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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

Gene

GNG8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB
  2. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. cellular response to glucagon stimulus Source: Reactome
  2. energy reserve metabolic process Source: Reactome
  3. G-protein coupled receptor signaling pathway Source: UniProtKB
  4. nervous system development Source: Ensembl
  5. small molecule metabolic process Source: Reactome
  6. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_15457. G-protein activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18283. G alpha (q) signalling events.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_18407. G alpha (12/13) signalling events.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19231. G alpha (i) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_20653. ADP signalling through P2Y purinoceptor 12.
REACT_21254. Presynaptic function of Kainate receptors.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
REACT_23946. Prostacyclin signalling through prostacyclin receptor.
REACT_24023. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_263982. Ca2+ pathway.
REACT_75831. Activation of G protein gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
Alternative name(s):
Gamma-9
Gene namesi
Name:GNG8
Synonyms:GNG9, GNGT9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:19664. GNG8.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. heterotrimeric G-protein complex Source: InterPro
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134921496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6767Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8PRO_0000012649Add
BLAST
Propeptidei68 – 703Removed in mature formBy similarityPRO_0000012650

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei67 – 671Cysteine methyl esterBy similarity
Lipidationi67 – 671S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ9UK08.
PRIDEiQ9UK08.

Expressioni

Gene expression databases

BgeeiQ9UK08.
CleanExiHS_GNG8.
GenevestigatoriQ9UK08.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Binary interactionsi

WithEntry#Exp.IntActNotes
CXCR5P323023EBI-9074207,EBI-2835269

Protein-protein interaction databases

BioGridi125148. 5 interactions.
IntActiQ9UK08. 1 interaction.
STRINGi9606.ENSP00000300873.

Structurei

3D structure databases

ProteinModelPortaliQ9UK08.
SMRiQ9UK08. Positions 8-63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG267672.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiQ9UK08.
KOiK04544.
OMAiRMMVSKA.
OrthoDBiEOG7H1JP7.
PhylomeDBiQ9UK08.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UK08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNMAKIAE ARKTVEQLKL EVNIDRMKVS QAAAELLAFC ETHAKDDPLV
60 70
TPVPAAENPF RDKRLFCVLL
Length:70
Mass (Da):7,841
Last modified:April 30, 2000 - v1
Checksum:i153205CC7F38EE40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188179 Genomic DNA. Translation: AAF04569.1.
AF493875 mRNA. Translation: AAM12589.1.
BC095514 mRNA. Translation: AAH95514.1.
CCDSiCCDS12687.1.
RefSeqiNP_150283.1. NM_033258.1.
UniGeneiHs.283961.

Genome annotation databases

EnsembliENST00000300873; ENSP00000300873; ENSG00000167414.
GeneIDi94235.
KEGGihsa:94235.
UCSCiuc010xyd.2. human.

Polymorphism databases

DMDMi12232629.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188179 Genomic DNA. Translation: AAF04569.1.
AF493875 mRNA. Translation: AAM12589.1.
BC095514 mRNA. Translation: AAH95514.1.
CCDSiCCDS12687.1.
RefSeqiNP_150283.1. NM_033258.1.
UniGeneiHs.283961.

3D structure databases

ProteinModelPortaliQ9UK08.
SMRiQ9UK08. Positions 8-63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125148. 5 interactions.
IntActiQ9UK08. 1 interaction.
STRINGi9606.ENSP00000300873.

Polymorphism databases

DMDMi12232629.

Proteomic databases

PaxDbiQ9UK08.
PRIDEiQ9UK08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300873; ENSP00000300873; ENSG00000167414.
GeneIDi94235.
KEGGihsa:94235.
UCSCiuc010xyd.2. human.

Organism-specific databases

CTDi94235.
GeneCardsiGC19M047137.
HGNCiHGNC:19664. GNG8.
neXtProtiNX_Q9UK08.
PharmGKBiPA134921496.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG267672.
GeneTreeiENSGT00760000119218.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiQ9UK08.
KOiK04544.
OMAiRMMVSKA.
OrthoDBiEOG7H1JP7.
PhylomeDBiQ9UK08.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiREACT_15457. G-protein activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18283. G alpha (q) signalling events.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_18407. G alpha (12/13) signalling events.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19231. G alpha (i) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_20653. ADP signalling through P2Y purinoceptor 12.
REACT_21254. Presynaptic function of Kainate receptors.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
REACT_23946. Prostacyclin signalling through prostacyclin receptor.
REACT_24023. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_263982. Ca2+ pathway.
REACT_75831. Activation of G protein gated Potassium channels.

Miscellaneous databases

GenomeRNAii94235.
NextBioi78476.
PROiQ9UK08.

Gene expression databases

BgeeiQ9UK08.
CleanExiHS_GNG8.
GenevestigatoriQ9UK08.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes."
    Hurowitz E.H., Melnyk J.M., Chen Y.J., Kouros-Mehr H., Simon M.I., Shizuya H.
    DNA Res. 7:111-120(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGBG8_HUMAN
AccessioniPrimary (citable) accession number: Q9UK08
Secondary accession number(s): Q4VBM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2000
Last sequence update: April 30, 2000
Last modified: March 31, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.