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Q9UJY4

- GGA2_HUMAN

UniProt

Q9UJY4 - GGA2_HUMAN

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Protein

ADP-ribosylation factor-binding protein GGA2

Gene
GGA2, KIAA1080
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.

GO - Molecular functioni

  1. ADP-ribosylation factor binding Source: UniProtKB
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. intracellular protein transport Source: UniProtKB
  2. vesicle-mediated transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-binding protein GGA2
Alternative name(s):
Gamma-adaptin-related protein 2
Golgi-localized, gamma ear-containing, ARF-binding protein 2
VHS domain and ear domain of gamma-adaptin
Short name:
Vear
Gene namesi
Name:GGA2
Synonyms:KIAA1080
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:16064. GGA2.

Subcellular locationi

Golgi apparatustrans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. clathrin adaptor complex Source: InterPro
  2. clathrin-coated vesicle Source: UniProtKB
  3. endosome membrane Source: UniProtKB-SubCell
  4. Golgi apparatus Source: HPA
  5. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi349 – 3535LIDLE → AADAA: Partial loss of clathrin-binding. 1 Publication

Organism-specific databases

PharmGKBiPA28658.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 613613ADP-ribosylation factor-binding protein GGA2PRO_0000212682Add
BLAST

Post-translational modificationi

Ubiquitinated By similarity.

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ9UJY4.
PaxDbiQ9UJY4.
PRIDEiQ9UJY4.

PTM databases

PhosphoSiteiQ9UJY4.

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

ArrayExpressiQ9UJY4.
BgeeiQ9UJY4.
CleanExiHS_GGA2.
GenevestigatoriQ9UJY4.

Organism-specific databases

HPAiCAB034422.
HPA043313.

Interactioni

Subunit structurei

Monomer. Interacts with NECAP1, TSG101, UBC and AFTPH/aftiphilin. Interacts with CNST By similarity. Interacts with GGA1 and GGA3. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the type-I membrane proteins SORT1, SORL1, LRP3, M6PR/CD-MPR, IGF2R/CI-MPR and BACE1. Binds the accessory proteins CCDC91, P200, SYNRG, EPN4 and NECAP2.14 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RABEP1Q152766EBI-447646,EBI-447043

Protein-protein interaction databases

BioGridi116697. 31 interactions.
DIPiDIP-31601N.
IntActiQ9UJY4. 16 interactions.
MINTiMINT-126110.
STRINGi9606.ENSP00000311962.

Structurei

Secondary structure

1
613
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi26 – 349
Helixi43 – 5513
Helixi58 – 7114
Helixi76 – 9217
Helixi95 – 1017
Helixi104 – 1129
Helixi125 – 14117
Helixi146 – 15712

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MHQX-ray2.20A/B25-172[»]
ProteinModelPortaliQ9UJY4.
SMRiQ9UJY4. Positions 25-167, 188-316, 471-605.

Miscellaneous databases

EvolutionaryTraceiQ9UJY4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 163131VHSAdd
BLAST
Domaini188 – 315128GATAdd
BLAST
Domaini484 – 605122GAEAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni316 – 483168Unstructured hingeAdd
BLAST

Domaini

The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif).
The GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis.
The unstructured hinge region contains clathrin-binding but no autoinhibitory (AC-LL) motifs.
The GAE domain binds accessory proteins regulating GGAs function.

Sequence similaritiesi

Belongs to the GGA protein family.
Contains 1 GAE domain.
Contains 1 GAT domain.
Contains 1 VHS domain.

Phylogenomic databases

eggNOGiNOG321636.
HOGENOMiHOG000231169.
HOVERGENiHBG015945.
InParanoidiQ9UJY4.
KOiK12404.
OMAiMKNCPLI.
OrthoDBiEOG7V49Z0.
PhylomeDBiQ9UJY4.
TreeFamiTF318574.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
2.60.40.1230. 1 hit.
InterProiIPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR008153. Clathrin_g-adaptin_app.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR008942. ENTH_VHS.
IPR004152. GAT.
IPR002014. VHS.
IPR018205. VHS_subgr.
[Graphical view]
PfamiPF02883. Alpha_adaptinC2. 1 hit.
PF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
SMARTiSM00809. Alpha_adaptinC2. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF49348. SSF49348. 1 hit.
PROSITEiPS50180. GAE. 1 hit.
PS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UJY4-1 [UniParc]FASTAAdd to Basket

« Hide

MAATAVAAAV AGTESAQGPP GPAASLELWL NKATDPSMSE QDWSAIQNFC    50
EQVNTDPNGP THAPWLLAHK IQSPQEKEAL YALTVLEMCM NHCGEKFHSE 100
VAKFRFLNEL IKVLSPKYLG SWATGKVKGR VIEILFSWTV WFPEDIKIRD 150
AYQMLKKQGI IKQDPKLPVD KILPPPSPWP KSSIFDADEE KSKLLTRLLK 200
SNHPEDLQAA NRLIKNLVKE EQEKSEKVSK RVSAVEEVRS HVKVLQEMLS 250
MYRRPGQAPP DQEALQVVYE RCEKLRPTLF RLASDTTDDD DALAEILQAN 300
DLLTQGVLLY KQVMEGRVTF GNRVTSSLGD IPVSRVFQNP AGCMKTCPLI 350
DLEVDNGPAQ MGTVVPSLLH QDLAALGISD APVTGMVSGQ NCCEEKRNPS 400
SSTLPGGGVQ NPSADRNLLD LLSAQPAPCP LNYVSQKSVP KEVPPGTKSS 450
PGWSWEAGPL APSPSSQNTP LAQVFVPLES VKPSSLPPLI VYDRNGFRIL 500
LHFSQTGAPG HPEVQVLLLT MMSTAPQPVW DIMFQVAVPK SMRVKLQPAS 550
SSKLPAFSPL MPPAVISQML LLDNPHKEPI RLRYKLTFNQ GGQPFSEVGE 600
VKDFPDLAVL GAA 613
Length:613
Mass (Da):67,150
Last modified:April 3, 2007 - v3
Checksum:i4B627ABA474A069C
GO

Sequence cautioni

The sequence AAK38634.1 differs from that shown. Reason: Frameshift at position 193.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti424 – 4241A → P.4 Publications
Corresponds to variant rs1135045 [ dbSNP | Ensembl ].
VAR_028275

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti281 – 2811R → W in AAF05708. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF190863 mRNA. Translation: AAF05708.1.
AF233522 mRNA. Translation: AAF35394.1.
AF165531 mRNA. Translation: AAF42806.1.
AC002400 Genomic DNA. Translation: AAC05813.1.
CH471145 Genomic DNA. Translation: EAW55827.1.
CH471145 Genomic DNA. Translation: EAW55828.1.
BC000284 mRNA. Translation: AAH00284.1.
AF323754 mRNA. Translation: AAK38634.1. Frameshift.
AB029003 mRNA. Translation: BAA83032.1.
CCDSiCCDS10611.1.
PIRiT00744.
RefSeqiNP_055859.1. NM_015044.4.
UniGeneiHs.460336.

Genome annotation databases

EnsembliENST00000309859; ENSP00000311962; ENSG00000103365.
GeneIDi23062.
KEGGihsa:23062.
UCSCiuc002dlq.3. human.

Polymorphism databases

DMDMi143811397.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF190863 mRNA. Translation: AAF05708.1 .
AF233522 mRNA. Translation: AAF35394.1 .
AF165531 mRNA. Translation: AAF42806.1 .
AC002400 Genomic DNA. Translation: AAC05813.1 .
CH471145 Genomic DNA. Translation: EAW55827.1 .
CH471145 Genomic DNA. Translation: EAW55828.1 .
BC000284 mRNA. Translation: AAH00284.1 .
AF323754 mRNA. Translation: AAK38634.1 . Frameshift.
AB029003 mRNA. Translation: BAA83032.1 .
CCDSi CCDS10611.1.
PIRi T00744.
RefSeqi NP_055859.1. NM_015044.4.
UniGenei Hs.460336.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1MHQ X-ray 2.20 A/B 25-172 [» ]
ProteinModelPortali Q9UJY4.
SMRi Q9UJY4. Positions 25-167, 188-316, 471-605.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116697. 31 interactions.
DIPi DIP-31601N.
IntActi Q9UJY4. 16 interactions.
MINTi MINT-126110.
STRINGi 9606.ENSP00000311962.

PTM databases

PhosphoSitei Q9UJY4.

Polymorphism databases

DMDMi 143811397.

Proteomic databases

MaxQBi Q9UJY4.
PaxDbi Q9UJY4.
PRIDEi Q9UJY4.

Protocols and materials databases

DNASUi 23062.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309859 ; ENSP00000311962 ; ENSG00000103365 .
GeneIDi 23062.
KEGGi hsa:23062.
UCSCi uc002dlq.3. human.

Organism-specific databases

CTDi 23062.
GeneCardsi GC16M023474.
HGNCi HGNC:16064. GGA2.
HPAi CAB034422.
HPA043313.
MIMi 606005. gene.
neXtProti NX_Q9UJY4.
PharmGKBi PA28658.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG321636.
HOGENOMi HOG000231169.
HOVERGENi HBG015945.
InParanoidi Q9UJY4.
KOi K12404.
OMAi MKNCPLI.
OrthoDBi EOG7V49Z0.
PhylomeDBi Q9UJY4.
TreeFami TF318574.

Miscellaneous databases

ChiTaRSi GGA2. human.
EvolutionaryTracei Q9UJY4.
GeneWikii GGA2.
GenomeRNAii 23062.
NextBioi 44137.
PROi Q9UJY4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UJY4.
Bgeei Q9UJY4.
CleanExi HS_GGA2.
Genevestigatori Q9UJY4.

Family and domain databases

Gene3Di 1.25.40.90. 1 hit.
2.60.40.1230. 1 hit.
InterProi IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR008153. Clathrin_g-adaptin_app.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR008942. ENTH_VHS.
IPR004152. GAT.
IPR002014. VHS.
IPR018205. VHS_subgr.
[Graphical view ]
Pfami PF02883. Alpha_adaptinC2. 1 hit.
PF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view ]
SMARTi SM00809. Alpha_adaptinC2. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view ]
SUPFAMi SSF48464. SSF48464. 1 hit.
SSF49348. SSF49348. 1 hit.
PROSITEi PS50180. GAE. 1 hit.
PS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A family of ADP-ribosylation factor effectors that can alter transport through the trans-Golgi."
    Boman A.L., Zhang C.-J., Zhu X., Kahn R.A.
    Mol. Biol. Cell 11:1241-1255(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-424.
  2. "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome."
    Hirst J., Lui W.W.Y., Bright N.A., Totty N., Seaman M.N.J., Robinson M.S.
    J. Cell Biol. 149:67-80(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-424.
  3. "Vear, a novel Golgi-associated protein with VHS and gamma-adaptin 'ear' domains."
    Poussu A., Lohi O., Lehto V.-P.
    J. Biol. Chem. 275:7176-7183(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-424.
    Tissue: Eye.
  7. "The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein."
    Nielsen M.S., Madsen P., Christensen E.I., Nykjaer A., Gliemann J., Kasper D., Pohlmann R., Petersen C.M.
    EMBO J. 20:2180-2190(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-455, VARIANT PRO-424, INTERACTION WITH SORT1.
    Tissue: Mammary gland.
  8. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-613.
    Tissue: Brain.
  9. "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin."
    Takatsu H., Yoshino K., Nakayama K.
    Biochem. Biophys. Res. Commun. 271:719-725(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SYNRG.
  10. "The GGAs promote ARF-dependent recruitment of clathrin to the TGN."
    Puertollano R., Randazzo P.A., Presley J.F., Hartnell L.M., Bonifacino J.S.
    Cell 105:93-102(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CLATHRIN, MUTAGENESIS OF 349-LEU--GLU-353.
  11. "Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains."
    Takatsu H., Katoh Y., Shiba Y., Nakayama K.
    J. Biol. Chem. 276:28541-28545(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SORT; LRP3 AND IGF2R.
  12. "Sorting of mannose 6-phosphate receptors mediated by the GGAs."
    Puertollano R., Aguilar R.C., Gorshkova I., Crouch R.J., Bonifacino J.S.
    Science 292:1712-1716(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IGF2R.
  13. "GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors."
    Takatsu H., Yoshino K., Toda K., Nakayama K.
    Biochem. J. 365:369-378(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARF1; ARF5 AND ARF6.
  14. "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding."
    Jacobsen L., Madsen P., Nielsen M.S., Geraerts W.P.M., Gliemann J., Smit A.B., Petersen C.M.
    FEBS Lett. 511:155-158(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SORL1.
  15. "Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins."
    Doray B., Bruns K., Ghosh P., Kornfeld S.
    J. Biol. Chem. 277:18477-18482(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH M6PR AND IGF2R.
  16. "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi."
    Kalthoff C., Groos S., Kohl R., Mahrhold S., Ungewickell E.J.
    Mol. Biol. Cell 13:4060-4073(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EPN4.
  17. "Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins."
    He X., Zhu G., Koelsch G., Rodgers K.K., Zhang X.C., Tang J.
    Biochemistry 42:12174-12180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BACE1.
  18. "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex."
    Mattera R., Arighi C.N., Lodge R., Zerial M., Bonifacino J.S.
    EMBO J. 22:78-88(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RABEP1 AND RABGEF1.
  19. "Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin."
    Lui W.W.Y., Collins B.M., Hirst J., Motley A., Millar C., Schu P., Owen D.J., Robinson M.S.
    Mol. Biol. Cell 14:2385-2398(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CCDC91; P200 AND SYNRG.
  20. "Mammalian GGAs act together to sort mannose 6-phosphate receptors."
    Ghosh P., Griffith J., Geuze H.J., Kornfeld S.
    J. Cell Biol. 163:755-766(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GGA1 AND GGA3.
  21. "Definition of the consensus motif recognized by gamma-adaptin ear domains."
    Mattera R., Ritter B., Sidhu S.S., McPherson P.S., Bonifacino J.S.
    J. Biol. Chem. 279:8018-8028(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NECAP2.
  22. "Interactions of GGA3 with the ubiquitin sorting machinery."
    Puertollano R., Bonifacino J.S.
    Nat. Cell Biol. 6:244-251(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  23. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  24. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  25. "Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket."
    Zhu G., He X., Zhai P., Terzyan S., Tang J., Zhang X.C.
    FEBS Lett. 537:171-176(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 25-167.

Entry informationi

Entry nameiGGA2_HUMAN
AccessioniPrimary (citable) accession number: Q9UJY4
Secondary accession number(s): D3DWF0
, O14564, Q9NYN2, Q9UPS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: April 3, 2007
Last modified: July 9, 2014
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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