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Q9UJW9 (SRTD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SERTA domain-containing protein 3
Alternative name(s):
Replication protein-binding trans-activator
Short name=RPA-binding trans-activator
Gene names
Name:SERTAD3
Synonyms:RBT1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length196 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Strong transcriptional coactivator. Ref.1

Subunit structure

Interacts with RPA2. Ref.1

Subcellular location

Nucleus Ref.1.

Sequence similarities

Contains 1 SERTA domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

RPA2P159275EBI-748621,EBI-621404
USHBP1Q8N6Y04EBI-748621,EBI-739895

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 196196SERTA domain-containing protein 3
PRO_0000191615

Regions

Domain26 – 7348SERTA

Experimental info

Sequence conflict21V → E in AAF05761. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9UJW9 [UniParc].

Last modified February 1, 2005. Version 2.
Checksum: 9C54AFA126F17AF1

FASTA19621,769
        10         20         30         40         50         60 
MVGGLKRKHS DLEEEEERWE WSPAGLQSYQ QALLRISLDK VQRSLGPRAP SLRRHVLIHN 

        70         80         90        100        110        120 
TLQQLQAALR LAPAPALPPE PLFLGEEDFS LSATIGSILR ELDTSMDGTE PPQNPVTPLG 

       130        140        150        160        170        180 
LQNEVPPQPD PVFLEALSSR YLGDSGLDDF FLDIDTSAVE KEPARAPPEP PHNLFCAPGS 

       190 
WEWNELDHIM EIILGS 

« Hide

References

« Hide 'large scale' references
[1]"RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A."
Cho J.M., Song D.J., Bergeron J., Benlimame N., Wold M.S., Alaoui-Jamali M.A.
Nucleic Acids Res. 28:3478-3485(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RPA2.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary and Uterus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF192529 mRNA. Translation: AAF05761.1.
AK074604 mRNA. Translation: BAG51975.1.
CH471126 Genomic DNA. Translation: EAW56966.1.
BC014061 mRNA. Translation: AAH14061.1.
BC050643 mRNA. Translation: AAH50643.1.
CCDSCCDS12558.1.
RefSeqNP_037500.2. NM_013368.3.
NP_976219.1. NM_203344.2.
XP_005258889.1. XM_005258832.1.
XP_006723242.1. XM_006723179.1.
UniGeneHs.515412.

3D structure databases

ProteinModelPortalQ9UJW9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118983. 4 interactions.
IntActQ9UJW9. 18 interactions.
STRING9606.ENSP00000325414.

PTM databases

PhosphoSiteQ9UJW9.

Polymorphism databases

DMDM60415943.

Proteomic databases

PaxDbQ9UJW9.
PRIDEQ9UJW9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000322354; ENSP00000325414; ENSG00000167565.
ENST00000392028; ENSP00000375882; ENSG00000167565.
GeneID29946.
KEGGhsa:29946.
UCSCuc002onu.4. human.

Organism-specific databases

CTD29946.
GeneCardsGC19M040946.
HGNCHGNC:17931. SERTAD3.
MIM612125. gene.
neXtProtNX_Q9UJW9.
PharmGKBPA134941720.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46358.
HOGENOMHOG000133073.
HOVERGENHBG055009.
InParanoidQ9UJW9.
OMAQLQAALC.
OrthoDBEOG7K0ZF2.
PhylomeDBQ9UJW9.
TreeFamTF101069.

Gene expression databases

ArrayExpressQ9UJW9.
BgeeQ9UJW9.
CleanExHS_SERTAD3.
GenevestigatorQ9UJW9.

Family and domain databases

InterProIPR009263. SERTA_dom.
[Graphical view]
PfamPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEPS51053. SERTA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi29946.
NextBio52615.
PROQ9UJW9.
SOURCESearch...

Entry information

Entry nameSRTD3_HUMAN
AccessionPrimary (citable) accession number: Q9UJW9
Secondary accession number(s): B3KQB3, Q96CQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM