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Reviewed, UniProtKB/Swiss-Prot Q9UJU6 (DBNL_HUMAN)

Last modified January 19, 2010. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Drebrin-like protein
Alternative name(s):
    Drebrin-F
    SH3 domain-containing protein 7
    Cervical SH3P7
    HPK1-interacting protein of 55 kDa
      Short name=HIP-55
    Cervical mucin-associated protein
Gene names
Name: DBNL
Synonyms: CMAP, SH3P7
ORF Names: PP5423
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length430 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Actin-binding adapter protein. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Its association with dynamin suggests that it may also connect the actin cytoskeleton to endocytic function. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin. Ref.12

Subunit structure

Interacts with SHANK2 and SHANK3 By similarity. Interacts with FGD1, dynamin, MAP4K1 and PRAM1. Ref.1 Ref.13

Subcellular location

Cytoplasmcytoskeleton. Cell projectionlamellipodium. Note: Cortical cytoskeleton. Associates with lamellipodial actin.

Domain

The SH3 domain mediates interaction with SHANK2, SHANK3 and PRAM1.

Miscellaneous

Degraded by caspases during apoptosis.

Sequence similarities

Belongs to the ABP1 family.

Contains 1 ADF-H domain.

Contains 1 SH3 domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UJU6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UJU6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     234-234: Q → QS
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9UJU6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     234-234: Q → QS
     251-251: Q → QGSTCASLQ
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 430430Drebrin-like protein
PRO_0000079793

Regions

Domain4 – 133130ADF-H
Domain371 – 43060SH3
Coiled coil176 – 23156 Potential

Sites

Site361 – 3622Cleavage; by caspase-3

Amino acid modifications

Modified residue1621Phosphotyrosine Ref.14 Ref.15 Ref.18
Modified residue1761N6-acetyllysine Ref.26
Modified residue1781Phosphoserine Ref.20
Modified residue2321Phosphoserine Ref.17 Ref.21 Ref.22 Ref.24 Ref.25
Modified residue2691Phosphoserine Ref.20 Ref.22 Ref.24 Ref.25
Modified residue2701Phosphothreonine Ref.24
Modified residue2721Phosphoserine Ref.20
Modified residue2751Phosphoserine Ref.20 Ref.21 Ref.24 Ref.25
Modified residue2831Phosphoserine Ref.20 Ref.22 Ref.16 Ref.19
Modified residue2881N6-acetyllysine Ref.26
Modified residue2911Phosphothreonine Ref.20
Modified residue3341Phosphotyrosine By similarity
Modified residue3441Phosphotyrosine By similarity

Natural variations

Alternative sequence2341Q → QS in isoform 2 and isoform 3.
VSP_011398
Alternative sequence2511Q → QGSTCASLQ in isoform 3.
VSP_011399

Experimental info

Mutagenesis3611D → A: Abolishes cleavage by caspase-3. Ref.13
Sequence conflict81N → K in AAG17262. Ref.4
Sequence conflict981A → S in AAF81273. Ref.3
Sequence conflict981A → S in AAG13120. Ref.3
Sequence conflict2351R → S in AAF81273. Ref.3
Sequence conflict2351R → S in AAG13120. Ref.3
Sequence conflict4301E → D in CAG33448. Ref.6

Secondary structure

....................... 430
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 7E8C42ED047257AE

FASTA43048,207
        10         20         30         40         50         60 
MAANLSRNGP ALQEAYVRVV TEKSPTDWAL FTYEGNSNDI RVAGTGEGGL EEMVEELNSG 

        70         80         90        100        110        120 
KVMYAFCRVK DPNSGLPKFV LINWTGEGVN DVRKGACASH VSTMASFLKG AHVTINARAE 

       130        140        150        160        170        180 
EDVEPECIME KVAKASGANY SFHKESGRFQ DVGPQAPVGS VYQKTNAVSE IKRVGKDSFW 

       190        200        210        220        230        240 
AKAEKEEENR RLEEKRRAEE AQRQLEQERR ERELREAARR EQRYQEQGGE ASPQRTWEQQ 

       250        260        270        280        290        300 
QEVVSRNRNE QESAVHPREI FKQKERAMST TSISSPQPGK LRSPFLQKQL TQPETHFGRE 

       310        320        330        340        350        360 
PAAAISRPRA DLPAEEPAPS TPPCLVQAEE EAVYEEPPEQ ETFYEQPPLV QQQGAGSEHI 

       370        380        390        400        410        420 
DHHIQGQGLS GQGLCARALY DYQAADDTEI SFDPENLITG IEVIDEGWWR GYGPDGHFGM 

       430 
FPANYVELIE 

« Hide

Isoform 2.

Checksum: D18F9D316FFD0B4E
Show »

FASTA43148,294
Isoform 3.

Checksum: 8C044FBD0E82C6D5
Show »

FASTA43949,042

References

« Hide 'large scale' references
[1]"A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1."
Ensenat D., Yao Z., Wang X.-S., Kori R., Zhou G., Lee S.C., Tan T.-H.
J. Biol. Chem. 274:33945-33950(1999) [PubMed: 10567356] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH MAP4K1.
[2]"Molecular cloning of cDNA encoding drebrin F."
Zhang W., Yuan Z., Wan T., He L., Cao X.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Expression cloning of a novel cervical mucin-associated protein (CMAP)."
Toribara N.W., Ho S.B., Wang R., Arthur M., Shekels L.L., Spurr-Michaud S., Keutmann H.T., Hill J.A., Gipson I.K.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Cervix.
[4]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed: 15498874] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Mammary gland.
[6]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[7]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed: 12690205] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain and Eye.
[10]"SH3P7 is a cytoskeleton adapter protein and is coupled to signal transduction from lymphocyte antigen receptors."
Larbolette O., Wollscheid B., Schweikert J., Nielsen P.J., Wienands J.
Mol. Cell. Biol. 19:1539-1546(1999) [PubMed: 9891087] [Abstract]
Cited for: IDENTIFICATION.
[11]"Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis."
Chen Y.-R., Kori R., John B., Tan T.-H.
Biochem. Biophys. Res. Commun. 288:981-989(2001) [PubMed: 11689006] [Abstract]
Cited for: DEGRADATION BY CASPASES.
[12]"Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis."
Le Bras S., Foucault I., Foussat A., Brignone C., Acuto O., Deckert M.
J. Biol. Chem. 279:15550-15560(2004) [PubMed: 14729663] [Abstract]
Cited for: FUNCTION.
[13]"PRAM-1 potentiates arsenic trioxide-induced JNK activation."
Denis F.M., Benecke A., Di Gioia Y., Touw I.P., Cayre Y.E., Lutz P.G.
J. Biol. Chem. 280:9043-9048(2005) [PubMed: 15637062] [Abstract]
Cited for: INTERACTION WITH PRAM1, CLEAVAGE BY CASPASES, MUTAGENESIS OF ASP-361.
[14]"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-162, MASS SPECTROMETRY.
[15]"Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry."
Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J., Bodenmiller B., Watts J.D., Hood L., Aebersold R.
Nat. Methods 2:591-598(2005) [PubMed: 16094384] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-162, MASS SPECTROMETRY.
Tissue: T-cell.
[16]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283, MASS SPECTROMETRY.
Tissue: Epithelium.
[17]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, MASS SPECTROMETRY.
Tissue: Epithelium.
[18]"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer."
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. expand/collapse author list , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.
Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-162, MASS SPECTROMETRY.
[19]"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283, MASS SPECTROMETRY.
Tissue: Epithelium.
[20]"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry."
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178; SER-269; SER-272; SER-275; SER-283 AND THR-291, MASS SPECTROMETRY.
[21]"Phosphoproteome of resting human platelets."
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232 AND SER-275, MASS SPECTROMETRY.
Tissue: Platelet.
[22]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232; SER-269 AND SER-283, MASS SPECTROMETRY.
[23]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[24]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232; SER-269; THR-270 AND SER-275, MASS SPECTROMETRY.
[25]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232; SER-269 AND SER-275, MASS SPECTROMETRY.
Tissue: T-cell.
[26]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed: 19608861] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-176 AND LYS-288, MASS SPECTROMETRY.
[27]"Solution structure of the cofilin homology domain of HIP-55 (drebrin-like protein)."
RIKEN structural genomics initiative (RSGI)
Submitted (NOV-2005) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 1-133.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF197060 mRNA. Translation: AAF13701.1.
AF077353 mRNA. Translation: AAF80228.1.
AF250287 mRNA. Translation: AAF81273.1.
AF151364 mRNA. Translation: AAG13120.1.
AF218020 mRNA. Translation: AAG17262.2.
AK027367 mRNA. Translation: BAB55065.1.
CR457167 mRNA. Translation: CAG33448.1.
CH236960 Genomic DNA. Translation: EAL23770.1.
CH471128 Genomic DNA. Translation: EAW61132.1.
BC011677 mRNA. Translation: AAH11677.1.
BC031687 mRNA. Translation: AAH31687.1.
IPIIPI00101968.
IPI00396437.
IPI00456925.
RefSeqNP_001014436.1.
NP_001116428.1.
NP_054782.2.
UniGeneHs.436500

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1X67NMR-A1-133[»]
SMRQ9UJU6. Positions 373-428.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9UJU6. 9 interactions.
STRINGQ9UJU6.

PTM databases

PhosphoSiteQ9UJU6.

2-D gel databases

OGPQ9UJU6.

Proteomic databases

PRIDEQ9UJU6.

Genome annotation databases

EnsemblENST00000448521; ENSP00000411701; ENSG00000136279; Homo sapiens. [Genome view]
ENST00000452461; ENSP00000412539; ENSG00000136279; Homo sapiens. [Genome view]
GeneID28988.
KEGGhsa:28988.
UCSCuc003tjo.2. human.
uc003tjp.2. human.
uc003tjq.2. human.

Organism-specific databases

CTD28988.
GeneCardsGC07P044050.
H-InvDBHIX0006640.
HGNCHGNC:2696. DBNL.
HPAHPA020265.
MIM610106. gene.
PharmGKBPA27164.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG20095.
HOVERGENQ9UJU6.
OMAWSKMNEE.

Enzyme and pathway databases

Pathway_Interaction_DBtcrjnkpathway. JNK signaling in the CD4+ TCR pathway.
tcrpathway. TCR signaling in naive CD4+ T cells.
ReactomeREACT_578. Apoptosis.

Gene expression databases

ArrayExpressQ9UJU6.
BgeeQ9UJU6.
CleanExHS_DBNL.
GenevestigatorQ9UJU6.
GermOnlineENSG00000136279. Homo sapiens.

Family and domain databases

InterProIPR002108. Actin-bd_cofilin/tropomyosin.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00241. Cofilin_ADF. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTSM00102. ADF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
PROSITEPS51263. ADF_H. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio51899.
PMAP-CutDBQ9UJU6.
SOURCESearch...

Entry information

Entry nameDBNL_HUMAN
AccessionPrimary (citable) accession number: Q9UJU6
Secondary accession number(s): A4D2I9 expand/collapse secondary AC list , P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: May 1, 2000
Last modified: January 19, 2010
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents