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Q9UJT0

- TBE_HUMAN

UniProt

Q9UJT0 - TBE_HUMAN

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Protein

Tubulin epsilon chain

Gene

TUBE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi148 – 1547GTPSequence Analysis

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-KW
  3. structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

  1. centrosome cycle Source: ProtInc
  2. protein polymerization Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin epsilon chain
Alternative name(s):
Epsilon-tubulin
Gene namesi
Name:TUBE1
Synonyms:TUBE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:20775. TUBE1.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome
Note: Associated with pericentriolar material.

GO - Cellular componenti

  1. microtubule Source: UniProtKB-KW
  2. pericentriolar material Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134936770.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Tubulin epsilon chainPRO_0000048486Add
BLAST

Proteomic databases

MaxQBiQ9UJT0.
PaxDbiQ9UJT0.
PRIDEiQ9UJT0.

PTM databases

PhosphoSiteiQ9UJT0.

Expressioni

Gene expression databases

BgeeiQ9UJT0.
CleanExiHS_TUBE1.
ExpressionAtlasiQ9UJT0. baseline and differential.
GenevestigatoriQ9UJT0.

Organism-specific databases

HPAiHPA032073.
HPA032074.

Interactioni

Protein-protein interaction databases

BioGridi119353. 5 interactions.
STRINGi9606.ENSP00000357651.

Structurei

3D structure databases

ProteinModelPortaliQ9UJT0.
SMRiQ9UJT0. Positions 5-456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiCOG5023.
GeneTreeiENSGT00760000119061.
HOGENOMiHOG000165713.
HOVERGENiHBG098062.
InParanoidiQ9UJT0.
KOiK10391.
OMAiKKKAHLH.
PhylomeDBiQ9UJT0.
TreeFamiTF330882.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR004057. Epsilon_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PTHR11588:SF13. PTHR11588:SF13. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01519. EPSLNTUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 2 hits.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UJT0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQSVVVQVG QCGNQIGCCF WDLALREHAA VNQKGIYDEA ISSFFRNVDT
60 70 80 90 100
RVVGDGGSIS KGKICSLKAR AVLIDMEEGV VNEILQGPLR DVFDTKQLIT
110 120 130 140 150
DISGSGNNWA VGHKVFGSLY QDQILEKFRK SAEHCDCLQC FFIIHSMGGG
160 170 180 190 200
TGSGLGTFLL KVLEDEFPEV YRFVTSIYPS GEDDVITSPY NSILAMKELN
210 220 230 240 250
EHADCVLPID NQSLFDIISK IDLMVNSGKL GTTVKPKSLV TSSSGALKKQ
260 270 280 290 300
HKKPFDAMNN IVANLLLNLT SSARFEGSLN MDLNEISMNL VPFPQLHYLV
310 320 330 340 350
SSLTPLYTLT DVNIPPRRLD QMFSDAFSKD HQLLRADPKH SLYLACALMV
360 370 380 390 400
RGNVQISDLR RNIERLKPSL QFVSWNQEGW KTSLCSVPPV GHSHSLLALA
410 420 430 440 450
NNTCVKPTFM ELKERFMRLY KKKAHLHHYL QVEGMEESCF TEAVSSLSAL
460 470
IQEYDQLDAT KNMPVQDLPR LSIAM
Length:475
Mass (Da):52,932
Last modified:May 1, 2000 - v1
Checksum:i3E8E717CBA6AFC80
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911D → G in AAH31101. (PubMed:15489334)Curated
Sequence conflicti469 – 4691P → R in AAH31101. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201334 mRNA. Translation: AAF09585.1.
Z99289 Genomic DNA. Translation: CAI42327.1.
CH471051 Genomic DNA. Translation: EAW48272.1.
BC025405 mRNA. Translation: AAH25405.1.
BC031101 mRNA. Translation: AAH31101.1.
CCDSiCCDS5100.1.
RefSeqiNP_057346.1. NM_016262.4.
UniGeneiHs.34851.

Genome annotation databases

EnsembliENST00000368662; ENSP00000357651; ENSG00000074935.
GeneIDi51175.
KEGGihsa:51175.
UCSCiuc003pvq.3. human.

Polymorphism databases

DMDMi8928405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201334 mRNA. Translation: AAF09585.1 .
Z99289 Genomic DNA. Translation: CAI42327.1 .
CH471051 Genomic DNA. Translation: EAW48272.1 .
BC025405 mRNA. Translation: AAH25405.1 .
BC031101 mRNA. Translation: AAH31101.1 .
CCDSi CCDS5100.1.
RefSeqi NP_057346.1. NM_016262.4.
UniGenei Hs.34851.

3D structure databases

ProteinModelPortali Q9UJT0.
SMRi Q9UJT0. Positions 5-456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119353. 5 interactions.
STRINGi 9606.ENSP00000357651.

Chemistry

DrugBanki DB00570. Vinblastine.

PTM databases

PhosphoSitei Q9UJT0.

Polymorphism databases

DMDMi 8928405.

Proteomic databases

MaxQBi Q9UJT0.
PaxDbi Q9UJT0.
PRIDEi Q9UJT0.

Protocols and materials databases

DNASUi 51175.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368662 ; ENSP00000357651 ; ENSG00000074935 .
GeneIDi 51175.
KEGGi hsa:51175.
UCSCi uc003pvq.3. human.

Organism-specific databases

CTDi 51175.
GeneCardsi GC06M112391.
HGNCi HGNC:20775. TUBE1.
HPAi HPA032073.
HPA032074.
MIMi 607345. gene.
neXtProti NX_Q9UJT0.
PharmGKBi PA134936770.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5023.
GeneTreei ENSGT00760000119061.
HOGENOMi HOG000165713.
HOVERGENi HBG098062.
InParanoidi Q9UJT0.
KOi K10391.
OMAi KKKAHLH.
PhylomeDBi Q9UJT0.
TreeFami TF330882.

Miscellaneous databases

GeneWikii TUBE1.
GenomeRNAii 51175.
NextBioi 54129.
PROi Q9UJT0.
SOURCEi Search...

Gene expression databases

Bgeei Q9UJT0.
CleanExi HS_TUBE1.
ExpressionAtlasi Q9UJT0. baseline and differential.
Genevestigatori Q9UJT0.

Family and domain databases

Gene3Di 1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProi IPR004057. Epsilon_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view ]
PANTHERi PTHR11588. PTHR11588. 1 hit.
PTHR11588:SF13. PTHR11588:SF13. 1 hit.
Pfami PF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view ]
PRINTSi PR01519. EPSLNTUBULIN.
PR01161. TUBULIN.
SMARTi SM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52490. SSF52490. 2 hits.
SSF55307. SSF55307. 1 hit.
PROSITEi PS00227. TUBULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function."
    Chang P., Stearns T.
    Nat. Cell Biol. 2:30-35(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiTBE_HUMAN
AccessioniPrimary (citable) accession number: Q9UJT0
Secondary accession number(s): Q5H8W8, Q8NEG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3