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Q9UJW7

- ZN229_HUMAN

UniProt

Q9UJW7 - ZN229_HUMAN

Protein

Zinc finger protein 229

Gene

ZNF229

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri291 – 31525C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri349 – 37123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri377 – 39923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri405 – 42723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri433 – 45523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri461 – 48323C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri489 – 51123C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri517 – 53923C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri545 – 56622C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri572 – 59423C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri600 – 62223C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri628 – 65023C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri656 – 67823C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri684 – 70623C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri712 – 73423C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri740 – 76223C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri768 – 79023C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri796 – 81823C2H2-type 18PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: RefGenome
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 229
    Gene namesi
    Name:ZNF229
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:13022. ZNF229.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37601.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 825825Zinc finger protein 229PRO_0000047470Add
    BLAST

    Proteomic databases

    PaxDbiQ9UJW7.
    PRIDEiQ9UJW7.

    2D gel databases

    REPRODUCTION-2DPAGEQ9UJW7.

    PTM databases

    PhosphoSiteiQ9UJW7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UJW7.
    BgeeiQ9UJW7.
    CleanExiHS_ZNF229.
    GenevestigatoriQ9UJW7.

    Organism-specific databases

    HPAiHPA001494.

    Interactioni

    Protein-protein interaction databases

    BioGridi113555. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UJW7.
    SMRiQ9UJW7. Positions 238-825.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 10875KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 18 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri291 – 31525C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri349 – 37123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri377 – 39923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri405 – 42723C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri433 – 45523C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri461 – 48323C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri489 – 51123C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri517 – 53923C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri545 – 56622C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri572 – 59423C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri600 – 62223C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri628 – 65023C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri656 – 67823C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri684 – 70623C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri712 – 73423C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri740 – 76223C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri768 – 79023C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri796 – 81823C2H2-type 18PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ9UJW7.
    KOiK09228.
    OMAiIWEEVAG.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ9UJW7.

    Family and domain databases

    Gene3Di3.30.160.60. 17 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 17 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 16 hits.
    PS50157. ZINC_FINGER_C2H2_2. 17 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UJW7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    METLTSRHEK RALHSQASAI SQDREEKIMS QEPLSFKDVA VVFTEEELEL    50
    LDSTQRQLYQ DVMQENFRNL LSVGERNPLG DKNGKDTEYI QDEELRFFSH 100
    KELSSCKIWE EVAGELPGSQ DCRVNLQGKD FQFSEDAAPH QGWEGASTPC 150
    FPIENSLDSL QGDGLIGLEN QQFPAWRAIR PIPIQGSWAK AFVNQLGDVQ 200
    ERCKNLDTED TVYKCNWDDD SFCWISCHVD HRFPEIDKPC GCNKCRKDCI 250
    KNSVLHRINP GENGLKSNEY RNGFRDDADL PPHPRVPLKE KLCQYDEFSE 300
    GLRHSAHLNR HQRVPTGEKS VKSLERGRGV RQNTHIRNHP RAPVGDMPYR 350
    CDVCGKGFRY KSVLLIHQGV HTGRRPYKCE ECGKAFGRSS NLLVHQRVHT 400
    GEKPYKCSEC GKGFSYSSVL QVHQRLHTGE KPYTCSECGK GFCAKSALHK 450
    HQHIHPGEKP YSCGECGKGF SCSSHLSSHQ KTHTGERPYQ CDKCGKGFSH 500
    NSYLQAHQRV HMGQHLYKCN VCGKSFSYSS GLLMHQRLHT GEKPYKCECG 550
    KSFGRSSDLH IHQRVHTGEK PYKCSECGKG FRRNSDLHSH QRVHTGERPY 600
    VCDVCGKGFI YSSDLLIHQR VHTGEKPYKC AECGKGFSYS SGLLIHQRVH 650
    TGEKPYRCQE CGKGFRCTSS LHKHQRVHTG KKPYTCDQCG KGFSYGSNLR 700
    THQRLHTGEK PYTCCECGKG FRYGSGLLSH KRVHTGEKPY RCHVCGKGYS 750
    QSSHLQGHQR VHTGEKPYKC EECGKGFGRN SCLHVHQRVH TGEKPYTCGV 800
    CGKGFSYTSG LRNHQRVHLG ENPYK 825
    Length:825
    Mass (Da):93,707
    Last modified:May 18, 2010 - v3
    Checksum:i301AE62BDAA872F6
    GO
    Isoform 2 (identifier: Q9UJW7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         75-80: Missing.

    Note: No experimental confirmation available. Gene prediction based on EST data.

    Show »
    Length:819
    Mass (Da):93,041
    Checksum:i0070ACBE4332D807
    GO

    Sequence cautioni

    The sequence AAG23970.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti156 – 1561S → F.1 Publication
    Corresponds to variant rs2571174 [ dbSNP | Ensembl ].
    VAR_057408
    Natural varianti337 – 3371R → C.
    Corresponds to variant rs12151338 [ dbSNP | Ensembl ].
    VAR_057409
    Natural varianti417 – 4171S → N.
    Corresponds to variant rs57014690 [ dbSNP | Ensembl ].
    VAR_061942
    Natural varianti662 – 6621G → R.1 Publication
    Corresponds to variant rs1434579 [ dbSNP | Ensembl ].
    VAR_060426
    Natural varianti804 – 8041G → R.
    Corresponds to variant rs10409807 [ dbSNP | Ensembl ].
    VAR_060427

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei75 – 806Missing in isoform 2. CuratedVSP_054778

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC084239 Genomic DNA. Translation: AAG23970.1. Sequence problems.
    BC150612 mRNA. Translation: AAI50613.1.
    AF192979 mRNA. Translation: AAF07964.1.
    AY166791 mRNA. Translation: AAO45840.1.
    AB209357 mRNA. Translation: BAD92594.1.
    CCDSiCCDS42574.1. [Q9UJW7-1]
    CCDS62706.1. [Q9UJW7-2]
    RefSeqiNP_055333.3. NM_014518.3.
    UniGeneiHs.709348.

    Genome annotation databases

    GeneIDi7772.
    KEGGihsa:7772.
    UCSCiuc002oze.1. human. [Q9UJW7-1]

    Polymorphism databases

    DMDMi296453070.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC084239 Genomic DNA. Translation: AAG23970.1 . Sequence problems.
    BC150612 mRNA. Translation: AAI50613.1 .
    AF192979 mRNA. Translation: AAF07964.1 .
    AY166791 mRNA. Translation: AAO45840.1 .
    AB209357 mRNA. Translation: BAD92594.1 .
    CCDSi CCDS42574.1. [Q9UJW7-1 ]
    CCDS62706.1. [Q9UJW7-2 ]
    RefSeqi NP_055333.3. NM_014518.3.
    UniGenei Hs.709348.

    3D structure databases

    ProteinModelPortali Q9UJW7.
    SMRi Q9UJW7. Positions 238-825.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113555. 1 interaction.

    PTM databases

    PhosphoSitei Q9UJW7.

    Polymorphism databases

    DMDMi 296453070.

    2D gel databases

    REPRODUCTION-2DPAGE Q9UJW7.

    Proteomic databases

    PaxDbi Q9UJW7.
    PRIDEi Q9UJW7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 7772.
    KEGGi hsa:7772.
    UCSCi uc002oze.1. human. [Q9UJW7-1 ]

    Organism-specific databases

    CTDi 7772.
    GeneCardsi GC19M044930.
    HGNCi HGNC:13022. ZNF229.
    HPAi HPA001494.
    neXtProti NX_Q9UJW7.
    PharmGKBi PA37601.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q9UJW7.
    KOi K09228.
    OMAi IWEEVAG.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q9UJW7.

    Miscellaneous databases

    ChiTaRSi ZNF229. human.
    GenomeRNAii 7772.
    NextBioi 30097.
    PROi Q9UJW7.

    Gene expression databases

    ArrayExpressi Q9UJW7.
    Bgeei Q9UJW7.
    CleanExi HS_ZNF229.
    Genevestigatori Q9UJW7.

    Family and domain databases

    Gene3Di 3.30.160.60. 17 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 17 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 16 hits.
    PS50157. ZINC_FINGER_C2H2_2. 17 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PHE-156.
      Tissue: Brain.
    3. "Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters."
      Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.
      Genome Res. 13:1097-1110(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-420 (ISOFORM 1).
      Tissue: Brain.
    4. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 397-825, VARIANT ARG-662.
      Tissue: Brain.

    Entry informationi

    Entry nameiZN229_HUMAN
    AccessioniPrimary (citable) accession number: Q9UJW7
    Secondary accession number(s): B2RWN3, Q59FV2, Q86WL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 121 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3