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Q9UK08 (GBG8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
Alternative name(s):
Gamma-9
Gene names
Name:GNG8
Synonyms:GNG9, GNGT9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length70 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Subunit structure

G proteins are composed of 3 units, alpha, beta and gamma.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Sequence similarities

Belongs to the G protein gamma family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CXCR5P323023EBI-9074207,EBI-2835269

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6767Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
PRO_0000012649
Propeptide68 – 703Removed in mature form By similarity
PRO_0000012650

Amino acid modifications

Modified residue671Cysteine methyl ester By similarity
Lipidation671S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9UK08 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 153205CC7F38EE40

FASTA707,841
        10         20         30         40         50         60 
MSNNMAKIAE ARKTVEQLKL EVNIDRMKVS QAAAELLAFC ETHAKDDPLV TPVPAAENPF 

        70 
RDKRLFCVLL 

« Hide

References

« Hide 'large scale' references
[1]"Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes."
Hurowitz E.H., Melnyk J.M., Chen Y.J., Kouros-Mehr H., Simon M.I., Shizuya H.
DNA Res. 7:111-120(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF188179 Genomic DNA. Translation: AAF04569.1.
AF493875 mRNA. Translation: AAM12589.1.
BC095514 mRNA. Translation: AAH95514.1.
RefSeqNP_150283.1. NM_033258.1.
UniGeneHs.283961.

3D structure databases

ProteinModelPortalQ9UK08.
SMRQ9UK08. Positions 8-63.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125148. 3 interactions.
IntActQ9UK08. 1 interaction.
STRING9606.ENSP00000300873.

Polymorphism databases

DMDM12232629.

Proteomic databases

PaxDbQ9UK08.
PRIDEQ9UK08.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000300873; ENSP00000300873; ENSG00000167414.
GeneID94235.
KEGGhsa:94235.
UCSCuc010xyd.2. human.

Organism-specific databases

CTD94235.
GeneCardsGC19M047137.
HGNCHGNC:19664. GNG8.
neXtProtNX_Q9UK08.
PharmGKBPA134921496.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG267672.
HOGENOMHOG000231034.
HOVERGENHBG014983.
InParanoidQ9UK08.
KOK04544.
OMARMMVSKA.
OrthoDBEOG7H1JP7.
PhylomeDBQ9UK08.
TreeFamTF319909.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_111217. Metabolism.
REACT_13685. Neuronal System.
REACT_15518. Transmembrane transport of small molecules.
REACT_604. Hemostasis.

Gene expression databases

BgeeQ9UK08.
CleanExHS_GNG8.
GenevestigatorQ9UK08.

Family and domain databases

Gene3D4.10.260.10. 1 hit.
InterProIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERPTHR13809. PTHR13809. 1 hit.
PfamPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSPR00321. GPROTEING.
SMARTSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMSSF48670. SSF48670. 1 hit.
PROSITEPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi94235.
NextBio78476.
PROQ9UK08.

Entry information

Entry nameGBG8_HUMAN
AccessionPrimary (citable) accession number: Q9UK08
Secondary accession number(s): Q4VBM5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM