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Q9UK08

- GBG8_HUMAN

UniProt

Q9UK08 - GBG8_HUMAN

Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

Gene

GNG8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB
    2. protein binding Source: IntAct
    3. signal transducer activity Source: UniProtKB

    GO - Biological processi

    1. cellular response to glucagon stimulus Source: Reactome
    2. energy reserve metabolic process Source: Reactome
    3. G-protein coupled receptor signaling pathway Source: UniProtKB
    4. GTP catabolic process Source: GOC
    5. nervous system development Source: Ensembl
    6. small molecule metabolic process Source: Reactome
    7. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Transducer

    Enzyme and pathway databases

    ReactomeiREACT_15457. G-protein activation.
    REACT_1665. Glucagon signaling in metabolic regulation.
    REACT_172761. Ca2+ pathway.
    REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_18283. G alpha (q) signalling events.
    REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
    REACT_18377. Glucagon-type ligand receptors.
    REACT_18407. G alpha (12/13) signalling events.
    REACT_19140. ADP signalling through P2Y purinoceptor 1.
    REACT_19145. G beta:gamma signalling through PLC beta.
    REACT_19231. G alpha (i) signalling events.
    REACT_19290. G beta:gamma signalling through PI3Kgamma.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_20647. Thromboxane signalling through TP receptor.
    REACT_20653. ADP signalling through P2Y purinoceptor 12.
    REACT_21254. Presynaptic function of Kainate receptors.
    REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
    REACT_23946. Prostacyclin signalling through prostacyclin receptor.
    REACT_24023. Regulation of water balance by renal Aquaporins.
    REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
    REACT_75831. Activation of G protein gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
    Alternative name(s):
    Gamma-9
    Gene namesi
    Name:GNG8
    Synonyms:GNG9, GNGT9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:19664. GNG8.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. heterotrimeric G-protein complex Source: InterPro
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134921496.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6767Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8PRO_0000012649Add
    BLAST
    Propeptidei68 – 703Removed in mature formBy similarityPRO_0000012650

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei67 – 671Cysteine methyl esterBy similarity
    Lipidationi67 – 671S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiQ9UK08.
    PRIDEiQ9UK08.

    Expressioni

    Gene expression databases

    BgeeiQ9UK08.
    CleanExiHS_GNG8.
    GenevestigatoriQ9UK08.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units, alpha, beta and gamma.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CXCR5P323023EBI-9074207,EBI-2835269

    Protein-protein interaction databases

    BioGridi125148. 3 interactions.
    IntActiQ9UK08. 1 interaction.
    STRINGi9606.ENSP00000300873.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UK08.
    SMRiQ9UK08. Positions 8-63.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G protein gamma family.Curated

    Phylogenomic databases

    eggNOGiNOG267672.
    HOGENOMiHOG000231034.
    HOVERGENiHBG014983.
    InParanoidiQ9UK08.
    KOiK04544.
    OMAiEKRLFCV.
    OrthoDBiEOG7H1JP7.
    PhylomeDBiQ9UK08.
    TreeFamiTF319909.

    Family and domain databases

    Gene3Di4.10.260.10. 1 hit.
    InterProiIPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view]
    PANTHERiPTHR13809. PTHR13809. 1 hit.
    PfamiPF00631. G-gamma. 1 hit.
    [Graphical view]
    PRINTSiPR00321. GPROTEING.
    SMARTiSM00224. GGL. 1 hit.
    [Graphical view]
    SUPFAMiSSF48670. SSF48670. 1 hit.
    PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UK08-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNNMAKIAE ARKTVEQLKL EVNIDRMKVS QAAAELLAFC ETHAKDDPLV   50
    TPVPAAENPF RDKRLFCVLL 70
    Length:70
    Mass (Da):7,841
    Last modified:May 1, 2000 - v1
    Checksum:i153205CC7F38EE40
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF188179 Genomic DNA. Translation: AAF04569.1.
    AF493875 mRNA. Translation: AAM12589.1.
    BC095514 mRNA. Translation: AAH95514.1.
    CCDSiCCDS12687.1.
    RefSeqiNP_150283.1. NM_033258.1.
    UniGeneiHs.283961.

    Genome annotation databases

    EnsembliENST00000300873; ENSP00000300873; ENSG00000167414.
    GeneIDi94235.
    KEGGihsa:94235.
    UCSCiuc010xyd.2. human.

    Polymorphism databases

    DMDMi12232629.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF188179 Genomic DNA. Translation: AAF04569.1 .
    AF493875 mRNA. Translation: AAM12589.1 .
    BC095514 mRNA. Translation: AAH95514.1 .
    CCDSi CCDS12687.1.
    RefSeqi NP_150283.1. NM_033258.1.
    UniGenei Hs.283961.

    3D structure databases

    ProteinModelPortali Q9UK08.
    SMRi Q9UK08. Positions 8-63.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125148. 3 interactions.
    IntActi Q9UK08. 1 interaction.
    STRINGi 9606.ENSP00000300873.

    Polymorphism databases

    DMDMi 12232629.

    Proteomic databases

    PaxDbi Q9UK08.
    PRIDEi Q9UK08.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300873 ; ENSP00000300873 ; ENSG00000167414 .
    GeneIDi 94235.
    KEGGi hsa:94235.
    UCSCi uc010xyd.2. human.

    Organism-specific databases

    CTDi 94235.
    GeneCardsi GC19M047137.
    HGNCi HGNC:19664. GNG8.
    neXtProti NX_Q9UK08.
    PharmGKBi PA134921496.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267672.
    HOGENOMi HOG000231034.
    HOVERGENi HBG014983.
    InParanoidi Q9UK08.
    KOi K04544.
    OMAi EKRLFCV.
    OrthoDBi EOG7H1JP7.
    PhylomeDBi Q9UK08.
    TreeFami TF319909.

    Enzyme and pathway databases

    Reactomei REACT_15457. G-protein activation.
    REACT_1665. Glucagon signaling in metabolic regulation.
    REACT_172761. Ca2+ pathway.
    REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
    REACT_18283. G alpha (q) signalling events.
    REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
    REACT_18377. Glucagon-type ligand receptors.
    REACT_18407. G alpha (12/13) signalling events.
    REACT_19140. ADP signalling through P2Y purinoceptor 1.
    REACT_19145. G beta:gamma signalling through PLC beta.
    REACT_19231. G alpha (i) signalling events.
    REACT_19290. G beta:gamma signalling through PI3Kgamma.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_20647. Thromboxane signalling through TP receptor.
    REACT_20653. ADP signalling through P2Y purinoceptor 12.
    REACT_21254. Presynaptic function of Kainate receptors.
    REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
    REACT_23946. Prostacyclin signalling through prostacyclin receptor.
    REACT_24023. Regulation of water balance by renal Aquaporins.
    REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
    REACT_75831. Activation of G protein gated Potassium channels.

    Miscellaneous databases

    GenomeRNAii 94235.
    NextBioi 78476.
    PROi Q9UK08.

    Gene expression databases

    Bgeei Q9UK08.
    CleanExi HS_GNG8.
    Genevestigatori Q9UK08.

    Family and domain databases

    Gene3Di 4.10.260.10. 1 hit.
    InterProi IPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view ]
    PANTHERi PTHR13809. PTHR13809. 1 hit.
    Pfami PF00631. G-gamma. 1 hit.
    [Graphical view ]
    PRINTSi PR00321. GPROTEING.
    SMARTi SM00224. GGL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48670. SSF48670. 1 hit.
    PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes."
      Hurowitz E.H., Melnyk J.M., Chen Y.J., Kouros-Mehr H., Simon M.I., Shizuya H.
      DNA Res. 7:111-120(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiGBG8_HUMAN
    AccessioniPrimary (citable) accession number: Q9UK08
    Secondary accession number(s): Q4VBM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3