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Q9UJY4

- GGA2_HUMAN

UniProt

Q9UJY4 - GGA2_HUMAN

Protein

ADP-ribosylation factor-binding protein GGA2

Gene

GGA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 143 (01 Oct 2014)
      Sequence version 3 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.

    GO - Molecular functioni

    1. ADP-ribosylation factor binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. intracellular protein transport Source: UniProtKB
    2. vesicle-mediated transport Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP-ribosylation factor-binding protein GGA2
    Alternative name(s):
    Gamma-adaptin-related protein 2
    Golgi-localized, gamma ear-containing, ARF-binding protein 2
    VHS domain and ear domain of gamma-adaptin
    Short name:
    Vear
    Gene namesi
    Name:GGA2
    Synonyms:KIAA1080
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:16064. GGA2.

    Subcellular locationi

    Golgi apparatustrans-Golgi network membrane 1 Publication; Peripheral membrane protein 1 Publication. Endosome membrane 1 Publication; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. clathrin adaptor complex Source: InterPro
    2. clathrin-coated vesicle Source: UniProtKB
    3. endosome membrane Source: UniProtKB-SubCell
    4. Golgi apparatus Source: HPA
    5. trans-Golgi network Source: UniProtKB

    Keywords - Cellular componenti

    Endosome, Golgi apparatus, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi349 – 3535LIDLE → AADAA: Partial loss of clathrin-binding. 1 Publication

    Organism-specific databases

    PharmGKBiPA28658.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 613613ADP-ribosylation factor-binding protein GGA2PRO_0000212682Add
    BLAST

    Post-translational modificationi

    Ubiquitinated.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiQ9UJY4.
    PaxDbiQ9UJY4.
    PRIDEiQ9UJY4.

    PTM databases

    PhosphoSiteiQ9UJY4.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.

    Gene expression databases

    ArrayExpressiQ9UJY4.
    BgeeiQ9UJY4.
    CleanExiHS_GGA2.
    GenevestigatoriQ9UJY4.

    Organism-specific databases

    HPAiCAB034422.
    HPA043313.

    Interactioni

    Subunit structurei

    Monomer. Interacts with NECAP1, TSG101, UBC and AFTPH/aftiphilin. Interacts with CNST By similarity. Interacts with GGA1 and GGA3. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the type-I membrane proteins SORT1, SORL1, LRP3, M6PR/CD-MPR, IGF2R/CI-MPR and BACE1. Binds the accessory proteins CCDC91, P200, SYNRG, EPN4 and NECAP2.By similarity14 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RABEP1Q152766EBI-447646,EBI-447043

    Protein-protein interaction databases

    BioGridi116697. 31 interactions.
    DIPiDIP-31601N.
    IntActiQ9UJY4. 17 interactions.
    MINTiMINT-126110.
    STRINGi9606.ENSP00000311962.

    Structurei

    Secondary structure

    1
    613
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi26 – 349
    Helixi43 – 5513
    Helixi58 – 7114
    Helixi76 – 9217
    Helixi95 – 1017
    Helixi104 – 1129
    Helixi125 – 14117
    Helixi146 – 15712

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1MHQX-ray2.20A/B25-172[»]
    ProteinModelPortaliQ9UJY4.
    SMRiQ9UJY4. Positions 25-167, 188-316, 471-605.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9UJY4.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 163131VHSPROSITE-ProRule annotationAdd
    BLAST
    Domaini188 – 315128GATPROSITE-ProRule annotationAdd
    BLAST
    Domaini484 – 605122GAEPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni316 – 483168Unstructured hingeAdd
    BLAST

    Domaini

    The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif).
    The GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis.
    The unstructured hinge region contains clathrin-binding but no autoinhibitory (AC-LL) motifs.
    The GAE domain binds accessory proteins regulating GGAs function.

    Sequence similaritiesi

    Belongs to the GGA protein family.Curated
    Contains 1 GAE domain.PROSITE-ProRule annotation
    Contains 1 GAT domain.PROSITE-ProRule annotation
    Contains 1 VHS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG321636.
    HOGENOMiHOG000231169.
    HOVERGENiHBG015945.
    InParanoidiQ9UJY4.
    KOiK12404.
    OMAiMKNCPLI.
    OrthoDBiEOG7V49Z0.
    PhylomeDBiQ9UJY4.
    TreeFamiTF318574.

    Family and domain databases

    Gene3Di1.25.40.90. 1 hit.
    2.60.40.1230. 1 hit.
    InterProiIPR008152. Clathrin_a/b/g-adaptin_app_Ig.
    IPR008153. Clathrin_g-adaptin_app.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    IPR008942. ENTH_VHS.
    IPR004152. GAT.
    IPR002014. VHS.
    IPR018205. VHS_subgr.
    [Graphical view]
    PfamiPF02883. Alpha_adaptinC2. 1 hit.
    PF03127. GAT. 1 hit.
    PF00790. VHS. 1 hit.
    [Graphical view]
    SMARTiSM00809. Alpha_adaptinC2. 1 hit.
    SM00288. VHS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48464. SSF48464. 1 hit.
    SSF49348. SSF49348. 1 hit.
    PROSITEiPS50180. GAE. 1 hit.
    PS50909. GAT. 1 hit.
    PS50179. VHS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UJY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAATAVAAAV AGTESAQGPP GPAASLELWL NKATDPSMSE QDWSAIQNFC    50
    EQVNTDPNGP THAPWLLAHK IQSPQEKEAL YALTVLEMCM NHCGEKFHSE 100
    VAKFRFLNEL IKVLSPKYLG SWATGKVKGR VIEILFSWTV WFPEDIKIRD 150
    AYQMLKKQGI IKQDPKLPVD KILPPPSPWP KSSIFDADEE KSKLLTRLLK 200
    SNHPEDLQAA NRLIKNLVKE EQEKSEKVSK RVSAVEEVRS HVKVLQEMLS 250
    MYRRPGQAPP DQEALQVVYE RCEKLRPTLF RLASDTTDDD DALAEILQAN 300
    DLLTQGVLLY KQVMEGRVTF GNRVTSSLGD IPVSRVFQNP AGCMKTCPLI 350
    DLEVDNGPAQ MGTVVPSLLH QDLAALGISD APVTGMVSGQ NCCEEKRNPS 400
    SSTLPGGGVQ NPSADRNLLD LLSAQPAPCP LNYVSQKSVP KEVPPGTKSS 450
    PGWSWEAGPL APSPSSQNTP LAQVFVPLES VKPSSLPPLI VYDRNGFRIL 500
    LHFSQTGAPG HPEVQVLLLT MMSTAPQPVW DIMFQVAVPK SMRVKLQPAS 550
    SSKLPAFSPL MPPAVISQML LLDNPHKEPI RLRYKLTFNQ GGQPFSEVGE 600
    VKDFPDLAVL GAA 613
    Length:613
    Mass (Da):67,150
    Last modified:April 3, 2007 - v3
    Checksum:i4B627ABA474A069C
    GO

    Sequence cautioni

    The sequence AAK38634.1 differs from that shown. Reason: Frameshift at position 193.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti281 – 2811R → W in AAF05708. (PubMed:10749927)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti424 – 4241A → P.4 Publications
    Corresponds to variant rs1135045 [ dbSNP | Ensembl ].
    VAR_028275

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF190863 mRNA. Translation: AAF05708.1.
    AF233522 mRNA. Translation: AAF35394.1.
    AF165531 mRNA. Translation: AAF42806.1.
    AC002400 Genomic DNA. Translation: AAC05813.1.
    CH471145 Genomic DNA. Translation: EAW55827.1.
    CH471145 Genomic DNA. Translation: EAW55828.1.
    BC000284 mRNA. Translation: AAH00284.1.
    AF323754 mRNA. Translation: AAK38634.1. Frameshift.
    AB029003 mRNA. Translation: BAA83032.1.
    CCDSiCCDS10611.1.
    PIRiT00744.
    RefSeqiNP_055859.1. NM_015044.4.
    UniGeneiHs.460336.

    Genome annotation databases

    EnsembliENST00000309859; ENSP00000311962; ENSG00000103365.
    GeneIDi23062.
    KEGGihsa:23062.
    UCSCiuc002dlq.3. human.

    Polymorphism databases

    DMDMi143811397.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF190863 mRNA. Translation: AAF05708.1 .
    AF233522 mRNA. Translation: AAF35394.1 .
    AF165531 mRNA. Translation: AAF42806.1 .
    AC002400 Genomic DNA. Translation: AAC05813.1 .
    CH471145 Genomic DNA. Translation: EAW55827.1 .
    CH471145 Genomic DNA. Translation: EAW55828.1 .
    BC000284 mRNA. Translation: AAH00284.1 .
    AF323754 mRNA. Translation: AAK38634.1 . Frameshift.
    AB029003 mRNA. Translation: BAA83032.1 .
    CCDSi CCDS10611.1.
    PIRi T00744.
    RefSeqi NP_055859.1. NM_015044.4.
    UniGenei Hs.460336.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1MHQ X-ray 2.20 A/B 25-172 [» ]
    ProteinModelPortali Q9UJY4.
    SMRi Q9UJY4. Positions 25-167, 188-316, 471-605.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116697. 31 interactions.
    DIPi DIP-31601N.
    IntActi Q9UJY4. 17 interactions.
    MINTi MINT-126110.
    STRINGi 9606.ENSP00000311962.

    PTM databases

    PhosphoSitei Q9UJY4.

    Polymorphism databases

    DMDMi 143811397.

    Proteomic databases

    MaxQBi Q9UJY4.
    PaxDbi Q9UJY4.
    PRIDEi Q9UJY4.

    Protocols and materials databases

    DNASUi 23062.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309859 ; ENSP00000311962 ; ENSG00000103365 .
    GeneIDi 23062.
    KEGGi hsa:23062.
    UCSCi uc002dlq.3. human.

    Organism-specific databases

    CTDi 23062.
    GeneCardsi GC16M023474.
    HGNCi HGNC:16064. GGA2.
    HPAi CAB034422.
    HPA043313.
    MIMi 606005. gene.
    neXtProti NX_Q9UJY4.
    PharmGKBi PA28658.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG321636.
    HOGENOMi HOG000231169.
    HOVERGENi HBG015945.
    InParanoidi Q9UJY4.
    KOi K12404.
    OMAi MKNCPLI.
    OrthoDBi EOG7V49Z0.
    PhylomeDBi Q9UJY4.
    TreeFami TF318574.

    Miscellaneous databases

    ChiTaRSi GGA2. human.
    EvolutionaryTracei Q9UJY4.
    GeneWikii GGA2.
    GenomeRNAii 23062.
    NextBioi 44137.
    PROi Q9UJY4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UJY4.
    Bgeei Q9UJY4.
    CleanExi HS_GGA2.
    Genevestigatori Q9UJY4.

