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Q9UJW7 (ZN229_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 229
Gene names
Name:ZNF229
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length825 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 18 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence AAG23970.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 825825Zinc finger protein 229
PRO_0000047470

Regions

Domain34 – 10875KRAB
Zinc finger291 – 31525C2H2-type 1; degenerate
Zinc finger349 – 37123C2H2-type 2
Zinc finger377 – 39923C2H2-type 3
Zinc finger405 – 42723C2H2-type 4
Zinc finger433 – 45523C2H2-type 5
Zinc finger461 – 48323C2H2-type 6
Zinc finger489 – 51123C2H2-type 7
Zinc finger517 – 53923C2H2-type 8
Zinc finger545 – 56622C2H2-type 9
Zinc finger572 – 59423C2H2-type 10
Zinc finger600 – 62223C2H2-type 11
Zinc finger628 – 65023C2H2-type 12
Zinc finger656 – 67823C2H2-type 13
Zinc finger684 – 70623C2H2-type 14
Zinc finger712 – 73423C2H2-type 15
Zinc finger740 – 76223C2H2-type 16
Zinc finger768 – 79023C2H2-type 17
Zinc finger796 – 81823C2H2-type 18

Natural variations

Natural variant1561S → F. Ref.2
Corresponds to variant rs2571174 [ dbSNP | Ensembl ].
VAR_057408
Natural variant3371R → C.
Corresponds to variant rs12151338 [ dbSNP | Ensembl ].
VAR_057409
Natural variant4171S → N.
Corresponds to variant rs57014690 [ dbSNP | Ensembl ].
VAR_061942
Natural variant6621G → R. Ref.4
Corresponds to variant rs1434579 [ dbSNP | Ensembl ].
VAR_060426
Natural variant8041G → R.
Corresponds to variant rs10409807 [ dbSNP | Ensembl ].
VAR_060427

Sequences

Sequence LengthMass (Da)Tools
Q9UJW7 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 301AE62BDAA872F6

FASTA82593,707
        10         20         30         40         50         60 
METLTSRHEK RALHSQASAI SQDREEKIMS QEPLSFKDVA VVFTEEELEL LDSTQRQLYQ 

        70         80         90        100        110        120 
DVMQENFRNL LSVGERNPLG DKNGKDTEYI QDEELRFFSH KELSSCKIWE EVAGELPGSQ 

       130        140        150        160        170        180 
DCRVNLQGKD FQFSEDAAPH QGWEGASTPC FPIENSLDSL QGDGLIGLEN QQFPAWRAIR 

       190        200        210        220        230        240 
PIPIQGSWAK AFVNQLGDVQ ERCKNLDTED TVYKCNWDDD SFCWISCHVD HRFPEIDKPC 

       250        260        270        280        290        300 
GCNKCRKDCI KNSVLHRINP GENGLKSNEY RNGFRDDADL PPHPRVPLKE KLCQYDEFSE 

       310        320        330        340        350        360 
GLRHSAHLNR HQRVPTGEKS VKSLERGRGV RQNTHIRNHP RAPVGDMPYR CDVCGKGFRY 

       370        380        390        400        410        420 
KSVLLIHQGV HTGRRPYKCE ECGKAFGRSS NLLVHQRVHT GEKPYKCSEC GKGFSYSSVL 

       430        440        450        460        470        480 
QVHQRLHTGE KPYTCSECGK GFCAKSALHK HQHIHPGEKP YSCGECGKGF SCSSHLSSHQ 

       490        500        510        520        530        540 
KTHTGERPYQ CDKCGKGFSH NSYLQAHQRV HMGQHLYKCN VCGKSFSYSS GLLMHQRLHT 

       550        560        570        580        590        600 
GEKPYKCECG KSFGRSSDLH IHQRVHTGEK PYKCSECGKG FRRNSDLHSH QRVHTGERPY 

       610        620        630        640        650        660 
VCDVCGKGFI YSSDLLIHQR VHTGEKPYKC AECGKGFSYS SGLLIHQRVH TGEKPYRCQE 

       670        680        690        700        710        720 
CGKGFRCTSS LHKHQRVHTG KKPYTCDQCG KGFSYGSNLR THQRLHTGEK PYTCCECGKG 

       730        740        750        760        770        780 
FRYGSGLLSH KRVHTGEKPY RCHVCGKGYS QSSHLQGHQR VHTGEKPYKC EECGKGFGRN 

       790        800        810        820 
SCLHVHQRVH TGEKPYTCGV CGKGFSYTSG LRNHQRVHLG ENPYK 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-156.
Tissue: Brain.
[3]"Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters."
Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.
Genome Res. 13:1097-1110(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-420.
Tissue: Brain.
[4]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 397-825, VARIANT ARG-662.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC084239 Genomic DNA. Translation: AAG23970.1. Sequence problems.
BC150612 mRNA. Translation: AAI50613.1.
AF192979 mRNA. Translation: AAF07964.1.
AY166791 mRNA. Translation: AAO45840.1.
AB209357 mRNA. Translation: BAD92594.1.
RefSeqNP_055333.2. NM_014518.2.
UniGeneHs.709348.

3D structure databases

ProteinModelPortalQ9UJW7.
SMRQ9UJW7. Positions 30-82, 238-825.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113555. 1 interaction.

PTM databases

PhosphoSiteQ9UJW7.

Polymorphism databases

DMDM296453070.

2D gel databases

REPRODUCTION-2DPAGEQ9UJW7.

Proteomic databases

PaxDbQ9UJW7.
PRIDEQ9UJW7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000588931; ENSP00000466519; ENSG00000167383.
GeneID7772.
KEGGhsa:7772.
UCSCuc002oze.1. human.

Organism-specific databases

CTD7772.
GeneCardsGC19M044930.
HGNCHGNC:13022. ZNF229.
HPAHPA001494.
neXtProtNX_Q9UJW7.
PharmGKBPA37601.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ9UJW7.
KOK09228.
OMAIWEEVAG.
OrthoDBEOG7KSX7Q.

Gene expression databases

ArrayExpressQ9UJW7.
BgeeQ9UJW7.
CleanExHS_ZNF229.
GenevestigatorQ9UJW7.

Family and domain databases

Gene3D3.30.160.60. 17 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF229. human.
GenomeRNAi7772.
NextBio30097.
PROQ9UJW7.

Entry information

Entry nameZN229_HUMAN
AccessionPrimary (citable) accession number: Q9UJW7
Secondary accession number(s): B2RWN3, Q59FV2, Q86WL9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 18, 2010
Last modified: March 19, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM