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Q9UJY1

- HSPB8_HUMAN

UniProt

Q9UJY1 - HSPB8_HUMAN

Protein

Heat shock protein beta-8

Gene

HSPB8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Displays temperature-dependent chaperone activity.

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell death Source: UniProtKB-KW
    2. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heat shock protein beta-8
    Short name:
    HspB8
    Alternative name(s):
    Alpha-crystallin C chain
    E2-induced gene 1 protein
    Protein kinase H11
    Small stress protein-like protein HSP22
    Gene namesi
    Name:HSPB8
    Synonyms:CRYAC, E2IG1, HSP22
    ORF Names:PP1629
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:30171. HSPB8.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: Translocates to nuclear foci during heat shock.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. intracellular Source: LIFEdb
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Neuronopathy, distal hereditary motor, 2A (HMN2A) [MIM:158590]: A neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti141 – 1411K → E in HMN2A; strengthen interaction with HSPB1. 1 Publication
    VAR_018504
    Natural varianti141 – 1411K → N in HMN2A and CMT2L; strengthen interaction with HSPB1. 2 Publications
    VAR_018505
    Charcot-Marie-Tooth disease 2L (CMT2L) [MIM:608673]: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti141 – 1411K → N in HMN2A and CMT2L; strengthen interaction with HSPB1. 2 Publications
    VAR_018505

    Keywords - Diseasei

    Charcot-Marie-Tooth disease, Disease mutation, Neurodegeneration, Neuropathy

    Organism-specific databases

    MIMi158590. phenotype.
    608673. phenotype.
    Orphaneti99945. Autosomal dominant Charcot-Marie-Tooth disease type 2L.
    139525. Distal hereditary motor neuropathy type 2.
    PharmGKBiPA134900173.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 196196Heat shock protein beta-8PRO_0000125945Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Phosphoserine2 Publications
    Modified residuei63 – 631Phosphothreonine; by PKC; in vitro1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9UJY1.
    PaxDbiQ9UJY1.
    PRIDEiQ9UJY1.

    PTM databases

    PhosphoSiteiQ9UJY1.

    Expressioni

    Tissue specificityi

    Predominantly expressed in skeletal muscle and heart.1 Publication

    Inductioni

    By 17-beta-estradiol.

    Gene expression databases

    BgeeiQ9UJY1.
    CleanExiHS_HSPB8.
    GenevestigatoriQ9UJY1.

    Organism-specific databases

    HPAiHPA015876.

    Interactioni

    Subunit structurei

    Monomer. Interacts with HSPB1. Interacts with DNAJB6.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself6EBI-739074,EBI-739074
    BAG3O958174EBI-739074,EBI-747185
    CRYABP025112EBI-739074,EBI-739060
    HSPB1P047923EBI-739074,EBI-352682
    HSPB2Q160823EBI-739074,EBI-739395
    HSPB6O145582EBI-739074,EBI-739095
    HSPB7Q9UBY95EBI-739074,EBI-739361

    Protein-protein interaction databases

    BioGridi117689. 13 interactions.
    IntActiQ9UJY1. 12 interactions.
    MINTiMINT-1456822.
    STRINGi9606.ENSP00000281938.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UJY1.
    SMRiQ9UJY1. Positions 6-170.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG271659.
    HOGENOMiHOG000233955.
    HOVERGENiHBG054766.
    InParanoidiQ9UJY1.
    KOiK08879.
    OMAiPFGESSF.
    OrthoDBiEOG7WHHBK.
    PhylomeDBiQ9UJY1.
    TreeFamiTF105049.

    Family and domain databases

    Gene3Di2.60.40.790. 1 hit.
    InterProiIPR002068. a-crystallin/Hsp20_dom.
    IPR001436. Alpha-crystallin/HSP.
    IPR008978. HSP20-like_chaperone.
    [Graphical view]
    PfamiPF00011. HSP20. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036514. Sm_HSP_B1. 1 hit.
    PRINTSiPR00299. ACRYSTALLIN.
    SUPFAMiSSF49764. SSF49764. 1 hit.
    PROSITEiPS01031. HSP20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UJY1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADGQMPFSC HYPSRLRRDP FRDSPLSSRL LDDGFGMDPF PDDLTASWPD    50
    WALPRLSSAW PGTLRSGMVP RGPTATARFG VPAEGRTPPP FPGEPWKVCV 100
    NVHSFKPEEL MVKTKDGYVE VSGKHEEKQQ EGGIVSKNFT KKIQLPAEVD 150
    PVTVFASLSP EGLLIIEAPQ VPPYSTFGES SFNNELPQDS QEVTCT 196
    Length:196
    Mass (Da):21,604
    Last modified:May 1, 2000 - v1
    Checksum:iB76058CED52292CB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti51 – 511W → C in AAD55359. (PubMed:10833516)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti67 – 671G → S in a glioblastoma multiforme sample; somatic mutation. 1 Publication
    VAR_042244
    Natural varianti78 – 781R → M.1 Publication
    Corresponds to variant rs55826713 [ dbSNP | Ensembl ].
    VAR_042245
    Natural varianti141 – 1411K → E in HMN2A; strengthen interaction with HSPB1. 1 Publication
    VAR_018504
    Natural varianti141 – 1411K → N in HMN2A and CMT2L; strengthen interaction with HSPB1. 2 Publications
    VAR_018505

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF191017 mRNA. Translation: AAF09481.1.
    AF250138 mRNA. Translation: AAF65562.1.
    AF133207 mRNA. Translation: AAD55359.1.
    AL136936 mRNA. Translation: CAB66870.1.
    AF217987 mRNA. Translation: AAG17230.1.
    BT006876 mRNA. Translation: AAP35522.1.
    CR533453 mRNA. Translation: CAG38484.1.
    AK312501 mRNA. Translation: BAG35403.1.
    CH471054 Genomic DNA. Translation: EAW98144.1.
    BC002673 mRNA. Translation: AAH02673.1.
    CCDSiCCDS9189.1.
    RefSeqiNP_055180.1. NM_014365.2.
    UniGeneiHs.400095.

    Genome annotation databases

    EnsembliENST00000281938; ENSP00000281938; ENSG00000152137.
    GeneIDi26353.
    KEGGihsa:26353.
    UCSCiuc001txb.3. human.

    Polymorphism databases

    DMDMi13431576.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Inherited peripheral neuropathies mutation db

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF191017 mRNA. Translation: AAF09481.1 .
    AF250138 mRNA. Translation: AAF65562.1 .
    AF133207 mRNA. Translation: AAD55359.1 .
    AL136936 mRNA. Translation: CAB66870.1 .
    AF217987 mRNA. Translation: AAG17230.1 .
    BT006876 mRNA. Translation: AAP35522.1 .
    CR533453 mRNA. Translation: CAG38484.1 .
    AK312501 mRNA. Translation: BAG35403.1 .
    CH471054 Genomic DNA. Translation: EAW98144.1 .
    BC002673 mRNA. Translation: AAH02673.1 .
    CCDSi CCDS9189.1.
    RefSeqi NP_055180.1. NM_014365.2.
    UniGenei Hs.400095.

    3D structure databases

    ProteinModelPortali Q9UJY1.
    SMRi Q9UJY1. Positions 6-170.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117689. 13 interactions.
    IntActi Q9UJY1. 12 interactions.
    MINTi MINT-1456822.
    STRINGi 9606.ENSP00000281938.

    PTM databases

    PhosphoSitei Q9UJY1.

    Polymorphism databases

    DMDMi 13431576.

    Proteomic databases

    MaxQBi Q9UJY1.
    PaxDbi Q9UJY1.
    PRIDEi Q9UJY1.

    Protocols and materials databases

    DNASUi 26353.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000281938 ; ENSP00000281938 ; ENSG00000152137 .
    GeneIDi 26353.
    KEGGi hsa:26353.
    UCSCi uc001txb.3. human.

    Organism-specific databases

    CTDi 26353.
    GeneCardsi GC12P119616.
    GeneReviewsi HSPB8.
    HGNCi HGNC:30171. HSPB8.
    HPAi HPA015876.
    MIMi 158590. phenotype.
    608014. gene.
    608673. phenotype.
    neXtProti NX_Q9UJY1.
    Orphaneti 99945. Autosomal dominant Charcot-Marie-Tooth disease type 2L.
    139525. Distal hereditary motor neuropathy type 2.
    PharmGKBi PA134900173.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG271659.
    HOGENOMi HOG000233955.
    HOVERGENi HBG054766.
    InParanoidi Q9UJY1.
    KOi K08879.
    OMAi PFGESSF.
    OrthoDBi EOG7WHHBK.
    PhylomeDBi Q9UJY1.
    TreeFami TF105049.

    Miscellaneous databases

    ChiTaRSi HSPB8. human.
    GeneWikii HSPB8.
    GenomeRNAii 26353.
    NextBioi 48689.
    PROi Q9UJY1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UJY1.
    CleanExi HS_HSPB8.
    Genevestigatori Q9UJY1.

    Family and domain databases

    Gene3Di 2.60.40.790. 1 hit.
    InterProi IPR002068. a-crystallin/Hsp20_dom.
    IPR001436. Alpha-crystallin/HSP.
    IPR008978. HSP20-like_chaperone.
    [Graphical view ]
    Pfami PF00011. HSP20. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036514. Sm_HSP_B1. 1 hit.
    PRINTSi PR00299. ACRYSTALLIN.
    SUPFAMi SSF49764. SSF49764. 1 hit.
    PROSITEi PS01031. HSP20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Effects of estrogen on global gene expression: identification of novel targets of estrogen action."
      Charpentier A.H., Bednarek A.K., Daniel R.L., Hawkins K.A., Laflin K.J., Gaddis S., MacLeod M.C., Aldaz C.M.
      Cancer Res. 60:5977-5983(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 (3DHSP27)."
      Benndorf R., Sun X., Gilmont R.R., Biederman K.J., Molloy M.P., Goodmurphy C.W., Cheng H., Andrews P.C., Welsh M.J.
      J. Biol. Chem. 276:26753-26761(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH HSPB1.
    3. "A novel human gene similar to the protein kinase (PK) coding domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) codes for a serine-threonine PK and is expressed in melanoma cells."
      Smith C.C., Yu Y.X., Kulka M., Aurelian L.
      J. Biol. Chem. 275:25690-25699(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Melanoma.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    5. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thalamus.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    11. "Phosphopeptide derivatization signatures to identify serine and threonine phosphorylated peptides by mass spectrometry."
      Molloy M.P., Andrews P.C.
      Anal. Chem. 73:5387-5394(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-63, IDENTIFICATION BY MASS SPECTROMETRY.
    12. "Characterization of two novel human small heat shock proteins: protein kinase-related HspB8 and testis-specific HspB9."
      Kappe G., Verschuure P., Philipsen R.L.A., Staalduinen A.A., Van de Boogaart P., Boelens W.C., de Jong W.W.
      Biochim. Biophys. Acta 1520:1-6(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    13. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. "HSPB7 is a SC35 speckle resident small heat shock protein."
      Vos M.J., Kanon B., Kampinga H.H.
      Biochim. Biophys. Acta 1793:1343-1353(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. Cited for: INTERACTION WITH DNAJB6.
    18. Cited for: VARIANTS HMN2A GLU-141 AND ASN-141.
    19. "Small heat-shock protein 22 mutated in autosomal dominant Charcot-Marie-Tooth disease type 2L."
      Tang B.-S., Zhao G.-H., Luo W., Xia K., Cai F., Pan Q., Zhang R.-X., Zhang F.F., Liu X.-M., Chen B., Zhang C., Shen L., Jiang H., Long Z.G., Dai H.-P.
      Hum. Genet. 116:222-224(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CMT2L ASN-141.
    20. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-67 AND MET-78.

    Entry informationi

    Entry nameiHSPB8_HUMAN
    AccessioniPrimary (citable) accession number: Q9UJY1
    Secondary accession number(s): B2R6A6, Q6FIH3, Q9UKS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was reported to have a protein kinase activity and to act as a Mn2+-dependent serine-threonine-specific protein kinase.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3