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Protein

Testis-specific serine kinase substrate

Gene

TSKS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

GO - Biological processi

  • negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126467-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific serine kinase substrate
Short name:
Testis-specific kinase substrate
Alternative name(s):
STK22 substrate 1
Gene namesi
Name:TSKS
Synonyms:STK22S1, TSKS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30719. TSKS.

Subcellular locationi

GO - Cellular componenti

  • acrosomal vesicle Source: GO_Central
  • centriole Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000126467.
PharmGKBiPA164727339.

Polymorphism and mutation databases

BioMutaiTSKS.
DMDMi44888550.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000656651 – 592Testis-specific serine kinase substrateAdd BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei217PhosphoserineBy similarity1
Modified residuei288Phosphoserine; by TSSK1 and TSSK2By similarity1
Modified residuei316PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on serine residue(s) by STK22A/TSSK1 and STK22B/TSSK2.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UJT2.
PaxDbiQ9UJT2.
PeptideAtlasiQ9UJT2.
PRIDEiQ9UJT2.

PTM databases

iPTMnetiQ9UJT2.
PhosphoSitePlusiQ9UJT2.

Expressioni

Tissue specificityi

Highly expressed in testis. Expressed at low levels in prostate, female breast, placenta, ovary and thymus.2 Publications

Gene expression databases

BgeeiENSG00000126467.
ExpressionAtlasiQ9UJT2. baseline and differential.
GenevisibleiQ9UJT2. HS.

Organism-specific databases

HPAiHPA045729.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TSSK2Q96PF25EBI-852101,EBI-852089

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121902. 26 interactors.
IntActiQ9UJT2. 7 interactors.
MINTiMINT-7241476.
STRINGi9606.ENSP00000246801.

Structurei

3D structure databases

ProteinModelPortaliQ9UJT2.
SMRiQ9UJT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IEF7. Eukaryota.
ENOG410YKYG. LUCA.
GeneTreeiENSGT00390000002611.
HOGENOMiHOG000121770.
HOVERGENiHBG050300.
InParanoidiQ9UJT2.
KOiK16492.
OMAiKTIWQSK.
OrthoDBiEOG091G074P.
PhylomeDBiQ9UJT2.
TreeFamiTF337594.

Family and domain databases

InterProiIPR028214. TSKS.
[Graphical view]
PfamiPF15358. TSKS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UJT2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASVVVKTIW QSKEIHEAGD TPTGVESCSQ LVPEAPRRVT SRAKGIPKKK
60 70 80 90 100
KAVSFHGVEP QMSHQPMHWC LNLKRSSACT NVSLLNLAAM EPTDSTGTDS
110 120 130 140 150
TVEDLSGQLT LAGPPASPTL PWDPDDADIT EILSGVNSGL VRAKDSITSL
160 170 180 190 200
KEKTNRVNQH VQSLQSECSV LSENLERRRQ EAEELEGYCI QLKENCWKVT
210 220 230 240 250
RSVEDAEIKT NVLKQNSALL EEKLRYLQQQ LQDETPRRQE AELQEPEEKQ
260 270 280 290 300
EPEEKQEPEE KQKPEAGLSW NSLGPAATSQ GCPGPPGSPD KPSRPHGLVP
310 320 330 340 350
AGWGMGPRAG EGPYVSEQEL QKLFTGIEEL RREVSSLTAR WHQEEGAVQE
360 370 380 390 400
ALRLLGGLGG RVDGFLGQWE RAQREQAQTA RDLQELRGRA DELCTMVERS
410 420 430 440 450
AVSVASLRSE LEGLGPLKPI LEEFGRQFQN SRRGPDLSMN LDRSHQGNCA
460 470 480 490 500
RCASQGSQLS TESLQQLLDR ALTSLVDEVK QRGLTPACPS CQRLHKKILE
510 520 530 540 550
LERQALAKHV RAEALSSTLR LAQDEALRAK NLLLTDKMKP EEKMATLDHL
560 570 580 590
HLKMCSLHDH LSNLPLEGST GTMGGGSSAG TPPKQGGSAP EQ
Length:592
Mass (Da):65,050
Last modified:March 1, 2001 - v3
Checksum:i87B262601EECE121
GO
Isoform 2 (identifier: Q9UJT2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-200: Missing.
     201-221: RSVEDAEIKTNVLKQNSALLE → MGDSCPAVTFRSQKENRAGLQ
     254-259: Missing.

