Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9UJW9

- SRTD3_HUMAN

UniProt

Q9UJW9 - SRTD3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

SERTA domain-containing protein 3

Gene

SERTAD3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Strong transcriptional coactivator.1 Publication

GO - Biological processi

  1. negative regulation of cell growth Source: MGI
  2. positive regulation of transcription, DNA-templated Source: Ensembl
  3. regulation of transcription, DNA-templated Source: UniProtKB
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SERTA domain-containing protein 3
Alternative name(s):
Replication protein-binding trans-activator
Short name:
RPA-binding trans-activator
Gene namesi
Name:SERTAD3
Synonyms:RBT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:17931. SERTAD3.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134941720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196SERTA domain-containing protein 3PRO_0000191615Add
BLAST

Proteomic databases

PaxDbiQ9UJW9.
PRIDEiQ9UJW9.

PTM databases

PhosphoSiteiQ9UJW9.

Expressioni

Gene expression databases

BgeeiQ9UJW9.
CleanExiHS_SERTAD3.
ExpressionAtlasiQ9UJW9. baseline and differential.
GenevestigatoriQ9UJW9.

Interactioni

Subunit structurei

Interacts with RPA2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RPA2P159275EBI-748621,EBI-621404
USHBP1Q8N6Y04EBI-748621,EBI-739895

Protein-protein interaction databases

BioGridi118983. 5 interactions.
IntActiQ9UJW9. 19 interactions.
STRINGi9606.ENSP00000325414.

Structurei

3D structure databases

ProteinModelPortaliQ9UJW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 7348SERTAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SERTA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG46358.
GeneTreeiENSGT00730000111546.
HOGENOMiHOG000133073.
HOVERGENiHBG055009.
InParanoidiQ9UJW9.
OMAiQLQAALC.
OrthoDBiEOG7K0ZF2.
PhylomeDBiQ9UJW9.
TreeFamiTF101069.

Family and domain databases

InterProiIPR009263. SERTA_dom.
[Graphical view]
PfamiPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEiPS51053. SERTA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UJW9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVGGLKRKHS DLEEEEERWE WSPAGLQSYQ QALLRISLDK VQRSLGPRAP
60 70 80 90 100
SLRRHVLIHN TLQQLQAALR LAPAPALPPE PLFLGEEDFS LSATIGSILR
110 120 130 140 150
ELDTSMDGTE PPQNPVTPLG LQNEVPPQPD PVFLEALSSR YLGDSGLDDF
160 170 180 190
FLDIDTSAVE KEPARAPPEP PHNLFCAPGS WEWNELDHIM EIILGS
Length:196
Mass (Da):21,769
Last modified:February 1, 2005 - v2
Checksum:i9C54AFA126F17AF1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21V → E in AAF05761. (PubMed:10982866)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192529 mRNA. Translation: AAF05761.1.
AK074604 mRNA. Translation: BAG51975.1.
CH471126 Genomic DNA. Translation: EAW56966.1.
BC014061 mRNA. Translation: AAH14061.1.
BC050643 mRNA. Translation: AAH50643.1.
CCDSiCCDS12558.1.
RefSeqiNP_037500.2. NM_013368.3.
NP_976219.1. NM_203344.2.
XP_005258889.1. XM_005258832.1.
XP_006723242.1. XM_006723179.1.
UniGeneiHs.515412.

Genome annotation databases

EnsembliENST00000322354; ENSP00000325414; ENSG00000167565.
ENST00000392028; ENSP00000375882; ENSG00000167565.
GeneIDi29946.
KEGGihsa:29946.
UCSCiuc002onu.4. human.

Polymorphism databases

DMDMi60415943.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192529 mRNA. Translation: AAF05761.1 .
AK074604 mRNA. Translation: BAG51975.1 .
CH471126 Genomic DNA. Translation: EAW56966.1 .
BC014061 mRNA. Translation: AAH14061.1 .
BC050643 mRNA. Translation: AAH50643.1 .
CCDSi CCDS12558.1.
RefSeqi NP_037500.2. NM_013368.3.
NP_976219.1. NM_203344.2.
XP_005258889.1. XM_005258832.1.
XP_006723242.1. XM_006723179.1.
UniGenei Hs.515412.

3D structure databases

ProteinModelPortali Q9UJW9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118983. 5 interactions.
IntActi Q9UJW9. 19 interactions.
STRINGi 9606.ENSP00000325414.

PTM databases

PhosphoSitei Q9UJW9.

Polymorphism databases

DMDMi 60415943.

Proteomic databases

PaxDbi Q9UJW9.
PRIDEi Q9UJW9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000322354 ; ENSP00000325414 ; ENSG00000167565 .
ENST00000392028 ; ENSP00000375882 ; ENSG00000167565 .
GeneIDi 29946.
KEGGi hsa:29946.
UCSCi uc002onu.4. human.

Organism-specific databases

CTDi 29946.
GeneCardsi GC19M040946.
HGNCi HGNC:17931. SERTAD3.
MIMi 612125. gene.
neXtProti NX_Q9UJW9.
PharmGKBi PA134941720.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46358.
GeneTreei ENSGT00730000111546.
HOGENOMi HOG000133073.
HOVERGENi HBG055009.
InParanoidi Q9UJW9.
OMAi QLQAALC.
OrthoDBi EOG7K0ZF2.
PhylomeDBi Q9UJW9.
TreeFami TF101069.

Miscellaneous databases

GenomeRNAii 29946.
NextBioi 52615.
PROi Q9UJW9.
SOURCEi Search...

Gene expression databases

Bgeei Q9UJW9.
CleanExi HS_SERTAD3.
ExpressionAtlasi Q9UJW9. baseline and differential.
Genevestigatori Q9UJW9.

Family and domain databases

InterProi IPR009263. SERTA_dom.
[Graphical view ]
Pfami PF06031. SERTA. 1 hit.
[Graphical view ]
PROSITEi PS51053. SERTA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A."
    Cho J.M., Song D.J., Bergeron J., Benlimame N., Wold M.S., Alaoui-Jamali M.A.
    Nucleic Acids Res. 28:3478-3485(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RPA2.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary and Uterus.

Entry informationi

Entry nameiSRTD3_HUMAN
AccessioniPrimary (citable) accession number: Q9UJW9
Secondary accession number(s): B3KQB3, Q96CQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: October 29, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3