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Protein

Zinc finger protein 225

Gene

ZNF225

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri624 – 646C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 18; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159904-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 225
Gene namesi
Name:ZNF225
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13018. ZNF225.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000256294.
PharmGKBiPA37597.

Polymorphism and mutation databases

BioMutaiZNF225.
DMDMi110825755.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474661 – 706Zinc finger protein 225Add BLAST706

Proteomic databases

EPDiQ9UK10.
PaxDbiQ9UK10.
PeptideAtlasiQ9UK10.
PRIDEiQ9UK10.

PTM databases

iPTMnetiQ9UK10.
PhosphoSitePlusiQ9UK10.

Expressioni

Gene expression databases

BgeeiENSG00000256294.
CleanExiHS_ZNF225.
ExpressionAtlasiQ9UK10. baseline and differential.
GenevisibleiQ9UK10. HS.

Organism-specific databases

HPAiHPA073778.

Interactioni

Protein-protein interaction databases

BioGridi113551. 1 interactor.
STRINGi9606.ENSP00000262894.

Structurei

3D structure databases

ProteinModelPortaliQ9UK10.
SMRiQ9UK10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 78KRABPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Contains 18 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 198C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri624 – 646C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 18; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UK10.
KOiK09228.
OMAiSEGRKCK.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9UK10.
TreeFamiTF341885.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UK10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTLKEAVTF KDVAVVFTEE ELRLLDLAQR KLYREVMLEN FRNLLSVGHQ
60 70 80 90 100
SLHRDTFHFL KEEKFWMMET ATQREGNLGG KIQMEMETVS ESGTHEGLFS
110 120 130 140 150
HQTWEQISSD LTRFQDSMVN SFQFSKQDDM PCQVDAGLSI IHVRQKPSEG
160 170 180 190 200
RTCKKSFSDV SVLDLHQQLQ SREKSHTCDE CGKSFCYSSA LRIHQRVHMG
210 220 230 240 250
EKLYNCDVCG KEFNQSSHLQ IHQRIHTGEK PFKCEQCGKG FSRRSGLYVH
260 270 280 290 300
RKLHTGVKPH ICEKCGKAFI HDSQLQEHQR IHTGEKPFKC DICCKSFRSR
310 320 330 340 350
ANLNRHSMVH MREKPFRCDT CGKSFGLKSA LNSHRMVHTG EKRYKCEECG
360 370 380 390 400
KRFIYRQDLY KHQIDHTGEK PYNCKECGKS FRWASGLSRH VRVHSGETTF
410 420 430 440 450
KCEECGKGFY TNSQRYSHQR AHSGEKPYRC EECGKGYKRR LDLDFHQRVH
460 470 480 490 500
RGEKPYNCKE CGKSFGWASC LLNHQRIHSG EKPFKCEECG KRFTQNSQLY
510 520 530 540 550
THRRVHSGEK PFKCEECGKR FTQNSQLYSH RRVHTGVKPY KCEECGKGFN
560 570 580 590 600
SKFNLDMHQR VHTGERPYNC KECGKSFSRA SSILNHKRLH GDEKPFKCEE
610 620 630 640 650
CGKRFTENSQ LHSHQRVHTG EKPYKCEKCG KSFRWASTHL THQRLHSREK
660 670 680 690 700
LLQCEDCGKS IVHSSCLKDQ QRDQSGEKTS KCEDCGKRYK RRLNLDTLLS

LFLNDT
Length:706
Mass (Da):82,471
Last modified:July 25, 2006 - v2
Checksum:i4C357A3AB1E32FB2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144 – 147RQKP → KTET in AAF04107 (PubMed:12743021).Curated4
Sequence conflicti219L → Q in AAF04107 (PubMed:12743021).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03356050Q → R.Corresponds to variant rs34863330dbSNPEnsembl.1
Natural variantiVAR_033561679T → S.Corresponds to variant rs16978738dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187991 mRNA. Translation: AAF04107.1.
AK223477 mRNA. Translation: BAD97197.1.
AK292437 mRNA. Translation: BAF85126.1.
AC021092 Genomic DNA. Translation: AAF24967.1.
AC074331 Genomic DNA. Translation: AAF88105.1.
CH471126 Genomic DNA. Translation: EAW57255.1.
BC108912 mRNA. Translation: AAI08913.1.
CCDSiCCDS46100.1.
RefSeqiNP_001308614.1. NM_001321685.1.
NP_037494.2. NM_013362.3.
XP_011525587.1. XM_011527285.2.
XP_011525588.1. XM_011527286.2.
UniGeneiHs.279567.
Hs.709835.

Genome annotation databases

EnsembliENST00000262894; ENSP00000262894; ENSG00000256294.
ENST00000590612; ENSP00000468686; ENSG00000256294.
GeneIDi7768.
KEGGihsa:7768.
UCSCiuc002oyj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187991 mRNA. Translation: AAF04107.1.
AK223477 mRNA. Translation: BAD97197.1.
AK292437 mRNA. Translation: BAF85126.1.
AC021092 Genomic DNA. Translation: AAF24967.1.
AC074331 Genomic DNA. Translation: AAF88105.1.
CH471126 Genomic DNA. Translation: EAW57255.1.
BC108912 mRNA. Translation: AAI08913.1.
CCDSiCCDS46100.1.
RefSeqiNP_001308614.1. NM_001321685.1.
NP_037494.2. NM_013362.3.
XP_011525587.1. XM_011527285.2.
XP_011525588.1. XM_011527286.2.
UniGeneiHs.279567.
Hs.709835.

3D structure databases

ProteinModelPortaliQ9UK10.
SMRiQ9UK10.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113551. 1 interactor.
STRINGi9606.ENSP00000262894.

PTM databases

iPTMnetiQ9UK10.
PhosphoSitePlusiQ9UK10.

Polymorphism and mutation databases

BioMutaiZNF225.
DMDMi110825755.

Proteomic databases

EPDiQ9UK10.
PaxDbiQ9UK10.
PeptideAtlasiQ9UK10.
PRIDEiQ9UK10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262894; ENSP00000262894; ENSG00000256294.
ENST00000590612; ENSP00000468686; ENSG00000256294.
GeneIDi7768.
KEGGihsa:7768.
UCSCiuc002oyj.2. human.

Organism-specific databases

CTDi7768.
GeneCardsiZNF225.
HGNCiHGNC:13018. ZNF225.
HPAiHPA073778.
neXtProtiNX_Q9UK10.
OpenTargetsiENSG00000256294.
PharmGKBiPA37597.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UK10.
KOiK09228.
OMAiSEGRKCK.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9UK10.
TreeFamiTF341885.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159904-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GeneWikiiZNF225.
GenomeRNAii7768.
PROiQ9UK10.

Gene expression databases

BgeeiENSG00000256294.
CleanExiHS_ZNF225.
ExpressionAtlasiQ9UK10. baseline and differential.
GenevisibleiQ9UK10. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN225_HUMAN
AccessioniPrimary (citable) accession number: Q9UK10
Secondary accession number(s): A8K8S2
, Q53F12, Q9NS46, Q9UID8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 25, 2006
Last modified: November 30, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.