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Q9UK10

- ZN225_HUMAN

UniProt

Q9UK10 - ZN225_HUMAN

Protein

Zinc finger protein 225

Gene

ZNF225

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri176 – 19823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri204 – 22623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri232 – 25423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri260 – 28223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri288 – 31023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri316 – 33823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri344 – 36623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri372 – 39423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri400 – 42223C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri428 – 45023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri456 – 47823C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri484 – 50623C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri512 – 53423C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri540 – 56223C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri568 – 59023C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri596 – 61823C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri624 – 64623C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri652 – 67423C2H2-type 18; degeneratePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 225
    Gene namesi
    Name:ZNF225
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:13018. ZNF225.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37597.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 706706Zinc finger protein 225PRO_0000047466Add
    BLAST

    Proteomic databases

    PRIDEiQ9UK10.

    PTM databases

    PhosphoSiteiQ9UK10.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UK10.
    BgeeiQ9UK10.
    CleanExiHS_ZNF225.
    GenevestigatoriQ9UK10.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000262894.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UK10.
    SMRiQ9UK10. Positions 7-49, 145-697.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 7871KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 18 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri176 – 19823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri204 – 22623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri232 – 25423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri260 – 28223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri288 – 31023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri316 – 33823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri344 – 36623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri372 – 39423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri400 – 42223C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri428 – 45023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri456 – 47823C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri484 – 50623C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri512 – 53423C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri540 – 56223C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri568 – 59023C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri596 – 61823C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri624 – 64623C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri652 – 67423C2H2-type 18; degeneratePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ9UK10.
    KOiK09228.
    OMAiMREKPFR.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ9UK10.
    TreeFamiTF341885.

    Family and domain databases

    Gene3Di3.30.160.60. 17 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 17 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 17 hits.
    PS50157. ZINC_FINGER_C2H2_2. 18 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UK10-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTLKEAVTF KDVAVVFTEE ELRLLDLAQR KLYREVMLEN FRNLLSVGHQ    50
    SLHRDTFHFL KEEKFWMMET ATQREGNLGG KIQMEMETVS ESGTHEGLFS 100
    HQTWEQISSD LTRFQDSMVN SFQFSKQDDM PCQVDAGLSI IHVRQKPSEG 150
    RTCKKSFSDV SVLDLHQQLQ SREKSHTCDE CGKSFCYSSA LRIHQRVHMG 200
    EKLYNCDVCG KEFNQSSHLQ IHQRIHTGEK PFKCEQCGKG FSRRSGLYVH 250
    RKLHTGVKPH ICEKCGKAFI HDSQLQEHQR IHTGEKPFKC DICCKSFRSR 300
    ANLNRHSMVH MREKPFRCDT CGKSFGLKSA LNSHRMVHTG EKRYKCEECG 350
    KRFIYRQDLY KHQIDHTGEK PYNCKECGKS FRWASGLSRH VRVHSGETTF 400
    KCEECGKGFY TNSQRYSHQR AHSGEKPYRC EECGKGYKRR LDLDFHQRVH 450
    RGEKPYNCKE CGKSFGWASC LLNHQRIHSG EKPFKCEECG KRFTQNSQLY 500
    THRRVHSGEK PFKCEECGKR FTQNSQLYSH RRVHTGVKPY KCEECGKGFN 550
    SKFNLDMHQR VHTGERPYNC KECGKSFSRA SSILNHKRLH GDEKPFKCEE 600
    CGKRFTENSQ LHSHQRVHTG EKPYKCEKCG KSFRWASTHL THQRLHSREK 650
    LLQCEDCGKS IVHSSCLKDQ QRDQSGEKTS KCEDCGKRYK RRLNLDTLLS 700
    LFLNDT 706
    Length:706
    Mass (Da):82,471
    Last modified:July 25, 2006 - v2
    Checksum:i4C357A3AB1E32FB2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti144 – 1474RQKP → KTET in AAF04107. (PubMed:12743021)Curated
    Sequence conflicti219 – 2191L → Q in AAF04107. (PubMed:12743021)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501Q → R.
    Corresponds to variant rs34863330 [ dbSNP | Ensembl ].
    VAR_033560
    Natural varianti679 – 6791T → S.
    Corresponds to variant rs16978738 [ dbSNP | Ensembl ].
    VAR_033561

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF187991 mRNA. Translation: AAF04107.1.
    AK223477 mRNA. Translation: BAD97197.1.
    AK292437 mRNA. Translation: BAF85126.1.
    AC021092 Genomic DNA. Translation: AAF24967.1.
    AC074331 Genomic DNA. Translation: AAF88105.1.
    CH471126 Genomic DNA. Translation: EAW57255.1.
    BC108912 mRNA. Translation: AAI08913.1.
    CCDSiCCDS46100.1.
    RefSeqiNP_037494.2. NM_013362.2.
    XP_005259279.1. XM_005259222.1.
    UniGeneiHs.279567.

    Genome annotation databases

    EnsembliENST00000262894; ENSP00000262894; ENSG00000256294.
    ENST00000590612; ENSP00000468686; ENSG00000256294.
    GeneIDi7768.
    KEGGihsa:7768.
    UCSCiuc002oyj.1. human.

    Polymorphism databases

    DMDMi110825755.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF187991 mRNA. Translation: AAF04107.1 .
    AK223477 mRNA. Translation: BAD97197.1 .
    AK292437 mRNA. Translation: BAF85126.1 .
    AC021092 Genomic DNA. Translation: AAF24967.1 .
    AC074331 Genomic DNA. Translation: AAF88105.1 .
    CH471126 Genomic DNA. Translation: EAW57255.1 .
    BC108912 mRNA. Translation: AAI08913.1 .
    CCDSi CCDS46100.1.
    RefSeqi NP_037494.2. NM_013362.2.
    XP_005259279.1. XM_005259222.1.
    UniGenei Hs.279567.

    3D structure databases

    ProteinModelPortali Q9UK10.
    SMRi Q9UK10. Positions 7-49, 145-697.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000262894.

    PTM databases

    PhosphoSitei Q9UK10.

    Polymorphism databases

    DMDMi 110825755.

    Proteomic databases

    PRIDEi Q9UK10.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262894 ; ENSP00000262894 ; ENSG00000256294 .
    ENST00000590612 ; ENSP00000468686 ; ENSG00000256294 .
    GeneIDi 7768.
    KEGGi hsa:7768.
    UCSCi uc002oyj.1. human.

    Organism-specific databases

    CTDi 7768.
    GeneCardsi GC19P044617.
    HGNCi HGNC:13018. ZNF225.
    neXtProti NX_Q9UK10.
    PharmGKBi PA37597.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q9UK10.
    KOi K09228.
    OMAi MREKPFR.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q9UK10.
    TreeFami TF341885.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GeneWikii ZNF225.
    GenomeRNAii 7768.
    NextBioi 30071.
    PROi Q9UK10.

    Gene expression databases

    ArrayExpressi Q9UK10.
    Bgeei Q9UK10.
    CleanExi HS_ZNF225.
    Genevestigatori Q9UK10.

    Family and domain databases

    Gene3Di 3.30.160.60. 17 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 17 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 17 hits.
    PS50157. ZINC_FINGER_C2H2_2. 18 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters."
      Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.
      Genome Res. 13:1097-1110(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Synovial cell.
    4. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiZN225_HUMAN
    AccessioniPrimary (citable) accession number: Q9UK10
    Secondary accession number(s): A8K8S2
    , Q53F12, Q9NS46, Q9UID8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3