Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9UJW9

- SRTD3_HUMAN

UniProt

Q9UJW9 - SRTD3_HUMAN

Protein

SERTA domain-containing protein 3

Gene

SERTAD3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (01 Feb 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Strong transcriptional coactivator.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. negative regulation of cell growth Source: MGI
    2. positive regulation of transcription, DNA-templated Source: Ensembl
    3. regulation of transcription, DNA-templated Source: UniProtKB
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SERTA domain-containing protein 3
    Alternative name(s):
    Replication protein-binding trans-activator
    Short name:
    RPA-binding trans-activator
    Gene namesi
    Name:SERTAD3
    Synonyms:RBT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:17931. SERTAD3.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134941720.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 196196SERTA domain-containing protein 3PRO_0000191615Add
    BLAST

    Proteomic databases

    PaxDbiQ9UJW9.
    PRIDEiQ9UJW9.

    PTM databases

    PhosphoSiteiQ9UJW9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UJW9.
    BgeeiQ9UJW9.
    CleanExiHS_SERTAD3.
    GenevestigatoriQ9UJW9.

    Interactioni

    Subunit structurei

    Interacts with RPA2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RPA2P159275EBI-748621,EBI-621404
    USHBP1Q8N6Y04EBI-748621,EBI-739895

    Protein-protein interaction databases

    BioGridi118983. 4 interactions.
    IntActiQ9UJW9. 18 interactions.
    STRINGi9606.ENSP00000325414.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UJW9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 7348SERTAPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SERTA domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG46358.
    HOGENOMiHOG000133073.
    HOVERGENiHBG055009.
    InParanoidiQ9UJW9.
    OMAiQLQAALC.
    OrthoDBiEOG7K0ZF2.
    PhylomeDBiQ9UJW9.
    TreeFamiTF101069.

    Family and domain databases

    InterProiIPR009263. SERTA_dom.
    [Graphical view]
    PfamiPF06031. SERTA. 1 hit.
    [Graphical view]
    PROSITEiPS51053. SERTA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UJW9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVGGLKRKHS DLEEEEERWE WSPAGLQSYQ QALLRISLDK VQRSLGPRAP    50
    SLRRHVLIHN TLQQLQAALR LAPAPALPPE PLFLGEEDFS LSATIGSILR 100
    ELDTSMDGTE PPQNPVTPLG LQNEVPPQPD PVFLEALSSR YLGDSGLDDF 150
    FLDIDTSAVE KEPARAPPEP PHNLFCAPGS WEWNELDHIM EIILGS 196
    Length:196
    Mass (Da):21,769
    Last modified:February 1, 2005 - v2
    Checksum:i9C54AFA126F17AF1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21V → E in AAF05761. (PubMed:10982866)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF192529 mRNA. Translation: AAF05761.1.
    AK074604 mRNA. Translation: BAG51975.1.
    CH471126 Genomic DNA. Translation: EAW56966.1.
    BC014061 mRNA. Translation: AAH14061.1.
    BC050643 mRNA. Translation: AAH50643.1.
    CCDSiCCDS12558.1.
    RefSeqiNP_037500.2. NM_013368.3.
    NP_976219.1. NM_203344.2.
    XP_005258889.1. XM_005258832.1.
    XP_006723242.1. XM_006723179.1.
    UniGeneiHs.515412.

    Genome annotation databases

    EnsembliENST00000322354; ENSP00000325414; ENSG00000167565.
    ENST00000392028; ENSP00000375882; ENSG00000167565.
    GeneIDi29946.
    KEGGihsa:29946.
    UCSCiuc002onu.4. human.

    Polymorphism databases

    DMDMi60415943.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF192529 mRNA. Translation: AAF05761.1 .
    AK074604 mRNA. Translation: BAG51975.1 .
    CH471126 Genomic DNA. Translation: EAW56966.1 .
    BC014061 mRNA. Translation: AAH14061.1 .
    BC050643 mRNA. Translation: AAH50643.1 .
    CCDSi CCDS12558.1.
    RefSeqi NP_037500.2. NM_013368.3.
    NP_976219.1. NM_203344.2.
    XP_005258889.1. XM_005258832.1.
    XP_006723242.1. XM_006723179.1.
    UniGenei Hs.515412.

    3D structure databases

    ProteinModelPortali Q9UJW9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118983. 4 interactions.
    IntActi Q9UJW9. 18 interactions.
    STRINGi 9606.ENSP00000325414.

    PTM databases

    PhosphoSitei Q9UJW9.

    Polymorphism databases

    DMDMi 60415943.

    Proteomic databases

    PaxDbi Q9UJW9.
    PRIDEi Q9UJW9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322354 ; ENSP00000325414 ; ENSG00000167565 .
    ENST00000392028 ; ENSP00000375882 ; ENSG00000167565 .
    GeneIDi 29946.
    KEGGi hsa:29946.
    UCSCi uc002onu.4. human.

    Organism-specific databases

    CTDi 29946.
    GeneCardsi GC19M040946.
    HGNCi HGNC:17931. SERTAD3.
    MIMi 612125. gene.
    neXtProti NX_Q9UJW9.
    PharmGKBi PA134941720.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46358.
    HOGENOMi HOG000133073.
    HOVERGENi HBG055009.
    InParanoidi Q9UJW9.
    OMAi QLQAALC.
    OrthoDBi EOG7K0ZF2.
    PhylomeDBi Q9UJW9.
    TreeFami TF101069.

    Miscellaneous databases

    GenomeRNAii 29946.
    NextBioi 52615.
    PROi Q9UJW9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UJW9.
    Bgeei Q9UJW9.
    CleanExi HS_SERTAD3.
    Genevestigatori Q9UJW9.

    Family and domain databases

    InterProi IPR009263. SERTA_dom.
    [Graphical view ]
    Pfami PF06031. SERTA. 1 hit.
    [Graphical view ]
    PROSITEi PS51053. SERTA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A."
      Cho J.M., Song D.J., Bergeron J., Benlimame N., Wold M.S., Alaoui-Jamali M.A.
      Nucleic Acids Res. 28:3478-3485(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RPA2.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary and Uterus.

    Entry informationi

    Entry nameiSRTD3_HUMAN
    AccessioniPrimary (citable) accession number: Q9UJW9
    Secondary accession number(s): B3KQB3, Q96CQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3