Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 221

Gene

ZNF221

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 192C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 221
Gene namesi
Name:ZNF221
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000159905.14
HGNCiHGNC:13014 ZNF221
neXtProtiNX_Q9UK13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159905
PharmGKBiPA37593

Polymorphism and mutation databases

BioMutaiZNF221
DMDMi311033541

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474621 – 617Zinc finger protein 221Add BLAST617

Proteomic databases

MaxQBiQ9UK13
PaxDbiQ9UK13
PeptideAtlasiQ9UK13
PRIDEiQ9UK13

PTM databases

iPTMnetiQ9UK13
PhosphoSitePlusiQ9UK13

Expressioni

Gene expression databases

BgeeiENSG00000159905
CleanExiHS_ZNF221

Organism-specific databases

HPAiHPA059435

Interactioni

Protein-protein interaction databases

BioGridi1134543 interactors.
IntActiQ9UK13 3 interactors.
STRINGi9606.ENSP00000251269

Structurei

3D structure databases

ProteinModelPortaliQ9UK13
SMRiQ9UK13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 100KRABPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri170 – 192C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 220C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri226 – 248C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00870000136402
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9UK13
KOiK09228
OMAiCKFPEVE
PhylomeDBiQ9UK13

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

Sequencei

Sequence statusi: Complete.

Q9UK13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISPSLELLH SGLCKFPEVE GKMTTFKEAV TFKDVAVVFT EEELGLLDPA
60 70 80 90 100
QRKLYRDVML ENFRNLLSVG NQPFHQDTFH FLGKEKFWKM KTTSQREGNS
110 120 130 140 150
GGKIQIEMET VPEAGPHEEW SCQQIWEQIA SDLTRSQNSI RNSSQFFKEG
160 170 180 190 200
DVPCQIEARL SISHVQQKPY RCNECKQSFS DVSVFDLHQQ SHSGEKSHTC
210 220 230 240 250
GECGKSFCYS PALHIHQRVH MGEKCYKCDV CGKEFNQSSH LQTHQRVHTG
260 270 280 290 300
EKPFKCGQCG KGFHSRSALN VHCKLHTGEK PYNCEECGKA FIHDSQLQEH
310 320 330 340 350
QRIHTGEKPF KCDICGKSFR VRSRLNRHSM VHTGEKPFRC DTCGKNFRQR
360 370 380 390 400
SALNSHSMVH IEEKPYKCEQ CGKGFICRRD FCKHQMVHTG EKPYNCKECG
410 420 430 440 450
KTFRWSSCLL NHQQVHSGQK SFKCEECGKG FYTNSRRSSH QRSHNGEKPY
460 470 480 490 500
NCEECGKDYK RRLDLEFHQR VHTGERPYNC KECGKSFGWA SCLLKHQRLH
510 520 530 540 550
SGEKPFKCEE CGKRFTQSSQ LHSHQTCHTG EKLYKCEQCE KGYNSKFNLD
560 570 580 590 600
MHQRVHGGER PYNCKECGKS FGWASCLLKH QRLHSGEKPL KSGVWEEIYS
610
EFTASFTSVS LCGRKAI
Length:617
Mass (Da):71,197
Last modified:March 28, 2018 - v4
Checksum:i0E27FCDEDA0EC1D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14C → Y in AAF04103 (PubMed:12743021).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033557165V → M. Corresponds to variant dbSNP:rs16976937Ensembl.1
Natural variantiVAR_033558179F → I4 PublicationsCorresponds to variant dbSNP:rs454301Ensembl.1
Natural variantiVAR_033559256C → R4 PublicationsCorresponds to variant dbSNP:rs439676Ensembl.1
Natural variantiVAR_024201337P → A. Corresponds to variant dbSNP:rs435590Ensembl.1
Natural variantiVAR_024202519S → T4 PublicationsCorresponds to variant dbSNP:rs365745Ensembl.1
Natural variantiVAR_024203557G → R4 PublicationsCorresponds to variant dbSNP:rs366111Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187987 mRNA Translation: AAF04103.1
AC035150 Genomic DNA Translation: AAF63029.1
AK314207 mRNA Translation: BAG36883.1
AC006213 Genomic DNA No translation available.
KF459580 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57237.1
BC111981 mRNA Translation: AAI11982.1
BC113426 mRNA Translation: AAI13427.1
CCDSiCCDS12633.1
RefSeqiNP_001284517.1, NM_001297588.1
NP_001284518.1, NM_001297589.1
NP_037491.2, NM_013359.2
XP_016882721.1, XM_017027232.1
UniGeneiHs.631598

Genome annotation databases

EnsembliENST00000251269; ENSP00000251269; ENSG00000159905
ENST00000587682; ENSP00000467367; ENSG00000159905
ENST00000592350; ENSP00000467446; ENSG00000159905
ENST00000622072; ENSP00000477876; ENSG00000159905
GeneIDi7638
KEGGihsa:7638

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN221_HUMAN
AccessioniPrimary (citable) accession number: Q9UK13
Secondary accession number(s): A0A087WT08
, B2RAI6, K7EIT6, Q2M2H2, Q9P1U8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 28, 2018
Last modified: April 25, 2018
This is version 149 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome