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Protein

Tubulointerstitial nephritis antigen

Gene

TINAG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei49 – 502Cleavage; by furinSequence Analysis

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: ProtInc
  2. nucleotide binding Source: ProtInc
  3. polysaccharide binding Source: InterPro
  4. scavenger receptor activity Source: InterPro

GO - Biological processi

  1. cell adhesion Source: UniProtKB
  2. immune response Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Protein family/group databases

MEROPSiC01.973.

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulointerstitial nephritis antigen
Short name:
TIN-Ag
Gene namesi
Name:TINAG
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:14599. TINAG.

Subcellular locationi

  1. Secretedextracellular spaceextracellular matrixbasement membrane 2 Publications

GO - Cellular componenti

  1. basement membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37905.

Polymorphism and mutation databases

BioMutaiTINAG.
DMDMi317373501.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476Tubulointerstitial nephritis antigenPRO_0000050600Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi63 ↔ 70AlternatePROSITE-ProRule annotation
Disulfide bondi70 ↔ 102AlternatePROSITE-ProRule annotation
Disulfide bondi81 ↔ 95AlternatePROSITE-ProRule annotation
Disulfide bondi81 ↔ 83AlternatePROSITE-ProRule annotation
Disulfide bondi87 ↔ 94PROSITE-ProRule annotation
Disulfide bondi95 ↔ 102AlternatePROSITE-ProRule annotation
Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi455 – 4551N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus 2 alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UJW2.
PRIDEiQ9UJW2.

PTM databases

PhosphoSiteiQ9UJW2.

Expressioni

Tissue specificityi

Expressed in the kidney cortex, small intestine and cornea.3 Publications

Developmental stagei

Initially observed in the Bowman capsule during early glomerular capillary loop formation in the kidney. In more developmentally mature glomeruli, following transition from early to mid-capillary loop stage, expression is higher in the proximal tubular basement membrane than in the distal basement membrane and Bowman capsule.1 Publication

Gene expression databases

BgeeiQ9UJW2.
CleanExiHS_TINAG.
ExpressionAtlasiQ9UJW2. baseline and differential.
GenevestigatoriQ9UJW2.

Organism-specific databases

HPAiHPA035427.

Interactioni

Protein-protein interaction databases

BioGridi118107. 2 interactions.
IntActiQ9UJW2. 2 interactions.
STRINGi9606.ENSP00000259782.

Structurei

3D structure databases

ProteinModelPortaliQ9UJW2.
SMRiQ9UJW2. Positions 170-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 10749SMBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation
Contains 1 SMB (somatomedin-B) domain.Curated

Phylogenomic databases

eggNOGiNOG310046.
GeneTreeiENSGT00780000121937.
HOGENOMiHOG000241342.
HOVERGENiHBG053961.
InParanoidiQ9UJW2.
OMAiWGQLTSS.
PhylomeDBiQ9UJW2.
TreeFamiTF313765.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR001212. Somatomedin_B_dom.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
PF01033. Somatomedin_B. 1 hit.
[Graphical view]
SMARTiSM00645. Pept_C1. 1 hit.
SM00201. SO. 1 hit.
[Graphical view]
PROSITEiPS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
PS00640. THIOL_PROTEASE_ASN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UJW2-1) [UniParc]FASTAAdd to basket

Also known as: TIN11 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWTGYKILIF SYLTTEIWME KQYLSQREVD LEAYFTRNHT VLQGTRFKRA
60 70 80 90 100
IFQGQYCRNF GCCEDRDDGC VTEFYAANAL CYCDKFCDRE NSDCCPDYKS
110 120 130 140 150
FCREEKEWPP HTQPWYPEGC FKDGQHYEEG SVIKENCNSC TCSGQQWKCS
160 170 180 190 200
QHVCLVRSEL IEQVNKGDYG WTAQNYSQFW GMTLEDGFKF RLGTLPPSPM
210 220 230 240 250
LLSMNEMTAS LPATTDLPEF FVASYKWPGW THGPLDQKNC AASWAFSTAS
260 270 280 290 300
VAADRIAIQS KGRYTANLSP QNLISCCAKN RHGCNSGSID RAWWYLRKRG
310 320 330 340 350
LVSHACYPLF KDQNATNNGC AMASRSDGRG KRHATKPCPN NVEKSNRIYQ
360 370 380 390 400
CSPPYRVSSN ETEIMKEIMQ NGPVQAIMQV REDFFHYKTG IYRHVTSTNK
410 420 430 440 450
ESEKYRKLQT HAVKLTGWGT LRGAQGQKEK FWIAANSWGK SWGENGYFRI
460 470
LRGVNESDIE KLIIAAWGQL TSSDEP

Note: Major isoform.

Length:476
Mass (Da):54,605
Last modified:January 11, 2011 - v3
Checksum:i6D90C734DAC3A5AE
GO
Isoform 2 (identifier: Q9UJW2-2) [UniParc]FASTAAdd to basket

Also known as: TIN21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     119-169: Missing.
     209-300: Missing.

Show »
Length:333
Mass (Da):38,724
Checksum:iE708C6B55D9DBF9A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 82IL → FS in AAF08931 (PubMed:10752525).Curated
Sequence conflicti7 – 82IL → FS in AAF08932 (PubMed:10752525).Curated
Sequence conflicti175 – 1751N → I in AAF08932 (PubMed:10752525).Curated
Sequence conflicti199 – 1991P → L in BAA84949 (PubMed:10652240).Curated
Sequence conflicti333 – 3331H → D in AAF08931 (PubMed:10752525).Curated
Sequence conflicti333 – 3331H → D in AAF08932 (PubMed:10752525).Curated
Sequence conflicti381 – 3811R → H in BAA84949 (PubMed:10652240).Curated
Sequence conflicti421 – 4211L → R in AAF08932 (PubMed:10752525).Curated
Sequence conflicti437 – 4371S → F in AAF08931 (PubMed:10752525).Curated
Sequence conflicti437 – 4371S → F in AAF08932 (PubMed:10752525).Curated
Sequence conflicti463 – 4631I → V in AAF08931 (PubMed:10752525).Curated
Sequence conflicti463 – 4631I → V in AAF08932 (PubMed:10752525).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31T → A.
Corresponds to variant rs16885197 [ dbSNP | Ensembl ].
VAR_047091
Natural varianti22 – 221Q → R.
Corresponds to variant rs2297980 [ dbSNP | Ensembl ].
VAR_047092
Natural varianti158 – 1581S → P.2 Publications
Corresponds to variant rs1058768 [ dbSNP | Ensembl ].
VAR_047093
Natural varianti413 – 4131V → I.
Corresponds to variant rs34011963 [ dbSNP | Ensembl ].
VAR_047094
Natural varianti433 – 4331I → L.
Corresponds to variant rs3736352 [ dbSNP | Ensembl ].
VAR_047095

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei119 – 16951Missing in isoform 2. 1 PublicationVSP_050567Add
BLAST
Alternative sequencei209 – 30092Missing in isoform 2. 1 PublicationVSP_050568Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022277 mRNA. Translation: BAA84949.1.
AF195116 mRNA. Translation: AAF08931.1.
AF195117 mRNA. Translation: AAF08932.1.
AK312918 mRNA. Translation: BAG35763.1.
AL589946, AL359380 Genomic DNA. Translation: CAH70302.1.
AL359380, AL589946 Genomic DNA. Translation: CAI16272.1.
CH471081 Genomic DNA. Translation: EAX04437.1.
CCDSiCCDS4955.1. [Q9UJW2-1]
PIRiJC7189.
RefSeqiNP_055279.3. NM_014464.3. [Q9UJW2-1]
UniGeneiHs.127011.

Genome annotation databases

GeneIDi27283.
KEGGihsa:27283.
UCSCiuc003pcj.2. human. [Q9UJW2-1]

Polymorphism and mutation databases

BioMutaiTINAG.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022277 mRNA. Translation: BAA84949.1.
AF195116 mRNA. Translation: AAF08931.1.
AF195117 mRNA. Translation: AAF08932.1.
AK312918 mRNA. Translation: BAG35763.1.
AL589946, AL359380 Genomic DNA. Translation: CAH70302.1.
AL359380, AL589946 Genomic DNA. Translation: CAI16272.1.
CH471081 Genomic DNA. Translation: EAX04437.1.
CCDSiCCDS4955.1. [Q9UJW2-1]
PIRiJC7189.
RefSeqiNP_055279.3. NM_014464.3. [Q9UJW2-1]
UniGeneiHs.127011.

3D structure databases

ProteinModelPortaliQ9UJW2.
SMRiQ9UJW2. Positions 170-466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118107. 2 interactions.
IntActiQ9UJW2. 2 interactions.
STRINGi9606.ENSP00000259782.

Protein family/group databases

MEROPSiC01.973.

PTM databases

PhosphoSiteiQ9UJW2.

Polymorphism and mutation databases

BioMutaiTINAG.
DMDMi317373501.

Proteomic databases

PaxDbiQ9UJW2.
PRIDEiQ9UJW2.

Protocols and materials databases

DNASUi27283.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi27283.
KEGGihsa:27283.
UCSCiuc003pcj.2. human. [Q9UJW2-1]

Organism-specific databases

CTDi27283.
GeneCardsiGC06P054220.
H-InvDBHIX0025004.
HGNCiHGNC:14599. TINAG.
HPAiHPA035427.
MIMi606749. gene.
neXtProtiNX_Q9UJW2.
PharmGKBiPA37905.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG310046.
GeneTreeiENSGT00780000121937.
HOGENOMiHOG000241342.
HOVERGENiHBG053961.
InParanoidiQ9UJW2.
OMAiWGQLTSS.
PhylomeDBiQ9UJW2.
TreeFamiTF313765.

Miscellaneous databases

GeneWikiiTINAG.
GenomeRNAii27283.
NextBioi50212.
PROiQ9UJW2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UJW2.
CleanExiHS_TINAG.
ExpressionAtlasiQ9UJW2. baseline and differential.
GenevestigatoriQ9UJW2.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR001212. Somatomedin_B_dom.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
PF01033. Somatomedin_B. 1 hit.
[Graphical view]
SMARTiSM00645. Pept_C1. 1 hit.
SM00201. SO. 1 hit.
[Graphical view]
PROSITEiPS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
PS00640. THIOL_PROTEASE_ASN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, expression, and chromosomal localization of a human tubulointerstitial nephritis antigen."
    Ikeda M., Takemura T., Hino S., Yoshioka K.
    Biochem. Biophys. Res. Commun. 268:225-230(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT PRO-158.
    Tissue: Kidney1 Publication.
  2. "Identification of two alternatively spliced forms of human tubulointerstitial nephritis antigen (TIN-Ag)."
    Zhou B., Nelson T.R., Kashtan C., Gleason B., Michael A.F., Vlassi M., Charonis A.S.
    J. Am. Soc. Nephrol. 11:658-668(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANT PRO-158.
    Tissue: Kidney1 Publication.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Identification of a target antigen in human anti-tubular basement membrane nephritis."
    Fliger F.D., Wieslander J., Brentjens J.R., Andres G.A., Butkowski R.J.
    Kidney Int. 31:800-807(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, INVOLVEMENT IN TUBULOINTERSTITIAL NEPHRITIS.
    Tissue: Kidney1 Publication.
  7. "Distribution of tubulointerstitial nephritis antigen and evidence for multiple forms."
    Butkowski R.J., Kleppel M.M., Katz A., Michael A.F., Fish A.J.
    Kidney Int. 40:838-846(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  8. "Role of antibodies to tubulointerstitial nephritis antigen in human anti-tubular basement membrane nephritis associated with membranous nephropathy."
    Katz A., Fish A.J., Santamaria P., Nevins T.E., Kim Y., Butkowski R.J.
    Am. J. Med. 93:691-698(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISEASE.
  9. "Receptors in proximal tubular epithelial cells for tubulointerstitial nephritis antigen."
    Chen Y., Krishnamurti U., Wayner E.A., Michael A.F., Charonis A.S.
    Kidney Int. 49:153-157(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Tubulointerstitial nephritis antigen (TIN-ag) is expressed in distinct segments of the developing human nephron."
    Nelson T.R., Kim Y., Michael A.F., Butkowski R.J., Charonis A.S.
    Connect. Tissue Res. 37:53-60(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiTINAG_HUMAN
AccessioniPrimary (citable) accession number: Q9UJW2
Secondary accession number(s): Q5T467, Q9UJW1, Q9ULZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: January 11, 2011
Last modified: April 29, 2015
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antibodies against TINAG are found in sera of patients with tubulointerstitial nephritis, a rare autoimmune disorder that causes acute and chronic renal injury.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.