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Q9UJW7

- ZN229_HUMAN

UniProt

Q9UJW7 - ZN229_HUMAN

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Protein

Zinc finger protein 229

Gene

ZNF229

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri291 – 31525C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri461 – 48323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri489 – 51123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri517 – 53923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri545 – 56622C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri572 – 59423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri600 – 62223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri628 – 65023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri656 – 67823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri684 – 70623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri712 – 73423C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri740 – 76223C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri768 – 79023C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri796 – 81823C2H2-type 18PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 229
Gene namesi
Name:ZNF229
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:13022. ZNF229.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37601.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 825825Zinc finger protein 229PRO_0000047470Add
BLAST

Proteomic databases

PaxDbiQ9UJW7.
PRIDEiQ9UJW7.

2D gel databases

REPRODUCTION-2DPAGEQ9UJW7.

PTM databases

PhosphoSiteiQ9UJW7.

Expressioni

Gene expression databases

BgeeiQ9UJW7.
CleanExiHS_ZNF229.
GenevestigatoriQ9UJW7.

Organism-specific databases

HPAiHPA001494.

Interactioni

Protein-protein interaction databases

BioGridi113555. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9UJW7.
SMRiQ9UJW7. Positions 238-825.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 10875KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 18 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri291 – 31525C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri461 – 48323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri489 – 51123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri517 – 53923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri545 – 56622C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri572 – 59423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri600 – 62223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri628 – 65023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri656 – 67823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri684 – 70623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri712 – 73423C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri740 – 76223C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri768 – 79023C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri796 – 81823C2H2-type 18PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119262.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UJW7.
KOiK09228.
OMAiIWEEVAG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9UJW7.

Family and domain databases

Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UJW7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METLTSRHEK RALHSQASAI SQDREEKIMS QEPLSFKDVA VVFTEEELEL
60 70 80 90 100
LDSTQRQLYQ DVMQENFRNL LSVGERNPLG DKNGKDTEYI QDEELRFFSH
110 120 130 140 150
KELSSCKIWE EVAGELPGSQ DCRVNLQGKD FQFSEDAAPH QGWEGASTPC
160 170 180 190 200
FPIENSLDSL QGDGLIGLEN QQFPAWRAIR PIPIQGSWAK AFVNQLGDVQ
210 220 230 240 250
ERCKNLDTED TVYKCNWDDD SFCWISCHVD HRFPEIDKPC GCNKCRKDCI
260 270 280 290 300
KNSVLHRINP GENGLKSNEY RNGFRDDADL PPHPRVPLKE KLCQYDEFSE
310 320 330 340 350
GLRHSAHLNR HQRVPTGEKS VKSLERGRGV RQNTHIRNHP RAPVGDMPYR
360 370 380 390 400
CDVCGKGFRY KSVLLIHQGV HTGRRPYKCE ECGKAFGRSS NLLVHQRVHT
410 420 430 440 450
GEKPYKCSEC GKGFSYSSVL QVHQRLHTGE KPYTCSECGK GFCAKSALHK
460 470 480 490 500
HQHIHPGEKP YSCGECGKGF SCSSHLSSHQ KTHTGERPYQ CDKCGKGFSH
510 520 530 540 550
NSYLQAHQRV HMGQHLYKCN VCGKSFSYSS GLLMHQRLHT GEKPYKCECG
560 570 580 590 600
KSFGRSSDLH IHQRVHTGEK PYKCSECGKG FRRNSDLHSH QRVHTGERPY
610 620 630 640 650
VCDVCGKGFI YSSDLLIHQR VHTGEKPYKC AECGKGFSYS SGLLIHQRVH
660 670 680 690 700
TGEKPYRCQE CGKGFRCTSS LHKHQRVHTG KKPYTCDQCG KGFSYGSNLR
710 720 730 740 750
THQRLHTGEK PYTCCECGKG FRYGSGLLSH KRVHTGEKPY RCHVCGKGYS
760 770 780 790 800
QSSHLQGHQR VHTGEKPYKC EECGKGFGRN SCLHVHQRVH TGEKPYTCGV
810 820
CGKGFSYTSG LRNHQRVHLG ENPYK
Length:825
Mass (Da):93,707
Last modified:May 18, 2010 - v3
Checksum:i301AE62BDAA872F6
GO
Isoform 2 (identifier: Q9UJW7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-80: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »
Length:819
Mass (Da):93,041
Checksum:i0070ACBE4332D807
GO

Sequence cautioni

The sequence AAG23970.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti156 – 1561S → F.1 Publication
Corresponds to variant rs2571174 [ dbSNP | Ensembl ].
VAR_057408
Natural varianti337 – 3371R → C.
Corresponds to variant rs12151338 [ dbSNP | Ensembl ].
VAR_057409
Natural varianti417 – 4171S → N.
Corresponds to variant rs57014690 [ dbSNP | Ensembl ].
VAR_061942
Natural varianti662 – 6621G → R.1 Publication
Corresponds to variant rs1434579 [ dbSNP | Ensembl ].
VAR_060426
Natural varianti804 – 8041G → R.
Corresponds to variant rs10409807 [ dbSNP | Ensembl ].
VAR_060427

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei75 – 806Missing in isoform 2. CuratedVSP_054778

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC084239 Genomic DNA. Translation: AAG23970.1. Sequence problems.
BC150612 mRNA. Translation: AAI50613.1.
AF192979 mRNA. Translation: AAF07964.1.
AY166791 mRNA. Translation: AAO45840.1.
AB209357 mRNA. Translation: BAD92594.1.
CCDSiCCDS42574.1. [Q9UJW7-1]
CCDS62706.1. [Q9UJW7-2]
RefSeqiNP_055333.3. NM_014518.3.
UniGeneiHs.709348.

Genome annotation databases

EnsembliENST00000614049; ENSP00000479884; ENSG00000278318.
GeneIDi7772.
KEGGihsa:7772.
UCSCiuc002oze.1. human. [Q9UJW7-1]

Polymorphism databases

DMDMi296453070.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC084239 Genomic DNA. Translation: AAG23970.1 . Sequence problems.
BC150612 mRNA. Translation: AAI50613.1 .
AF192979 mRNA. Translation: AAF07964.1 .
AY166791 mRNA. Translation: AAO45840.1 .
AB209357 mRNA. Translation: BAD92594.1 .
CCDSi CCDS42574.1. [Q9UJW7-1 ]
CCDS62706.1. [Q9UJW7-2 ]
RefSeqi NP_055333.3. NM_014518.3.
UniGenei Hs.709348.

3D structure databases

ProteinModelPortali Q9UJW7.
SMRi Q9UJW7. Positions 238-825.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113555. 1 interaction.

PTM databases

PhosphoSitei Q9UJW7.

Polymorphism databases

DMDMi 296453070.

2D gel databases

REPRODUCTION-2DPAGE Q9UJW7.

Proteomic databases

PaxDbi Q9UJW7.
PRIDEi Q9UJW7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000614049 ; ENSP00000479884 ; ENSG00000278318 .
GeneIDi 7772.
KEGGi hsa:7772.
UCSCi uc002oze.1. human. [Q9UJW7-1 ]

Organism-specific databases

CTDi 7772.
GeneCardsi GC19M044930.
HGNCi HGNC:13022. ZNF229.
HPAi HPA001494.
neXtProti NX_Q9UJW7.
PharmGKBi PA37601.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000119262.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q9UJW7.
KOi K09228.
OMAi IWEEVAG.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q9UJW7.

Miscellaneous databases

ChiTaRSi ZNF229. human.
GenomeRNAii 7772.
NextBioi 30097.
PROi Q9UJW7.

Gene expression databases

Bgeei Q9UJW7.
CleanExi HS_ZNF229.
Genevestigatori Q9UJW7.

Family and domain databases

Gene3Di 3.30.160.60. 17 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PHE-156.
    Tissue: Brain.
  3. "Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters."
    Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.
    Genome Res. 13:1097-1110(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-420 (ISOFORM 1).
    Tissue: Brain.
  4. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 397-825, VARIANT ARG-662.
    Tissue: Brain.

Entry informationi

Entry nameiZN229_HUMAN
AccessioniPrimary (citable) accession number: Q9UJW7
Secondary accession number(s): B2RWN3, Q59FV2, Q86WL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3