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Protein

SERTA domain-containing protein 3

Gene

SERTAD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Strong transcriptional coactivator.1 Publication

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SERTA domain-containing protein 3
Alternative name(s):
Replication protein-binding trans-activator
Short name:
RPA-binding trans-activator
Gene namesi
Name:SERTAD3
Synonyms:RBT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:17931. SERTAD3.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: HPA
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167565.
PharmGKBiPA134941720.

Polymorphism and mutation databases

BioMutaiSERTAD3.
DMDMi60415943.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916151 – 196SERTA domain-containing protein 3Add BLAST196

Proteomic databases

EPDiQ9UJW9.
PaxDbiQ9UJW9.
PeptideAtlasiQ9UJW9.
PRIDEiQ9UJW9.

PTM databases

iPTMnetiQ9UJW9.
PhosphoSitePlusiQ9UJW9.

Expressioni

Gene expression databases

BgeeiENSG00000167565.
CleanExiHS_SERTAD3.
ExpressionAtlasiQ9UJW9. baseline and differential.
GenevisibleiQ9UJW9. HS.

Organism-specific databases

HPAiHPA068262.

Interactioni

Subunit structurei

Interacts with RPA2.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi118983. 7 interactors.
IntActiQ9UJW9. 44 interactors.
STRINGi9606.ENSP00000325414.

Structurei

3D structure databases

ProteinModelPortaliQ9UJW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 73SERTAPROSITE-ProRule annotationAdd BLAST48

Phylogenomic databases

eggNOGiENOG410JAJA. Eukaryota.
ENOG41119NJ. LUCA.
GeneTreeiENSGT00730000111546.
HOGENOMiHOG000133073.
HOVERGENiHBG055009.
InParanoidiQ9UJW9.
OMAiEDEKWDW.
OrthoDBiEOG090A0ECX.
PhylomeDBiQ9UJW9.
TreeFamiTF101069.

Family and domain databases

InterProiView protein in InterPro
IPR009263. SERTA_dom.
PfamiView protein in Pfam
PF06031. SERTA. 1 hit.
PROSITEiView protein in PROSITE
PS51053. SERTA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UJW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGGLKRKHS DLEEEEERWE WSPAGLQSYQ QALLRISLDK VQRSLGPRAP
60 70 80 90 100
SLRRHVLIHN TLQQLQAALR LAPAPALPPE PLFLGEEDFS LSATIGSILR
110 120 130 140 150
ELDTSMDGTE PPQNPVTPLG LQNEVPPQPD PVFLEALSSR YLGDSGLDDF
160 170 180 190
FLDIDTSAVE KEPARAPPEP PHNLFCAPGS WEWNELDHIM EIILGS
Length:196
Mass (Da):21,769
Last modified:February 1, 2005 - v2
Checksum:i9C54AFA126F17AF1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2V → E in AAF05761 (PubMed:10982866).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192529 mRNA. Translation: AAF05761.1.
AK074604 mRNA. Translation: BAG51975.1.
CH471126 Genomic DNA. Translation: EAW56966.1.
BC014061 mRNA. Translation: AAH14061.1.
BC050643 mRNA. Translation: AAH50643.1.
CCDSiCCDS12558.1.
RefSeqiNP_037500.2. NM_013368.3.
NP_976219.1. NM_203344.2.
XP_005258889.1. XM_005258832.3.
XP_006723242.1. XM_006723179.3.
UniGeneiHs.515412.

Genome annotation databases

EnsembliENST00000322354; ENSP00000325414; ENSG00000167565.
ENST00000392028; ENSP00000375882; ENSG00000167565.
GeneIDi29946.
KEGGihsa:29946.
UCSCiuc002onu.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192529 mRNA. Translation: AAF05761.1.
AK074604 mRNA. Translation: BAG51975.1.
CH471126 Genomic DNA. Translation: EAW56966.1.
BC014061 mRNA. Translation: AAH14061.1.
BC050643 mRNA. Translation: AAH50643.1.
CCDSiCCDS12558.1.
RefSeqiNP_037500.2. NM_013368.3.
NP_976219.1. NM_203344.2.
XP_005258889.1. XM_005258832.3.
XP_006723242.1. XM_006723179.3.
UniGeneiHs.515412.

3D structure databases

ProteinModelPortaliQ9UJW9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118983. 7 interactors.
IntActiQ9UJW9. 44 interactors.
STRINGi9606.ENSP00000325414.

PTM databases

iPTMnetiQ9UJW9.
PhosphoSitePlusiQ9UJW9.

Polymorphism and mutation databases

BioMutaiSERTAD3.
DMDMi60415943.

Proteomic databases

EPDiQ9UJW9.
PaxDbiQ9UJW9.
PeptideAtlasiQ9UJW9.
PRIDEiQ9UJW9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322354; ENSP00000325414; ENSG00000167565.
ENST00000392028; ENSP00000375882; ENSG00000167565.
GeneIDi29946.
KEGGihsa:29946.
UCSCiuc002onu.5. human.

Organism-specific databases

CTDi29946.
GeneCardsiSERTAD3.
HGNCiHGNC:17931. SERTAD3.
HPAiHPA068262.
MIMi612125. gene.
neXtProtiNX_Q9UJW9.
OpenTargetsiENSG00000167565.
PharmGKBiPA134941720.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAJA. Eukaryota.
ENOG41119NJ. LUCA.
GeneTreeiENSGT00730000111546.
HOGENOMiHOG000133073.
HOVERGENiHBG055009.
InParanoidiQ9UJW9.
OMAiEDEKWDW.
OrthoDBiEOG090A0ECX.
PhylomeDBiQ9UJW9.
TreeFamiTF101069.

Miscellaneous databases

GenomeRNAii29946.
PROiQ9UJW9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167565.
CleanExiHS_SERTAD3.
ExpressionAtlasiQ9UJW9. baseline and differential.
GenevisibleiQ9UJW9. HS.

Family and domain databases

InterProiView protein in InterPro
IPR009263. SERTA_dom.
PfamiView protein in Pfam
PF06031. SERTA. 1 hit.
PROSITEiView protein in PROSITE
PS51053. SERTA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSRTD3_HUMAN
AccessioniPrimary (citable) accession number: Q9UJW9
Secondary accession number(s): B3KQB3, Q96CQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: February 15, 2017
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.