UniProtKB - Q9UJU3 (ZN112_HUMAN)
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Protein
Zinc finger protein 112
Gene
ZNF112
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 258 – 280 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 443 – 465 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 471 – 493 | C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 497 – 519 | C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 525 – 547 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 553 – 575 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 581 – 603 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 609 – 631 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 637 – 659 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 665 – 687 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 693 – 715 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 721 – 743 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 749 – 771 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 777 – 799 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 805 – 827 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 833 – 855 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 861 – 883 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA binding transcription factor activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- regulation of transcription, DNA-templated Source: GO_Central
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-HSA-212436 Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 112Short name: Zfp-112 Alternative name(s): Zinc finger protein 228 |
Gene namesi | Name:ZNF112 Synonyms:ZFP112, ZNF228 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000062370.16 |
HGNCi | HGNC:12892 ZNF112 |
neXtProti | NX_Q9UJU3 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000062370 |
PharmGKBi | PA162409701 |
Polymorphism and mutation databases
BioMutai | ZNF112 |
DMDMi | 311033503 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047469 | 1 – 913 | Zinc finger protein 112Add BLAST | 913 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 256 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 890 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
PaxDbi | Q9UJU3 |
PeptideAtlasi | Q9UJU3 |
PRIDEi | Q9UJU3 |
PTM databases
iPTMneti | Q9UJU3 |
PhosphoSitePlusi | Q9UJU3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000062370 |
CleanExi | HS_ZFP112 |
ExpressionAtlasi | Q9UJU3 baseline and differential |
Genevisiblei | Q9UJU3 HS |
Organism-specific databases
HPAi | HPA023856 |
Interactioni
Protein-protein interaction databases
BioGridi | 1135546 interactors. |
STRINGi | 9606.ENSP00000337081 |
Structurei
3D structure databases
ProteinModelPortali | Q9UJU3 |
SMRi | Q9UJU3 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 79 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 258 – 280 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 443 – 465 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 471 – 493 | C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 497 – 519 | C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 525 – 547 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 553 – 575 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 581 – 603 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 609 – 631 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 637 – 659 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 665 – 687 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 693 – 715 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 721 – 743 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 749 – 771 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 777 – 799 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 805 – 827 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 833 – 855 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 861 – 883 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721 Eukaryota COG5048 LUCA |
GeneTreei | ENSGT00870000136402 |
HOGENOMi | HOG000234617 |
HOVERGENi | HBG018163 |
InParanoidi | Q9UJU3 |
KOi | K09228 |
OMAi | HSWRKMY |
OrthoDBi | EOG091G02KC |
PhylomeDBi | Q9UJU3 |
Family and domain databases
CDDi | cd07765 KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
Pfami | View protein in Pfam PF01352 KRAB, 1 hit |
SMARTi | View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 13 hits |
SUPFAMi | SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 11 hits |
PROSITEi | View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 13 hits PS50157 ZINC_FINGER_C2H2_2, 17 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9UJU3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MTKFQEMVTF KDVAVVFTEE ELGLLDSVQR KLYRDVMLEN FRNLLLVAHQ
60 70 80 90 100
PFKPDLISQL EREEKLLMVE TETPRDGCSG RKNQQKMESI QEVTVSYFSP
110 120 130 140 150
KELSSRQTWQ QSAGGLIRCQ DFLKVFQGKN SQLQEQGNSL GQVWAGIPVQ
160 170 180 190 200
ISEDKNYIFT HIGNGSNYIK SQGYPSWRAH HSWRKMYLKE SHNYQCRCQQ
210 220 230 240 250
ISMKNHFCKC DSVSWLSHHN DKLEVHRKEN YSCHDCGEDI MKVSLLNQES
260 270 280 290 300
IQTEEKPYPC TGYRKAFSND SSSEVHQQFH LEGKPYTYSS CGKGCNYSSL
310 320 330 340 350
LHIHQNIERE DDIENSHLKS YQRVHTEEKP CKCGEYGENF NHCSPLNTYE
360 370 380 390 400
LIHTGEMSYR HNIYEKAFSH SLDLNSIFRV HTRDEPHEYE ENENVFNQSS
410 420 430 440 450
CLQVHQKIHT EEKLYTDIEY GKSFICSSNL DIQHRVHMEE NSYNSEECGN
460 470 480 490 500
GFSLASHFQD LQIVHTKEQP YKRYVCSNSF SHNLYLQGHP KIHIGEKPRK
510 520 530 540 550
EHGNGFNWSS KLKDHQRVHT GQKPYKCNIC GKGFNHRSVL NVHQRVHTGE
560 570 580 590 600
KPYKCEECDK GFSRSSYLQA HQRVHTGEKP YKCEECGKGF SRNSYLQGHQ
610 620 630 640 650
RVHTGEKPYK CEECGKGFSR SSHLQGHQRV HTGEKPFKCE ECGKGFSWSF
660 670 680 690 700
NLQIHQRVHT GEKPYKCEEC GKGFSKASTL LAHQRVHTGE KPYQCDECGK
710 720 730 740 750
SFSQRSYLQS HQSVHSGERP YICEVCGKGF SQRAYLQGHQ RVHTRVKPYK
760 770 780 790 800
CEMCGKGFSQ SSRLEAHRRV HTGGKPYKCE VCTKGFSESS RLQAHQRVHV
810 820 830 840 850
EGRPYKCEQC GKGFSGYSSL QAHHRVHTGE KPYKCEVCGK GFSQRSNLQA
860 870 880 890 900
HQRVHTGEKP YKCDACGKGF RWSSGLLIHQ RVHSSDKFYK SEDYGKDYPS
910
SENLHRNEDS VLF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 – 5 | KFQ → VSK in AAF12816 (PubMed:12743021).Curated | 3 | |
Sequence conflicti | 113 | A → T in AAF12816 (PubMed:12743021).Curated | 1 | |
Sequence conflicti | 143 | V → A in AAF12816 (PubMed:12743021).Curated | 1 | |
Sequence conflicti | 222 | K → E in AAF12816 (PubMed:12743021).Curated | 1 | |
Sequence conflicti | 261 | T → S in AAF12816 (PubMed:12743021).Curated | 1 | |
Sequence conflicti | 392 | N → S in AAF12816 (PubMed:12743021).Curated | 1 | |
Sequence conflicti | 813 | G → A in AAF12816 (PubMed:12743021).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060414 | 54 | P → S. Corresponds to variant dbSNP:rs11673395Ensembl. | 1 | |
Natural variantiVAR_057377 | 159 | F → L2 PublicationsCorresponds to variant dbSNP:rs4280359Ensembl. | 1 | |
Natural variantiVAR_057378 | 163 | G → E. Corresponds to variant dbSNP:rs16978965Ensembl. | 1 | |
Natural variantiVAR_057379 | 287 | T → K. Corresponds to variant dbSNP:rs10419604Ensembl. | 1 | |
Natural variantiVAR_060415 | 446 | E → Q3 PublicationsCorresponds to variant dbSNP:rs2722723Ensembl. | 1 | |
Natural variantiVAR_060416 | 485 | Y → H3 PublicationsCorresponds to variant dbSNP:rs2722722Ensembl. | 1 | |
Natural variantiVAR_057380 | 780 | E → A. Corresponds to variant dbSNP:rs2609881Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039929 | 1 – 6 | Missing in isoform 2. 1 Publication | 6 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF198358 mRNA Translation: AAF12816.1 AC084239 Genomic DNA Translation: AAG23968.1 AC138473 Genomic DNA No translation available. CH471126 Genomic DNA Translation: EAW57269.1 BC101753 mRNA Translation: AAI01754.1 |
CCDSi | CCDS12637.1 [Q9UJU3-2] CCDS54276.1 [Q9UJU3-1] |
RefSeqi | NP_001076804.1, NM_001083335.1 [Q9UJU3-1] NP_001335211.1, NM_001348282.1 [Q9UJU3-2] NP_001335212.1, NM_001348283.1 [Q9UJU3-2] |
UniGenei | Hs.48589 |
Genome annotation databases
Ensembli | ENST00000337401; ENSP00000337081; ENSG00000062370 [Q9UJU3-1] ENST00000354340; ENSP00000346305; ENSG00000062370 [Q9UJU3-2] |
GeneIDi | 7771 |
KEGGi | hsa:7771 |
UCSCi | uc002ozc.5 human [Q9UJU3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | ZN112_HUMAN | |
Accessioni | Q9UJU3Primary (citable) accession number: Q9UJU3 Secondary accession number(s): A4FU53, Q9HCA7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 2, 2010 | |
Last modified: | February 28, 2018 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |