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Protein

Uncharacterized protein C3orf18

Gene

C3orf18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C3orf18
Alternative name(s):
Protein G20
Gene namesi
Name:C3orf18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000088543.14.
HGNCiHGNC:24837. C3orf18.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51161.
OpenTargetsiENSG00000088543.
PharmGKBiPA134941482.

Polymorphism and mutation databases

BioMutaiC3orf18.
DMDMi317373334.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002288411 – 162Uncharacterized protein C3orf18Add BLAST162

Proteomic databases

PaxDbiQ9UK00.
PeptideAtlasiQ9UK00.
PRIDEiQ9UK00.

PTM databases

iPTMnetiQ9UK00.
PhosphoSitePlusiQ9UK00.

Expressioni

Gene expression databases

BgeeiENSG00000088543.
CleanExiHS_C3orf18.
ExpressionAtlasiQ9UK00. baseline and differential.
GenevisibleiQ9UK00. HS.

Organism-specific databases

HPAiHPA012105.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349732.

Structurei

3D structure databases

ProteinModelPortaliQ9UK00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J1WR. Eukaryota.
ENOG410Y7Q7. LUCA.
GeneTreeiENSGT00410000025882.
HOGENOMiHOG000294070.
HOVERGENiHBG081003.
InParanoidiQ9UK00.
OMAiNSTKIPD.
OrthoDBiEOG091G1C3H.
PhylomeDBiQ9UK00.
TreeFamiTF332764.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UK00-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSRTASARG WFSSRPPTSE SDLEPATDGP ASETTTLSPE ATTFNDTRIP
60 70 80 90 100
DAAGGTAGVG TMLLSFGIIT VIGLAVALVL YIRKKKRLEK LRHQLMPMYN
110 120 130 140 150
FDPTEEQDEL EQELLEHGRD AASVQAATSV QAMQGKTTLP SQGPLQRPSR
160
LVFTDVANAI HA
Length:162
Mass (Da):17,468
Last modified:January 11, 2011 - v2
Checksum:iD5B5DEFFE0E06D6E
GO
Isoform 2 (identifier: Q9UK00-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-78: Missing.

Note: No experimental confirmation available.
Show »
Length:142
Mass (Da):15,497
Checksum:iF058A1B7F0FEF0A8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0257208A → D. Corresponds to variant dbSNP:rs386598Ensembl.1
Natural variantiVAR_025721162A → V4 PublicationsCorresponds to variant dbSNP:rs1034405Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04488059 – 78Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188706 mRNA. Translation: AAF01050.1.
AK308074 mRNA. No translation available.
AL833938 mRNA. Translation: CAD38793.1.
AC096920 Genomic DNA. No translation available.
BC034766 mRNA. Translation: AAH34766.1.
CCDSiCCDS2829.1. [Q9UK00-1]
CCDS54589.1. [Q9UK00-2]
RefSeqiNP_001165211.1. NM_001171740.2. [Q9UK00-1]
NP_001165212.1. NM_001171741.2. [Q9UK00-1]
NP_001165214.2. NM_001171743.2. [Q9UK00-2]
NP_057294.2. NM_016210.4. [Q9UK00-1]
XP_011532092.1. XM_011533790.1. [Q9UK00-2]
XP_016862036.1. XM_017006547.1. [Q9UK00-2]
UniGeneiHs.517860.

Genome annotation databases

EnsembliENST00000357203; ENSP00000349732; ENSG00000088543. [Q9UK00-1]
ENST00000426034; ENSP00000387606; ENSG00000088543. [Q9UK00-1]
ENST00000441239; ENSP00000414124; ENSG00000088543. [Q9UK00-2]
ENST00000449241; ENSP00000404913; ENSG00000088543. [Q9UK00-1]
GeneIDi51161.
KEGGihsa:51161.
UCSCiuc003dar.4. human. [Q9UK00-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCC018_HUMAN
AccessioniPrimary (citable) accession number: Q9UK00
Secondary accession number(s): C9JNP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: January 11, 2011
Last modified: September 27, 2017
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations