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Protein

Zinc finger protein 223

Gene

ZNF223

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000142048-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 223
Gene namesi
Name:ZNF223
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13016. ZNF223.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7766.
OpenTargetsiENSG00000178386.
PharmGKBiPA37595.

Polymorphism and mutation databases

BioMutaiZNF223.
DMDMi311033504.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474641 – 482Zinc finger protein 223Add BLAST482

Proteomic databases

EPDiQ9UK11.
PaxDbiQ9UK11.
PeptideAtlasiQ9UK11.
PRIDEiQ9UK11.

PTM databases

iPTMnetiQ9UK11.
PhosphoSitePlusiQ9UK11.

Expressioni

Gene expression databases

BgeeiENSG00000178386.
ExpressionAtlasiQ9UK11. baseline and differential.
GenevisibleiQ9UK11. HS.

Organism-specific databases

HPAiHPA067823.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-10322867,EBI-10172290
MDFIQ997503EBI-10322867,EBI-724076
ZC4H2Q9NQZ63EBI-10322867,EBI-747993

Protein-protein interaction databases

BioGridi113549. 23 interactors.
IntActiQ9UK11. 3 interactors.
STRINGi9606.ENSP00000467018.

Structurei

3D structure databases

ProteinModelPortaliQ9UK11.
SMRiQ9UK11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 78KRABPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UK11.
KOiK09228.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9UK11.
TreeFamiTF341885.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UK11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMSKEAVTF KDVAVVFTEE ELGLLDLAQR KLYRDVMLEN FRNLLSVGHQ
60 70 80 90 100
PFHRDTFHFL REEKFWMMDI ATQREGNSGG KIQPEMKTFP EAGPHEGWSC
110 120 130 140 150
QQIWEEIASD LTRPQDSTIK SSQFFEQGDA HSQVEEGLSI MHTGQKPSNC
160 170 180 190 200
GKCKQSFSDM SIFDLPQQIR SAEKSHSCDE CGKSFCYISA LHIHQRVHLG
210 220 230 240 250
EKLFKCDVCG KEFSQSLHLQ THQRVHTGEK PFKCEQCGRG FRCRSALTVH
260 270 280 290 300
CKLHMGEKHY NCEACGRAFI HDFQLQKHQR IHTGEKPFKC EICSVSFRLR
310 320 330 340 350
SSLNRHCVVH TGKKPNSTGE YGKGFIRRLD LCKHQTIHTG EKPYNCKECG
360 370 380 390 400
KSFRRSSYLL IHQRVHTGEK PYKCDKCGKS YITKSGLDLH HRAHTGERPY
410 420 430 440 450
NCDDCGKSFR QASSILNHKR LHCRKKPFKC EDCGKKLVYR SYRKDQQKNH
460 470 480
SGENPSKCED CGKRYKRRLN LDIILSLFLN DT
Length:482
Mass (Da):55,763
Last modified:November 2, 2010 - v2
Checksum:i2543E98D86F55E51
GO

Sequence cautioni

The sequence AAB03531 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25L → M in AAF04105 (PubMed:12743021).Curated1
Sequence conflicti153C → S in AAF04105 (PubMed:12743021).Curated1
Sequence conflicti294 – 295SV → GK in AAF04105 (PubMed:12743021).Curated2
Sequence conflicti298R → C in AAF04105 (PubMed:12743021).Curated1
Sequence conflicti308V → M in AAF04105 (PubMed:12743021).Curated1
Sequence conflicti312 – 323GKKPN…GEYGK → AEKLYKSEKYGR in AAF04105 (PubMed:12743021).CuratedAdd BLAST12
Sequence conflicti327R → D in AAF04105 (PubMed:12743021).Curated1
Sequence conflicti332C → H in AAF04105 (PubMed:12743021).Curated1
Sequence conflicti336T → M in AAF04105 (PubMed:12743021).Curated1
Sequence conflicti339 – 341TGE → MGQ in AAF04105 (PubMed:12743021).Curated3
Sequence conflicti354 – 355RR → KW in AAF04105 (PubMed:12743021).Curated2
Sequence conflicti361I → V in AAF04105 (PubMed:12743021).Curated1
Sequence conflicti375 – 376DK → EE in AAF04105 (PubMed:12743021).Curated2
Sequence conflicti380S → G in AAF04105 (PubMed:12743021).Curated1
Sequence conflicti383T → S in AAF04105 (PubMed:12743021).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06042460L → I.Corresponds to variant rs4130101dbSNPEnsembl.1
Natural variantiVAR_060425138L → I.3 PublicationsCorresponds to variant rs6509138dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187989 mRNA. Translation: AAF04105.1.
AK292327 mRNA. Translation: BAF85016.1.
AC092072 Genomic DNA. No translation available.
BC022466 mRNA. Translation: AAH22466.1.
U46189 Genomic DNA. Translation: AAB03531.1. Sequence problems.
AC084219 Genomic DNA. Translation: AAG23844.1.
CCDSiCCDS12635.1.
RefSeqiNP_037493.3. NM_013361.5.
XP_016882747.1. XM_017027258.1.
XP_016882748.1. XM_017027259.1.
UniGeneiHs.720813.

Genome annotation databases

EnsembliENST00000434772; ENSP00000401947; ENSG00000178386.
GeneIDi7766.
KEGGihsa:7766.
UCSCiuc002oyf.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187989 mRNA. Translation: AAF04105.1.
AK292327 mRNA. Translation: BAF85016.1.
AC092072 Genomic DNA. No translation available.
BC022466 mRNA. Translation: AAH22466.1.
U46189 Genomic DNA. Translation: AAB03531.1. Sequence problems.
AC084219 Genomic DNA. Translation: AAG23844.1.
CCDSiCCDS12635.1.
RefSeqiNP_037493.3. NM_013361.5.
XP_016882747.1. XM_017027258.1.
XP_016882748.1. XM_017027259.1.
UniGeneiHs.720813.

3D structure databases

ProteinModelPortaliQ9UK11.
SMRiQ9UK11.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113549. 23 interactors.
IntActiQ9UK11. 3 interactors.
STRINGi9606.ENSP00000467018.

PTM databases

iPTMnetiQ9UK11.
PhosphoSitePlusiQ9UK11.

Polymorphism and mutation databases

BioMutaiZNF223.
DMDMi311033504.

Proteomic databases

EPDiQ9UK11.
PaxDbiQ9UK11.
PeptideAtlasiQ9UK11.
PRIDEiQ9UK11.

Protocols and materials databases

DNASUi7766.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000434772; ENSP00000401947; ENSG00000178386.
GeneIDi7766.
KEGGihsa:7766.
UCSCiuc002oyf.2. human.

Organism-specific databases

CTDi7766.
DisGeNETi7766.
GeneCardsiZNF223.
HGNCiHGNC:13016. ZNF223.
HPAiHPA067823.
neXtProtiNX_Q9UK11.
OpenTargetsiENSG00000178386.
PharmGKBiPA37595.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UK11.
KOiK09228.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9UK11.
TreeFamiTF341885.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000142048-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF223. human.
GenomeRNAii7766.
PROiQ9UK11.

Gene expression databases

BgeeiENSG00000178386.
ExpressionAtlasiQ9UK11. baseline and differential.
GenevisibleiQ9UK11. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN223_HUMAN
AccessioniPrimary (citable) accession number: Q9UK11
Secondary accession number(s): Q15736, Q8TBJ3, Q9HCA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.