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Q9UJY1

- HSPB8_HUMAN

UniProt

Q9UJY1 - HSPB8_HUMAN

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Protein

Heat shock protein beta-8

Gene

HSPB8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Displays temperature-dependent chaperone activity.

GO - Molecular functioni

  1. identical protein binding Source: IntAct

GO - Biological processi

  1. cell death Source: UniProtKB-KW
  2. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-8
Short name:
HspB8
Alternative name(s):
Alpha-crystallin C chain
E2-induced gene 1 protein
Protein kinase H11
Small stress protein-like protein HSP22
Gene namesi
Name:HSPB8
Synonyms:CRYAC, E2IG1, HSP22
ORF Names:PP1629
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:30171. HSPB8.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication
Note: Translocates to nuclear foci during heat shock.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. intracellular Source: LIFEdb
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Neuronopathy, distal hereditary motor, 2A (HMN2A) [MIM:158590]: A neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti141 – 1411K → E in HMN2A; strengthen interaction with HSPB1. 1 Publication
VAR_018504
Natural varianti141 – 1411K → N in HMN2A and CMT2L; strengthen interaction with HSPB1. 2 Publications
VAR_018505
Charcot-Marie-Tooth disease 2L (CMT2L) [MIM:608673]: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti141 – 1411K → N in HMN2A and CMT2L; strengthen interaction with HSPB1. 2 Publications
VAR_018505

Keywords - Diseasei

Charcot-Marie-Tooth disease, Disease mutation, Neurodegeneration, Neuropathy

Organism-specific databases

MIMi158590. phenotype.
608673. phenotype.
Orphaneti99945. Autosomal dominant Charcot-Marie-Tooth disease type 2L.
139525. Distal hereditary motor neuropathy type 2.
PharmGKBiPA134900173.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196Heat shock protein beta-8PRO_0000125945Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Phosphoserine2 Publications
Modified residuei63 – 631Phosphothreonine; by PKC; in vitro1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UJY1.
PaxDbiQ9UJY1.
PRIDEiQ9UJY1.

PTM databases

PhosphoSiteiQ9UJY1.

Expressioni

Tissue specificityi

Predominantly expressed in skeletal muscle and heart.1 Publication

Inductioni

By 17-beta-estradiol.

Gene expression databases

BgeeiQ9UJY1.
CleanExiHS_HSPB8.
GenevestigatoriQ9UJY1.

Organism-specific databases

HPAiHPA015876.

Interactioni

Subunit structurei

Monomer. Interacts with HSPB1. Interacts with DNAJB6.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself6EBI-739074,EBI-739074
BAG3O958174EBI-739074,EBI-747185
CRYABP025112EBI-739074,EBI-739060
HSPB1P047923EBI-739074,EBI-352682
HSPB2Q160823EBI-739074,EBI-739395
HSPB6O145582EBI-739074,EBI-739095
HSPB7Q9UBY95EBI-739074,EBI-739361

Protein-protein interaction databases

BioGridi117689. 14 interactions.
IntActiQ9UJY1. 12 interactions.
MINTiMINT-1456822.
STRINGi9606.ENSP00000281938.

Structurei

3D structure databases

ProteinModelPortaliQ9UJY1.
SMRiQ9UJY1. Positions 6-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG271659.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233955.
HOVERGENiHBG054766.
InParanoidiQ9UJY1.
KOiK08879.
OMAiPFGESSF.
OrthoDBiEOG7WHHBK.
PhylomeDBiQ9UJY1.
TreeFamiTF105049.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. a-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PIRSFiPIRSF036514. Sm_HSP_B1. 1 hit.
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UJY1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADGQMPFSC HYPSRLRRDP FRDSPLSSRL LDDGFGMDPF PDDLTASWPD
60 70 80 90 100
WALPRLSSAW PGTLRSGMVP RGPTATARFG VPAEGRTPPP FPGEPWKVCV
110 120 130 140 150
NVHSFKPEEL MVKTKDGYVE VSGKHEEKQQ EGGIVSKNFT KKIQLPAEVD
160 170 180 190
PVTVFASLSP EGLLIIEAPQ VPPYSTFGES SFNNELPQDS QEVTCT
Length:196
Mass (Da):21,604
Last modified:May 1, 2000 - v1
Checksum:iB76058CED52292CB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511W → C in AAD55359. (PubMed:10833516)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti67 – 671G → S in a glioblastoma multiforme sample; somatic mutation. 1 Publication
VAR_042244
Natural varianti78 – 781R → M.1 Publication
Corresponds to variant rs55826713 [ dbSNP | Ensembl ].
VAR_042245
Natural varianti141 – 1411K → E in HMN2A; strengthen interaction with HSPB1. 1 Publication
VAR_018504
Natural varianti141 – 1411K → N in HMN2A and CMT2L; strengthen interaction with HSPB1. 2 Publications
VAR_018505

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF191017 mRNA. Translation: AAF09481.1.
AF250138 mRNA. Translation: AAF65562.1.
AF133207 mRNA. Translation: AAD55359.1.
AL136936 mRNA. Translation: CAB66870.1.
AF217987 mRNA. Translation: AAG17230.1.
BT006876 mRNA. Translation: AAP35522.1.
CR533453 mRNA. Translation: CAG38484.1.
AK312501 mRNA. Translation: BAG35403.1.
CH471054 Genomic DNA. Translation: EAW98144.1.
BC002673 mRNA. Translation: AAH02673.1.
CCDSiCCDS9189.1.
RefSeqiNP_055180.1. NM_014365.2.
UniGeneiHs.400095.

Genome annotation databases

EnsembliENST00000281938; ENSP00000281938; ENSG00000152137.
GeneIDi26353.
KEGGihsa:26353.
UCSCiuc001txb.3. human.

Polymorphism databases

DMDMi13431576.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Inherited peripheral neuropathies mutation db

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF191017 mRNA. Translation: AAF09481.1 .
AF250138 mRNA. Translation: AAF65562.1 .
AF133207 mRNA. Translation: AAD55359.1 .
AL136936 mRNA. Translation: CAB66870.1 .
AF217987 mRNA. Translation: AAG17230.1 .
BT006876 mRNA. Translation: AAP35522.1 .
CR533453 mRNA. Translation: CAG38484.1 .
AK312501 mRNA. Translation: BAG35403.1 .
CH471054 Genomic DNA. Translation: EAW98144.1 .
BC002673 mRNA. Translation: AAH02673.1 .
CCDSi CCDS9189.1.
RefSeqi NP_055180.1. NM_014365.2.
UniGenei Hs.400095.

3D structure databases

ProteinModelPortali Q9UJY1.
SMRi Q9UJY1. Positions 6-170.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117689. 14 interactions.
IntActi Q9UJY1. 12 interactions.
MINTi MINT-1456822.
STRINGi 9606.ENSP00000281938.

PTM databases

PhosphoSitei Q9UJY1.

Polymorphism databases

DMDMi 13431576.

Proteomic databases

MaxQBi Q9UJY1.
PaxDbi Q9UJY1.
PRIDEi Q9UJY1.

Protocols and materials databases

DNASUi 26353.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000281938 ; ENSP00000281938 ; ENSG00000152137 .
GeneIDi 26353.
KEGGi hsa:26353.
UCSCi uc001txb.3. human.

Organism-specific databases

CTDi 26353.
GeneCardsi GC12P119616.
GeneReviewsi HSPB8.
HGNCi HGNC:30171. HSPB8.
HPAi HPA015876.
MIMi 158590. phenotype.
608014. gene.
608673. phenotype.
neXtProti NX_Q9UJY1.
Orphaneti 99945. Autosomal dominant Charcot-Marie-Tooth disease type 2L.
139525. Distal hereditary motor neuropathy type 2.
PharmGKBi PA134900173.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG271659.
GeneTreei ENSGT00760000119238.
HOGENOMi HOG000233955.
HOVERGENi HBG054766.
InParanoidi Q9UJY1.
KOi K08879.
OMAi PFGESSF.
OrthoDBi EOG7WHHBK.
PhylomeDBi Q9UJY1.
TreeFami TF105049.

Miscellaneous databases

ChiTaRSi HSPB8. human.
GeneWikii HSPB8.
GenomeRNAii 26353.
NextBioi 48689.
PROi Q9UJY1.
SOURCEi Search...

Gene expression databases

Bgeei Q9UJY1.
CleanExi HS_HSPB8.
Genevestigatori Q9UJY1.

Family and domain databases

Gene3Di 2.60.40.790. 1 hit.
InterProi IPR002068. a-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR008978. HSP20-like_chaperone.
[Graphical view ]
Pfami PF00011. HSP20. 1 hit.
[Graphical view ]
PIRSFi PIRSF036514. Sm_HSP_B1. 1 hit.
PRINTSi PR00299. ACRYSTALLIN.
SUPFAMi SSF49764. SSF49764. 1 hit.
PROSITEi PS01031. HSP20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Effects of estrogen on global gene expression: identification of novel targets of estrogen action."
    Charpentier A.H., Bednarek A.K., Daniel R.L., Hawkins K.A., Laflin K.J., Gaddis S., MacLeod M.C., Aldaz C.M.
    Cancer Res. 60:5977-5983(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 (3DHSP27)."
    Benndorf R., Sun X., Gilmont R.R., Biederman K.J., Molloy M.P., Goodmurphy C.W., Cheng H., Andrews P.C., Welsh M.J.
    J. Biol. Chem. 276:26753-26761(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH HSPB1.
  3. "A novel human gene similar to the protein kinase (PK) coding domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) codes for a serine-threonine PK and is expressed in melanoma cells."
    Smith C.C., Yu Y.X., Kulka M., Aurelian L.
    J. Biol. Chem. 275:25690-25699(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Melanoma.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  5. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  11. "Phosphopeptide derivatization signatures to identify serine and threonine phosphorylated peptides by mass spectrometry."
    Molloy M.P., Andrews P.C.
    Anal. Chem. 73:5387-5394(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-63, IDENTIFICATION BY MASS SPECTROMETRY.
  12. "Characterization of two novel human small heat shock proteins: protein kinase-related HspB8 and testis-specific HspB9."
    Kappe G., Verschuure P., Philipsen R.L.A., Staalduinen A.A., Van de Boogaart P., Boelens W.C., de Jong W.W.
    Biochim. Biophys. Acta 1520:1-6(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  13. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "HSPB7 is a SC35 speckle resident small heat shock protein."
    Vos M.J., Kanon B., Kampinga H.H.
    Biochim. Biophys. Acta 1793:1343-1353(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. Cited for: INTERACTION WITH DNAJB6.
  18. Cited for: VARIANTS HMN2A GLU-141 AND ASN-141.
  19. "Small heat-shock protein 22 mutated in autosomal dominant Charcot-Marie-Tooth disease type 2L."
    Tang B.-S., Zhao G.-H., Luo W., Xia K., Cai F., Pan Q., Zhang R.-X., Zhang F.F., Liu X.-M., Chen B., Zhang C., Shen L., Jiang H., Long Z.G., Dai H.-P.
    Hum. Genet. 116:222-224(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CMT2L ASN-141.
  20. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-67 AND MET-78.

Entry informationi

Entry nameiHSPB8_HUMAN
AccessioniPrimary (citable) accession number: Q9UJY1
Secondary accession number(s): B2R6A6, Q6FIH3, Q9UKS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was reported to have a protein kinase activity and to act as a Mn2+-dependent serine-threonine-specific protein kinase.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3