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Protein

F-box/LRR-repeat protein 7

Gene

FBXL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 7
Alternative name(s):
F-box and leucine-rich repeat protein 7
F-box protein FBL6/FBL7
Gene namesi
Name:FBXL7
Synonyms:FBL6, FBL7, KIAA0840
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:13604. FBXL7.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB-KW
  • SCF ubiquitin ligase complex Source: UniProtKB
  • ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi23194.
OpenTargetsiENSG00000183580.
PharmGKBiPA28027.

Polymorphism and mutation databases

DMDMi37537858.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198491 – 491F-box/LRR-repeat protein 7Add BLAST491

Proteomic databases

EPDiQ9UJT9.
PaxDbiQ9UJT9.
PeptideAtlasiQ9UJT9.
PRIDEiQ9UJT9.

PTM databases

iPTMnetiQ9UJT9.
PhosphoSitePlusiQ9UJT9.

Expressioni

Gene expression databases

BgeeiENSG00000183580.
CleanExiHS_FBXL7.
ExpressionAtlasiQ9UJT9. baseline and differential.
GenevisibleiQ9UJT9. HS.

Organism-specific databases

HPAiHPA055464.

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) composed of CUL1, SKP1, RBX1 and FBXL7. Interacts with AURKA; interaction takes place during mitosis but not in interphase (By similarity).By similarity

Protein-protein interaction databases

BioGridi116803. 8 interactors.
IntActiQ9UJT9. 7 interactors.
STRINGi9606.ENSP00000423630.

Structurei

3D structure databases

ProteinModelPortaliQ9UJT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 157F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati170 – 195LRR 1Add BLAST26
Repeati196 – 221LRR 2Add BLAST26
Repeati222 – 247LRR 3Add BLAST26
Repeati253 – 281LRR 4Add BLAST29
Repeati282 – 307LRR 5Add BLAST26
Repeati308 – 333LRR 6Add BLAST26
Repeati334 – 359LRR 7Add BLAST26
Repeati360 – 385LRR 8Add BLAST26
Repeati386 – 411LRR 9Add BLAST26
Repeati412 – 437LRR 10Add BLAST26
Repeati438 – 463LRR 11Add BLAST26

Sequence similaritiesi

Belongs to the FBXL7 family.Curated
Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 11 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT22. Eukaryota.
ENOG410YA1Y. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000116328.
HOVERGENiHBG051591.
InParanoidiQ9UJT9.
KOiK10273.
OMAiLMLETVI.
OrthoDBiEOG091G06QE.
PhylomeDBiQ9UJT9.
TreeFamiTF313434.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 5 hits.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 11 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UJT9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGANNGKQYG SEGKGSSSIS SDVSSSTDHT PTKAQKNVAT SEDSDLSMRT
60 70 80 90 100
LSTPSPALIC PPNLPGFQNG RGSSTSSSSI TGETVAMVHS PPPTRLTHPL
110 120 130 140 150
IRLASRPQKE QASIDRLPDH SMVQIFSFLP TNQLCRCARV CRRWYNLAWD
160 170 180 190 200
PRLWRTIRLT GETINVDRAL KVLTRRLCQD TPNVCLMLET VTVSGCRRLT
210 220 230 240 250
DRGLYTIAQC CPELRRLEVS GCYNISNEAV FDVVSLCPNL EHLDVSGCSK
260 270 280 290 300
VTCISLTREA SIKLSPLHGK QISIRYLDMT DCFVLEDEGL HTIAAHCTQL
310 320 330 340 350
THLYLRRCVR LTDEGLRYLV IYCASIKELS VSDCRFVSDF GLREIAKLES
360 370 380 390 400
RLRYLSIAHC GRVTDVGIRY VAKYCSKLRY LNARGCEGIT DHGVEYLAKN
410 420 430 440 450
CTKLKSLDIG KCPLVSDTGL ECLALNCFNL KRLSLKSCES ITGQGLQIVA
460 470 480 490
ANCFDLQTLN VQDCEVSVEA LRFVKRHCKR CVIEHTNPAF F
Length:491
Mass (Da):54,575
Last modified:May 1, 2000 - v1
Checksum:iA70C092A4E748C69
GO
Isoform 2 (identifier: Q9UJT9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Note: No experimental confirmation available.
Show »
Length:444
Mass (Da):49,844
Checksum:iE815536979F050AB
GO

Sequence cautioni

The sequence BAA74863 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0547511 – 47Missing in isoform 2. CuratedAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199356 mRNA. Translation: AAF09248.1.
AB020647 mRNA. Translation: BAA74863.2. Different initiation.
AC091970 Genomic DNA. No translation available.
AC091872 Genomic DNA. No translation available.
AC027332 Genomic DNA. No translation available.
AC010638 Genomic DNA. No translation available.
AC010477 Genomic DNA. No translation available.
CH471102 Genomic DNA. Translation: EAX08029.1.
BC075061 mRNA. Translation: AAH75061.1.
BC136424 mRNA. Translation: AAI36425.1.
AF174593 mRNA. Translation: AAF04514.1.
CCDSiCCDS54833.1. [Q9UJT9-1]
CCDS64129.1. [Q9UJT9-2]
RefSeqiNP_001265246.1. NM_001278317.1. [Q9UJT9-2]
NP_036436.1. NM_012304.4. [Q9UJT9-1]
XP_011512300.1. XM_011513998.1. [Q9UJT9-2]
UniGeneiHs.433057.

Genome annotation databases

EnsembliENST00000504595; ENSP00000423630; ENSG00000183580. [Q9UJT9-1]
ENST00000510662; ENSP00000425184; ENSG00000183580. [Q9UJT9-2]
GeneIDi23194.
KEGGihsa:23194.
UCSCiuc003jfn.3. human. [Q9UJT9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199356 mRNA. Translation: AAF09248.1.
AB020647 mRNA. Translation: BAA74863.2. Different initiation.
AC091970 Genomic DNA. No translation available.
AC091872 Genomic DNA. No translation available.
AC027332 Genomic DNA. No translation available.
AC010638 Genomic DNA. No translation available.
AC010477 Genomic DNA. No translation available.
CH471102 Genomic DNA. Translation: EAX08029.1.
BC075061 mRNA. Translation: AAH75061.1.
BC136424 mRNA. Translation: AAI36425.1.
AF174593 mRNA. Translation: AAF04514.1.
CCDSiCCDS54833.1. [Q9UJT9-1]
CCDS64129.1. [Q9UJT9-2]
RefSeqiNP_001265246.1. NM_001278317.1. [Q9UJT9-2]
NP_036436.1. NM_012304.4. [Q9UJT9-1]
XP_011512300.1. XM_011513998.1. [Q9UJT9-2]
UniGeneiHs.433057.

3D structure databases

ProteinModelPortaliQ9UJT9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116803. 8 interactors.
IntActiQ9UJT9. 7 interactors.
STRINGi9606.ENSP00000423630.

PTM databases

iPTMnetiQ9UJT9.
PhosphoSitePlusiQ9UJT9.

Polymorphism and mutation databases

DMDMi37537858.

Proteomic databases

EPDiQ9UJT9.
PaxDbiQ9UJT9.
PeptideAtlasiQ9UJT9.
PRIDEiQ9UJT9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000504595; ENSP00000423630; ENSG00000183580. [Q9UJT9-1]
ENST00000510662; ENSP00000425184; ENSG00000183580. [Q9UJT9-2]
GeneIDi23194.
KEGGihsa:23194.
UCSCiuc003jfn.3. human. [Q9UJT9-1]

Organism-specific databases

CTDi23194.
DisGeNETi23194.
GeneCardsiFBXL7.
HGNCiHGNC:13604. FBXL7.
HPAiHPA055464.
MIMi605656. gene.
neXtProtiNX_Q9UJT9.
OpenTargetsiENSG00000183580.
PharmGKBiPA28027.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT22. Eukaryota.
ENOG410YA1Y. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000116328.
HOVERGENiHBG051591.
InParanoidiQ9UJT9.
KOiK10273.
OMAiLMLETVI.
OrthoDBiEOG091G06QE.
PhylomeDBiQ9UJT9.
TreeFamiTF313434.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-HSA-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiFBXL7. human.
GeneWikiiFBXL7.
GenomeRNAii23194.
PROiQ9UJT9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183580.
CleanExiHS_FBXL7.
ExpressionAtlasiQ9UJT9. baseline and differential.
GenevisibleiQ9UJT9. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 5 hits.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 11 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBXL7_HUMAN
AccessioniPrimary (citable) accession number: Q9UJT9
Secondary accession number(s): B9EGF1, D6RDY7, O94926
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.