SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9UJW8

- ZN180_HUMAN

UniProt

Q9UJW8 - ZN180_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Zinc finger protein 180

Gene
ZNF180
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri353 – 37523C2H2-type 1Add
BLAST
Zinc fingeri381 – 40323C2H2-type 2Add
BLAST
Zinc fingeri409 – 43123C2H2-type 3Add
BLAST
Zinc fingeri437 – 45923C2H2-type 4Add
BLAST
Zinc fingeri465 – 48723C2H2-type 5Add
BLAST
Zinc fingeri493 – 51523C2H2-type 6Add
BLAST
Zinc fingeri521 – 54323C2H2-type 7Add
BLAST
Zinc fingeri549 – 57123C2H2-type 8Add
BLAST
Zinc fingeri577 – 59923C2H2-type 9Add
BLAST
Zinc fingeri605 – 62723C2H2-type 10Add
BLAST
Zinc fingeri633 – 65523C2H2-type 11Add
BLAST
Zinc fingeri661 – 68323C2H2-type 12Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 180
Alternative name(s):
HHZ168
Gene namesi
Name:ZNF180
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:12970. ZNF180.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37552.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 692692Zinc finger protein 180PRO_0000047442Add
BLAST

Proteomic databases

MaxQBiQ9UJW8.
PaxDbiQ9UJW8.
PRIDEiQ9UJW8.

PTM databases

PhosphoSiteiQ9UJW8.

Expressioni

Gene expression databases

ArrayExpressiQ9UJW8.
BgeeiQ9UJW8.
CleanExiHS_ZNF180.
GenevestigatoriQ9UJW8.

Organism-specific databases

HPAiHPA028979.
HPA028980.

Interactioni

Protein-protein interaction databases

BioGridi113521. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9UJW8.
SMRiQ9UJW8. Positions 246-684.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 14574KRABAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UJW8.
KOiK09228.
OMAiEVAFTQR.
PhylomeDBiQ9UJW8.
TreeFamiTF350793.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UJW8-1 [UniParc]FASTAAdd to Basket

« Hide

MRACAGSTRE AGSGAQDLST LLCLEESMEE QDEKPPEPPK ACAQDSFLPQ    50
EIIIKVEGED TGSLTIPSQE GVNFKIVTVD FTREEQGTWN PAQRTLDRDV 100
ILENHRDLVS WDLATAVGKK DSTSKQRIFD EEPANGVKIE RFTRDDPWLS 150
SCEEVDDCKD QLEKQQEKQE ILLQEVAFTQ RKAVIHERVC KSDETGEKSG 200
LNSSLFSSPV IPIRNHFHKH VSHAKKWHLN AAVNSHQKIN ENETLYENNE 250
CGKPPQSIHL IQFTRTQTKD KCYGFSDRIQ SFCHGTPLHI HEKIHGGGKT 300
FDFKECGQVL NPKISHNEQQ RIPFEESQYK CSETSHSSSL TQNMRNNSEE 350
KPFECNQCGK SFSWSSHLVA HQRTHTGEKP YECSECGKSF SRSSHLVSHQ 400
RTHTGEKPYR CNQCGKSFSQ SYVLVVHQRT HTGEKPYECN QCGKSFRQSY 450
KLIAHQRTHT GEKPYECNQC GKSFIQSYKL IAHQRIHTGE KPYECNQCGK 500
SFSQSYKLVA HQRTHTGEKP FECNQCGKSF SWSSQLVAHQ RTHTGEKPYE 550
CSECGKSFNR SSHLVMHQRI HTGEKPYECN QCGKSFSQSY VLVVHQRTHT 600
GEKPYECSQC GKSFRQSSCL TQHQRTHTGE KPFECNQCGK TFSLSARLIV 650
HQRTHTGEKP FTCIQCGKAF INSYKLIRHQ ATHTEEKLYE CN 692
Length:692
Mass (Da):79,111
Last modified:March 6, 2007 - v2
Checksum:i689812AB1E277525
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411A → V.1 Publication
Corresponds to variant rs2571108 [ dbSNP | Ensembl ].
VAR_030864
Natural varianti89 – 891W → C.1 Publication
Corresponds to variant rs2253563 [ dbSNP | Ensembl ].
VAR_030865
Natural varianti272 – 2721C → S.1 Publication
Corresponds to variant rs1897820 [ dbSNP | Ensembl ].
VAR_030866

