Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9UJW2

- TINAG_HUMAN

UniProt

Q9UJW2 - TINAG_HUMAN

Protein

Tubulointerstitial nephritis antigen

Gene

TINAG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei49 – 502Cleavage; by furinSequence Analysis

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: ProtInc
    2. nucleotide binding Source: ProtInc
    3. polysaccharide binding Source: InterPro
    4. scavenger receptor activity Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: UniProtKB
    2. immune response Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Protein family/group databases

    MEROPSiC01.973.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tubulointerstitial nephritis antigen
    Short name:
    TIN-Ag
    Gene namesi
    Name:TINAG
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:14599. TINAG.

    Subcellular locationi

    Secretedextracellular spaceextracellular matrixbasement membrane 2 Publications

    GO - Cellular componenti

    1. basement membrane Source: UniProtKB

    Keywords - Cellular componenti

    Basement membrane, Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37905.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 476476Tubulointerstitial nephritis antigenPRO_0000050600Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi63 ↔ 70AlternatePROSITE-ProRule annotation
    Disulfide bondi70 ↔ 102AlternatePROSITE-ProRule annotation
    Disulfide bondi81 ↔ 95AlternatePROSITE-ProRule annotation
    Disulfide bondi81 ↔ 83AlternatePROSITE-ProRule annotation
    Disulfide bondi87 ↔ 94PROSITE-ProRule annotation
    Disulfide bondi95 ↔ 102AlternatePROSITE-ProRule annotation
    Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi455 – 4551N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus 2 alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9UJW2.
    PRIDEiQ9UJW2.

    PTM databases

    PhosphoSiteiQ9UJW2.

    Expressioni

    Tissue specificityi

    Expressed in the kidney cortex, small intestine and cornea.3 Publications

    Developmental stagei

    Initially observed in the Bowman capsule during early glomerular capillary loop formation in the kidney. In more developmentally mature glomeruli, following transition from early to mid-capillary loop stage, expression is higher in the proximal tubular basement membrane than in the distal basement membrane and Bowman capsule.1 Publication

    Gene expression databases

    ArrayExpressiQ9UJW2.
    BgeeiQ9UJW2.
    CleanExiHS_TINAG.
    GenevestigatoriQ9UJW2.

    Organism-specific databases

    HPAiHPA035427.

    Interactioni

    Protein-protein interaction databases

    BioGridi118107. 2 interactions.
    IntActiQ9UJW2. 2 interactions.
    STRINGi9606.ENSP00000259782.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UJW2.
    SMRiQ9UJW2. Positions 170-466.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini59 – 10749SMBPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C1 family.PROSITE-ProRule annotation
    Contains 1 SMB (somatomedin-B) domain.Curated

    Phylogenomic databases

    eggNOGiNOG310046.
    HOGENOMiHOG000241342.
    HOVERGENiHBG053961.
    InParanoidiQ9UJW2.
    OMAiWGQLTSS.
    PhylomeDBiQ9UJW2.
    TreeFamiTF313765.

    Family and domain databases

    InterProiIPR025661. Pept_asp_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR001212. Somatomedin_B_dom.
    [Graphical view]
    PANTHERiPTHR12411. PTHR12411. 1 hit.
    PfamiPF00112. Peptidase_C1. 1 hit.
    PF01033. Somatomedin_B. 1 hit.
    [Graphical view]
    SMARTiSM00645. Pept_C1. 1 hit.
    SM00201. SO. 1 hit.
    [Graphical view]
    PROSITEiPS00524. SMB_1. 1 hit.
    PS50958. SMB_2. 1 hit.
    PS00640. THIOL_PROTEASE_ASN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UJW2-1) [UniParc]FASTAAdd to Basket

    Also known as: TIN11 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWTGYKILIF SYLTTEIWME KQYLSQREVD LEAYFTRNHT VLQGTRFKRA    50
    IFQGQYCRNF GCCEDRDDGC VTEFYAANAL CYCDKFCDRE NSDCCPDYKS 100
    FCREEKEWPP HTQPWYPEGC FKDGQHYEEG SVIKENCNSC TCSGQQWKCS 150
    QHVCLVRSEL IEQVNKGDYG WTAQNYSQFW GMTLEDGFKF RLGTLPPSPM 200
    LLSMNEMTAS LPATTDLPEF FVASYKWPGW THGPLDQKNC AASWAFSTAS 250
    VAADRIAIQS KGRYTANLSP QNLISCCAKN RHGCNSGSID RAWWYLRKRG 300
    LVSHACYPLF KDQNATNNGC AMASRSDGRG KRHATKPCPN NVEKSNRIYQ 350
    CSPPYRVSSN ETEIMKEIMQ NGPVQAIMQV REDFFHYKTG IYRHVTSTNK 400
    ESEKYRKLQT HAVKLTGWGT LRGAQGQKEK FWIAANSWGK SWGENGYFRI 450
    LRGVNESDIE KLIIAAWGQL TSSDEP 476

    Note: Major isoform.

