism-specific databases

HPAiHPA010661.
HPA070701.

Interactioni

Protein-protein interaction databases

BioGridi117322. 11 interactions.
STRINGi9606.ENSP00000262817.

Structurei

3D structure databases

ProteinModelPortaliQ9UK28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi340 – 3423Microbody targeting signalSequence analysis

Sequence similaritiesi

Belongs to the TMEM59 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF0S. Eukaryota.
ENOG410Y2GG. LUCA.
GeneTreeiENSGT00390000008279.
HOGENOMiHOG000015759.
HOVERGENiHBG018206.
InParanoidiQ9UK28.
OMAiTECEAAC.
OrthoDBiEOG091G0EVN.
PhylomeDBiQ9UK28.
TreeFamiTF331226.

Family and domain databases

InterProiIPR022065. Uncharacterised_TMEM59.
[Graphical view]
PfamiPF12280. BSMAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UK28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVALMPPP LLLLLLLASP PAASAPSARD PFAPQLGDTQ NCQLRCRDRD
60 70 80 90 100
LGPQPSQAGL EGASESPYDR AVLISACERG CRLFSICRFV ARSSKPNATQ
110 120 130 140 150
TECEAACVEA YVKEAEQQAC SHGCWSQPAE PEPEQKRKVL EAPSGALSLL
160 170 180 190 200
DLFSTLCNDL VNSAQGFVSS TWTYYLQTDN GKVVVFQTQP IVESLGFQGG
210 220 230 240 250
RLQRVEVTWR GSHPEALEVH VDPVGPLDKV RKAKIRVKTS SKAKVESEEP
260 270 280 290 300
QDNDFLSCMS RRSGLPRWIL ACCLFLSVLV MLWLSCSTLV TAPGQHLKFQ
310 320 330 340
PLTLEQHKGF MMEPDWPLYP PPSHACEDSL PPYKLKLDLT KL
Length:342
Mass (Da):37,619
Last modified:May 1, 2000 - v1
Checksum:iFB56B6B37AF62569
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186264 mRNA. Translation: AAF00529.1.
BC010446 mRNA. Translation: AAH10446.1.
CCDSiCCDS12383.1.
PIRiJC7110.
RefSeqiNP_036241.1. NM_012109.2.
UniGeneiHs.329850.

Genome annotation databases

EnsembliENST00000262817; ENSP00000262817; ENSG00000105696.
ENST00000600490; ENSP00000470879; ENSG00000105696.
GeneIDi25789.
KEGGihsa:25789.
UCSCiuc002njy.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186264 mRNA. Translation: AAF00529.1.
BC010446 mRNA. Translation: AAH10446.1.
CCDSiCCDS12383.1.
PIRiJC7110.
RefSeqiNP_036241.1. NM_012109.2.
UniGeneiHs.329850.

3D structure databases

ProteinModelPortaliQ9UK28.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117322. 11 interactions.
STRINGi9606.ENSP00000262817.

PTM databases

iPTMnetiQ9UK28.
PhosphoSiteiQ9UK28.

Polymorphism and mutation databases

BioMutaiTMEM59L.
DMDMi18203502.

Proteomic databases

EPDiQ9UK28.
PaxDbiQ9UK28.
PeptideAtlasiQ9UK28.
PRIDEiQ9UK28.

Protocols and materials databases

DNASUi25789.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262817; ENSP00000262817; ENSG00000105696.
ENST00000600490; ENSP00000470879; ENSG00000105696.
GeneIDi25789.
KEGGihsa:25789.
UCSCiuc002njy.5. human.

Organism-specific databases

CTDi25789.
GeneCardsiTMEM59L.
HGNCiHGNC:13237. TMEM59L.
HPAiHPA010661.
HPA070701.
neXtProtiNX_Q9UK28.
PharmGKBiPA162406615.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF0S. Eukaryota.
ENOG410Y2GG. LUCA.
GeneTreeiENSGT00390000008279.
HOGENOMiHOG000015759.
HOVERGENiHBG018206.
InParanoidiQ9UK28.
OMAiTECEAAC.
OrthoDBiEOG091G0EVN.
PhylomeDBiQ9UK28.
TreeFamiTF331226.

Miscellaneous databases

ChiTaRSiTMEM59L. human.
GenomeRNAii25789.
PROiQ9UK28.

Gene expression databases

BgeeiENSG00000105696.
CleanExiHS_TMEM59L.
ExpressionAtlasiQ9UK28. baseline and differential.
GenevisibleiQ9UK28. HS.

Family and domain databases

InterProiIPR022065. Uncharacterised_TMEM59.
[Graphical view]
PfamiPF12280. BSMAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM59L_HUMAN
AccessioniPrimary (citable) accession number: Q9UK28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.