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Protein

Zinc finger protein 221

Gene

ZNF221

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri170 – 19223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri198 – 22023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri226 – 24823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri254 – 27623C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri534 – 55623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri562 – 58423C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 221
Gene namesi
Name:ZNF221
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:13014. ZNF221.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37593.

Polymorphism and mutation databases

BioMutaiZNF221.
DMDMi311033541.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Zinc finger protein 221PRO_0000047462Add
BLAST

Proteomic databases

EPDiQ9UK13.
PaxDbiQ9UK13.
PeptideAtlasiQ9UK13.
PRIDEiQ9UK13.

PTM databases

iPTMnetiQ9UK13.
PhosphoSiteiQ9UK13.

Expressioni

Gene expression databases

BgeeiQ9UK13.
CleanExiHS_ZNF221.

Organism-specific databases

HPAiHPA059435.

Interactioni

Protein-protein interaction databases

BioGridi113454. 3 interactions.
STRINGi9606.ENSP00000251269.

Structurei

3D structure databases

ProteinModelPortaliQ9UK13.
SMRiQ9UK13. Positions 29-70, 164-591.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 10071KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri170 – 19223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri198 – 22023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri226 – 24823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri254 – 27623C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri338 – 36023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri366 – 38823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri534 – 55623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri562 – 58423C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UK13.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9UK13.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UK13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISPSLELLH SGLCKFPEVE GKMTTFKEAV TFKDVAVVFT EEELGLLDPA
60 70 80 90 100
QRKLYRDVML ENFRNLLSVG NQPFHQDTFH FLGKEKFWKM KTTSQREGNS
110 120 130 140 150
GGKIQIEMET VPEAGPHEEW SCQQIWEQIA SDLTRSQNSI RNSSQFFKEG
160 170 180 190 200
DVPCQIEARL SISHVQQKPY RCNECKQSFS DVSVFDLHQQ SHSGEKSHTC
210 220 230 240 250
GECGKSFCYS PALHIHQRVH MGEKCYKCDV CGKEFNQSSH LQTHQRVHTG
260 270 280 290 300
EKPFKCGQCG KGFHSRSALN VHCKLHTGEK PYNCEECGKA FIHDSQLQEH
310 320 330 340 350
QRIHTGEKPF KCDICGKSFR VRSRLNRHSM VHTGEKAFRC DTCGKNFRQR
360 370 380 390 400
SALNSHSMVH IEEKPYKCEQ CGKGFICRRD FCKHQMVHTG EKPYNCKECG
410 420 430 440 450
KTFRWSSCLL NHQQVHSGQK SFKCEECGKG FYTNSRRSSH QRSHNGEKPY
460 470 480 490 500
NCEECGKDYK RRLDLEFHQR VHTGERPYNC KECGKSFGWA SCLLKHQRLH
510 520 530 540 550
SGEKPFKCEE CGKRFTQSSQ LHSHQTCHTG EKLYKCEQCE KGYNSKFNLD
560 570 580 590 600
MHQRVHGGER PYNCKECGKS FGWASCLLKH QRLHSGEKPL KSGVWEEIYS
610
EFTASFTSVS LCGRKAI
Length:617
Mass (Da):71,170
Last modified:November 2, 2010 - v3
Checksum:i0A73E99BD1057164
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141C → Y in AAF04103 (PubMed:12743021).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti165 – 1651V → M.
Corresponds to variant rs16976937 [ dbSNP | Ensembl ].
VAR_033557
Natural varianti179 – 1791F → I.4 Publications
Corresponds to variant rs454301 [ dbSNP | Ensembl ].
VAR_033558
Natural varianti256 – 2561C → R.4 Publications
Corresponds to variant rs439676 [ dbSNP | Ensembl ].
VAR_033559
Natural varianti337 – 3371A → P.4 Publications
Corresponds to variant rs435590 [ dbSNP | Ensembl ].
VAR_024201
Natural varianti519 – 5191S → T.4 Publications
Corresponds to variant rs365745 [ dbSNP | Ensembl ].
VAR_024202
Natural varianti557 – 5571G → R.4 Publications
Corresponds to variant rs366111 [ dbSNP | Ensembl ].
VAR_024203

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187987 mRNA. Translation: AAF04103.1.
AC035150 Genomic DNA. Translation: AAF63029.1.
AK314207 mRNA. Translation: BAG36883.1.
AC006213 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57237.1.
BC111981 mRNA. Translation: AAI11982.1.
BC113426 mRNA. Translation: AAI13427.1.
CCDSiCCDS12633.1.
RefSeqiNP_001284517.1. NM_001297588.1.
NP_037491.2. NM_013359.2.
UniGeneiHs.631598.

Genome annotation databases

GeneIDi7638.
KEGGihsa:7638.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187987 mRNA. Translation: AAF04103.1.
AC035150 Genomic DNA. Translation: AAF63029.1.
AK314207 mRNA. Translation: BAG36883.1.
AC006213 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57237.1.
BC111981 mRNA. Translation: AAI11982.1.
BC113426 mRNA. Translation: AAI13427.1.
CCDSiCCDS12633.1.
RefSeqiNP_001284517.1. NM_001297588.1.
NP_037491.2. NM_013359.2.
UniGeneiHs.631598.

3D structure databases

ProteinModelPortaliQ9UK13.
SMRiQ9UK13. Positions 29-70, 164-591.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113454. 3 interactions.
STRINGi9606.ENSP00000251269.

PTM databases

iPTMnetiQ9UK13.
PhosphoSiteiQ9UK13.

Polymorphism and mutation databases

BioMutaiZNF221.
DMDMi311033541.

Proteomic databases

EPDiQ9UK13.
PaxDbiQ9UK13.
PeptideAtlasiQ9UK13.
PRIDEiQ9UK13.

Protocols and materials databases

DNASUi7638.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7638.
KEGGihsa:7638.

Organism-specific databases

CTDi7638.
GeneCardsiZNF221.
HGNCiHGNC:13014. ZNF221.
HPAiHPA059435.
neXtProtiNX_Q9UK13.
PharmGKBiPA37593.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UK13.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9UK13.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii7638.
PROiQ9UK13.

Gene expression databases

BgeeiQ9UK13.
CleanExiHS_ZNF221.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters."
    Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.
    Genome Res. 13:1097-1110(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ILE-179; ARG-256; PRO-337; THR-519 AND ARG-557.
  2. "Sequence analysis of a 1Mb region in 19q13.2 containing a zinc finger gene cluster."
    Kodoyianni V., Ge Y., Krummel G.K., Kvikstad E., Grable L., Severin J., Gordon L., Shannon M., Brower A., Olsen A.S., Smith L.M.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-179; ARG-256; PRO-337; THR-519 AND ARG-557.
    Tissue: Testis.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ILE-179; ARG-256; PRO-337; THR-519 AND ARG-557.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-179; ARG-256; PRO-337; THR-519 AND ARG-557.
    Tissue: Brain.

Entry informationi

Entry nameiZN221_HUMAN
AccessioniPrimary (citable) accession number: Q9UK13
Secondary accession number(s): B2RAI6, Q2M2H2, Q9P1U8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 2, 2010
Last modified: July 6, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.