    Length:476
    Mass (Da):54,605
    Last modified:January 11, 2011 - v3
    Checksum:i6D90C734DAC3A5AE
    GO
    Isoform 2 (identifier: Q9UJW2-2) [UniParc]FASTAAdd to Basket

    Also known as: TIN21 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         119-169: Missing.
         209-300: Missing.

    Show »
    Length:333
    Mass (Da):38,724
    Checksum:iE708C6B55D9DBF9A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 82IL → FS in AAF08931. (PubMed:10752525)Curated
    Sequence conflicti7 – 82IL → FS in AAF08932. (PubMed:10752525)Curated
    Sequence conflicti175 – 1751N → I in AAF08932. (PubMed:10752525)Curated
    Sequence conflicti199 – 1991P → L in BAA84949. (PubMed:10652240)Curated
    Sequence conflicti333 – 3331H → D in AAF08931. (PubMed:10752525)Curated
    Sequence conflicti333 – 3331H → D in AAF08932. (PubMed:10752525)Curated
    Sequence conflicti381 – 3811R → H in BAA84949. (PubMed:10652240)Curated
    Sequence conflicti421 – 4211L → R in AAF08932. (PubMed:10752525)Curated
    Sequence conflicti437 – 4371S → F in AAF08931. (PubMed:10752525)Curated
    Sequence conflicti437 – 4371S → F in AAF08932. (PubMed:10752525)Curated
    Sequence conflicti463 – 4631I → V in AAF08931. (PubMed:10752525)Curated
    Sequence conflicti463 – 4631I → V in AAF08932. (PubMed:10752525)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31T → A.
    Corresponds to variant rs16885197 [ dbSNP | Ensembl ].
    VAR_047091
    Natural varianti22 – 221Q → R.
    Corresponds to variant rs2297980 [ dbSNP | Ensembl ].
    VAR_047092
    Natural varianti158 – 1581S → P.2 Publications
    Corresponds to variant rs1058768 [ dbSNP | Ensembl ].
    VAR_047093
    Natural varianti413 – 4131V → I.
    Corresponds to variant rs34011963 [ dbSNP | Ensembl ].
    VAR_047094
    Natural varianti433 – 4331I → L.
    Corresponds to variant rs3736352 [ dbSNP | Ensembl ].
    VAR_047095

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei119 – 16951Missing in isoform 2. 1 PublicationVSP_050567Add
    BLAST
    Alternative sequencei209 – 30092Missing in isoform 2. 1 PublicationVSP_050568Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB022277 mRNA. Translation: BAA84949.1.
    AF195116 mRNA. Translation: AAF08931.1.
    AF195117 mRNA. Translation: AAF08932.1.
    AK312918 mRNA. Translation: BAG35763.1.
    AL589946, AL359380 Genomic DNA. Translation: CAH70302.1.
    AL359380, AL589946 Genomic DNA. Translation: CAI16272.1.
    CH471081 Genomic DNA. Translation: EAX04437.1.
    CCDSiCCDS4955.1. [Q9UJW2-1]
    PIRiJC7189.
    RefSeqiNP_055279.3. NM_014464.3. [Q9UJW2-1]
    UniGeneiHs.127011.

    Genome annotation databases

    EnsembliENST00000259782; ENSP00000259782; ENSG00000137251. [Q9UJW2-1]
    GeneIDi27283.
    KEGGihsa:27283.
    UCSCiuc003pcj.2. human. [Q9UJW2-1]

    Polymorphism databases

    DMDMi317373501.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB022277 mRNA. Translation: BAA84949.1 .
    AF195116 mRNA. Translation: AAF08931.1 .
    AF195117 mRNA. Translation: AAF08932.1 .
    AK312918 mRNA. Translation: BAG35763.1 .
    AL589946 , AL359380 Genomic DNA. Translation: CAH70302.1 .
    AL359380 , AL589946 Genomic DNA. Translation: CAI16272.1 .
    CH471081 Genomic DNA. Translation: EAX04437.1 .
    CCDSi CCDS4955.1. [Q9UJW2-1 ]
    PIRi JC7189.
    RefSeqi NP_055279.3. NM_014464.3. [Q9UJW2-1 ]
    UniGenei Hs.127011.

    3D structure databases

    ProteinModelPortali Q9UJW2.
    SMRi Q9UJW2. Positions 170-466.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118107. 2 interactions.
    IntActi Q9UJW2. 2 interactions.
    STRINGi 9606.ENSP00000259782.

    Protein family/group databases

    MEROPSi C01.973.

    PTM databases

    PhosphoSitei Q9UJW2.

    Polymorphism databases

    DMDMi 317373501.

    Proteomic databases

    PaxDbi Q9UJW2.
    PRIDEi Q9UJW2.

    Protocols and materials databases

    DNASUi 27283.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259782 ; ENSP00000259782 ; ENSG00000137251 . [Q9UJW2-1 ]
    GeneIDi 27283.
    KEGGi hsa:27283.
    UCSCi uc003pcj.2. human. [Q9UJW2-1 ]

    Organism-specific databases

    CTDi 27283.
    GeneCardsi GC06P054220.
    H-InvDB HIX0025004.
    HGNCi HGNC:14599. TINAG.
    HPAi HPA035427.
    MIMi 606749. gene.
    neXtProti NX_Q9UJW2.
    PharmGKBi PA37905.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG310046.
    HOGENOMi HOG000241342.
    HOVERGENi HBG053961.
    InParanoidi Q9UJW2.
    OMAi WGQLTSS.
    PhylomeDBi Q9UJW2.
    TreeFami TF313765.

    Miscellaneous databases

    GeneWikii TINAG.
    GenomeRNAii 27283.
    NextBioi 50212.
    PROi Q9UJW2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UJW2.
    Bgeei Q9UJW2.
    CleanExi HS_TINAG.
    Genevestigatori Q9UJW2.

    Family and domain databases

    InterProi IPR025661. Pept_asp_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR001212. Somatomedin_B_dom.
    [Graphical view ]
    PANTHERi PTHR12411. PTHR12411. 1 hit.
    Pfami PF00112. Peptidase_C1. 1 hit.
    PF01033. Somatomedin_B. 1 hit.
    [Graphical view ]
    SMARTi SM00645. Pept_C1. 1 hit.
    SM00201. SO. 1 hit.
    [Graphical view ]
    PROSITEi PS00524. SMB_1. 1 hit.
    PS50958. SMB_2. 1 hit.
    PS00640. THIOL_PROTEASE_ASN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, expression, and chromosomal localization of a human tubulointerstitial nephritis antigen."
      Ikeda M., Takemura T., Hino S., Yoshioka K.
      Biochem. Biophys. Res. Commun. 268:225-230(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT PRO-158.
      Tissue: Kidney1 Publication.
    2. "Identification of two alternatively spliced forms of human tubulointerstitial nephritis antigen (TIN-Ag)."
      Zhou B., Nelson T.R., Kashtan C., Gleason B., Michael A.F., Vlassi M., Charonis A.S.
      J. Am. Soc. Nephrol. 11:658-668(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANT PRO-158.
      Tissue: Kidney1 Publication.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Identification of a target antigen in human anti-tubular basement membrane nephritis."
      Fliger F.D., Wieslander J., Brentjens J.R., Andres G.A., Butkowski R.J.
      Kidney Int. 31:800-807(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, INVOLVEMENT IN TUBULOINTERSTITIAL NEPHRITIS.
      Tissue: Kidney1 Publication.
    7. "Distribution of tubulointerstitial nephritis antigen and evidence for multiple forms."
      Butkowski R.J., Kleppel M.M., Katz A., Michael A.F., Fish A.J.
      Kidney Int. 40:838-846(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    8. "Role of antibodies to tubulointerstitial nephritis antigen in human anti-tubular basement membrane nephritis associated with membranous nephropathy."
      Katz A., Fish A.J., Santamaria P., Nevins T.E., Kim Y., Butkowski R.J.
      Am. J. Med. 93:691-698(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISEASE.
    9. "Receptors in proximal tubular epithelial cells for tubulointerstitial nephritis antigen."
      Chen Y., Krishnamurti U., Wayner E.A., Michael A.F., Charonis A.S.
      Kidney Int. 49:153-157(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "Tubulointerstitial nephritis antigen (TIN-ag) is expressed in distinct segments of the developing human nephron."
      Nelson T.R., Kim Y., Michael A.F., Butkowski R.J., Charonis A.S.
      Connect. Tissue Res. 37:53-60(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiTINAG_HUMAN
    AccessioniPrimary (citable) accession number: Q9UJW2
    Secondary accession number(s): Q5T467, Q9UJW1, Q9ULZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 117 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Antibodies against TINAG are found in sera of patients with tubulointerstitial nephritis, a rare autoimmune disorder that causes acute and chronic renal injury.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3