    Family and domain databases

    Gene3Di 1.25.40.90. 1 hit.
    2.60.40.1230. 1 hit.
    InterProi IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
    IPR008153. Clathrin_g-adaptin_app.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    IPR008942. ENTH_VHS.
    IPR004152. GAT.
    IPR002014. VHS.
    IPR018205. VHS_subgr.
    [Graphical view ]
    Pfami PF02883. Alpha_adaptinC2. 1 hit.
    PF03127. GAT. 1 hit.
    PF00790. VHS. 1 hit.
    [Graphical view ]
    SMARTi SM00809. Alpha_adaptinC2. 1 hit.
    SM00288. VHS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48464. SSF48464. 1 hit.
    SSF49348. SSF49348. 1 hit.
    PROSITEi PS50180. GAE. 1 hit.
    PS50909. GAT. 1 hit.
    PS50179. VHS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A family of ADP-ribosylation factor effectors that can alter transport through the trans-Golgi."
      Boman A.L., Zhang C.-J., Zhu X., Kahn R.A.
      Mol. Biol. Cell 11:1241-1255(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-424.
    2. "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome."
      Hirst J., Lui W.W.Y., Bright N.A., Totty N., Seaman M.N.J., Robinson M.S.
      J. Cell Biol. 149:67-80(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-424.
    3. "Vear, a novel Golgi-associated protein with VHS and gamma-adaptin 'ear' domains."
      Poussu A., Lohi O., Lehto V.-P.
      J. Biol. Chem. 275:7176-7183(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-424.
      Tissue: Eye.
    7. "The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein."
      Nielsen M.S., Madsen P., Christensen E.I., Nykjaer A., Gliemann J., Kasper D., Pohlmann R., Petersen C.M.
      EMBO J. 20:2180-2190(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-455, VARIANT PRO-424, INTERACTION WITH SORT1.
      Tissue: Mammary gland.
    8. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-613.
      Tissue: Brain.
    9. "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin."
      Takatsu H., Yoshino K., Nakayama K.
      Biochem. Biophys. Res. Commun. 271:719-725(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SYNRG.
    10. "The GGAs promote ARF-dependent recruitment of clathrin to the TGN."
      Puertollano R., Randazzo P.A., Presley J.F., Hartnell L.M., Bonifacino J.S.
      Cell 105:93-102(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CLATHRIN, MUTAGENESIS OF 349-LEU--GLU-353.
    11. "Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains."
      Takatsu H., Katoh Y., Shiba Y., Nakayama K.
      J. Biol. Chem. 276:28541-28545(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SORT; LRP3 AND IGF2R.
    12. "Sorting of mannose 6-phosphate receptors mediated by the GGAs."
      Puertollano R., Aguilar R.C., Gorshkova I., Crouch R.J., Bonifacino J.S.
      Science 292:1712-1716(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IGF2R.
    13. "GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors."
      Takatsu H., Yoshino K., Toda K., Nakayama K.
      Biochem. J. 365:369-378(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARF1; ARF5 AND ARF6.
    14. "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding."
      Jacobsen L., Madsen P., Nielsen M.S., Geraerts W.P.M., Gliemann J., Smit A.B., Petersen C.M.
      FEBS Lett. 511:155-158(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SORL1.
    15. "Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins."
      Doray B., Bruns K., Ghosh P., Kornfeld S.
      J. Biol. Chem. 277:18477-18482(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH M6PR AND IGF2R.
    16. "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi."
      Kalthoff C., Groos S., Kohl R., Mahrhold S., Ungewickell E.J.
      Mol. Biol. Cell 13:4060-4073(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EPN4.
    17. "Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins."
      He X., Zhu G., Koelsch G., Rodgers K.K., Zhang X.C., Tang J.
      Biochemistry 42:12174-12180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BACE1.
    18. "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex."
      Mattera R., Arighi C.N., Lodge R., Zerial M., Bonifacino J.S.
      EMBO J. 22:78-88(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RABEP1 AND RABGEF1.
    19. "Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin."
      Lui W.W.Y., Collins B.M., Hirst J., Motley A., Millar C., Schu P., Owen D.J., Robinson M.S.
      Mol. Biol. Cell 14:2385-2398(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CCDC91; P200 AND SYNRG.
    20. "Mammalian GGAs act together to sort mannose 6-phosphate receptors."
      Ghosh P., Griffith J., Geuze H.J., Kornfeld S.
      J. Cell Biol. 163:755-766(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GGA1 AND GGA3.
    21. "Definition of the consensus motif recognized by gamma-adaptin ear domains."
      Mattera R., Ritter B., Sidhu S.S., McPherson P.S., Bonifacino J.S.
      J. Biol. Chem. 279:8018-8028(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NECAP2.
    22. "Interactions of GGA3 with the ubiquitin sorting machinery."
      Puertollano R., Bonifacino J.S.
      Nat. Cell Biol. 6:244-251(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    23. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    24. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    25. "Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket."
      Zhu G., He X., Zhai P., Terzyan S., Tang J., Zhang X.C.
      FEBS Lett. 537:171-176(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 25-167.

    Entry informationi

    Entry nameiGGA2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UJY4
    Secondary accession number(s): D3DWF0
    , O14564, Q9NYN2, Q9UPS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 143 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3