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Protein

Zinc finger protein 180

Gene

ZNF180

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri353 – 375C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 180
Alternative name(s):
HHZ168
Gene namesi
Name:ZNF180
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167384.10
HGNCiHGNC:12970 ZNF180
MIMi606740 gene
neXtProtiNX_Q9UJW8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37552

Polymorphism and mutation databases

DMDMi134044257

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474421 – 692Zinc finger protein 180Add BLAST692

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki138Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki159Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki168Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki198Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki226Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki304Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki313Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki330Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9UJW8
PaxDbiQ9UJW8
PeptideAtlasiQ9UJW8
PRIDEiQ9UJW8

PTM databases

iPTMnetiQ9UJW8
PhosphoSitePlusiQ9UJW8

Expressioni

Gene expression databases

BgeeiENSG00000167384
CleanExiHS_ZNF180
ExpressionAtlasiQ9UJW8 baseline and differential
GenevisibleiQ9UJW8 HS

Organism-specific databases

HPAiHPA028979
HPA028980

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi1135213 interactors.
IntActiQ9UJW8 4 interactors.
STRINGi9606.ENSP00000221327

Structurei

3D structure databases

ProteinModelPortaliQ9UJW8
SMRiQ9UJW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 145KRABPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri353 – 375C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9UJW8
KOiK09228
OrthoDBiEOG091G02KC
PhylomeDBiQ9UJW8
TreeFamiTF350793

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UJW8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRACAGSTRE AGSGAQDLST LLCLEESMEE QDEKPPEPPK ACAQDSFLPQ
60 70 80 90 100
EIIIKVEGED TGSLTIPSQE GVNFKIVTVD FTREEQGTWN PAQRTLDRDV
110 120 130 140 150
ILENHRDLVS WDLATAVGKK DSTSKQRIFD EEPANGVKIE RFTRDDPWLS
160 170 180 190 200
SCEEVDDCKD QLEKQQEKQE ILLQEVAFTQ RKAVIHERVC KSDETGEKSG
210 220 230 240 250
LNSSLFSSPV IPIRNHFHKH VSHAKKWHLN AAVNSHQKIN ENETLYENNE
260 270 280 290 300
CGKPPQSIHL IQFTRTQTKD KCYGFSDRIQ SFCHGTPLHI HEKIHGGGKT
310 320 330 340 350
FDFKECGQVL NPKISHNEQQ RIPFEESQYK CSETSHSSSL TQNMRNNSEE
360 370 380 390 400
KPFECNQCGK SFSWSSHLVA HQRTHTGEKP YECSECGKSF SRSSHLVSHQ
410 420 430 440 450
RTHTGEKPYR CNQCGKSFSQ SYVLVVHQRT HTGEKPYECN QCGKSFRQSY
460 470 480 490 500
KLIAHQRTHT GEKPYECNQC GKSFIQSYKL IAHQRIHTGE KPYECNQCGK
510 520 530 540 550
SFSQSYKLVA HQRTHTGEKP FECNQCGKSF SWSSQLVAHQ RTHTGEKPYE
560 570 580 590 600
CSECGKSFNR SSHLVMHQRI HTGEKPYECN QCGKSFSQSY VLVVHQRTHT
610 620 630 640 650
GEKPYECSQC GKSFRQSSCL TQHQRTHTGE KPFECNQCGK TFSLSARLIV
660 670 680 690
HQRTHTGEKP FTCIQCGKAF INSYKLIRHQ ATHTEEKLYE CN
Length:692
Mass (Da):79,111
Last modified:March 6, 2007 - v2
Checksum:i689812AB1E277525
GO
Isoform 2 (identifier: Q9UJW8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Show »
Length:665
Mass (Da):76,372
Checksum:i24C9D08125BA15CA
GO
Isoform 3 (identifier: Q9UJW8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-69: ACAQDSFLPQEIIIKVEGEDTGSLTIPSQ → ACAQ

Show »
Length:667
Mass (Da):76,412
Checksum:i4944A5771CF70A13
GO
Isoform 4 (identifier: Q9UJW8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MRACAGSTREAGSG → MRRVYAGSWKRCA

Show »
Length:691
Mass (Da):79,342
Checksum:i209909E647DD864C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti558F → L in BAG53668 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03086441A → V1 PublicationCorresponds to variant dbSNP:rs2571108Ensembl.1
Natural variantiVAR_03086589W → C1 PublicationCorresponds to variant dbSNP:rs2253563Ensembl.1
Natural variantiVAR_030866272C → S1 PublicationCorresponds to variant dbSNP:rs1897820Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0567061 – 27Missing in isoform 2. CuratedAdd BLAST27
Alternative sequenceiVSP_0567051 – 14MRACA…EAGSG → MRRVYAGSWKRCA in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_05670741 – 69ACAQD…TIPSQ → ACAQ in isoform 3. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192913 mRNA Translation: AAF07950.1
AK122688 mRNA Translation: BAG53668.1
AK315193 mRNA Translation: BAG37633.1
AC069278 Genomic DNA Translation: AAF71790.1
CH471126 Genomic DNA Translation: EAW57275.1
CH471126 Genomic DNA Translation: EAW57276.1
CH471126 Genomic DNA Translation: EAW57279.1
BC033642 mRNA Translation: AAH33642.1
BC113015 mRNA Translation: AAI13016.1
CCDSiCCDS12639.1 [Q9UJW8-1]
CCDS62707.1 [Q9UJW8-2]
CCDS62708.1 [Q9UJW8-3]
RefSeqiNP_001265437.2, NM_001278508.2
NP_001265438.2, NM_001278509.2
NP_001275688.2, NM_001288759.2
NP_001275689.1, NM_001288760.2
NP_001275690.1, NM_001288761.2
NP_001275691.1, NM_001288762.2
NP_001278562.1, NM_001291633.1
NP_037388.3, NM_013256.5
UniGeneiHs.22305
Hs.720205
Hs.737614

Genome annotation databases

EnsembliENST00000221327; ENSP00000221327; ENSG00000167384
GeneIDi7733
KEGGihsa:7733
UCSCiuc002ozf.6 human [Q9UJW8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN180_HUMAN
AccessioniPrimary (citable) accession number: Q9UJW8
Secondary accession number(s): B2RCN6
, B3KV56, K7EQX9, Q58F03, Q9P1U2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: March 6, 2007
Last modified: March 28, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome