Q9UJW8 (ZN180_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 180

Alternative name(s):
HHZ168

Gene names

Name:

ZNF180

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	692 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 12 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 692	692	Zinc finger protein 180		PRO_0000047442
Regions
	Domain	72 – 145	74	KRAB
	Zinc finger	353 – 375	23	C2H2-type 1
	Zinc finger	381 – 403	23	C2H2-type 2
	Zinc finger	409 – 431	23	C2H2-type 3
	Zinc finger	437 – 459	23	C2H2-type 4
	Zinc finger	465 – 487	23	C2H2-type 5
	Zinc finger	493 – 515	23	C2H2-type 6
	Zinc finger	521 – 543	23	C2H2-type 7
	Zinc finger	549 – 571	23	C2H2-type 8
	Zinc finger	577 – 599	23	C2H2-type 9
	Zinc finger	605 – 627	23	C2H2-type 10
	Zinc finger	633 – 655	23	C2H2-type 11
	Zinc finger	661 – 683	23	C2H2-type 12
Natural variations
	Natural variant	41	1	A → V. Ref.1 Corresponds to variant rs2571108 [ dbSNP | Ensembl ].		VAR_030864
	Natural variant	89	1	W → C. Ref.1 Corresponds to variant rs2253563 [ dbSNP | Ensembl ].		VAR_030865
	Natural variant	272	1	C → S. Ref.1 Corresponds to variant rs1897820 [ dbSNP | Ensembl ].		VAR_030866

Sequences

	Sequence		Length	Mass (Da)
	Q9UJW8 [UniParc]. Last modified March 6, 2007. Version 2. Checksum: 689812AB1E277525	FASTA	692	79,111
	10 20 30 40 50 60 MRACAGSTRE AGSGAQDLST LLCLEESMEE QDEKPPEPPK ACAQDSFLPQ EIIIKVEGED 70 80 90 100 110 120 TGSLTIPSQE GVNFKIVTVD FTREEQGTWN PAQRTLDRDV ILENHRDLVS WDLATAVGKK 130 140 150 160 170 180 DSTSKQRIFD EEPANGVKIE RFTRDDPWLS SCEEVDDCKD QLEKQQEKQE ILLQEVAFTQ 190 200 210 220 230 240 RKAVIHERVC KSDETGEKSG LNSSLFSSPV IPIRNHFHKH VSHAKKWHLN AAVNSHQKIN 250 260 270 280 290 300 ENETLYENNE CGKPPQSIHL IQFTRTQTKD KCYGFSDRIQ SFCHGTPLHI HEKIHGGGKT 310 320 330 340 350 360 FDFKECGQVL NPKISHNEQQ RIPFEESQYK CSETSHSSSL TQNMRNNSEE KPFECNQCGK 370 380 390 400 410 420 SFSWSSHLVA HQRTHTGEKP YECSECGKSF SRSSHLVSHQ RTHTGEKPYR CNQCGKSFSQ 430 440 450 460 470 480 SYVLVVHQRT HTGEKPYECN QCGKSFRQSY KLIAHQRTHT GEKPYECNQC GKSFIQSYKL 490 500 510 520 530 540 IAHQRIHTGE KPYECNQCGK SFSQSYKLVA HQRTHTGEKP FECNQCGKSF SWSSQLVAHQ 550 560 570 580 590 600 RTHTGEKPYE CSECGKSFNR SSHLVMHQRI HTGEKPYECN QCGKSFSQSY VLVVHQRTHT 610 620 630 640 650 660 GEKPYECSQC GKSFRQSSCL TQHQRTHTGE KPFECNQCGK TFSLSARLIV HQRTHTGEKP 670 680 690 FTCIQCGKAF INSYKLIRHQ ATHTEEKLYE CN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters." Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L. Genome Res. 13:1097-1110(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-41 AND CYS-89 AND SER-272.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF192913 mRNA. Translation: AAF07950.1. AK315193 mRNA. Translation: BAG37633.1. AC069278 Genomic DNA. Translation: AAF71790.1. CH471126 Genomic DNA. Translation: EAW57279.1.
IPI	IPI00001684.
RefSeq	NP_037388.2. NM_013256.3.
UniGene	Hs.22305.
3D structure databases
ProteinModelPortal	Q9UJW8.
ModBase	Search...
PTM databases
PhosphoSite	Q9UJW8.
Polymorphism databases
DMDM	134044257.
Proteomic databases
PaxDb	Q9UJW8.
PRIDE	Q9UJW8.
Protocols and materials databases
DNASU	7733.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000221327; ENSP00000221327; ENSG00000167384.
GeneID	7733.
KEGG	hsa:7733.
UCSC	uc002ozf.4. human.
Organism-specific databases
CTD	7733.
GeneCards	GC19M044979.
HGNC	HGNC:12970. ZNF180.
HPA	HPA028979. HPA028980.
MIM	606740. gene.
neXtProt	NX_Q9UJW8.
PharmGKB	PA37552.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q9UJW8.
KO	K09228.
OMA	EVAFTQR.
OrthoDB	EOG4CC40S.
PhylomeDB	Q9UJW8.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q9UJW8.
Bgee	Q9UJW8.
CleanEx	HS_ZNF180.
Genevestigator	Q9UJW8.
GermOnline	ENSG00000167384. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 12 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 12 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 12 hits. PS50157. ZINC_FINGER_C2H2_2. 12 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7733.
NextBio	29944.
SOURCE	Search...

Entry information

Entry name

ZN180_HUMAN

Accession

Primary (citable) accession number: Q9UJW8
Secondary accession number(s): B2RCN6, Q9P1U2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	March 6, 2007
Last modified:	May 1, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.