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Protein

Zinc finger protein 180

Gene

ZNF180

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri353 – 37523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri409 – 43123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 45923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 48723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri521 – 54323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri549 – 57123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri577 – 59923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri605 – 62723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri633 – 65523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri661 – 68323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 180
Alternative name(s):
HHZ168
Gene namesi
Name:ZNF180
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12970. ZNF180.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37552.

Polymorphism and mutation databases

DMDMi134044257.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 692692Zinc finger protein 180PRO_0000047442Add
BLAST

Proteomic databases

MaxQBiQ9UJW8.
PaxDbiQ9UJW8.
PRIDEiQ9UJW8.

PTM databases

PhosphoSiteiQ9UJW8.

Expressioni

Gene expression databases

BgeeiQ9UJW8.
CleanExiHS_ZNF180.
ExpressionAtlasiQ9UJW8. baseline and differential.
GenevestigatoriQ9UJW8.

Organism-specific databases

HPAiHPA028979.
HPA028980.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KIFC3Q9BVG83EBI-10322527,EBI-2125614
KRTAP10-7P604093EBI-10322527,EBI-10172290
NDEL1Q9GZM83EBI-10322527,EBI-928842

Protein-protein interaction databases

BioGridi113521. 4 interactions.
IntActiQ9UJW8. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9UJW8.
SMRiQ9UJW8. Positions 256-684.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 14574KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri353 – 37523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri409 – 43123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 45923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 48723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri521 – 54323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri549 – 57123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri577 – 59923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri605 – 62723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri633 – 65523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri661 – 68323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UJW8.
KOiK09228.
OMAiDFKECGQ.
PhylomeDBiQ9UJW8.
TreeFamiTF350793.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UJW8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRACAGSTRE AGSGAQDLST LLCLEESMEE QDEKPPEPPK ACAQDSFLPQ
60 70 80 90 100
EIIIKVEGED TGSLTIPSQE GVNFKIVTVD FTREEQGTWN PAQRTLDRDV
110 120 130 140 150
ILENHRDLVS WDLATAVGKK DSTSKQRIFD EEPANGVKIE RFTRDDPWLS
160 170 180 190 200
SCEEVDDCKD QLEKQQEKQE ILLQEVAFTQ RKAVIHERVC KSDETGEKSG
210 220 230 240 250
LNSSLFSSPV IPIRNHFHKH VSHAKKWHLN AAVNSHQKIN ENETLYENNE
260 270 280 290 300
CGKPPQSIHL IQFTRTQTKD KCYGFSDRIQ SFCHGTPLHI HEKIHGGGKT
310 320 330 340 350
FDFKECGQVL NPKISHNEQQ RIPFEESQYK CSETSHSSSL TQNMRNNSEE
360 370 380 390 400
KPFECNQCGK SFSWSSHLVA HQRTHTGEKP YECSECGKSF SRSSHLVSHQ
410 420 430 440 450
RTHTGEKPYR CNQCGKSFSQ SYVLVVHQRT HTGEKPYECN QCGKSFRQSY
460 470 480 490 500
KLIAHQRTHT GEKPYECNQC GKSFIQSYKL IAHQRIHTGE KPYECNQCGK
510 520 530 540 550
SFSQSYKLVA HQRTHTGEKP FECNQCGKSF SWSSQLVAHQ RTHTGEKPYE
560 570 580 590 600
CSECGKSFNR SSHLVMHQRI HTGEKPYECN QCGKSFSQSY VLVVHQRTHT
610 620 630 640 650
GEKPYECSQC GKSFRQSSCL TQHQRTHTGE KPFECNQCGK TFSLSARLIV
660 670 680 690
HQRTHTGEKP FTCIQCGKAF INSYKLIRHQ ATHTEEKLYE CN
Length:692
Mass (Da):79,111
Last modified:March 6, 2007 - v2
Checksum:i689812AB1E277525
GO
Isoform 2 (identifier: Q9UJW8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Show »
Length:665
Mass (Da):76,372
Checksum:i24C9D08125BA15CA
GO
Isoform 3 (identifier: Q9UJW8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-69: ACAQDSFLPQEIIIKVEGEDTGSLTIPSQ → ACAQ

Show »
Length:667
Mass (Da):76,412
Checksum:i4944A5771CF70A13
GO
Isoform 4 (identifier: Q9UJW8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MRACAGSTREAGSG → MRRVYAGSWKRCA

Show »
Length:691
Mass (Da):79,342
Checksum:i209909E647DD864C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti558 – 5581F → L in BAG53668 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411A → V.1 Publication
Corresponds to variant rs2571108 [ dbSNP | Ensembl ].
VAR_030864
Natural varianti89 – 891W → C.1 Publication
Corresponds to variant rs2253563 [ dbSNP | Ensembl ].
VAR_030865
Natural varianti272 – 2721C → S.1 Publication
Corresponds to variant rs1897820 [ dbSNP | Ensembl ].
VAR_030866

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2727Missing in isoform 2. CuratedVSP_056706Add
BLAST
Alternative sequencei1 – 1414MRACA…EAGSG → MRRVYAGSWKRCA in isoform 4. 1 PublicationVSP_056705Add
BLAST
Alternative sequencei41 – 6929ACAQD…TIPSQ → ACAQ in isoform 3. 1 PublicationVSP_056707Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192913 mRNA. Translation: AAF07950.1.
AK122688 mRNA. Translation: BAG53668.1.
AK315193 mRNA. Translation: BAG37633.1.
AC069278 Genomic DNA. Translation: AAF71790.1.
CH471126 Genomic DNA. Translation: EAW57275.1.
CH471126 Genomic DNA. Translation: EAW57276.1.
CH471126 Genomic DNA. Translation: EAW57279.1.
BC033642 mRNA. Translation: AAH33642.1.
BC113015 mRNA. Translation: AAI13016.1.
CCDSiCCDS12639.1. [Q9UJW8-1]
CCDS62707.1. [Q9UJW8-2]
CCDS62708.1. [Q9UJW8-3]
RefSeqiNP_001265437.2. NM_001278508.2.
NP_001265438.2. NM_001278509.2.
NP_001275688.2. NM_001288759.2.
NP_001275689.1. NM_001288760.2.
NP_001275690.1. NM_001288761.2.
NP_001275691.1. NM_001288762.2.
NP_001278562.1. NM_001291633.1.
NP_037388.3. NM_013256.5.
UniGeneiHs.22305.
Hs.720205.
Hs.737614.

Genome annotation databases

EnsembliENST00000221327; ENSP00000221327; ENSG00000167384.
GeneIDi7733.
KEGGihsa:7733.
UCSCiuc002ozf.4. human. [Q9UJW8-1]
uc002ozg.4. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192913 mRNA. Translation: AAF07950.1.
AK122688 mRNA. Translation: BAG53668.1.
AK315193 mRNA. Translation: BAG37633.1.
AC069278 Genomic DNA. Translation: AAF71790.1.
CH471126 Genomic DNA. Translation: EAW57275.1.
CH471126 Genomic DNA. Translation: EAW57276.1.
CH471126 Genomic DNA. Translation: EAW57279.1.
BC033642 mRNA. Translation: AAH33642.1.
BC113015 mRNA. Translation: AAI13016.1.
CCDSiCCDS12639.1. [Q9UJW8-1]
CCDS62707.1. [Q9UJW8-2]
CCDS62708.1. [Q9UJW8-3]
RefSeqiNP_001265437.2. NM_001278508.2.
NP_001265438.2. NM_001278509.2.
NP_001275688.2. NM_001288759.2.
NP_001275689.1. NM_001288760.2.
NP_001275690.1. NM_001288761.2.
NP_001275691.1. NM_001288762.2.
NP_001278562.1. NM_001291633.1.
NP_037388.3. NM_013256.5.
UniGeneiHs.22305.
Hs.720205.
Hs.737614.

3D structure databases

ProteinModelPortaliQ9UJW8.
SMRiQ9UJW8. Positions 256-684.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113521. 4 interactions.
IntActiQ9UJW8. 3 interactions.

PTM databases

PhosphoSiteiQ9UJW8.

Polymorphism and mutation databases

DMDMi134044257.

Proteomic databases

MaxQBiQ9UJW8.
PaxDbiQ9UJW8.
PRIDEiQ9UJW8.

Protocols and materials databases

DNASUi7733.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221327; ENSP00000221327; ENSG00000167384.
GeneIDi7733.
KEGGihsa:7733.
UCSCiuc002ozf.4. human. [Q9UJW8-1]
uc002ozg.4. human.

Organism-specific databases

CTDi7733.
GeneCardsiGC19M044979.
HGNCiHGNC:12970. ZNF180.
HPAiHPA028979.
HPA028980.
MIMi606740. gene.
neXtProtiNX_Q9UJW8.
PharmGKBiPA37552.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UJW8.
KOiK09228.
OMAiDFKECGQ.
PhylomeDBiQ9UJW8.
TreeFamiTF350793.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF180. human.
GenomeRNAii7733.
NextBioi29944.
PROiQ9UJW8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UJW8.
CleanExiHS_ZNF180.
ExpressionAtlasiQ9UJW8. baseline and differential.
GenevestigatoriQ9UJW8.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters."
    Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.
    Genome Res. 13:1097-1110(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS VAL-41; CYS-89 AND SER-272.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANTS VAL-41; CYS-89 AND SER-272 (ISOFORM 3).
    Tissue: Amygdala and Spleen.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Skin.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiZN180_HUMAN
AccessioniPrimary (citable) accession number: Q9UJW8
Secondary accession number(s): B2RCN6
, B3KV56, K7EQX9, Q58F03, Q9P1U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: March 6, 2007
Last modified: May 27, 2015
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.