Q9UJT1 (TBD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tubulin delta chain

Alternative name(s):
Delta-tubulin

Gene names

Name:	TUBD1
Synonyms:	TUBD

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head By similarity.
Subcellular location	Cytoplasm › cytoskeleton › centrosome › centriole. Cytoplasm. Nucleus. Note: Associated with centrioles. Both cytoplasmic and nuclear.
Sequence similarities	Belongs to the tubulin family.

Ontologies

Keywords
Biological process	Differentiation Spermatogenesis
Cellular component	Cytoplasm Cytoskeleton Microtubule Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	GTP-binding Nucleotide-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW microtubule-based process Inferred from electronic annotation. Source: InterPro multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW protein polymerization Inferred from electronic annotation. Source: InterPro spermatogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Golgi apparatus Inferred from direct assay. Source: HPA centriole Traceable author statement Ref.1. Source: ProtInc microtubule Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from direct assay. Source: HPA
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro structural constituent of cytoskeleton Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q9UJT1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UJT1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     257-311: Missing.

Isoform 3 (identifier: Q9UJT1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     58-311: Missing.

Isoform 4 (identifier: Q9UJT1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 453	453	Tubulin delta chain		PRO_0000048484
Regions
	Nucleotide binding	143 – 149	7	GTP Potential
Natural variations
	Alternative sequence	1 – 216	216	Missing in isoform 4.		VSP_045196
	Alternative sequence	58 – 311	254	Missing in isoform 3.		VSP_006680
	Alternative sequence	257 – 311	55	Missing in isoform 2.		VSP_006681
	Natural variant	76	1	M → T. Ref.1 Ref.2 Corresponds to variant rs1292053 [ dbSNP | Ensembl ].		VAR_030000
Experimental info
	Sequence conflict	398	1	N → D in BAB14825. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 2D78AB3D9EEB9158	FASTA	453	51,034
	10 20 30 40 50 60 MSIVTVQLGQ CGNQIGFEVF DALLSDSHSS QGLCSMRENE AYQASCKERF FSEEENGVPI 70 80 90 100 110 120 ARAVLVDMEP KVINQMLSKA AQSGQWKYGQ HACFCQKQGS GNNWAYGYSV HGPRHEESIM 130 140 150 160 170 180 NIIRKEVEKC DSFSGFFIIM SMAGGTGSGL GAFVTQNLED QYSNSLKMNQ IIWPYGTGEV 190 200 210 220 230 240 IVQNYNSILT LSHLYRSSDA LLLHENDAIH KICAKLMNIK QISFSDINQV LAHQLGSVFQ 250 260 270 280 290 300 PTYSAESSFH YRRNPLGDLM EHLVPHPEFK MLSVRNIPHM SENSLAYTTF TWAGLLKHLR 310 320 330 340 350 360 QMLISNAKME EGIDRHVWPP LSGLPPLSKM SLNKDLHFNT SIANLVILRG KDVQSADVEG 370 380 390 400 410 420 FKDPALYTSW LKPVNAFNVW KTQRAFSKYE KSAVLVSNSQ FLVKPLDMIV GKAWNMFASK 430 440 450 AYIHQYTKFG IEEEDFLDSF TSLEQVVASY CNL
	Isoform 2 [UniParc]. Checksum: BEE6B7C9F36B5541	FASTA	398	44,658
	10 20 30 40 50 60 MSIVTVQLGQ CGNQIGFEVF DALLSDSHSS QGLCSMRENE AYQASCKERF FSEEENGVPI 70 80 90 100 110 120 ARAVLVDMEP KVINQMLSKA AQSGQWKYGQ HACFCQKQGS GNNWAYGYSV HGPRHEESIM 130 140 150 160 170 180 NIIRKEVEKC DSFSGFFIIM SMAGGTGSGL GAFVTQNLED QYSNSLKMNQ IIWPYGTGEV 190 200 210 220 230 240 IVQNYNSILT LSHLYRSSDA LLLHENDAIH KICAKLMNIK QISFSDINQV LAHQLGSVFQ 250 260 270 280 290 300 PTYSAESSFH YRRNPLGIDR HVWPPLSGLP PLSKMSLNKD LHFNTSIANL VILRGKDVQS 310 320 330 340 350 360 ADVEGFKDPA LYTSWLKPVN AFNVWKTQRA FSKYEKSAVL VSNSQFLVKP LDMIVGKAWN 370 380 390 MFASKAYIHQ YTKFGIEEED FLDSFTSLEQ VVASYCNL
	Isoform 3 [UniParc]. Checksum: ECCC2578542A1114	FASTA	199	22,381
	10 20 30 40 50 60 MSIVTVQLGQ CGNQIGFEVF DALLSDSHSS QGLCSMRENE AYQASCKERF FSEEENGGID 70 80 90 100 110 120 RHVWPPLSGL PPLSKMSLNK DLHFNTSIAN LVILRGKDVQ SADVEGFKDP ALYTSWLKPV 130 140 150 160 170 180 NAFNVWKTQR AFSKYEKSAV LVSNSQFLVK PLDMIVGKAW NMFASKAYIH QYTKFGIEEE 190 DFLDSFTSLE QVVASYCNL
	Isoform 4 [UniParc]. Checksum: D16AE1CDD4E5E1C4	FASTA	237	27,074
	10 20 30 40 50 60 MNIKQISFSD INQVLAHQLG SVFQPTYSAE SSFHYRRNPL GDLMEHLVPH PEFKMLSVRN 70 80 90 100 110 120 IPHMSENSLA YTTFTWAGLL KHLRQMLISN AKMEEGIDRH VWPPLSGLPP LSKMSLNKDL 130 140 150 160 170 180 HFNTSIANLV ILRGKDVQSA DVEGFKDPAL YTSWLKPVNA FNVWKTQRAF SKYEKSAVLV 190 200 210 220 230 SNSQFLVKPL DMIVGKAWNM FASKAYIHQY TKFGIEEEDF LDSFTSLEQV VASYCNL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function." Chang P., Stearns T. Nat. Cell Biol. 2:30-35(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-76.
[2]	"Delta-tubulin is a component of intercellular bridges and both the early and mature perinuclear rings during spermatogenesis." Kato A., Nagata Y., Todokoro K. Dev. Biol. 269:196-205(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-76.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4). Tissue: Embryo and Stomach.
[4]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF201333 mRNA. Translation: AAF09584.1. AB030837 mRNA. Translation: BAD16590.1. AK024096 mRNA. Translation: BAB14825.1. AK301312 mRNA. Translation: BAG62863.1. AC004686 Genomic DNA. No translation available. CH471109 Genomic DNA. Translation: EAW94385.1. CH471109 Genomic DNA. Translation: EAW94387.1. BC000258 mRNA. Translation: AAH00258.1.
IPI	IPI00007120. IPI00217181. IPI00332938. IPI00979886.
RefSeq	NP_001180538.1. NM_001193609.1. NP_001180539.1. NM_001193610.1. NP_001180540.1. NM_001193611.1. NP_001180541.1. NM_001193612.1. NP_001180542.1. NM_001193613.1. NP_057345.2. NM_016261.3.
UniGene	Hs.463638.
3D structure databases
ProteinModelPortal	Q9UJT1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000320797.
PTM databases
PhosphoSite	Q9UJT1.
Polymorphism databases
DMDM	124056483.
Proteomic databases
PaxDb	Q9UJT1.
PRIDE	Q9UJT1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000325752; ENSP00000320797; ENSG00000108423. ENST00000340993; ENSP00000342399; ENSG00000108423. ENST00000346141; ENSP00000342561; ENSG00000108423. ENST00000539018; ENSP00000441757; ENSG00000108423. ENST00000592426; ENSP00000468518; ENSG00000108423.
GeneID	51174.
KEGG	hsa:51174.
UCSC	uc002ixw.2. human. uc002ixx.2. human. uc010ddi.2. human.
Organism-specific databases
CTD	51174.
GeneCards	GC17M057936.
HGNC	HGNC:16811. TUBD1.
HPA	CAB004609. HPA023980. HPA027090.
MIM	607344. gene.
neXtProt	NX_Q9UJT1.
PharmGKB	PA134909953.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5023.
HOGENOM	HOG000006615.
HOVERGEN	HBG000807.
InParanoid	Q9UJT1.
KO	K10390.
OMA	GSFHYRR.
OrthoDB	EOG4229K3.
PhylomeDB	Q9UJT1.
Gene expression databases
ArrayExpress	Q9UJT1.
Bgee	Q9UJT1.
CleanEx	HS_TUBD1.
Genevestigator	Q9UJT1.
GermOnline	ENSG00000108423. Homo sapiens.
Family and domain databases
Gene3D	1.10.287.600. 1 hit. 3.40.50.1440. 1 hit.
InterPro	IPR002967. Delta_tubulin. IPR008280. Tub_FtsZ_C. IPR000217. Tubulin. IPR023123. Tubulin_C. IPR017975. Tubulin_CS. IPR003008. Tubulin_FtsZ_GTPase. [Graphical view]
PANTHER	PTHR11588. PTHR11588. 1 hit. PTHR11588:SF4. PTHR11588:SF4. 1 hit.
Pfam	PF00091. Tubulin. 1 hit. [Graphical view]
PRINTS	PR01224. DELTATUBULIN. PR01161. TUBULIN.
SMART	SM00864. Tubulin. 1 hit. [Graphical view]
SUPFAM	SSF55307. Tub_FtsZ_C. 1 hit. SSF52490. Tubulin_FtsZ. 1 hit.
PROSITE	PS00227. TUBULIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TUBD1. human.
GenomeRNAi	51174.
NextBio	54125.
SOURCE	Search...

Entry information

Entry name

TBD_HUMAN

Accession

Primary (citable) accession number: Q9UJT1
Secondary accession number(s): B4DW01 , D3DU02, Q9BWG9, Q9H7Z8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 119 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.