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Protein

Oxidative stress-induced growth inhibitor 1

Gene

OSGIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the differentiation and proliferation of normal cells through the regulation of cell death.2 Publications

Miscellaneous

Loss of OSGIN1 protein disturbs the balance between cell growth, differentiation, and cell death in normal tissue, resulting in uncontrolled growth and formation of tumors.

GO - Molecular functioni

  • growth factor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Oxidative stress-induced growth inhibitor 1
Alternative name(s):
Ovary, kidney and liver protein 38
Short name:
huOKL38
Pregnancy-induced growth inhibitor OKL38
Gene namesi
Name:OSGIN1
Synonyms:OKL38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000140961.12.
HGNCiHGNC:30093. OSGIN1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi29948.
OpenTargetsiENSG00000140961.
PharmGKBiPA162398489.

Polymorphism and mutation databases

BioMutaiOSGIN1.
DMDMi334302887.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001653711 – 560Oxidative stress-induced growth inhibitor 1Add BLAST560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei95PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9UJX0.
PeptideAtlasiQ9UJX0.
PRIDEiQ9UJX0.

PTM databases

iPTMnetiQ9UJX0.
PhosphoSitePlusiQ9UJX0.

Expressioni

Tissue specificityi

Ubiquitous. Highest expression in the ovary, testis, kidney, and liver.2 Publications

Inductioni

By pregnancy.

Gene expression databases

BgeeiENSG00000140961.
CleanExiHS_OSGIN1.
ExpressionAtlasiQ9UJX0. baseline and differential.
GenevisibleiQ9UJX0. HS.

Organism-specific databases

HPAiHPA019239.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • growth factor activity Source: UniProtKB

Protein-protein interaction databases

BioGridi118985. 26 interactors.
IntActiQ9UJX0. 42 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9UJX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OKL38 family.Curated

Phylogenomic databases

eggNOGiENOG410IF6I. Eukaryota.
ENOG410ZAI8. LUCA.
GeneTreeiENSGT00390000006658.
HOGENOMiHOG000007354.
HOVERGENiHBG050933.
InParanoidiQ9UJX0.
OMAiIHAFRRP.
OrthoDBiEOG091G02F9.
PhylomeDBiQ9UJX0.
TreeFamiTF313502.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiView protein in InterPro
IPR036188. FAD/NAD-bd_sf.
IPR029731. OKL38_fam.
IPR029724. OSGIN1.
PANTHERiPTHR15192. PTHR15192. 1 hit.
PTHR15192:SF15. PTHR15192:SF15. 1 hit.
SUPFAMiSSF51905. SSF51905. 3 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q9UJX0-1) [UniParc]FASTAAdd to basket
Also known as: 2b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKWRPRGCC RGNMQCRQEV PATLTSSELF STRNQPQPQP QPLLADAPVP
60 70 80 90 100
WAVASRMCLT PGQGCGHQGQ DEGPLPAPSP PPAMSSSRKD HLGASSSEPL
110 120 130 140 150
PVIIVGNGPS GICLSYLLSG YTPYTKPDAI HPHPLLQRKL TEAPGVSILD
160 170 180 190 200
QDLDYLSEGL EGRSQSPVAL LFDALLRPDT DFGGNMKSVL TWKHRKEHAI
210 220 230 240 250
PHVVLGRNLP GGAWHSIEGS MVILSQGQWM GLPDLEVKDW MQKKRRGLRN
260 270 280 290 300
SRATAGDIAH YYRDYVVKKG LGHNFVSGAV VTAVEWGTPD PSSCGAQDSS
310 320 330 340 350
PLFQVSGFLT RNQAQQPFSL WARNVVLATG TFDSPARLGI PGEALPFIHH
360 370 380 390 400
ELSALEAATR VGAVTPASDP VLIIGAGLSA ADAVLYARHY NIPVIHAFRR
410 420 430 440 450
AVDDPGLVFN QLPKMLYPEY HKVHQMMREQ SILSPSPYEG YRSLPRHQLL
460 470 480 490 500
CFKEDCQAVF QDLEGVEKVF GVSLVLVLIG SHPDLSFLPG AGADFAVDPD
510 520 530 540 550
QPLSAKRNPI DVDPFTYQST RQEGLYAMGP LAGDNFVRFV QGGALAVASS
560
LLRKETRKPP
Length:560
Mass (Da):60,849
Last modified:May 31, 2011 - v3
Checksum:iFBF10381DAADE80E
GO
Isoform 1 (identifier: Q9UJX0-2) [UniParc]FASTAAdd to basket
Also known as: 1a, 2a

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:477
Mass (Da):51,992
Checksum:i29E936C20B23E7C0
GO
Isoform 3 (identifier: Q9UJX0-3)
Also known as: 2c
Sequence is not available
Length:
Mass (Da):

Sequence cautioni

The sequence AAF06662 differs from that shown. Reason: Frameshift at positions 493, 523, 534 and 554.Curated
The sequence AAK01722 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57 – 59MCL → LCV in AAK01722 (PubMed:14570898).Curated3
Sequence conflicti57 – 59MCL → LCV in AAP14662 (PubMed:14570898).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0652376P → L1 PublicationCorresponds to variant dbSNP:rs4782865Ensembl.1
Natural variantiVAR_06523834N → T1 PublicationCorresponds to variant dbSNP:rs28555129Ensembl.1
Natural variantiVAR_06523957M → L. Corresponds to variant dbSNP:rs2244899Ensembl.1
Natural variantiVAR_06524059L → V. Corresponds to variant dbSNP:rs2244898Ensembl.1
Natural variantiVAR_056575439E → D. Corresponds to variant dbSNP:rs35145453Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0105001 – 83Missing in isoform 1. 3 PublicationsAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334780 Genomic DNA. Translation: AAK01722.2. Sequence problems.
AY258066 mRNA. Translation: AAP14662.1.
AY258067 mRNA. Translation: AAP14663.1.
AY258068 mRNA. Translation: AAP14664.1.
AY037158 mRNA. Translation: AAK67637.1.
AK290383 mRNA. Translation: BAF83072.1.
AC040169 Genomic DNA. No translation available.
CH471114 Genomic DNA. Translation: EAW95511.1.
BC093687 mRNA. Translation: AAH93687.2.
BC113417 mRNA. Translation: AAI13418.2.
BC032476 mRNA. Translation: AAH32476.1.
AF191740 mRNA. Translation: AAF06662.1. Frameshift.
CCDSiCCDS10939.1. [Q9UJX0-2]
RefSeqiNP_892026.1. NM_182981.2. [Q9UJX0-2]
UniGeneiHs.128055.

Genome annotation databases

EnsembliENST00000343939; ENSP00000343376; ENSG00000140961. [Q9UJX0-1]
ENST00000361711; ENSP00000355374; ENSG00000140961. [Q9UJX0-2]
ENST00000393306; ENSP00000376983; ENSG00000140961. [Q9UJX0-2]
GeneIDi29948.
KEGGihsa:29948.
UCSCiuc002fha.4. human. [Q9UJX0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOSGI1_HUMAN
AccessioniPrimary (citable) accession number: Q9UJX0
Secondary accession number(s): Q52M33
, Q86UQ1, Q96S88, Q9BZ70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 31, 2011
Last modified: October 25, 2017
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families