Q9UJW7 (ZN229_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 229

Gene names

Name:

ZNF229

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	825 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 18 C2H2-type zinc fingers. Contains 1 KRAB domain.
Sequence caution	The sequence AAG23970.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 825	825	Zinc finger protein 229		PRO_0000047470
Regions
	Domain	34 – 108	75	KRAB
	Zinc finger	291 – 315	25	C2H2-type 1; degenerate
	Zinc finger	349 – 371	23	C2H2-type 2
	Zinc finger	377 – 399	23	C2H2-type 3
	Zinc finger	405 – 427	23	C2H2-type 4
	Zinc finger	433 – 455	23	C2H2-type 5
	Zinc finger	461 – 483	23	C2H2-type 6
	Zinc finger	489 – 511	23	C2H2-type 7
	Zinc finger	517 – 539	23	C2H2-type 8
	Zinc finger	545 – 566	22	C2H2-type 9
	Zinc finger	572 – 594	23	C2H2-type 10
	Zinc finger	600 – 622	23	C2H2-type 11
	Zinc finger	628 – 650	23	C2H2-type 12
	Zinc finger	656 – 678	23	C2H2-type 13
	Zinc finger	684 – 706	23	C2H2-type 14
	Zinc finger	712 – 734	23	C2H2-type 15
	Zinc finger	740 – 762	23	C2H2-type 16
	Zinc finger	768 – 790	23	C2H2-type 17
	Zinc finger	796 – 818	23	C2H2-type 18
Natural variations
	Natural variant	156	1	S → F. Ref.2 Corresponds to variant rs2571174 [ dbSNP | Ensembl ].		VAR_057408
	Natural variant	337	1	R → C. Corresponds to variant rs12151338 [ dbSNP | Ensembl ].		VAR_057409
	Natural variant	417	1	S → N. Corresponds to variant rs57014690 [ dbSNP | Ensembl ].		VAR_061942
	Natural variant	662	1	G → R. Ref.4 Corresponds to variant rs1434579 [ dbSNP | Ensembl ].		VAR_060426
	Natural variant	804	1	G → R. Corresponds to variant rs10409807 [ dbSNP | Ensembl ].		VAR_060427

Sequences

	Sequence		Length	Mass (Da)
	Q9UJW7 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 301AE62BDAA872F6	FASTA	825	93,707
	10 20 30 40 50 60 METLTSRHEK RALHSQASAI SQDREEKIMS QEPLSFKDVA VVFTEEELEL LDSTQRQLYQ 70 80 90 100 110 120 DVMQENFRNL LSVGERNPLG DKNGKDTEYI QDEELRFFSH KELSSCKIWE EVAGELPGSQ 130 140 150 160 170 180 DCRVNLQGKD FQFSEDAAPH QGWEGASTPC FPIENSLDSL QGDGLIGLEN QQFPAWRAIR 190 200 210 220 230 240 PIPIQGSWAK AFVNQLGDVQ ERCKNLDTED TVYKCNWDDD SFCWISCHVD HRFPEIDKPC 250 260 270 280 290 300 GCNKCRKDCI KNSVLHRINP GENGLKSNEY RNGFRDDADL PPHPRVPLKE KLCQYDEFSE 310 320 330 340 350 360 GLRHSAHLNR HQRVPTGEKS VKSLERGRGV RQNTHIRNHP RAPVGDMPYR CDVCGKGFRY 370 380 390 400 410 420 KSVLLIHQGV HTGRRPYKCE ECGKAFGRSS NLLVHQRVHT GEKPYKCSEC GKGFSYSSVL 430 440 450 460 470 480 QVHQRLHTGE KPYTCSECGK GFCAKSALHK HQHIHPGEKP YSCGECGKGF SCSSHLSSHQ 490 500 510 520 530 540 KTHTGERPYQ CDKCGKGFSH NSYLQAHQRV HMGQHLYKCN VCGKSFSYSS GLLMHQRLHT 550 560 570 580 590 600 GEKPYKCECG KSFGRSSDLH IHQRVHTGEK PYKCSECGKG FRRNSDLHSH QRVHTGERPY 610 620 630 640 650 660 VCDVCGKGFI YSSDLLIHQR VHTGEKPYKC AECGKGFSYS SGLLIHQRVH TGEKPYRCQE 670 680 690 700 710 720 CGKGFRCTSS LHKHQRVHTG KKPYTCDQCG KGFSYGSNLR THQRLHTGEK PYTCCECGKG 730 740 750 760 770 780 FRYGSGLLSH KRVHTGEKPY RCHVCGKGYS QSSHLQGHQR VHTGEKPYKC EECGKGFGRN 790 800 810 820 SCLHVHQRVH TGEKPYTCGV CGKGFSYTSG LRNHQRVHLG ENPYK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-156. Tissue: Brain.
[3]	"Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters." Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L. Genome Res. 13:1097-1110(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-420. Tissue: Brain.
[4]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 397-825, VARIANT ARG-662. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC084239 Genomic DNA. Translation: AAG23970.1. Sequence problems. BC150612 mRNA. Translation: AAI50613.1. AF192979 mRNA. Translation: AAF07964.1. AY166791 mRNA. Translation: AAO45840.1. AB209357 mRNA. Translation: BAD92594.1.
IPI	IPI00798156.
RefSeq	NP_055333.2. NM_014518.2.
UniGene	Hs.709348.
3D structure databases
ProteinModelPortal	Q9UJW7.
SMR	Q9UJW7. Positions 238-825.
ModBase	Search...
PTM databases
PhosphoSite	Q9UJW7.
Polymorphism databases
DMDM	296453070.
2D gel databases
REPRODUCTION-2DPAGE	Q9UJW7.
Proteomic databases
PaxDb	Q9UJW7.
PRIDE	Q9UJW7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000588931; ENSP00000466519; ENSG00000167383.
GeneID	7772.
KEGG	hsa:7772.
UCSC	uc002oze.1. human.
Organism-specific databases
CTD	7772.
GeneCards	GC19M044930.
HGNC	HGNC:13022. ZNF229.
HPA	HPA001494.
neXtProt	NX_Q9UJW7.
PharmGKB	PA37601.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q9UJW7.
KO	K09228.
OMA	GYSQSSH.
OrthoDB	EOG40P462.
Gene expression databases
Bgee	Q9UJW7.
CleanEx	HS_ZNF229.
Genevestigator	Q9UJW7.
GermOnline	ENSG00000167383. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 17 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 17 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 16 hits. PS50157. ZINC_FINGER_C2H2_2. 17 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZNF229. human.
GenomeRNAi	7772.
NextBio	30097.

Entry information

Entry name

ZN229_HUMAN

Accession

Primary (citable) accession number: Q9UJW7
Secondary accession number(s): B2RWN3, Q59FV2, Q86WL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 109 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.