ZNF112

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	Length	Description	Actions
Zinc fingerⁱ	258 – 280	23	C2H2-type 1; degeneratePROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	443 – 465	23	C2H2-type 2; degeneratePROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	471 – 493	23	C2H2-type 3; degeneratePROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	497 – 519	23	C2H2-type 4; degeneratePROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	525 – 547	23	C2H2-type 5PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	553 – 575	23	C2H2-type 6PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	581 – 603	23	C2H2-type 7PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	609 – 631	23	C2H2-type 8PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	637 – 659	23	C2H2-type 9PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	665 – 687	23	C2H2-type 10PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	693 – 715	23	C2H2-type 11PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	721 – 743	23	C2H2-type 12PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	749 – 771	23	C2H2-type 13PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	777 – 799	23	C2H2-type 14PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	805 – 827	23	C2H2-type 15PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	833 – 855	23	C2H2-type 16PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	861 – 883	23	C2H2-type 17PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436. Generic Transcription Pathway.

Reactomeⁱ

R-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 112 Short name: Zfp-112 Alternative name(s): Zinc finger protein 228
Gene namesⁱ	Name:ZNF112 Synonyms:ZFP112, ZNF228
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

HGNCⁱ	HGNC:12892. ZNF112.

HGNCⁱ

HGNC:12892. ZNF112.

Subcellular locationⁱ

Nucleus Curated

GO - Cellular componentⁱ

nucleus Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA162409701.

PharmGKBⁱ

PA162409701.

Polymorphism and mutation databases

BioMutaⁱ	ZNF112.
DMDMⁱ	311033503.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 913	913	Zinc finger protein 112		PRO_0000047469	Add BLAST

Proteomic databases

PaxDbⁱ	Q9UJU3.
PeptideAtlasⁱ	Q9UJU3.
PRIDEⁱ	Q9UJU3.

PTM databases

iPTMnetⁱ	Q9UJU3.
PhosphoSiteⁱ	Q9UJU3.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000062370.
CleanExⁱ	HS_ZFP112.
ExpressionAtlasⁱ	Q9UJU3. baseline and differential.
Genevisibleⁱ	Q9UJU3. HS.

Organism-specific databases

HPAⁱ	HPA023856.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	113554. 1 interaction.
STRINGⁱ	9606.ENSP00000337081.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UJU3.
SMRⁱ	Q9UJU3. Positions 220-884.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Domainⁱ	8 – 79	72	KRABPROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00119			Add BLAST

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Contains 17 C2H2-type zinc fingers.PROSITE-ProRule annotation

Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature key	Position(s)	Length	Description	Actions
Zinc fingerⁱ	258 – 280	23	C2H2-type 1; degeneratePROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	443 – 465	23	C2H2-type 2; degeneratePROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	471 – 493	23	C2H2-type 3; degeneratePROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	497 – 519	23	C2H2-type 4; degeneratePROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	525 – 547	23	C2H2-type 5PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	553 – 575	23	C2H2-type 6PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	581 – 603	23	C2H2-type 7PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	609 – 631	23	C2H2-type 8PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	637 – 659	23	C2H2-type 9PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	665 – 687	23	C2H2-type 10PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	693 – 715	23	C2H2-type 11PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	721 – 743	23	C2H2-type 12PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	749 – 771	23	C2H2-type 13PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	777 – 799	23	C2H2-type 14PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	805 – 827	23	C2H2-type 15PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	833 – 855	23	C2H2-type 16PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST
Zinc fingerⁱ	861 – 883	23	C2H2-type 17PROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00042	Add BLAST

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721. Eukaryota. COG5048. LUCA.
GeneTreeⁱ	ENSGT00840000129740.
HOGENOMⁱ	HOG000234617.
HOVERGENⁱ	HBG018163.
InParanoidⁱ	Q9UJU3.
KOⁱ	K09228.
OMAⁱ	HSWRKMY.
OrthoDBⁱ	EOG091G02KC.
PhylomeDBⁱ	Q9UJU3.

Family and domain databases

CDDⁱ	cd07765. KRAB_A-box. 1 hit.
Gene3Dⁱ	3.30.160.60. 19 hits.
InterProⁱ	IPR001909. KRAB. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfamⁱ	PF01352. KRAB. 1 hit. PF00096. zf-C2H2. 5 hits. [Graphical view]
SMARTⁱ	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 13 hits. [Graphical view]
SUPFAMⁱ	SSF109640. SSF109640. 1 hit.
PROSITEⁱ	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 13 hits. PS50157. ZINC_FINGER_C2H2_2. 17 hits. [Graphical view]

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q9UJU3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MTKFQEMVTF KDVAVVFTEE ELGLLDSVQR KLYRDVMLEN FRNLLLVAHQ 
        60         70         80         90        100
PFKPDLISQL EREEKLLMVE TETPRDGCSG RKNQQKMESI QEVTVSYFSP 
       110        120        130        140        150
KELSSRQTWQ QSAGGLIRCQ DFLKVFQGKN SQLQEQGNSL GQVWAGIPVQ 
       160        170        180        190        200
ISEDKNYIFT HIGNGSNYIK SQGYPSWRAH HSWRKMYLKE SHNYQCRCQQ 
       210        220        230        240        250
ISMKNHFCKC DSVSWLSHHN DKLEVHRKEN YSCHDCGEDI MKVSLLNQES 
       260        270        280        290        300
IQTEEKPYPC TGYRKAFSND SSSEVHQQFH LEGKPYTYSS CGKGCNYSSL 
       310        320        330        340        350
LHIHQNIERE DDIENSHLKS YQRVHTEEKP CKCGEYGENF NHCSPLNTYE 
       360        370        380        390        400
LIHTGEMSYR HNIYEKAFSH SLDLNSIFRV HTRDEPHEYE ENENVFNQSS 
       410        420        430        440        450
CLQVHQKIHT EEKLYTDIEY GKSFICSSNL DIQHRVHMEE NSYNSEECGN 
       460        470        480        490        500
GFSLASHFQD LQIVHTKEQP YKRYVCSNSF SHNLYLQGHP KIHIGEKPRK 
       510        520        530        540        550
EHGNGFNWSS KLKDHQRVHT GQKPYKCNIC GKGFNHRSVL NVHQRVHTGE 
       560        570        580        590        600
KPYKCEECDK GFSRSSYLQA HQRVHTGEKP YKCEECGKGF SRNSYLQGHQ 
       610        620        630        640        650
RVHTGEKPYK CEECGKGFSR SSHLQGHQRV HTGEKPFKCE ECGKGFSWSF 
       660        670        680        690        700
NLQIHQRVHT GEKPYKCEEC GKGFSKASTL LAHQRVHTGE KPYQCDECGK 
       710        720        730        740        750
SFSQRSYLQS HQSVHSGERP YICEVCGKGF SQRAYLQGHQ RVHTRVKPYK 
       760        770        780        790        800
CEMCGKGFSQ SSRLEAHRRV HTGGKPYKCE VCTKGFSESS RLQAHQRVHV 
       810        820        830        840        850
EGRPYKCEQC GKGFSGYSSL QAHHRVHTGE KPYKCEVCGK GFSQRSNLQA 
       860        870        880        890        900
HQRVHTGEKP YKCDACGKGF RWSSGLLIHQ RVHSSDKFYK SEDYGKDYPS 
       910 
SENLHRNEDS VLF

Length:913

Mass (Da):105,842

Last modified:November 2, 2010 - v2

Checksum:ⁱ45F1E5A0EFBDFFC0

GO

Isoform 2 (identifier: Q9UJU3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-6: Missing.

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        10         20         30         40         50
MVTFKDVAVV FTEEELGLLD SVQRKLYRDV MLENFRNLLL VAHQPFKPDL 
        60         70         80         90        100
ISQLEREEKL LMVETETPRD GCSGRKNQQK MESIQEVTVS YFSPKELSSR 
       110        120        130        140        150
QTWQQSAGGL IRCQDFLKVF QGKNSQLQEQ GNSLGQVWAG IPVQISEDKN 
       160        170        180        190        200
YIFTHIGNGS NYIKSQGYPS WRAHHSWRKM YLKESHNYQC RCQQISMKNH 
       210        220        230        240        250
FCKCDSVSWL SHHNDKLEVH RKENYSCHDC GEDIMKVSLL NQESIQTEEK 
       260        270        280        290        300
PYPCTGYRKA FSNDSSSEVH QQFHLEGKPY TYSSCGKGCN YSSLLHIHQN 
       310        320        330        340        350
IEREDDIENS HLKSYQRVHT EEKPCKCGEY GENFNHCSPL NTYELIHTGE 
       360        370        380        390        400
MSYRHNIYEK AFSHSLDLNS IFRVHTRDEP HEYEENENVF NQSSCLQVHQ 
       410        420        430        440        450
KIHTEEKLYT DIEYGKSFIC SSNLDIQHRV HMEENSYNSE ECGNGFSLAS 
       460        470        480        490        500
HFQDLQIVHT KEQPYKRYVC SNSFSHNLYL QGHPKIHIGE KPRKEHGNGF 
       510        520        530        540        550
NWSSKLKDHQ RVHTGQKPYK CNICGKGFNH RSVLNVHQRV HTGEKPYKCE 
       560        570        580        590        600
ECDKGFSRSS YLQAHQRVHT GEKPYKCEEC GKGFSRNSYL QGHQRVHTGE 
       610        620        630        640        650
KPYKCEECGK GFSRSSHLQG HQRVHTGEKP FKCEECGKGF SWSFNLQIHQ 
       660        670        680        690        700
RVHTGEKPYK CEECGKGFSK ASTLLAHQRV HTGEKPYQCD ECGKSFSQRS 
       710        720        730        740        750
YLQSHQSVHS GERPYICEVC GKGFSQRAYL QGHQRVHTRV KPYKCEMCGK 
       760        770        780        790        800
GFSQSSRLEA HRRVHTGGKP YKCEVCTKGF SESSRLQAHQ RVHVEGRPYK 
       810        820        830        840        850
CEQCGKGFSG YSSLQAHHRV HTGEKPYKCE VCGKGFSQRS NLQAHQRVHT 
       860        870        880        890        900
GEKPYKCDAC GKGFRWSSGL LIHQRVHSSD KFYKSEDYGK DYPSSENLHR 

NEDSVLF

Show »

Length:907

Mass (Da):105,077

Checksum:ⁱ7F61E43A71DD354F

GO

Experimental Info

Feature key	Position(s)	Length	Description
Sequence conflictⁱ	3 – 5	3	KFQ → VSK in AAF12816 (PubMed:12743021).Curated
Sequence conflictⁱ	113 – 113	1	A → T in AAF12816 (PubMed:12743021).Curated
Sequence conflictⁱ	143 – 143	1	V → A in AAF12816 (PubMed:12743021).Curated
Sequence conflictⁱ	222 – 222	1	K → E in AAF12816 (PubMed:12743021).Curated
Sequence conflictⁱ	261 – 261	1	T → S in AAF12816 (PubMed:12743021).Curated
Sequence conflictⁱ	392 – 392	1	N → S in AAF12816 (PubMed:12743021).Curated
Sequence conflictⁱ	813 – 813	1	G → A in AAF12816 (PubMed:12743021).Curated

Natural variant

Feature key	Position(s)	Length	Description	Feature identifier
Natural variantⁱ	54 – 54	1	P → S. Corresponds to variant rs11673395 [ dbSNP \| Ensembl ].	VAR_060414
Natural variantⁱ	159 – 159	1	F → L.2 Publications Manual assertion based on experiment inⁱ Ref.4 Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LEU-159; GLN-446 AND HIS-485. Ref.5 "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS LEU-159; GLN-446 AND HIS-485. Corresponds to variant rs4280359 [ dbSNP \| Ensembl ].	VAR_057377
Natural variantⁱ	163 – 163	1	G → E. Corresponds to variant rs16978965 [ dbSNP \| Ensembl ].	VAR_057378
Natural variantⁱ	287 – 287	1	T → K. Corresponds to variant rs10419604 [ dbSNP \| Ensembl ].	VAR_057379
Natural variantⁱ	446 – 446	1	E → Q.3 Publications Manual assertion based on experiment inⁱ Ref.1 "Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters." Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L. Genome Res. 13:1097-1110(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS GLN-446 AND HIS-485. Ref.4 Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LEU-159; GLN-446 AND HIS-485. Ref.5 "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS LEU-159; GLN-446 AND HIS-485. Corresponds to variant rs2722723 [ dbSNP \| Ensembl ].	VAR_060415
Natural variantⁱ	485 – 485	1	Y → H.3 Publications Manual assertion based on experiment inⁱ Ref.1 "Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters." Shannon M., Hamilton A.T., Gordon L., Branscomb E., Stubbs L. Genome Res. 13:1097-1110(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS GLN-446 AND HIS-485. Ref.4 Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS LEU-159; GLN-446 AND HIS-485. Ref.5 "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS LEU-159; GLN-446 AND HIS-485. Corresponds to variant rs2722722 [ dbSNP \| Ensembl ].	VAR_060416
Natural variantⁱ	780 – 780	1	E → A. Corresponds to variant rs2609881 [ dbSNP \| Ensembl ].	VAR_057380

Alternative sequence

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Alternative sequenceⁱ	1 – 6	6	Missing in isoform 2. 1 Publication Manual assertion based on opinion inⁱ Ref.5 "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS LEU-159; GLN-446 AND HIS-485.		VSP_039929

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF198358 mRNA. Translation: AAF12816.1. AC084239 Genomic DNA. Translation: AAG23968.1. AC138473 Genomic DNA. No translation available. CH471126 Genomic DNA. Translation: EAW57269.1. BC101753 mRNA. Translation: AAI01754.1.
CCDSⁱ	CCDS12637.1. [Q9UJU3-2] CCDS54276.1. [Q9UJU3-1]
RefSeqⁱ	NP_001076804.1. NM_001083335.1. [Q9UJU3-1]
UniGeneⁱ	Hs.48589.

Genome annotation databases

Ensemblⁱ	ENST00000337401; ENSP00000337081; ENSG00000062370. [Q9UJU3-1] ENST00000354340; ENSP00000346305; ENSG00000062370. [Q9UJU3-2]
GeneIDⁱ	7771.
KEGGⁱ	hsa:7771.
UCSCⁱ	uc002ozc.5. human. [Q9UJU3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF198358 mRNA. Translation: AAF12816.1. AC084239 Genomic DNA. Translation: AAG23968.1. AC138473 Genomic DNA. No translation available. CH471126 Genomic DNA. Translation: EAW57269.1. BC101753 mRNA. Translation: AAI01754.1.
CCDSⁱ	CCDS12637.1. [Q9UJU3-2] CCDS54276.1. [Q9UJU3-1]
RefSeqⁱ	NP_001076804.1. NM_001083335.1. [Q9UJU3-1]
UniGeneⁱ	Hs.48589.

3D structure databases

ProteinModelPortalⁱ	Q9UJU3.
SMRⁱ	Q9UJU3. Positions 220-884.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113554. 1 interaction.
STRINGⁱ	9606.ENSP00000337081.

PTM databases

iPTMnetⁱ	Q9UJU3.
PhosphoSiteⁱ	Q9UJU3.

Polymorphism and mutation databases

BioMutaⁱ	ZNF112.
DMDMⁱ	311033503.

Proteomic databases

PaxDbⁱ	Q9UJU3.
PeptideAtlasⁱ	Q9UJU3.
PRIDEⁱ	Q9UJU3.

Protocols and materials databases

DNASUⁱ	7771.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000337401; ENSP00000337081; ENSG00000062370. [Q9UJU3-1] ENST00000354340; ENSP00000346305; ENSG00000062370. [Q9UJU3-2]
GeneIDⁱ	7771.
KEGGⁱ	hsa:7771.
UCSCⁱ	uc002ozc.5. human. [Q9UJU3-1]

Organism-specific databases

CTDⁱ	7771.
GeneCardsⁱ	ZNF112.
HGNCⁱ	HGNC:12892. ZNF112.
HPAⁱ	HPA023856.
neXtProtⁱ	NX_Q9UJU3.
PharmGKBⁱ	PA162409701.
GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721. Eukaryota. COG5048. LUCA.
GeneTreeⁱ	ENSGT00840000129740.
HOGENOMⁱ	HOG000234617.
HOVERGENⁱ	HBG018163.
InParanoidⁱ	Q9UJU3.
KOⁱ	K09228.
OMAⁱ	HSWRKMY.
OrthoDBⁱ	EOG091G02KC.
PhylomeDBⁱ	Q9UJU3.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436. Generic Transcription Pathway.

Reactomeⁱ

R-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAiⁱ	7771.
PROⁱ	Q9UJU3.

Gene expression databases

Bgeeⁱ	ENSG00000062370.
CleanExⁱ	HS_ZFP112.
ExpressionAtlasⁱ	Q9UJU3. baseline and differential.
Genevisibleⁱ	Q9UJU3. HS.

Family and domain databases

CDDⁱ	cd07765. KRAB_A-box. 1 hit.
Gene3Dⁱ	3.30.160.60. 19 hits.
InterProⁱ	IPR001909. KRAB. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfamⁱ	PF01352. KRAB. 1 hit. PF00096. zf-C2H2. 5 hits. [Graphical view]
SMARTⁱ	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 13 hits. [Graphical view]
SUPFAMⁱ	SSF109640. SSF109640. 1 hit.
PROSITEⁱ	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 13 hits. PS50157. ZINC_FINGER_C2H2_2. 17 hits. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

ZN112_HUMAN

Accessionⁱ

Primary (citable) accession number: Q9UJU3
Secondary accession number(s): A4FU53, Q9HCA7

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 2, 2010
Last modified:	September 7, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

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UniProtKB - Q9UJU3 (ZN112_HUMAN)

UniProt

Q9UJU3 - ZN112_HUMAN

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Zinc finger protein 112

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<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Provides information on the disease(s) and phenotype(s) associated with a protein.</p><p><a href='../manual/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequences (2)i

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (2)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