Q9UK10 (ZN225_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 225

Gene names

Name:

ZNF225

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	706 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 18 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 706	706	Zinc finger protein 225		PRO_0000047466
Regions
	Domain	8 – 78	71	KRAB
	Zinc finger	176 – 198	23	C2H2-type 1
	Zinc finger	204 – 226	23	C2H2-type 2
	Zinc finger	232 – 254	23	C2H2-type 3
	Zinc finger	260 – 282	23	C2H2-type 4
	Zinc finger	288 – 310	23	C2H2-type 5
	Zinc finger	316 – 338	23	C2H2-type 6
	Zinc finger	344 – 366	23	C2H2-type 7
	Zinc finger	372 – 394	23	C2H2-type 8
	Zinc finger	400 – 422	23	C2H2-type 9
	Zinc finger	428 – 450	23	C2H2-type 10
	Zinc finger	456 – 478	23	C2H2-type 11
	Zinc finger	484 – 506	23	C2H2-type 12
	Zinc finger	512 – 534	23	C2H2-type 13
	Zinc finger	540 – 562	23	C2H2-type 14
	Zinc finger	568 – 590	23	C2H2-type 15
	Zinc finger	596 – 618	23	C2H2-type 16
	Zinc finger	624 – 646	23	C2H2-type 17
	Zinc finger	652 – 674	23	C2H2-type 18; degenerate
Natural variations
	Natural variant	50	1	Q → R. Corresponds to variant rs34863330 [ dbSNP | Ensembl ].		VAR_033560
	Natural variant	679	1	T → S. Corresponds to variant rs16978738 [ dbSNP | Ensembl ].		VAR_033561
Experimental info
	Sequence conflict	144 – 147	4	RQKP → KTET in AAF04107. Ref.1
	Sequence conflict	219	1	L → Q in AAF04107. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9UK10 [UniParc]. Last modified July 25, 2006. Version 2. Checksum: 4C357A3AB1E32FB2	FASTA	706	82,471
	10 20 30 40 50 60 MTTLKEAVTF KDVAVVFTEE ELRLLDLAQR KLYREVMLEN FRNLLSVGHQ SLHRDTFHFL 70 80 90 100 110 120 KEEKFWMMET ATQREGNLGG KIQMEMETVS ESGTHEGLFS HQTWEQISSD LTRFQDSMVN 130 140 150 160 170 180 SFQFSKQDDM PCQVDAGLSI IHVRQKPSEG RTCKKSFSDV SVLDLHQQLQ SREKSHTCDE 190 200 210 220 230 240 CGKSFCYSSA LRIHQRVHMG EKLYNCDVCG KEFNQSSHLQ IHQRIHTGEK PFKCEQCGKG 250 260 270 280 290 300 FSRRSGLYVH RKLHTGVKPH ICEKCGKAFI HDSQLQEHQR IHTGEKPFKC DICCKSFRSR 310 320 330 340 350 360 ANLNRHSMVH MREKPFRCDT CGKSFGLKSA LNSHRMVHTG EKRYKCEECG KRFIYRQDLY 370 380 390 400 410 420 KHQIDHTGEK PYNCKECGKS FRWASGLSRH VRVHSGETTF KCEECGKGFY TNSQRYSHQR 430 440 450 460 470 480 AHSGEKPYRC EECGKGYKRR LDLDFHQRVH RGEKPYNCKE CGKSFGWASC LLNHQRIHSG 490 500 510 520 530 540 EKPFKCEECG KRFTQNSQLY THRRVHSGEK PFKCEECGKR FTQNSQLYSH RRVHTGVKPY 550 560 570 580 590 600 KCEECGKGFN SKFNLDMHQR VHTGERPYNC KECGKSFSRA SSILNHKRLH GDEKPFKCEE 610 620 630 640 650 660 CGKRFTENSQ LHSHQRVHTG EKPYKCEKCG KSFRWASTHL THQRLHSREK LLQCEDCGKS 670 680 690 700 IVHSSCLKDQ QRDQSGEKTS KCEDCGKRYK RRLNLDTLLS LFLNDT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters." Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L. Genome Res. 13:1097-1110(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Synovial cell.
[4]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF187991 mRNA. Translation: AAF04107.1. AK223477 mRNA. Translation: BAD97197.1. AK292437 mRNA. Translation: BAF85126.1. AC021092 Genomic DNA. Translation: AAF24967.1. AC074331 Genomic DNA. Translation: AAF88105.1. CH471126 Genomic DNA. Translation: EAW57255.1. BC108912 mRNA. Translation: AAI08913.1.
IPI	IPI00007035.
RefSeq	NP_037494.2. NM_013362.2.
UniGene	Hs.279567.
3D structure databases
ProteinModelPortal	Q9UK10.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000262894.
PTM databases
PhosphoSite	Q9UK10.
Polymorphism databases
DMDM	110825755.
Proteomic databases
PRIDE	Q9UK10.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262894; ENSP00000262894; ENSG00000256294. ENST00000590612; ENSP00000468686; ENSG00000256294.
GeneID	7768.
KEGG	hsa:7768.
UCSC	uc002oyj.1. human.
Organism-specific databases
CTD	7768.
GeneCards	GC19P044617.
HGNC	HGNC:13018. ZNF225.
neXtProt	NX_Q9UK10.
PharmGKB	PA37597.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q9UK10.
KO	K09228.
OMA	LKEEKFW.
PhylomeDB	Q9UK10.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q9UK10.
Bgee	Q9UK10.
CleanEx	HS_ZNF225.
Genevestigator	Q9UK10.
GermOnline	ENSG00000159904. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 17 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 17 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 17 hits. PS50157. ZINC_FINGER_C2H2_2. 18 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7768.
NextBio	30071.

Entry information

Entry name

ZN225_HUMAN

Accession

Primary (citable) accession number: Q9UK10
Secondary accession number(s): A8K8S2 , Q53F12, Q9NS46, Q9UID8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	July 25, 2006
Last modified:	May 1, 2013
This is version 115 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.