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF192913 mRNA. Translation: AAF07950.1.
AK315193 mRNA. Translation: BAG37633.1.
AC069278 Genomic DNA. Translation: AAF71790.1.
CH471126 Genomic DNA. Translation: EAW57279.1.
CCDSiCCDS12639.1.
RefSeqiNP_001265437.2. NM_001278508.2.
NP_001265438.2. NM_001278509.2.
NP_001275688.2. NM_001288759.2.
NP_001275689.1. NM_001288760.2.
NP_001275690.1. NM_001288761.2.
NP_001275691.1. NM_001288762.2.
NP_001278562.1. NM_001291633.1.
NP_037388.3. NM_013256.5.
UniGeneiHs.22305.
Hs.720205.
Hs.737614.

Genome annotation databases

EnsembliENST00000221327; ENSP00000221327; ENSG00000167384.
GeneIDi7733.
KEGGihsa:7733.
UCSCiuc002ozf.4. human.

Polymorphism databases

DMDMi134044257.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF192913 mRNA. Translation: AAF07950.1 .
AK315193 mRNA. Translation: BAG37633.1 .
AC069278 Genomic DNA. Translation: AAF71790.1 .
CH471126 Genomic DNA. Translation: EAW57279.1 .
CCDSi CCDS12639.1.
RefSeqi NP_001265437.2. NM_001278508.2.
NP_001265438.2. NM_001278509.2.
NP_001275688.2. NM_001288759.2.
NP_001275689.1. NM_001288760.2.
NP_001275690.1. NM_001288761.2.
NP_001275691.1. NM_001288762.2.
NP_001278562.1. NM_001291633.1.
NP_037388.3. NM_013256.5.
UniGenei Hs.22305.
Hs.720205.
Hs.737614.

3D structure databases

ProteinModelPortali Q9UJW8.
SMRi Q9UJW8. Positions 246-684.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113521. 1 interaction.

PTM databases

PhosphoSitei Q9UJW8.

Polymorphism databases

DMDMi 134044257.

Proteomic databases

MaxQBi Q9UJW8.
PaxDbi Q9UJW8.
PRIDEi Q9UJW8.

Protocols and materials databases

DNASUi 7733.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000221327 ; ENSP00000221327 ; ENSG00000167384 .
GeneIDi 7733.
KEGGi hsa:7733.
UCSCi uc002ozf.4. human.

Organism-specific databases

CTDi 7733.
GeneCardsi GC19M044979.
HGNCi HGNC:12970. ZNF180.
HPAi HPA028979.
HPA028980.
MIMi 606740. gene.
neXtProti NX_Q9UJW8.
PharmGKBi PA37552.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q9UJW8.
KOi K09228.
OMAi EVAFTQR.
PhylomeDBi Q9UJW8.
TreeFami TF350793.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 7733.
NextBioi 29944.
PROi Q9UJW8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UJW8.
Bgeei Q9UJW8.
CleanExi HS_ZNF180.
Genevestigatori Q9UJW8.

Family and domain databases

Gene3Di 3.30.160.60. 12 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters."
    Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.
    Genome Res. 13:1097-1110(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-41 AND CYS-89 AND SER-272.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiZN180_HUMAN
AccessioniPrimary (citable) accession number: Q9UJW8
Secondary accession number(s): B2RCN6, Q9P1U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: March 6, 2007
Last modified: September 3, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi