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Protein

Zinc finger protein 112

Gene

ZNF112

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri258 – 28023C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri443 – 46523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri471 – 49323C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri497 – 51923C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri525 – 54723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri553 – 57523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri581 – 60323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri609 – 63123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri637 – 65923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri665 – 68723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri693 – 71523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri721 – 74323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri749 – 77123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri777 – 79923C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri805 – 82723C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri833 – 85523C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri861 – 88323C2H2-type 17PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 112
Short name:
Zfp-112
Alternative name(s):
Zinc finger protein 228
Gene namesi
Name:ZNF112
Synonyms:ZFP112, ZNF228
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12892. ZNF112.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409701.

Polymorphism and mutation databases

BioMutaiZNF112.
DMDMi311033503.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 913913Zinc finger protein 112PRO_0000047469Add
BLAST

Proteomic databases

PaxDbiQ9UJU3.
PeptideAtlasiQ9UJU3.
PRIDEiQ9UJU3.

PTM databases

iPTMnetiQ9UJU3.
PhosphoSiteiQ9UJU3.

Expressioni

Gene expression databases

BgeeiQ9UJU3.
CleanExiHS_ZFP112.
ExpressionAtlasiQ9UJU3. baseline and differential.
GenevisibleiQ9UJU3. HS.

Organism-specific databases

HPAiHPA023856.

Interactioni

Protein-protein interaction databases

BioGridi113554. 1 interaction.
STRINGi9606.ENSP00000337081.

Structurei

3D structure databases

ProteinModelPortaliQ9UJU3.
SMRiQ9UJU3. Positions 220-884.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 17 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri258 – 28023C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri443 – 46523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri471 – 49323C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri497 – 51923C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri525 – 54723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri553 – 57523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri581 – 60323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri609 – 63123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri637 – 65923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri665 – 68723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri693 – 71523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri721 – 74323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri749 – 77123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri777 – 79923C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri805 – 82723C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri833 – 85523C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri861 – 88323C2H2-type 17PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UJU3.
KOiK09228.
OMAiHSWRKMY.
PhylomeDBiQ9UJU3.

Family and domain databases

Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UJU3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTKFQEMVTF KDVAVVFTEE ELGLLDSVQR KLYRDVMLEN FRNLLLVAHQ
60 70 80 90 100
PFKPDLISQL EREEKLLMVE TETPRDGCSG RKNQQKMESI QEVTVSYFSP
110 120 130 140 150
KELSSRQTWQ QSAGGLIRCQ DFLKVFQGKN SQLQEQGNSL GQVWAGIPVQ
160 170 180 190 200
ISEDKNYIFT HIGNGSNYIK SQGYPSWRAH HSWRKMYLKE SHNYQCRCQQ
210 220 230 240 250
ISMKNHFCKC DSVSWLSHHN DKLEVHRKEN YSCHDCGEDI MKVSLLNQES
260 270 280 290 300
IQTEEKPYPC TGYRKAFSND SSSEVHQQFH LEGKPYTYSS CGKGCNYSSL
310 320 330 340 350
LHIHQNIERE DDIENSHLKS YQRVHTEEKP CKCGEYGENF NHCSPLNTYE
360 370 380 390 400
LIHTGEMSYR HNIYEKAFSH SLDLNSIFRV HTRDEPHEYE ENENVFNQSS
410 420 430 440 450
CLQVHQKIHT EEKLYTDIEY GKSFICSSNL DIQHRVHMEE NSYNSEECGN
460 470 480 490 500
GFSLASHFQD LQIVHTKEQP YKRYVCSNSF SHNLYLQGHP KIHIGEKPRK
510 520 530 540 550
EHGNGFNWSS KLKDHQRVHT GQKPYKCNIC GKGFNHRSVL NVHQRVHTGE
560 570 580 590 600
KPYKCEECDK GFSRSSYLQA HQRVHTGEKP YKCEECGKGF SRNSYLQGHQ
610 620 630 640 650
RVHTGEKPYK CEECGKGFSR SSHLQGHQRV HTGEKPFKCE ECGKGFSWSF
660 670 680 690 700
NLQIHQRVHT GEKPYKCEEC GKGFSKASTL LAHQRVHTGE KPYQCDECGK
710 720 730 740 750
SFSQRSYLQS HQSVHSGERP YICEVCGKGF SQRAYLQGHQ RVHTRVKPYK
760 770 780 790 800
CEMCGKGFSQ SSRLEAHRRV HTGGKPYKCE VCTKGFSESS RLQAHQRVHV
810 820 830 840 850
EGRPYKCEQC GKGFSGYSSL QAHHRVHTGE KPYKCEVCGK GFSQRSNLQA
860 870 880 890 900
HQRVHTGEKP YKCDACGKGF RWSSGLLIHQ RVHSSDKFYK SEDYGKDYPS
910
SENLHRNEDS VLF
Length:913
Mass (Da):105,842
Last modified:November 2, 2010 - v2
Checksum:i45F1E5A0EFBDFFC0
GO
Isoform 2 (identifier: Q9UJU3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.

Show »
Length:907
Mass (Da):105,077
Checksum:i7F61E43A71DD354F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 53KFQ → VSK in AAF12816 (PubMed:12743021).Curated
Sequence conflicti113 – 1131A → T in AAF12816 (PubMed:12743021).Curated
Sequence conflicti143 – 1431V → A in AAF12816 (PubMed:12743021).Curated
Sequence conflicti222 – 2221K → E in AAF12816 (PubMed:12743021).Curated
Sequence conflicti261 – 2611T → S in AAF12816 (PubMed:12743021).Curated
Sequence conflicti392 – 3921N → S in AAF12816 (PubMed:12743021).Curated
Sequence conflicti813 – 8131G → A in AAF12816 (PubMed:12743021).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541P → S.
Corresponds to variant rs11673395 [ dbSNP | Ensembl ].
VAR_060414
Natural varianti159 – 1591F → L.2 Publications
Corresponds to variant rs4280359 [ dbSNP | Ensembl ].
VAR_057377
Natural varianti163 – 1631G → E.
Corresponds to variant rs16978965 [ dbSNP | Ensembl ].
VAR_057378
Natural varianti287 – 2871T → K.
Corresponds to variant rs10419604 [ dbSNP | Ensembl ].
VAR_057379
Natural varianti446 – 4461E → Q.3 Publications
Corresponds to variant rs2722723 [ dbSNP | Ensembl ].
VAR_060415
Natural varianti485 – 4851Y → H.3 Publications
Corresponds to variant rs2722722 [ dbSNP | Ensembl ].
VAR_060416
Natural varianti780 – 7801E → A.
Corresponds to variant rs2609881 [ dbSNP | Ensembl ].
VAR_057380

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 66Missing in isoform 2. 1 PublicationVSP_039929

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198358 mRNA. Translation: AAF12816.1.
AC084239 Genomic DNA. Translation: AAG23968.1.
AC138473 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57269.1.
BC101753 mRNA. Translation: AAI01754.1.
CCDSiCCDS12637.1. [Q9UJU3-2]
CCDS54276.1. [Q9UJU3-1]
RefSeqiNP_001076804.1. NM_001083335.1. [Q9UJU3-1]
UniGeneiHs.48589.

Genome annotation databases

EnsembliENST00000337401; ENSP00000337081; ENSG00000062370. [Q9UJU3-1]
ENST00000354340; ENSP00000346305; ENSG00000062370. [Q9UJU3-2]
GeneIDi7771.
KEGGihsa:7771.
UCSCiuc002ozc.5. human. [Q9UJU3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198358 mRNA. Translation: AAF12816.1.
AC084239 Genomic DNA. Translation: AAG23968.1.
AC138473 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57269.1.
BC101753 mRNA. Translation: AAI01754.1.
CCDSiCCDS12637.1. [Q9UJU3-2]
CCDS54276.1. [Q9UJU3-1]
RefSeqiNP_001076804.1. NM_001083335.1. [Q9UJU3-1]
UniGeneiHs.48589.

3D structure databases

ProteinModelPortaliQ9UJU3.
SMRiQ9UJU3. Positions 220-884.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113554. 1 interaction.
STRINGi9606.ENSP00000337081.

PTM databases

iPTMnetiQ9UJU3.
PhosphoSiteiQ9UJU3.

Polymorphism and mutation databases

BioMutaiZNF112.
DMDMi311033503.

Proteomic databases

PaxDbiQ9UJU3.
PeptideAtlasiQ9UJU3.
PRIDEiQ9UJU3.

Protocols and materials databases

DNASUi7771.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337401; ENSP00000337081; ENSG00000062370. [Q9UJU3-1]
ENST00000354340; ENSP00000346305; ENSG00000062370. [Q9UJU3-2]
GeneIDi7771.
KEGGihsa:7771.
UCSCiuc002ozc.5. human. [Q9UJU3-1]

Organism-specific databases

CTDi7771.
GeneCardsiZNF112.
HGNCiHGNC:12892. ZNF112.
HPAiHPA023856.
neXtProtiNX_Q9UJU3.
PharmGKBiPA162409701.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UJU3.
KOiK09228.
OMAiHSWRKMY.
PhylomeDBiQ9UJU3.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii7771.
PROiQ9UJU3.

Gene expression databases

BgeeiQ9UJU3.
CleanExiHS_ZFP112.
ExpressionAtlasiQ9UJU3. baseline and differential.
GenevisibleiQ9UJU3. HS.

Family and domain databases

Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters."
    Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L.
    Genome Res. 13:1097-1110(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS GLN-446 AND HIS-485.
  2. "Sequence analysis of a 1Mb region in 19q13.2 containing a zinc finger gene cluster."
    Kodoyianni V., Ge Y., Krummel G.K., Kvikstad E., Grable L., Severin J., Gordon L., Shannon M., Brower A., Olsen A.S., Smith L.M.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1).
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LEU-159; GLN-446 AND HIS-485.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS LEU-159; GLN-446 AND HIS-485.
    Tissue: Liver.

Entry informationi

Entry nameiZN112_HUMAN
AccessioniPrimary (citable) accession number: Q9UJU3
Secondary accession number(s): A4FU53, Q9HCA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 2, 2010
Last modified: July 6, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.