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Protein

F-box/LRR-repeat protein 7

Gene

FBXL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 7
Alternative name(s):
F-box and leucine-rich repeat protein 7
F-box protein FBL6/FBL7
Gene namesi
Name:FBXL7
Synonyms:FBL6, FBL7, KIAA0840
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:13604. FBXL7.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB-KW
  • SCF ubiquitin ligase complex Source: UniProtKB
  • ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28027.

Polymorphism and mutation databases

DMDMi37537858.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491F-box/LRR-repeat protein 7PRO_0000119849Add
BLAST

Proteomic databases

MaxQBiQ9UJT9.
PaxDbiQ9UJT9.
PRIDEiQ9UJT9.

PTM databases

iPTMnetiQ9UJT9.
PhosphoSiteiQ9UJT9.

Expressioni

Gene expression databases

BgeeiQ9UJT9.
CleanExiHS_FBXL7.
ExpressionAtlasiQ9UJT9. baseline and differential.
GenevisibleiQ9UJT9. HS.

Organism-specific databases

HPAiHPA055464.

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) composed of CUL1, SKP1, RBX1 and FBXL7. Interacts with AURKA; interaction takes place during mitosis but not in interphase (By similarity).By similarity

Protein-protein interaction databases

BioGridi116803. 5 interactions.
IntActiQ9UJT9. 5 interactions.
STRINGi9606.ENSP00000423630.

Structurei

3D structure databases

ProteinModelPortaliQ9UJT9.
SMRiQ9UJT9. Positions 113-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 15747F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati170 – 19526LRR 1Add
BLAST
Repeati196 – 22126LRR 2Add
BLAST
Repeati222 – 24726LRR 3Add
BLAST
Repeati253 – 28129LRR 4Add
BLAST
Repeati282 – 30726LRR 5Add
BLAST
Repeati308 – 33326LRR 6Add
BLAST
Repeati334 – 35926LRR 7Add
BLAST
Repeati360 – 38526LRR 8Add
BLAST
Repeati386 – 41126LRR 9Add
BLAST
Repeati412 – 43726LRR 10Add
BLAST
Repeati438 – 46326LRR 11Add
BLAST

Sequence similaritiesi

Belongs to the FBXL7 family.Curated
Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 11 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT22. Eukaryota.
ENOG410YA1Y. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000116328.
HOVERGENiHBG051591.
InParanoidiQ9UJT9.
KOiK10273.
OMAiLMLETVI.
OrthoDBiEOG75MVWQ.
PhylomeDBiQ9UJT9.
TreeFamiTF313434.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 5 hits.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 11 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UJT9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGANNGKQYG SEGKGSSSIS SDVSSSTDHT PTKAQKNVAT SEDSDLSMRT
60 70 80 90 100
LSTPSPALIC PPNLPGFQNG RGSSTSSSSI TGETVAMVHS PPPTRLTHPL
110 120 130 140 150
IRLASRPQKE QASIDRLPDH SMVQIFSFLP TNQLCRCARV CRRWYNLAWD
160 170 180 190 200
PRLWRTIRLT GETINVDRAL KVLTRRLCQD TPNVCLMLET VTVSGCRRLT
210 220 230 240 250
DRGLYTIAQC CPELRRLEVS GCYNISNEAV FDVVSLCPNL EHLDVSGCSK
260 270 280 290 300
VTCISLTREA SIKLSPLHGK QISIRYLDMT DCFVLEDEGL HTIAAHCTQL
310 320 330 340 350
THLYLRRCVR LTDEGLRYLV IYCASIKELS VSDCRFVSDF GLREIAKLES
360 370 380 390 400
RLRYLSIAHC GRVTDVGIRY VAKYCSKLRY LNARGCEGIT DHGVEYLAKN
410 420 430 440 450
CTKLKSLDIG KCPLVSDTGL ECLALNCFNL KRLSLKSCES ITGQGLQIVA
460 470 480 490
ANCFDLQTLN VQDCEVSVEA LRFVKRHCKR CVIEHTNPAF F
Length:491
Mass (Da):54,575
Last modified:May 1, 2000 - v1
Checksum:iA70C092A4E748C69
GO
Isoform 2 (identifier: Q9UJT9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Note: No experimental confirmation available.
Show »
Length:444
Mass (Da):49,844
Checksum:iE815536979F050AB
GO

Sequence cautioni

The sequence BAA74863.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4747Missing in isoform 2. CuratedVSP_054751Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199356 mRNA. Translation: AAF09248.1.
AB020647 mRNA. Translation: BAA74863.2. Different initiation.
AC091970 Genomic DNA. No translation available.
AC091872 Genomic DNA. No translation available.
AC027332 Genomic DNA. No translation available.
AC010638 Genomic DNA. No translation available.
AC010477 Genomic DNA. No translation available.
CH471102 Genomic DNA. Translation: EAX08029.1.
BC075061 mRNA. Translation: AAH75061.1.
BC136424 mRNA. Translation: AAI36425.1.
AF174593 mRNA. Translation: AAF04514.1.
CCDSiCCDS54833.1. [Q9UJT9-1]
CCDS64129.1. [Q9UJT9-2]
RefSeqiNP_001265246.1. NM_001278317.1. [Q9UJT9-2]
NP_036436.1. NM_012304.4. [Q9UJT9-1]
XP_011512300.1. XM_011513998.1. [Q9UJT9-2]
UniGeneiHs.433057.

Genome annotation databases

EnsembliENST00000504595; ENSP00000423630; ENSG00000183580. [Q9UJT9-1]
ENST00000510662; ENSP00000425184; ENSG00000183580. [Q9UJT9-2]
GeneIDi23194.
KEGGihsa:23194.
UCSCiuc003jfn.3. human. [Q9UJT9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199356 mRNA. Translation: AAF09248.1.
AB020647 mRNA. Translation: BAA74863.2. Different initiation.
AC091970 Genomic DNA. No translation available.
AC091872 Genomic DNA. No translation available.
AC027332 Genomic DNA. No translation available.
AC010638 Genomic DNA. No translation available.
AC010477 Genomic DNA. No translation available.
CH471102 Genomic DNA. Translation: EAX08029.1.
BC075061 mRNA. Translation: AAH75061.1.
BC136424 mRNA. Translation: AAI36425.1.
AF174593 mRNA. Translation: AAF04514.1.
CCDSiCCDS54833.1. [Q9UJT9-1]
CCDS64129.1. [Q9UJT9-2]
RefSeqiNP_001265246.1. NM_001278317.1. [Q9UJT9-2]
NP_036436.1. NM_012304.4. [Q9UJT9-1]
XP_011512300.1. XM_011513998.1. [Q9UJT9-2]
UniGeneiHs.433057.

3D structure databases

ProteinModelPortaliQ9UJT9.
SMRiQ9UJT9. Positions 113-446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116803. 5 interactions.
IntActiQ9UJT9. 5 interactions.
STRINGi9606.ENSP00000423630.

PTM databases

iPTMnetiQ9UJT9.
PhosphoSiteiQ9UJT9.

Polymorphism and mutation databases

DMDMi37537858.

Proteomic databases

MaxQBiQ9UJT9.
PaxDbiQ9UJT9.
PRIDEiQ9UJT9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000504595; ENSP00000423630; ENSG00000183580. [Q9UJT9-1]
ENST00000510662; ENSP00000425184; ENSG00000183580. [Q9UJT9-2]
GeneIDi23194.
KEGGihsa:23194.
UCSCiuc003jfn.3. human. [Q9UJT9-1]

Organism-specific databases

CTDi23194.
GeneCardsiFBXL7.
HGNCiHGNC:13604. FBXL7.
HPAiHPA055464.
MIMi605656. gene.
neXtProtiNX_Q9UJT9.
PharmGKBiPA28027.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT22. Eukaryota.
ENOG410YA1Y. LUCA.
GeneTreeiENSGT00760000119059.
HOGENOMiHOG000116328.
HOVERGENiHBG051591.
InParanoidiQ9UJT9.
KOiK10273.
OMAiLMLETVI.
OrthoDBiEOG75MVWQ.
PhylomeDBiQ9UJT9.
TreeFamiTF313434.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiFBXL7. human.
GeneWikiiFBXL7.
GenomeRNAii23194.
PROiQ9UJT9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UJT9.
CleanExiHS_FBXL7.
ExpressionAtlasiQ9UJT9. baseline and differential.
GenevisibleiQ9UJT9. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF13516. LRR_6. 5 hits.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
SM00367. LRR_CC. 11 hits.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and expression analysis of new members of the mammalian F-box protein family."
    Ilyin G.P., Rialland M., Pigeon C., Guguen-Guillouzo C.
    Genomics 67:40-47(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Testis.
  7. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 41-483 (ISOFORM 1).

Entry informationi

Entry nameiFBXL7_HUMAN
AccessioniPrimary (citable) accession number: Q9UJT9
Secondary accession number(s): B9EGF1, D6RDY7, O94926
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.