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Protein

Dynactin subunit 4

Gene

DCTN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.

GO - Molecular functioni

  • protein N-terminus binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-2132295 MHC class II antigen presentation
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Dynactin subunit 4
Short name:
Dyn4
Alternative name(s):
Dynactin subunit p62
Gene namesi
Name:DCTN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000132912.12
HGNCiHGNC:15518 DCTN4
MIMi614758 gene
neXtProtiNX_Q9UJW0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi30C → S: Loss of ATP7B-binding; when associated with S-33; S-51; S-54; S-70, S-73; S-76; S-79; S-111; S-114; S-277 and S-280. 1 Publication1
Mutagenesisi33C → S: Loss of ATP7B-binding; when associated with S-30; S-51; S-54; S-70, S-73; S-76; S-79; S-111; S-114; S-277 and S-280. 1 Publication1
Mutagenesisi51C → S: Loss of ATP7B-binding; when associated with S-30; S-33; S-54; S-70, S-73; S-76; S-79; S-111; S-114; S-277 and S-280. 1 Publication1
Mutagenesisi54C → S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-70, S-73; S-76; S-79; S-111; S-114; S-277 and S-280. 1 Publication1
Mutagenesisi70C → S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-73; S-76; S-79; S-111; S-114; S-277 and S-280. 1 Publication1
Mutagenesisi73C → S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-76; S-79; S-111; S-114; S-277 and S-280. 1 Publication1
Mutagenesisi76C → S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-73; S-79; S-111; S-114; S-277 and S-280. 1 Publication1
Mutagenesisi79C → S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-73; S-76; S-111; S-114; S-277 and S-280. 1 Publication1
Mutagenesisi111C → S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-73; S-76; S-79; S-114; S-277 and S-280. 1 Publication1
Mutagenesisi114C → S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-73; S-76; S-79; S-111; S-277 and S-280. 1 Publication1
Mutagenesisi277C → S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-73; S-76; S-79; S-111; S-114 and S-280. 1 Publication1
Mutagenesisi280C → S: Loss of ATP7B-binding; when associated with S-30; S-33; S-51; S-54, S-70; S-73; S-76; S-79; S-111; S-114 and S-277. 1 Publication1

Organism-specific databases

DisGeNETi51164
MalaCardsiDCTN4
OpenTargetsiENSG00000132912
Orphaneti586 Cystic fibrosis
PharmGKBiPA27183

Polymorphism and mutation databases

BioMutaiDCTN4
DMDMi62900106

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000798232 – 460Dynactin subunit 4Add BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei196PhosphoserineCombined sources1
Cross-linki215Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei407PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UJW0
PaxDbiQ9UJW0
PeptideAtlasiQ9UJW0
PRIDEiQ9UJW0

PTM databases

iPTMnetiQ9UJW0
PhosphoSitePlusiQ9UJW0

Expressioni

Gene expression databases

BgeeiENSG00000132912
CleanExiHS_DCTN4
ExpressionAtlasiQ9UJW0 baseline and differential
GenevisibleiQ9UJW0 HS

Organism-specific databases

HPAiCAB017532
HPA038026

Interactioni

Subunit structurei

Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10 (By similarity). Binds directly to the ACTR1A subunit of dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein N-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119345, 47 interactors
CORUMiQ9UJW0
IntActiQ9UJW0, 20 interactors
MINTiQ9UJW0
STRINGi9606.ENSP00000414906

Structurei

3D structure databases

ProteinModelPortaliQ9UJW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili152 – 172Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the dynactin subunit 4 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3896 Eukaryota
ENOG410ZCK8 LUCA
GeneTreeiENSGT00390000006954
HOGENOMiHOG000007947
HOVERGENiHBG051324
InParanoidiQ9UJW0
KOiK10426
OMAiNCLENIP
OrthoDBiEOG091G0FIJ
PhylomeDBiQ9UJW0
TreeFamiTF105249

Family and domain databases

InterProiView protein in InterPro
IPR008603 DCTN4
PANTHERiPTHR13034 PTHR13034, 1 hit
PfamiView protein in Pfam
PF05502 Dynactin_p62, 2 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UJW0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLLQSDRV LYLVQGEKKV RAPLSQLYFC RYCSELRSLE CVSHEVDSHY
60 70 80 90 100
CPSCLENMPS AEAKLKKNRC ANCFDCPGCM HTLSTRATSI STQLPDDPAK
110 120 130 140 150
TTMKKAYYLA CGFCRWTSRD VGMADKSVAS GGWQEPENPH TQRMNKLIEY
160 170 180 190 200
YQQLAQKEKV ERDRKKLARR RNYMPLAFSD KYGLGTRLQR PRAGASISTL
210 220 230 240 250
AGLSLKEGED QKEIKIEPAQ AVDEVEPLPE DYYTRPVNLT EVTTLQQRLL
260 270 280 290 300
QPDFQPVCAS QLYPRHKHLL IKRSLRCRKC EHNLSKPEFN PTSIKFKIQL
310 320 330 340 350
VAVNYIPEVR IMSIPNLRYM KESQVLLTLT NPVENLTHVT LFECEEGDPD
360 370 380 390 400
DINSTAKVVV PPKELVLAGK DAAAEYDELA EPQDFQDDPD IIAFRKANKV
410 420 430 440 450
GIFIKVTPQR EEGEVTVCFK MKHDFKNLAA PIRPIEESDQ GTEVIWLTQH
460
VELSLGPLLP
Length:460
Mass (Da):52,337
Last modified:May 1, 2000 - v1
Checksum:i2105D6C0A713B11D
GO
Isoform 2 (identifier: Q9UJW0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.

Show »
Length:403
Mass (Da):45,757
Checksum:i4919CE2359032038
GO
Isoform 3 (identifier: Q9UJW0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-179: S → SQHTIHVV

Show »
Length:467
Mass (Da):53,152
Checksum:i2D4A445A6B764656
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05403795P → T1 PublicationCorresponds to variant dbSNP:rs11550931Ensembl.1
Natural variantiVAR_033847263Y → C. Corresponds to variant dbSNP:rs35772018Ensembl.1
Natural variantiVAR_024336342F → L1 PublicationCorresponds to variant dbSNP:rs11954652Ensembl.1
Natural variantiVAR_024337438S → N. Corresponds to variant dbSNP:rs3733923Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0413061 – 57Missing in isoform 2. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_041307179S → SQHTIHVV in isoform 3. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195120 mRNA Translation: AAF03896.1
AK125973 mRNA Translation: BAG54272.1
AK000299 mRNA Translation: BAA91066.1
AC008450 Genomic DNA No translation available.
AC008453 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61706.1
CH471062 Genomic DNA Translation: EAW61707.1
CH471062 Genomic DNA Translation: EAW61709.1
BC026323 mRNA Translation: AAH26323.1
CCDSiCCDS4310.1 [Q9UJW0-1]
CCDS47310.1 [Q9UJW0-3]
CCDS47311.1 [Q9UJW0-2]
RefSeqiNP_001129115.1, NM_001135643.1 [Q9UJW0-3]
NP_001129116.1, NM_001135644.1 [Q9UJW0-2]
NP_057305.1, NM_016221.3 [Q9UJW0-1]
XP_011535946.1, XM_011537644.1 [Q9UJW0-2]
XP_011535947.1, XM_011537645.1 [Q9UJW0-2]
UniGeneiHs.675564

Genome annotation databases

EnsembliENST00000424236; ENSP00000411251; ENSG00000132912 [Q9UJW0-2]
ENST00000446090; ENSP00000414906; ENSG00000132912 [Q9UJW0-3]
ENST00000447998; ENSP00000416968; ENSG00000132912 [Q9UJW0-1]
GeneIDi51164
KEGGihsa:51164
UCSCiuc003lsu.4 human [Q9UJW0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDCTN4_HUMAN
AccessioniPrimary (citable) accession number: Q9UJW0
Secondary accession number(s): B3KWW0
, D3DQH0, E5RGT5, Q8TAN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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