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Protein

Oxidative stress-induced growth inhibitor 1

Gene

OSGIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the differentiation and proliferation of normal cells through the regulation of cell death.2 Publications

GO - Molecular functioni

  • growth factor activity Source: UniProtKB
  • oxidoreductase activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Oxidative stress-induced growth inhibitor 1
Alternative name(s):
Ovary, kidney and liver protein 38
Short name:
huOKL38
Pregnancy-induced growth inhibitor OKL38
Gene namesi
Name:OSGIN1
Synonyms:OKL38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:30093. OSGIN1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162398489.

Polymorphism and mutation databases

BioMutaiOSGIN1.
DMDMi334302887.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Oxidative stress-induced growth inhibitor 1PRO_0000165371Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei95 – 951PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UJX0.
PaxDbiQ9UJX0.
PeptideAtlasiQ9UJX0.
PRIDEiQ9UJX0.

PTM databases

iPTMnetiQ9UJX0.
PhosphoSiteiQ9UJX0.

Expressioni

Tissue specificityi

Ubiquitous. Highest expression in the ovary, testis, kidney, and liver.2 Publications

Inductioni

By pregnancy.

Gene expression databases

BgeeiQ9UJX0.
CleanExiHS_OSGIN1.
ExpressionAtlasiQ9UJX0. baseline and differential.
GenevisibleiQ9UJX0. HS.

Organism-specific databases

HPAiHPA019239.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081173EBI-9057006,EBI-717810
CAPN3P208073EBI-9057006,EBI-5655000
CRXO431863EBI-9057006,EBI-748171
DNAJA3Q96EY1-23EBI-9057006,EBI-3952284
IKZF3Q9UKT93EBI-9057006,EBI-747204
INCA1Q0VD863EBI-9057006,EBI-6509505
LNX1Q8TBB13EBI-9057006,EBI-739832
MEIS2O147703EBI-9057006,EBI-2804934
MEOX2A4D1273EBI-9057006,EBI-10172134
RELQ048643EBI-9057006,EBI-307352
SAXO1Q8IYX73EBI-9057006,EBI-3957636
TCF12Q990813EBI-9057006,EBI-722877
TCF4P158843EBI-9057006,EBI-533224

GO - Molecular functioni

  • growth factor activity Source: UniProtKB

Protein-protein interaction databases

BioGridi118985. 26 interactions.
IntActiQ9UJX0. 21 interactions.
STRINGi9606.ENSP00000355374.

Structurei

3D structure databases

ProteinModelPortaliQ9UJX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OKL38 family.Curated

Phylogenomic databases

eggNOGiENOG410IF6I. Eukaryota.
ENOG410ZAI8. LUCA.
GeneTreeiENSGT00390000006658.
HOGENOMiHOG000007354.
HOVERGENiHBG050933.
InParanoidiQ9UJX0.
OMAiPGHRLLC.
OrthoDBiEOG7P2XSZ.
PhylomeDBiQ9UJX0.
TreeFamiTF313502.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR029731. OKL38_fam.
IPR029724. OSGIN1.
[Graphical view]
PANTHERiPTHR15192. PTHR15192. 1 hit.
PTHR15192:SF15. PTHR15192:SF15. 1 hit.
SUPFAMiSSF51905. SSF51905. 3 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q9UJX0-1) [UniParc]FASTAAdd to basket

Also known as: 2b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKWRPRGCC RGNMQCRQEV PATLTSSELF STRNQPQPQP QPLLADAPVP
60 70 80 90 100
WAVASRMCLT PGQGCGHQGQ DEGPLPAPSP PPAMSSSRKD HLGASSSEPL
110 120 130 140 150
PVIIVGNGPS GICLSYLLSG YTPYTKPDAI HPHPLLQRKL TEAPGVSILD
160 170 180 190 200
QDLDYLSEGL EGRSQSPVAL LFDALLRPDT DFGGNMKSVL TWKHRKEHAI
210 220 230 240 250
PHVVLGRNLP GGAWHSIEGS MVILSQGQWM GLPDLEVKDW MQKKRRGLRN
260 270 280 290 300
SRATAGDIAH YYRDYVVKKG LGHNFVSGAV VTAVEWGTPD PSSCGAQDSS
310 320 330 340 350
PLFQVSGFLT RNQAQQPFSL WARNVVLATG TFDSPARLGI PGEALPFIHH
360 370 380 390 400
ELSALEAATR VGAVTPASDP VLIIGAGLSA ADAVLYARHY NIPVIHAFRR
410 420 430 440 450
AVDDPGLVFN QLPKMLYPEY HKVHQMMREQ SILSPSPYEG YRSLPRHQLL
460 470 480 490 500
CFKEDCQAVF QDLEGVEKVF GVSLVLVLIG SHPDLSFLPG AGADFAVDPD
510 520 530 540 550
QPLSAKRNPI DVDPFTYQST RQEGLYAMGP LAGDNFVRFV QGGALAVASS
560
LLRKETRKPP
Length:560
Mass (Da):60,849
Last modified:May 31, 2011 - v3
Checksum:iFBF10381DAADE80E
GO
Isoform 1 (identifier: Q9UJX0-2) [UniParc]FASTAAdd to basket

Also known as: 1a, 2a

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:477
Mass (Da):51,992
Checksum:i29E936C20B23E7C0
GO
Isoform 3 (identifier: Q9UJX0-3)

Also known as: 2c

Sequence is not available
Length:
Mass (Da):

Sequence cautioni

The sequence AAF06662.1 differs from that shown. Reason: Frameshift at positions 493, 523, 534 and 554. Curated
The sequence AAK01722.2 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 593MCL → LCV in AAK01722 (PubMed:14570898).Curated
Sequence conflicti57 – 593MCL → LCV in AAP14662 (PubMed:14570898).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61P → L.1 Publication
Corresponds to variant rs4782865 [ dbSNP | Ensembl ].
VAR_065237
Natural varianti34 – 341N → T.1 Publication
Corresponds to variant rs28555129 [ dbSNP | Ensembl ].
VAR_065238
Natural varianti57 – 571M → L.
Corresponds to variant rs2244899 [ dbSNP | Ensembl ].
VAR_065239
Natural varianti59 – 591L → V.
Corresponds to variant rs2244898 [ dbSNP | Ensembl ].
VAR_065240
Natural varianti439 – 4391E → D.
Corresponds to variant rs35145453 [ dbSNP | Ensembl ].
VAR_056575

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8383Missing in isoform 1. 3 PublicationsVSP_010500Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334780 Genomic DNA. Translation: AAK01722.2. Sequence problems.
AY258066 mRNA. Translation: AAP14662.1.
AY258067 mRNA. Translation: AAP14663.1.
AY258068 mRNA. Translation: AAP14664.1.
AY037158 mRNA. Translation: AAK67637.1.
AK290383 mRNA. Translation: BAF83072.1.
AC040169 Genomic DNA. No translation available.
CH471114 Genomic DNA. Translation: EAW95511.1.
BC093687 mRNA. Translation: AAH93687.2.
BC113417 mRNA. Translation: AAI13418.2.
BC032476 mRNA. Translation: AAH32476.1.
AF191740 mRNA. Translation: AAF06662.1. Frameshift.
CCDSiCCDS10939.1. [Q9UJX0-2]
RefSeqiNP_892026.1. NM_182981.2. [Q9UJX0-2]
UniGeneiHs.128055.

Genome annotation databases

EnsembliENST00000343939; ENSP00000343376; ENSG00000140961. [Q9UJX0-1]
ENST00000361711; ENSP00000355374; ENSG00000140961. [Q9UJX0-2]
ENST00000393306; ENSP00000376983; ENSG00000140961. [Q9UJX0-2]
GeneIDi29948.
KEGGihsa:29948.
UCSCiuc002fha.4. human. [Q9UJX0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334780 Genomic DNA. Translation: AAK01722.2. Sequence problems.
AY258066 mRNA. Translation: AAP14662.1.
AY258067 mRNA. Translation: AAP14663.1.
AY258068 mRNA. Translation: AAP14664.1.
AY037158 mRNA. Translation: AAK67637.1.
AK290383 mRNA. Translation: BAF83072.1.
AC040169 Genomic DNA. No translation available.
CH471114 Genomic DNA. Translation: EAW95511.1.
BC093687 mRNA. Translation: AAH93687.2.
BC113417 mRNA. Translation: AAI13418.2.
BC032476 mRNA. Translation: AAH32476.1.
AF191740 mRNA. Translation: AAF06662.1. Frameshift.
CCDSiCCDS10939.1. [Q9UJX0-2]
RefSeqiNP_892026.1. NM_182981.2. [Q9UJX0-2]
UniGeneiHs.128055.

3D structure databases

ProteinModelPortaliQ9UJX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118985. 26 interactions.
IntActiQ9UJX0. 21 interactions.
STRINGi9606.ENSP00000355374.

PTM databases

iPTMnetiQ9UJX0.
PhosphoSiteiQ9UJX0.

Polymorphism and mutation databases

BioMutaiOSGIN1.
DMDMi334302887.

Proteomic databases

MaxQBiQ9UJX0.
PaxDbiQ9UJX0.
PeptideAtlasiQ9UJX0.
PRIDEiQ9UJX0.

Protocols and materials databases

DNASUi29948.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343939; ENSP00000343376; ENSG00000140961. [Q9UJX0-1]
ENST00000361711; ENSP00000355374; ENSG00000140961. [Q9UJX0-2]
ENST00000393306; ENSP00000376983; ENSG00000140961. [Q9UJX0-2]
GeneIDi29948.
KEGGihsa:29948.
UCSCiuc002fha.4. human. [Q9UJX0-1]

Organism-specific databases

CTDi29948.
GeneCardsiOSGIN1.
HGNCiHGNC:30093. OSGIN1.
HPAiHPA019239.
MIMi607975. gene.
neXtProtiNX_Q9UJX0.
PharmGKBiPA162398489.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF6I. Eukaryota.
ENOG410ZAI8. LUCA.
GeneTreeiENSGT00390000006658.
HOGENOMiHOG000007354.
HOVERGENiHBG050933.
InParanoidiQ9UJX0.
OMAiPGHRLLC.
OrthoDBiEOG7P2XSZ.
PhylomeDBiQ9UJX0.
TreeFamiTF313502.

Miscellaneous databases

GenomeRNAii29948.
PROiQ9UJX0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UJX0.
CleanExiHS_OSGIN1.
ExpressionAtlasiQ9UJX0. baseline and differential.
GenevisibleiQ9UJX0. HS.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR029731. OKL38_fam.
IPR029724. OSGIN1.
[Graphical view]
PANTHERiPTHR15192. PTHR15192. 1 hit.
PTHR15192:SF15. PTHR15192:SF15. 1 hit.
SUPFAMiSSF51905. SSF51905. 3 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic structure of human OKL38 gene and its differential expression in kidney carcinogenesis."
    Ong C.K., Ng C.Y., Leong C., Ng C.P., Foo K.T., Tan P.H., Huynh H.T.
    J. Biol. Chem. 279:743-754(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2 AND 3), FUNCTION, TISSUE SPECIFICITY, VARIANTS LEU-6 AND THR-34.
  2. Li N., Zhang M., Wan T., Zhang W., Cao X.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Leukocyte and Liver.
  7. "Cloning and characterization of a novel pregnancy-induced growth inhibitor in mammary gland."
    Huynh H.T., Ng C.Y., Ong C.K., Lim K.B., Chan T.W.M.
    Endocrinology 142:3607-3615(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 145-560, FUNCTION, TISSUE SPECIFICITY.
    Tissue: Mammary gland and Ovary.
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiOSGI1_HUMAN
AccessioniPrimary (citable) accession number: Q9UJX0
Secondary accession number(s): Q52M33
, Q86UQ1, Q96S88, Q9BZ70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 31, 2011
Last modified: July 6, 2016
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Loss of OSGIN1 protein disturbs the balance between cell growth, differentiation, and cell death in normal tissue, resulting in uncontrolled growth and formation of tumors.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.