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Protein

SERTA domain-containing protein 3

Gene

SERTAD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Strong transcriptional coactivator.1 Publication

GO - Biological processi

  1. negative regulation of cell growth Source: MGI
  2. positive regulation of transcription, DNA-templated Source: Ensembl
  3. regulation of transcription, DNA-templated Source: UniProtKB
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SERTA domain-containing protein 3
Alternative name(s):
Replication protein-binding trans-activator
Short name:
RPA-binding trans-activator
Gene namesi
Name:SERTAD3
Synonyms:RBT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:17931. SERTAD3.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134941720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196SERTA domain-containing protein 3PRO_0000191615Add
BLAST

Proteomic databases

PaxDbiQ9UJW9.
PRIDEiQ9UJW9.

PTM databases

PhosphoSiteiQ9UJW9.

Expressioni

Gene expression databases

BgeeiQ9UJW9.
CleanExiHS_SERTAD3.
ExpressionAtlasiQ9UJW9. baseline and differential.
GenevestigatoriQ9UJW9.

Interactioni

Subunit structurei

Interacts with RPA2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RPA2P159275EBI-748621,EBI-621404
USHBP1Q8N6Y04EBI-748621,EBI-739895

Protein-protein interaction databases

BioGridi118983. 8 interactions.
IntActiQ9UJW9. 19 interactions.
STRINGi9606.ENSP00000325414.

Structurei

3D structure databases

ProteinModelPortaliQ9UJW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 7348SERTAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SERTA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG46358.
GeneTreeiENSGT00730000111546.
HOGENOMiHOG000133073.
HOVERGENiHBG055009.
InParanoidiQ9UJW9.
OMAiEDEKWDW.
OrthoDBiEOG7K0ZF2.
PhylomeDBiQ9UJW9.
TreeFamiTF101069.

Family and domain databases

InterProiIPR009263. SERTA_dom.
[Graphical view]
PfamiPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEiPS51053. SERTA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UJW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGGLKRKHS DLEEEEERWE WSPAGLQSYQ QALLRISLDK VQRSLGPRAP
60 70 80 90 100
SLRRHVLIHN TLQQLQAALR LAPAPALPPE PLFLGEEDFS LSATIGSILR
110 120 130 140 150
ELDTSMDGTE PPQNPVTPLG LQNEVPPQPD PVFLEALSSR YLGDSGLDDF
160 170 180 190
FLDIDTSAVE KEPARAPPEP PHNLFCAPGS WEWNELDHIM EIILGS
Length:196
Mass (Da):21,769
Last modified:January 31, 2005 - v2
Checksum:i9C54AFA126F17AF1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21V → E in AAF05761 (PubMed:10982866).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192529 mRNA. Translation: AAF05761.1.
AK074604 mRNA. Translation: BAG51975.1.
CH471126 Genomic DNA. Translation: EAW56966.1.
BC014061 mRNA. Translation: AAH14061.1.
BC050643 mRNA. Translation: AAH50643.1.
CCDSiCCDS12558.1.
RefSeqiNP_037500.2. NM_013368.3.
NP_976219.1. NM_203344.2.
XP_005258889.1. XM_005258832.1.
XP_006723242.1. XM_006723179.1.
UniGeneiHs.515412.

Genome annotation databases

EnsembliENST00000322354; ENSP00000325414; ENSG00000167565.
ENST00000392028; ENSP00000375882; ENSG00000167565.
GeneIDi29946.
KEGGihsa:29946.
UCSCiuc002onu.4. human.

Polymorphism databases

DMDMi60415943.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192529 mRNA. Translation: AAF05761.1.
AK074604 mRNA. Translation: BAG51975.1.
CH471126 Genomic DNA. Translation: EAW56966.1.
BC014061 mRNA. Translation: AAH14061.1.
BC050643 mRNA. Translation: AAH50643.1.
CCDSiCCDS12558.1.
RefSeqiNP_037500.2. NM_013368.3.
NP_976219.1. NM_203344.2.
XP_005258889.1. XM_005258832.1.
XP_006723242.1. XM_006723179.1.
UniGeneiHs.515412.

3D structure databases

ProteinModelPortaliQ9UJW9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118983. 8 interactions.
IntActiQ9UJW9. 19 interactions.
STRINGi9606.ENSP00000325414.

PTM databases

PhosphoSiteiQ9UJW9.

Polymorphism databases

DMDMi60415943.

Proteomic databases

PaxDbiQ9UJW9.
PRIDEiQ9UJW9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322354; ENSP00000325414; ENSG00000167565.
ENST00000392028; ENSP00000375882; ENSG00000167565.
GeneIDi29946.
KEGGihsa:29946.
UCSCiuc002onu.4. human.

Organism-specific databases

CTDi29946.
GeneCardsiGC19M040946.
HGNCiHGNC:17931. SERTAD3.
MIMi612125. gene.
neXtProtiNX_Q9UJW9.
PharmGKBiPA134941720.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46358.
GeneTreeiENSGT00730000111546.
HOGENOMiHOG000133073.
HOVERGENiHBG055009.
InParanoidiQ9UJW9.
OMAiEDEKWDW.
OrthoDBiEOG7K0ZF2.
PhylomeDBiQ9UJW9.
TreeFamiTF101069.

Miscellaneous databases

GenomeRNAii29946.
NextBioi52615.
PROiQ9UJW9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UJW9.
CleanExiHS_SERTAD3.
ExpressionAtlasiQ9UJW9. baseline and differential.
GenevestigatoriQ9UJW9.

Family and domain databases

InterProiIPR009263. SERTA_dom.
[Graphical view]
PfamiPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEiPS51053. SERTA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A."
    Cho J.M., Song D.J., Bergeron J., Benlimame N., Wold M.S., Alaoui-Jamali M.A.
    Nucleic Acids Res. 28:3478-3485(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RPA2.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary and Uterus.

Entry informationi

Entry nameiSRTD3_HUMAN
AccessioniPrimary (citable) accession number: Q9UJW9
Secondary accession number(s): B3KQB3, Q96CQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2005
Last sequence update: January 31, 2005
Last modified: February 3, 2015
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.