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UniProtKB - Q9UJU3 (ZN112_HUMAN)

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Protein

Zinc finger protein 112

Gene

ZNF112

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri258 – 280C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri443 – 465C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri471 – 493C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri581 – 603C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri609 – 631C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri637 – 659C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri665 – 687C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri693 – 715C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri721 – 743C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri749 – 771C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri777 – 799C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri805 – 827C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri833 – 855C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri861 – 883C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 112
Short name:
Zfp-112
Alternative name(s):
Zinc finger protein 228
Gene namesi
Name:ZNF112
Synonyms:ZFP112, ZNF228
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000062370.16
HGNCiHGNC:12892 ZNF112
neXtProtiNX_Q9UJU3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000062370
PharmGKBiPA162409701

Polymorphism and mutation databases

BioMutaiZNF112
DMDMi311033503

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474691 – 913Zinc finger protein 112Add BLAST913

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki256Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki890Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9UJU3
PeptideAtlasiQ9UJU3
PRIDEiQ9UJU3

PTM databases

iPTMnetiQ9UJU3
PhosphoSitePlusiQ9UJU3

Expressioni

Gene expression databases

BgeeiENSG00000062370
CleanExiHS_ZFP112
ExpressionAtlasiQ9UJU3 baseline and differential
GenevisibleiQ9UJU3 HS

Organism-specific databases

HPAiHPA023856

Interactioni

Protein-protein interaction databases

BioGridi1135546 interactors.
STRINGi9606.ENSP00000337081

Structurei

3D structure databases

ProteinModelPortaliQ9UJU3
SMRiQ9UJU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri258 – 280C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri443 – 465C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri471 – 493C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri581 – 603C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri609 – 631C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri637 – 659C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri665 – 687C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri693 – 715C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri721 – 743C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri749 – 771C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri777 – 799C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri805 – 827C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri833 – 855C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri861 – 883C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00870000136402
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9UJU3
KOiK09228
OMAiHSWRKMY
OrthoDBiEOG091G02KC
PhylomeDBiQ9UJU3

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 11 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UJU3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTKFQEMVTF KDVAVVFTEE ELGLLDSVQR KLYRDVMLEN FRNLLLVAHQ 
        60         70         80         90        100
PFKPDLISQL EREEKLLMVE TETPRDGCSG RKNQQKMESI QEVTVSYFSP 
       110        120        130        140        150
KELSSRQTWQ QSAGGLIRCQ DFLKVFQGKN SQLQEQGNSL GQVWAGIPVQ 
       160        170        180        190        200
ISEDKNYIFT HIGNGSNYIK SQGYPSWRAH HSWRKMYLKE SHNYQCRCQQ 
       210        220        230        240        250
ISMKNHFCKC DSVSWLSHHN DKLEVHRKEN YSCHDCGEDI MKVSLLNQES 
       260        270        280        290        300
IQTEEKPYPC TGYRKAFSND SSSEVHQQFH LEGKPYTYSS CGKGCNYSSL 
       310        320        330        340        350
LHIHQNIERE DDIENSHLKS YQRVHTEEKP CKCGEYGENF NHCSPLNTYE 
       360        370        380        390        400
LIHTGEMSYR HNIYEKAFSH SLDLNSIFRV HTRDEPHEYE ENENVFNQSS 
       410        420        430        440        450
CLQVHQKIHT EEKLYTDIEY GKSFICSSNL DIQHRVHMEE NSYNSEECGN 
       460        470        480        490        500
GFSLASHFQD LQIVHTKEQP YKRYVCSNSF SHNLYLQGHP KIHIGEKPRK 
       510        520        530        540        550
EHGNGFNWSS KLKDHQRVHT GQKPYKCNIC GKGFNHRSVL NVHQRVHTGE 
       560        570        580        590        600
KPYKCEECDK GFSRSSYLQA HQRVHTGEKP YKCEECGKGF SRNSYLQGHQ 
       610        620        630        640        650
RVHTGEKPYK CEECGKGFSR SSHLQGHQRV HTGEKPFKCE ECGKGFSWSF 
       660        670        680        690        700
NLQIHQRVHT GEKPYKCEEC GKGFSKASTL LAHQRVHTGE KPYQCDECGK 
       710        720        730        740        750
SFSQRSYLQS HQSVHSGERP YICEVCGKGF SQRAYLQGHQ RVHTRVKPYK 
       760        770        780        790        800
CEMCGKGFSQ SSRLEAHRRV HTGGKPYKCE VCTKGFSESS RLQAHQRVHV 
       810        820        830        840        850
EGRPYKCEQC GKGFSGYSSL QAHHRVHTGE KPYKCEVCGK GFSQRSNLQA 
       860        870        880        890        900
HQRVHTGEKP YKCDACGKGF RWSSGLLIHQ RVHSSDKFYK SEDYGKDYPS 
       910 
SENLHRNEDS VLF
Length:913
Mass (Da):105,842
Last modified:November 2, 2010 - v2
Checksum:i45F1E5A0EFBDFFC0
GO
Isoform 2 (identifier: Q9UJU3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: Missing.

Show »
Length:907
Mass (Da):105,077
Checksum:i7F61E43A71DD354F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3 – 5KFQ → VSK in AAF12816 (PubMed:12743021).Curated3
Sequence conflicti113A → T in AAF12816 (PubMed:12743021).Curated1
Sequence conflicti143V → A in AAF12816 (PubMed:12743021).Curated1
Sequence conflicti222K → E in AAF12816 (PubMed:12743021).Curated1
Sequence conflicti261T → S in AAF12816 (PubMed:12743021).Curated1
Sequence conflicti392N → S in AAF12816 (PubMed:12743021).Curated1
Sequence conflicti813G → A in AAF12816 (PubMed:12743021).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06041454P → S. Corresponds to variant dbSNP:rs11673395Ensembl.1
Natural variantiVAR_057377159F → L2 PublicationsCorresponds to variant dbSNP:rs4280359Ensembl.1
Natural variantiVAR_057378163G → E. Corresponds to variant dbSNP:rs16978965Ensembl.1
Natural variantiVAR_057379287T → K. Corresponds to variant dbSNP:rs10419604Ensembl.1
Natural variantiVAR_060415446E → Q3 PublicationsCorresponds to variant dbSNP:rs2722723Ensembl.1
Natural variantiVAR_060416485Y → H3 PublicationsCorresponds to variant dbSNP:rs2722722Ensembl.1
Natural variantiVAR_057380780E → A. Corresponds to variant dbSNP:rs2609881Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0399291 – 6Missing in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198358 mRNA Translation: AAF12816.1
AC084239 Genomic DNA Translation: AAG23968.1
AC138473 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57269.1
BC101753 mRNA Translation: AAI01754.1
CCDSiCCDS12637.1 [Q9UJU3-2]
CCDS54276.1 [Q9UJU3-1]
RefSeqiNP_001076804.1, NM_001083335.1 [Q9UJU3-1]
NP_001335211.1, NM_001348282.1 [Q9UJU3-2]
NP_001335212.1, NM_001348283.1 [Q9UJU3-2]
UniGeneiHs.48589

Genome annotation databases

EnsembliENST00000337401; ENSP00000337081; ENSG00000062370 [Q9UJU3-1]
ENST00000354340; ENSP00000346305; ENSG00000062370 [Q9UJU3-2]
GeneIDi7771
KEGGihsa:7771
UCSCiuc002ozc.5 human [Q9UJU3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN112_HUMAN
AccessioniPrimary (citable) accession number: Q9UJU3
Secondary accession number(s): A4FU53, Q9HCA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 2, 2010
Last modified: February 28, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome