Q9UJW9 (SRTD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SERTA domain-containing protein 3

Alternative name(s):
Replication protein-binding trans-activator
Short name=RPA-binding trans-activator

Gene names

Name:	SERTAD3
Synonyms:	RBT1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Strong transcriptional coactivator. Ref.1
Subunit structure	Interacts with RPA2. Ref.1
Subcellular location	Nucleus Ref.1.
Sequence similarities	Contains 1 SERTA domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of cell growth Inferred from direct assay PubMed 16098148. Source: MGI positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay PubMed 16098148. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
USHBP1	Q8N6Y0	4	EBI-748621,EBI-739895

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 196	196	SERTA domain-containing protein 3		PRO_0000191615
Regions
	Domain	26 – 73	48	SERTA
Experimental info
	Sequence conflict	2	1	V → E in AAF05761. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9UJW9 [UniParc]. Last modified February 1, 2005. Version 2. Checksum: 9C54AFA126F17AF1	FASTA	196	21,769
	10 20 30 40 50 60 MVGGLKRKHS DLEEEEERWE WSPAGLQSYQ QALLRISLDK VQRSLGPRAP SLRRHVLIHN 70 80 90 100 110 120 TLQQLQAALR LAPAPALPPE PLFLGEEDFS LSATIGSILR ELDTSMDGTE PPQNPVTPLG 130 140 150 160 170 180 LQNEVPPQPD PVFLEALSSR YLGDSGLDDF FLDIDTSAVE KEPARAPPEP PHNLFCAPGS 190 WEWNELDHIM EIILGS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A." Cho J.M., Song D.J., Bergeron J., Benlimame N., Wold M.S., Alaoui-Jamali M.A. Nucleic Acids Res. 28:3478-3485(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RPA2.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary and Uterus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF192529 mRNA. Translation: AAF05761.1. AK074604 mRNA. Translation: BAG51975.1. CH471126 Genomic DNA. Translation: EAW56966.1. BC014061 mRNA. Translation: AAH14061.1. BC050643 mRNA. Translation: AAH50643.1.
IPI	IPI00073563.
RefSeq	NP_037500.2. NM_013368.3. NP_976219.1. NM_203344.2.
UniGene	Hs.515412.
3D structure databases
ProteinModelPortal	Q9UJW9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UJW9. 17 interactions.
STRING	9606.ENSP00000325414.
PTM databases
PhosphoSite	Q9UJW9.
Polymorphism databases
DMDM	60415943.
Proteomic databases
PaxDb	Q9UJW9.
PRIDE	Q9UJW9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000322354; ENSP00000325414; ENSG00000167565. ENST00000392028; ENSP00000375882; ENSG00000167565.
GeneID	29946.
KEGG	hsa:29946.
UCSC	uc002onu.4. human.
Organism-specific databases
CTD	29946.
GeneCards	GC19M040946.
HGNC	HGNC:17931. SERTAD3.
MIM	612125. gene.
neXtProt	NX_Q9UJW9.
PharmGKB	PA134941720.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46358.
HOGENOM	HOG000133073.
HOVERGEN	HBG055009.
InParanoid	Q9UJW9.
OMA	EDEKWDW.
OrthoDB	EOG4V9TS2.
PhylomeDB	Q9UJW9.
Gene expression databases
Bgee	Q9UJW9.
CleanEx	HS_SERTAD3.
Genevestigator	Q9UJW9.
GermOnline	ENSG00000167565. Homo sapiens.
Family and domain databases
InterPro	IPR009263. SERTA. [Graphical view]
Pfam	PF06031. SERTA. 1 hit. [Graphical view]
PROSITE	PS51053. SERTA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	29946.
NextBio	52615.
SOURCE	Search...

Entry information

Entry name

SRTD3_HUMAN

Accession

Primary (citable) accession number: Q9UJW9
Secondary accession number(s): B3KQB3, Q96CQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	February 1, 2005
Last modified:	April 3, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.