Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADP-ribosylation factor-binding protein GGA1

Gene

GGA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-977225. Amyloid fiber formation.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-binding protein GGA1
Alternative name(s):
Gamma-adaptin-related protein 1
Golgi-localized, gamma ear-containing, ARF-binding protein 1
Gene namesi
Name:GGA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:17842. GGA1.

Subcellular locationi

GO - Cellular componenti

  • clathrin adaptor complex Source: InterPro
  • endosome membrane Source: Reactome
  • Golgi apparatus Source: UniProtKB
  • intracellular membrane-bounded organelle Source: HPA
  • membrane Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi92 – 921N → A: Abolishes interaction with IGF2R. 1 Publication
Mutagenesisi182 – 1821L → A: Abolishes interaction with ARF1, UBC and TSG101. 1 Publication
Mutagenesisi194 – 1941N → A: Abolishes interaction with ARF1 and RABEP1. 1 Publication
Mutagenesisi197 – 1971I → A: Abolishes interaction with ARF1, UBC and TSG101. 1 Publication
Mutagenesisi198 – 1981K → A: Abolishes interaction with ARF1. 1 Publication
Mutagenesisi200 – 2001M → A: Abolishes interaction with ARF1. 1 Publication
Mutagenesisi204 – 2041D → A: Abolishes interaction with ARF1. 1 Publication
Mutagenesisi259 – 2591M → K: Abolishes interaction with RABEP1.
Mutagenesisi260 – 2601R → A: No effect on interaction with RABEP1. 1 Publication
Mutagenesisi260 – 2601R → E: Abolishes interaction with RABEP1 and UBC. 1 Publication
Mutagenesisi264 – 2641F → A: Abolishes interaction with RABEP1. 1 Publication
Mutagenesisi267 – 2671A → D: Abolishes interaction with RABEP1 and UBC. 1 Publication
Mutagenesisi277 – 2771L → A: Abolishes interaction with RABEP1, UBC and TSG101. 1 Publication
Mutagenesisi281 – 2811L → A: Abolishes interaction with RABEP1. 1 Publication
Mutagenesisi284 – 2841N → A: Abolishes interaction with RABEP1. 1 Publication
Mutagenesisi284 – 2841N → S: Abolishes interaction with RABEP1. 1 Publication
Mutagenesisi355 – 3551S → A: Increased interaction with IGF2R. Reduced phosphorylation. 1 Publication
Mutagenesisi355 – 3551S → D: Abolishes interaction with IGF2R. 1 Publication
Mutagenesisi356 – 3605LLDDE → AADAA: Partial loss of clathrin-binding. 1 Publication
Mutagenesisi358 – 3581D → A: Increased interaction with IGF2R. 1 Publication
Mutagenesisi361 – 3622LM → AA: Increased interaction with IGF2R. 1 Publication
Mutagenesisi563 – 5631A → D: Abolishes interaction with CCDC91. 1 Publication
Mutagenesisi564 – 5641V → D: Abolishes interaction with CCDC91. 1 Publication
Mutagenesisi570 – 5701V → E: Abolishes interaction with CCDC91. 1 Publication
Mutagenesisi572 – 5721L → E: Abolishes interaction with CCDC91. 1 Publication

Organism-specific databases

PharmGKBiPA28657.

Polymorphism and mutation databases

BioMutaiGGA1.
DMDMi14548066.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 639639ADP-ribosylation factor-binding protein GGA1PRO_0000212680Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei185 – 1851PhosphoserineCombined sources
Modified residuei355 – 3551Phosphoserine; by CK21 Publication
Modified residuei418 – 4181PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated by CK2 and dephosphorylated by PP2A. Phosphorylation of GGA1 allows the internal AC-LL motif to bind the VHS domain and to inhibit the recognition of cargo signals.1 Publication
Ubiquitinated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UJY5.
MaxQBiQ9UJY5.
PaxDbiQ9UJY5.
PeptideAtlasiQ9UJY5.
PRIDEiQ9UJY5.

PTM databases

iPTMnetiQ9UJY5.
PhosphoSiteiQ9UJY5.

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiENSG00000100083.
CleanExiHS_GGA1.
ExpressionAtlasiQ9UJY5. baseline and differential.
GenevisibleiQ9UJY5. HS.

Organism-specific databases

HPAiHPA048280.
HPA051016.

Interactioni

Subunit structurei

Monomer. Interacts with NECAP1. Interacts with CNST (By similarity). Interacts with GGA2 and GGA3. Binds to clathrin and activated ARFs, including ARF1 and ARF6. Interacts with RABEP1 and RABGEF1. Interacts with the type-I membrane proteins SORT1, SORL1, LRP3, M6PR/CD-MPR, IGF2R/CI-MPR and BACE1. Binds CCDC91, P200, SYNRG, EPN4, NECAP2 and AFTPH/aftiphilin. Interacts with TSG101 and UBC. Interacts with RNF11.By similarity19 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Arf6P623312EBI-447141,EBI-988682From a different organism.
C1orf216Q8TAB53EBI-447141,EBI-747505
DTNBO609414EBI-447141,EBI-740402
IGF2RP117172EBI-447141,EBI-1048580
MON2Q7Z3U72EBI-447141,EBI-358882
RABEP1Q152768EBI-447141,EBI-447043
RABGEF1O189732EBI-447141,EBI-447376From a different organism.
RNF11Q9Y3C53EBI-447141,EBI-396669
SORT1Q995232EBI-447141,EBI-1057058
UBBP0CG473EBI-447141,EBI-413034

Protein-protein interaction databases

BioGridi117540. 71 interactions.
IntActiQ9UJY5. 26 interactions.
MINTiMINT-126174.
STRINGi9606.ENSP00000341344.

Structurei

Secondary structure

1
639
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 53Combined sources
Helixi10 – 178Combined sources
Helixi27 – 3610Combined sources
Helixi37 – 393Combined sources
Beta strandi40 – 423Combined sources
Helixi43 – 5513Combined sources
Helixi60 – 7617Combined sources
Helixi79 – 857Combined sources
Helixi88 – 9811Combined sources
Turni100 – 1034Combined sources
Helixi104 – 1063Combined sources
Helixi109 – 12517Combined sources
Helixi130 – 14112Combined sources
Helixi172 – 18211Combined sources
Helixi187 – 20519Combined sources
Helixi212 – 23322Combined sources
Turni235 – 2384Combined sources
Helixi243 – 26725Combined sources
Helixi274 – 29825Combined sources
Helixi494 – 4974Combined sources
Helixi504 – 5063Combined sources
Beta strandi515 – 5206Combined sources
Beta strandi523 – 5319Combined sources
Beta strandi533 – 5353Combined sources
Beta strandi540 – 54910Combined sources
Beta strandi555 – 5639Combined sources
Beta strandi568 – 5725Combined sources
Beta strandi592 – 5998Combined sources
Beta strandi608 – 6169Combined sources
Beta strandi619 – 6279Combined sources
Turni633 – 6353Combined sources
Helixi636 – 6383Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J2JX-ray1.60B166-210[»]
1JWFX-ray2.10A1-147[»]
1JWGX-ray2.00A/B1-147[»]
1NA8X-ray2.30A/B494-639[»]
1NAFX-ray2.80A165-314[»]
1NWMX-ray2.40X166-302[»]
1O3XX-ray2.10A166-305[»]
1OM9X-ray2.50A/B494-639[»]
1OXZX-ray2.80A141-326[»]
1PY1X-ray2.60A/B/C/D2-157[»]
1UJJX-ray2.60A/B1-147[»]
1UJKX-ray1.90A/B1-147[»]
1X79X-ray2.41A210-302[»]
2DWXX-ray2.55A/B/C/D507-639[»]
P/Q376-388[»]
2DWYX-ray2.30A/B/C/D507-639[»]
3G2SX-ray1.70A/B1-147[»]
3G2TX-ray2.00A/B1-147[»]
3G2UX-ray2.30A/B1-147[»]
3G2VX-ray2.10A/B1-147[»]
3G2WX-ray2.40A/B1-147[»]
C/D351-364[»]
DisProtiDP00314.
ProteinModelPortaliQ9UJY5.
SMRiQ9UJY5. Positions 2-147, 171-302, 498-639.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UJY5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 147131VHSPROSITE-ProRule annotationAdd
BLAST
Domaini171 – 299129GATPROSITE-ProRule annotationAdd
BLAST
Domaini510 – 631122GAEPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni114 – 274161Interaction with ARF3Add
BLAST
Regioni300 – 509210Unstructured hingeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi358 – 3625Autoinhibitory

Domaini

The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif).
The GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis.
The unstructured hinge region contains clathrin-binding but no autoinhibitory (AC-LL) motifs.
The GAE domain binds accessory proteins regulating GGAs function.

Sequence similaritiesi

Belongs to the GGA protein family.Curated
Contains 1 GAE domain.PROSITE-ProRule annotation
Contains 1 GAT domain.PROSITE-ProRule annotation
Contains 1 VHS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1087. Eukaryota.
ENOG410Y26G. LUCA.
GeneTreeiENSGT00700000104396.
HOGENOMiHOG000231169.
HOVERGENiHBG015945.
InParanoidiQ9UJY5.
KOiK12404.
OMAiLRYKLIF.
OrthoDBiEOG091G0BQK.
PhylomeDBiQ9UJY5.
TreeFamiTF318574.

Family and domain databases

Gene3Di1.20.58.160. 1 hit.
1.25.40.90. 1 hit.
2.60.40.1230. 1 hit.
InterProiIPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR008153. Clathrin_g-adaptin_app.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR002014. VHS_dom.
[Graphical view]
PfamiPF02883. Alpha_adaptinC2. 1 hit.
PF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
SMARTiSM00809. Alpha_adaptinC2. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF49348. SSF49348. 1 hit.
PROSITEiPS50180. GAE. 1 hit.
PS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UJY5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPAMEPETL EARINRATNP LNKELDWASI NGFCEQLNED FEGPPLATRL
60 70 80 90 100
LAHKIQSPQE WEAIQALTVL ETCMKSCGKR FHDEVGKFRF LNELIKVVSP
110 120 130 140 150
KYLGSRTSEK VKNKILELLY SWTVGLPEEV KIAEAYQMLK KQGIVKSDPK
160 170 180 190 200
LPDDTTFPLP PPRPKNVIFE DEEKSKMLAR LLKSSHPEDL RAANKLIKEM
210 220 230 240 250
VQEDQKRMEK ISKRVNAIEE VNNNVKLLTE MVMSHSQGGA AAGSSEDLMK
260 270 280 290 300
ELYQRCERMR PTLFRLASDT EDNDEALAEI LQANDNLTQV INLYKQLVRG
310 320 330 340 350
EEVNGDATAG SIPGSTSALL DLSGLDLPPA GTTYPAMPTR PGEQASPEQP
360 370 380 390 400
SASVSLLDDE LMSLGLSDPT PPSGPSLDGT GWNSFQSSDA TEPPAPALAQ
410 420 430 440 450
APSMESRPPA QTSLPASSGL DDLDLLGKTL LQQSLPPESQ QVRWEKQQPT
460 470 480 490 500
PRLTLRDLQN KSSSCSSPSS SATSLLHTVS PEPPRPPQQP VPTELSLASI
510 520 530 540 550
TVPLESIKPS NILPVTVYDQ HGFRILFHFA RDPLPGRSDV LVVVVSMLST
560 570 580 590 600
APQPIRNIVF QSAVPKVMKV KLQPPSGTEL PAFNPIVHPS AITQVLLLAN
610 620 630
PQKEKVRLRY KLTFTMGDQT YNEMGDVDQF PPPETWGSL
Length:639
Mass (Da):70,384
Last modified:May 1, 2000 - v1
Checksum:iB0B6F089FA0F7DD5
GO
Isoform 2 (identifier: Q9UJY5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-101: Missing.

Note: No experimental confirmation available.
Show »
Length:606
Mass (Da):66,563
Checksum:i6231A20CC57997B1
GO
Isoform 3 (identifier: Q9UJY5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Show »
Length:566
Mass (Da):62,138
Checksum:iF96825C24B633E03
GO
Isoform 4 (identifier: Q9UJY5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     277-363: Missing.

Show »
Length:552
Mass (Da):61,379
Checksum:iAC507C9F975A32C3
GO
Isoform 5 (identifier: Q9UJY5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-89: LETCMKSCGKRFHDEVGKFR → RRGEATIRPPPCDDTKGGQD
     90-639: Missing.

Show »
Length:89
Mass (Da):9,969
Checksum:iF209D7D764D4CA7E
GO
Isoform 6 (identifier: Q9UJY5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-68: T → TVRRGEATIRPPPCDDTK

Note: No experimental confirmation available.
Show »
Length:656
Mass (Da):72,277
Checksum:i60EE957099B4847C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti239 – 2391G → S in a breast cancer sample; somatic mutation. 1 Publication
Corresponds to variant rs765255006 [ dbSNP | Ensembl ].
VAR_036522
Natural varianti484 – 4841P → A in a breast cancer sample; somatic mutation. 1 Publication
VAR_036523

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7373Missing in isoform 3. 1 PublicationVSP_042806Add
BLAST
Alternative sequencei68 – 681T → TVRRGEATIRPPPCDDTK in isoform 6. 1 PublicationVSP_057352
Alternative sequencei69 – 10133Missing in isoform 2. CuratedVSP_001744Add
BLAST
Alternative sequencei70 – 8920LETCM…VGKFR → RRGEATIRPPPCDDTKGGQD in isoform 5. 1 PublicationVSP_042807Add
BLAST
Alternative sequencei90 – 639550Missing in isoform 5. 1 PublicationVSP_042808Add
BLAST
Alternative sequencei277 – 36387Missing in isoform 4. 1 PublicationVSP_042809Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190862 mRNA. Translation: AAF05707.1.
AF218584 mRNA. Translation: AAF42847.1.
AF233521 mRNA. Translation: AAF35393.1.
CR456493 mRNA. Translation: CAG30379.1.
AK075256 mRNA. Translation: BAC11501.1.
AK122898 mRNA. Translation: BAG53788.1.
AK290548 mRNA. Translation: BAF83237.1.
AL035496, Z83844 Genomic DNA. Translation: CAI20951.1.
Z83844, AL035496 Genomic DNA. Translation: CAI20369.1.
AL035496, Z83844 Genomic DNA. Translation: CAQ08834.1.
Z83844, AL035496 Genomic DNA. Translation: CAQ09781.1.
CH471095 Genomic DNA. Translation: EAW60169.1.
BC000538 mRNA. Translation: AAH00538.2.
BC010917 mRNA. Translation: AAH10917.1.
BC029388 mRNA. Translation: AAH29388.1.
BC044629 mRNA. Translation: AAH44629.1.
AL110219 mRNA. Translation: CAB53679.1.
CCDSiCCDS13951.1. [Q9UJY5-1]
CCDS33643.1. [Q9UJY5-4]
CCDS54526.1. [Q9UJY5-3]
PIRiT14759.
RefSeqiNP_001001560.1. NM_001001560.2. [Q9UJY5-4]
NP_001166158.1. NM_001172687.1.
NP_001166159.1. NM_001172688.1. [Q9UJY5-3]
NP_037497.1. NM_013365.4. [Q9UJY5-1]
XP_005261574.1. XM_005261517.3. [Q9UJY5-6]
XP_005261577.1. XM_005261520.1. [Q9UJY5-3]
XP_006724292.1. XM_006724229.1. [Q9UJY5-3]
XP_011528424.1. XM_011530122.1. [Q9UJY5-6]
UniGeneiHs.499158.

Genome annotation databases

EnsembliENST00000325180; ENSP00000321288; ENSG00000100083. [Q9UJY5-4]
ENST00000343632; ENSP00000341344; ENSG00000100083. [Q9UJY5-1]
ENST00000381756; ENSP00000371175; ENSG00000100083. [Q9UJY5-6]
ENST00000406772; ENSP00000385287; ENSG00000100083. [Q9UJY5-3]
GeneIDi26088.
KEGGihsa:26088.
UCSCiuc003atc.4. human. [Q9UJY5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190862 mRNA. Translation: AAF05707.1.
AF218584 mRNA. Translation: AAF42847.1.
AF233521 mRNA. Translation: AAF35393.1.
CR456493 mRNA. Translation: CAG30379.1.
AK075256 mRNA. Translation: BAC11501.1.
AK122898 mRNA. Translation: BAG53788.1.
AK290548 mRNA. Translation: BAF83237.1.
AL035496, Z83844 Genomic DNA. Translation: CAI20951.1.
Z83844, AL035496 Genomic DNA. Translation: CAI20369.1.
AL035496, Z83844 Genomic DNA. Translation: CAQ08834.1.
Z83844, AL035496 Genomic DNA. Translation: CAQ09781.1.
CH471095 Genomic DNA. Translation: EAW60169.1.
BC000538 mRNA. Translation: AAH00538.2.
BC010917 mRNA. Translation: AAH10917.1.
BC029388 mRNA. Translation: AAH29388.1.
BC044629 mRNA. Translation: AAH44629.1.
AL110219 mRNA. Translation: CAB53679.1.
CCDSiCCDS13951.1. [Q9UJY5-1]
CCDS33643.1. [Q9UJY5-4]
CCDS54526.1. [Q9UJY5-3]
PIRiT14759.
RefSeqiNP_001001560.1. NM_001001560.2. [Q9UJY5-4]
NP_001166158.1. NM_001172687.1.
NP_001166159.1. NM_001172688.1. [Q9UJY5-3]
NP_037497.1. NM_013365.4. [Q9UJY5-1]
XP_005261574.1. XM_005261517.3. [Q9UJY5-6]
XP_005261577.1. XM_005261520.1. [Q9UJY5-3]
XP_006724292.1. XM_006724229.1. [Q9UJY5-3]
XP_011528424.1. XM_011530122.1. [Q9UJY5-6]
UniGeneiHs.499158.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J2JX-ray1.60B166-210[»]
1JWFX-ray2.10A1-147[»]
1JWGX-ray2.00A/B1-147[»]
1NA8X-ray2.30A/B494-639[»]
1NAFX-ray2.80A165-314[»]
1NWMX-ray2.40X166-302[»]
1O3XX-ray2.10A166-305[»]
1OM9X-ray2.50A/B494-639[»]
1OXZX-ray2.80A141-326[»]
1PY1X-ray2.60A/B/C/D2-157[»]
1UJJX-ray2.60A/B1-147[»]
1UJKX-ray1.90A/B1-147[»]
1X79X-ray2.41A210-302[»]
2DWXX-ray2.55A/B/C/D507-639[»]
P/Q376-388[»]
2DWYX-ray2.30A/B/C/D507-639[»]
3G2SX-ray1.70A/B1-147[»]
3G2TX-ray2.00A/B1-147[»]
3G2UX-ray2.30A/B1-147[»]
3G2VX-ray2.10A/B1-147[»]
3G2WX-ray2.40A/B1-147[»]
C/D351-364[»]
DisProtiDP00314.
ProteinModelPortaliQ9UJY5.
SMRiQ9UJY5. Positions 2-147, 171-302, 498-639.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117540. 71 interactions.
IntActiQ9UJY5. 26 interactions.
MINTiMINT-126174.
STRINGi9606.ENSP00000341344.

PTM databases

iPTMnetiQ9UJY5.
PhosphoSiteiQ9UJY5.

Polymorphism and mutation databases

BioMutaiGGA1.
DMDMi14548066.

Proteomic databases

EPDiQ9UJY5.
MaxQBiQ9UJY5.
PaxDbiQ9UJY5.
PeptideAtlasiQ9UJY5.
PRIDEiQ9UJY5.

Protocols and materials databases

DNASUi26088.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325180; ENSP00000321288; ENSG00000100083. [Q9UJY5-4]
ENST00000343632; ENSP00000341344; ENSG00000100083. [Q9UJY5-1]
ENST00000381756; ENSP00000371175; ENSG00000100083. [Q9UJY5-6]
ENST00000406772; ENSP00000385287; ENSG00000100083. [Q9UJY5-3]
GeneIDi26088.
KEGGihsa:26088.
UCSCiuc003atc.4. human. [Q9UJY5-1]

Organism-specific databases

CTDi26088.
GeneCardsiGGA1.
HGNCiHGNC:17842. GGA1.
HPAiHPA048280.
HPA051016.
MIMi606004. gene.
neXtProtiNX_Q9UJY5.
PharmGKBiPA28657.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1087. Eukaryota.
ENOG410Y26G. LUCA.
GeneTreeiENSGT00700000104396.
HOGENOMiHOG000231169.
HOVERGENiHBG015945.
InParanoidiQ9UJY5.
KOiK12404.
OMAiLRYKLIF.
OrthoDBiEOG091G0BQK.
PhylomeDBiQ9UJY5.
TreeFamiTF318574.

Enzyme and pathway databases

ReactomeiR-HSA-977225. Amyloid fiber formation.

Miscellaneous databases

ChiTaRSiGGA1. human.
EvolutionaryTraceiQ9UJY5.
GeneWikiiGGA1.
GenomeRNAii26088.
PROiQ9UJY5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100083.
CleanExiHS_GGA1.
ExpressionAtlasiQ9UJY5. baseline and differential.
GenevisibleiQ9UJY5. HS.

Family and domain databases

Gene3Di1.20.58.160. 1 hit.
1.25.40.90. 1 hit.
2.60.40.1230. 1 hit.
InterProiIPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR008153. Clathrin_g-adaptin_app.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR002014. VHS_dom.
[Graphical view]
PfamiPF02883. Alpha_adaptinC2. 1 hit.
PF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
SMARTiSM00809. Alpha_adaptinC2. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF49348. SSF49348. 1 hit.
PROSITEiPS50180. GAE. 1 hit.
PS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGGA1_HUMAN
AccessioniPrimary (citable) accession number: Q9UJY5
Secondary accession number(s): A8K3D3
, B0QYR7, Q5R3N1, Q5TG07, Q6IC75, Q86YA9, Q8NCS6, Q9BW94, Q9UG00, Q9UGW0, Q9UGW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 178 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.