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Protein

F-box only protein 2

Gene

FBXO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei173Important for carbohydrate bindingBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116661-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 2
Gene namesi
Name:FBXO2
Synonyms:FBX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:13581. FBXO2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: ParkinsonsUK-UCL
  • cytosol Source: UniProtKB
  • dendritic spine Source: Ensembl
  • endoplasmic reticulum Source: UniProtKB-KW
  • extracellular exosome Source: UniProtKB
  • organelle membrane Source: UniProtKB-SubCell
  • SCF ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000116661.
PharmGKBiPA31895.

Polymorphism and mutation databases

BioMutaiFBXO2.
DMDMi51338836.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198751 – 296F-box only protein 2Add BLAST296

Proteomic databases

EPDiQ9UK22.
MaxQBiQ9UK22.
PaxDbiQ9UK22.
PeptideAtlasiQ9UK22.
PRIDEiQ9UK22.

PTM databases

PhosphoSitePlusiQ9UK22.

Expressioni

Gene expression databases

BgeeiENSG00000116661.
CleanExiHS_FBXO2.
ExpressionAtlasiQ9UK22. baseline and differential.
GenevisibleiQ9UK22. HS.

Organism-specific databases

HPAiHPA005472.

Interactioni

Subunit structurei

Component of the SCF(FBXO2) complex consisting of CUL1, RBX1, SKP1 and FBXO2. Predominantly detected as heterodimer with SKP1; the heterodimer with SKP1 is not part of the SCF(FBXO2) complex (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SKP1P6320810EBI-4287196,EBI-307486

Protein-protein interaction databases

BioGridi117623. 43 interactors.
IntActiQ9UK22. 2 interactors.
MINTiMINT-5001615.
STRINGi9606.ENSP00000346240.

Structurei

3D structure databases

ProteinModelPortaliQ9UK22.
SMRiQ9UK22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 91F-boxPROSITE-ProRule annotationAdd BLAST48
Domaini113 – 296FBAPROSITE-ProRule annotationAdd BLAST184

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni210 – 212Carbohydrate bindingBy similarity3
Regioni278 – 279Carbohydrate bindingBy similarity2

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 1 FBA (F-box associated) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IK6V. Eukaryota.
ENOG4111MF5. LUCA.
GeneTreeiENSGT00390000003865.
HOGENOMiHOG000231084.
HOVERGENiHBG003593.
InParanoidiQ9UK22.
KOiK10099.
OMAiEFNSGQV.
OrthoDBiEOG091G0G3L.
PhylomeDBiQ9UK22.
TreeFamiTF320527.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR007397. F-box-assoc_dom.
IPR001810. F-box_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF04300. FBA. 1 hit.
[Graphical view]
SMARTiSM01198. FBA. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS51114. FBA. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UK22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGDGDPESV GQPEEASPEE QPEEASAEEE RPEDQQEEEA AAAAAYLDEL
60 70 80 90 100
PEPLLLRVLA ALPAAELVQA CRLVCLRWKE LVDGAPLWLL KCQQEGLVPE
110 120 130 140 150
GGVEEERDHW QQFYFLSKRR RNLLRNPCGE EDLEGWCDVE HGGDGWRVEE
160 170 180 190 200
LPGDSGVEFT HDESVKKYFA SSFEWCRKAQ VIDLQAEGYW EELLDTTQPA
210 220 230 240 250
IVVKDWYSGR SDAGCLYELT VKLLSEHENV LAEFSSGQVA VPQDSDGGGW
260 270 280 290
MEISHTFTDY GPGVRFVRFE HGGQDSVYWK GWFGARVTNS SVWVEP
Length:296
Mass (Da):33,328
Last modified:August 16, 2004 - v2
Checksum:i5226F19E27D884AF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45Missing in AAF01822 (PubMed:10531037).Curated1
Sequence conflicti125R → C in CAG46907 (Ref. 2) Curated1
Sequence conflicti163E → D in CAG46907 (Ref. 2) Curated1
Sequence conflicti275D → G in AAF04515 (PubMed:10531035).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049036118K → T.1 PublicationCorresponds to variant rs9614dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187318 mRNA. Translation: AAF01822.1.
CR542110 mRNA. Translation: CAG46907.1.
AK313019 mRNA. Translation: BAG35854.1.
AL031731 Genomic DNA. Translation: CAI20209.1.
CH471130 Genomic DNA. Translation: EAW71689.1.
BC025233 mRNA. Translation: AAH25233.1.
BC096747 mRNA. Translation: AAH96747.1.
AF174594 mRNA. Translation: AAF04515.1.
CCDSiCCDS130.1.
RefSeqiNP_036300.2. NM_012168.5.
UniGeneiHs.132753.
Hs.556006.

Genome annotation databases

EnsembliENST00000354287; ENSP00000346240; ENSG00000116661.
GeneIDi26232.
KEGGihsa:26232.
UCSCiuc001asj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187318 mRNA. Translation: AAF01822.1.
CR542110 mRNA. Translation: CAG46907.1.
AK313019 mRNA. Translation: BAG35854.1.
AL031731 Genomic DNA. Translation: CAI20209.1.
CH471130 Genomic DNA. Translation: EAW71689.1.
BC025233 mRNA. Translation: AAH25233.1.
BC096747 mRNA. Translation: AAH96747.1.
AF174594 mRNA. Translation: AAF04515.1.
CCDSiCCDS130.1.
RefSeqiNP_036300.2. NM_012168.5.
UniGeneiHs.132753.
Hs.556006.

3D structure databases

ProteinModelPortaliQ9UK22.
SMRiQ9UK22.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117623. 43 interactors.
IntActiQ9UK22. 2 interactors.
MINTiMINT-5001615.
STRINGi9606.ENSP00000346240.

PTM databases

PhosphoSitePlusiQ9UK22.

Polymorphism and mutation databases

BioMutaiFBXO2.
DMDMi51338836.

Proteomic databases

EPDiQ9UK22.
MaxQBiQ9UK22.
PaxDbiQ9UK22.
PeptideAtlasiQ9UK22.
PRIDEiQ9UK22.

Protocols and materials databases

DNASUi26232.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354287; ENSP00000346240; ENSG00000116661.
GeneIDi26232.
KEGGihsa:26232.
UCSCiuc001asj.4. human.

Organism-specific databases

CTDi26232.
GeneCardsiFBXO2.
HGNCiHGNC:13581. FBXO2.
HPAiHPA005472.
MIMi607112. gene.
neXtProtiNX_Q9UK22.
OpenTargetsiENSG00000116661.
PharmGKBiPA31895.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK6V. Eukaryota.
ENOG4111MF5. LUCA.
GeneTreeiENSGT00390000003865.
HOGENOMiHOG000231084.
HOVERGENiHBG003593.
InParanoidiQ9UK22.
KOiK10099.
OMAiEFNSGQV.
OrthoDBiEOG091G0G3L.
PhylomeDBiQ9UK22.
TreeFamiTF320527.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciZFISH:ENSG00000116661-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiFBXO2. human.
GeneWikiiFBXO2.
GenomeRNAii26232.
PROiQ9UK22.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116661.
CleanExiHS_FBXO2.
ExpressionAtlasiQ9UK22. baseline and differential.
GenevisibleiQ9UK22. HS.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR007397. F-box-assoc_dom.
IPR001810. F-box_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF04300. FBA. 1 hit.
[Graphical view]
SMARTiSM01198. FBA. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS51114. FBA. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX2_HUMAN
AccessioniPrimary (citable) accession number: Q9UK22
Secondary accession number(s): B2R7K7
, Q5TGY0, Q6FGJ7, Q8TB29, Q9UKC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.