Show »
Length:386
Mass (Da):42,359
Checksum:i173256D6886BF931
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti272S → G in AAL60464 (PubMed:15044604).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03627219G → R in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs149529240dbSNPEnsembl.1
Natural variantiVAR_051459167E → K.Corresponds to variant rs34701020dbSNPEnsembl.1
Natural variantiVAR_051460382D → G.1 PublicationCorresponds to variant rs2304202dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0095911 – 200Missing in isoform 2. CuratedAdd BLAST200
Alternative sequenceiVSP_009592201 – 221RSVED…SALLE → MGDSCPAVTFRSQKENRAGL Q in isoform 2. CuratedAdd BLAST21
Alternative sequenceiVSP_009593254 – 259Missing in isoform 2. Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200923 Genomic DNA. Translation: AAF12819.3.
AF411384 mRNA. Translation: AAL60464.1.
BC058862 mRNA. Translation: AAH58862.1.
CCDSiCCDS12780.1. [Q9UJT2-1]
PIRiJC7709.
RefSeqiNP_068379.1. NM_021733.1. [Q9UJT2-1]
UniGeneiHs.515858.

Genome annotation databases

EnsembliENST00000246801; ENSP00000246801; ENSG00000126467. [Q9UJT2-1]
GeneIDi60385.
KEGGihsa:60385.
UCSCiuc002ppm.4. human. [Q9UJT2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200923 Genomic DNA. Translation: AAF12819.3.
AF411384 mRNA. Translation: AAL60464.1.
BC058862 mRNA. Translation: AAH58862.1.
CCDSiCCDS12780.1. [Q9UJT2-1]
PIRiJC7709.
RefSeqiNP_068379.1. NM_021733.1. [Q9UJT2-1]
UniGeneiHs.515858.

3D structure databases

ProteinModelPortaliQ9UJT2.
SMRiQ9UJT2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121902. 26 interactors.
IntActiQ9UJT2. 7 interactors.
MINTiMINT-7241476.
STRINGi9606.ENSP00000246801.

PTM databases

iPTMnetiQ9UJT2.
PhosphoSitePlusiQ9UJT2.

Polymorphism and mutation databases

BioMutaiTSKS.
DMDMi44888550.

Proteomic databases

EPDiQ9UJT2.
PaxDbiQ9UJT2.
PeptideAtlasiQ9UJT2.
PRIDEiQ9UJT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246801; ENSP00000246801; ENSG00000126467. [Q9UJT2-1]
GeneIDi60385.
KEGGihsa:60385.
UCSCiuc002ppm.4. human. [Q9UJT2-1]

Organism-specific databases

CTDi60385.
GeneCardsiTSKS.
H-InvDBHIX0040005.
HIX0174448.
HGNCiHGNC:30719. TSKS.
HPAiHPA045729.
MIMi608253. gene.
neXtProtiNX_Q9UJT2.
OpenTargetsiENSG00000126467.
PharmGKBiPA164727339.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEF7. Eukaryota.
ENOG410YKYG. LUCA.
GeneTreeiENSGT00390000002611.
HOGENOMiHOG000121770.
HOVERGENiHBG050300.
InParanoidiQ9UJT2.
KOiK16492.
OMAiKTIWQSK.
OrthoDBiEOG091G074P.
PhylomeDBiQ9UJT2.
TreeFamiTF337594.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126467-MONOMER.

Miscellaneous databases

GenomeRNAii60385.
PROiQ9UJT2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126467.
ExpressionAtlasiQ9UJT2. baseline and differential.
GenevisibleiQ9UJT2. HS.

Family and domain databases

InterProiIPR028214. TSKS.
[Graphical view]
PfamiPF15358. TSKS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSKS_HUMAN
AccessioniPrimary (citable) accession number: Q9UJT2
Secondary accession number(s): Q8WXJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.