Q9UK08 (GBG8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

Alternative name(s):
Gamma-9

Gene names

Name:	GNG8
Synonyms:	GNG9, GNGT9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	70 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subunit structure	G proteins are composed of 3 units, alpha, beta and gamma.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Sequence similarities	Belongs to the G protein gamma family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Molecular function	Transducer
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Non-traceable author statement Ref.1. Source: UniProtKB cellular response to glucagon stimulus Traceable author statement. Source: Reactome energy reserve metabolic process Traceable author statement. Source: Reactome nervous system development Inferred from electronic annotation. Source: Compara synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	extracellular region Non-traceable author statement. Source: UniProtKB heterotrimeric G-protein complex Inferred from electronic annotation. Source: InterPro plasma membrane Traceable author statement. Source: Reactome
Molecular_function	GTPase activity Non-traceable author statement Ref.1. Source: UniProtKB signal transducer activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 67	67	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8		PRO_0000012649
	Propeptide	68 – 70	3	Removed in mature form By similarity		PRO_0000012650
Amino acid modifications
	Modified residue	67	1	Cysteine methyl ester By similarity
	Lipidation	67	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9UK08 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 153205CC7F38EE40	FASTA	70	7,841
	10 20 30 40 50 60 MSNNMAKIAE ARKTVEQLKL EVNIDRMKVS QAAAELLAFC ETHAKDDPLV TPVPAAENPF 70 RDKRLFCVLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes." Hurowitz E.H., Melnyk J.M., Chen Y.J., Kouros-Mehr H., Simon M.I., Shizuya H. DNA Res. 7:111-120(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF188179 Genomic DNA. Translation: AAF04569.1. AF493875 mRNA. Translation: AAM12589.1. BC095514 mRNA. Translation: AAH95514.1.
IPI	IPI00007022.
RefSeq	NP_150283.1. NM_033258.1.
UniGene	Hs.283961.
3D structure databases
ProteinModelPortal	Q9UK08.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000300873.
Polymorphism databases
DMDM	12232629.
Proteomic databases
PaxDb	Q9UK08.
PRIDE	Q9UK08.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300873; ENSP00000300873; ENSG00000167414.
GeneID	94235.
KEGG	hsa:94235.
UCSC	uc010xyd.2. human.
Organism-specific databases
CTD	94235.
GeneCards	GC19M047137.
HGNC	HGNC:19664. GNG8.
neXtProt	NX_Q9UK08.
PharmGKB	PA134921496.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG267672.
HOGENOM	HOG000231034.
HOVERGEN	HBG014983.
InParanoid	Q9UK08.
KO	K04544.
OMA	RMMVSKA.
OrthoDB	EOG4KH2WP.
PhylomeDB	Q9UK08.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction. REACT_111217. Metabolism. REACT_13685. Neuronal System. REACT_15518. Transmembrane transport of small molecules. REACT_604. Hemostasis.
Gene expression databases
Bgee	Q9UK08.
CleanEx	HS_GNG8.
Genevestigator	Q9UK08.
GermOnline	ENSG00000167414. Homo sapiens.
Family and domain databases
Gene3D	4.10.260.10. 1 hit.
InterPro	IPR015898. G-protein_gamma-like_dom. IPR001770. Gprotein-gamma. [Graphical view]
PANTHER	PTHR13809. PTHR13809. 1 hit.
Pfam	PF00631. G-gamma. 1 hit. [Graphical view]
PRINTS	PR00321. GPROTEING.
SMART	SM00224. GGL. 1 hit. [Graphical view]
SUPFAM	SSF48670. G-protein_gamma-like. 1 hit.
PROSITE	PS50058. G_PROTEIN_GAMMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	94235.
NextBio	78476.

Entry information

Entry name

GBG8_HUMAN

Accession

Primary (citable) accession number: Q9UK08
Secondary accession number(s): Q4VBM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.