SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9UJT0

- TBE_HUMAN

UniProt

Q9UJT0 - TBE_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Tubulin epsilon chain
Gene
TUBE1, TUBE
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi148 – 1547GTP Reviewed prediction

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: InterPro
  3. structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

  1. centrosome cycle Source: ProtInc
  2. protein polymerization Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin epsilon chain
Alternative name(s):
Epsilon-tubulin
Gene namesi
Name:TUBE1
Synonyms:TUBE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:20775. TUBE1.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome
Note: Associated with pericentriolar material.

GO - Cellular componenti

  1. microtubule Source: UniProtKB-KW
  2. pericentriolar material Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134936770.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Tubulin epsilon chain
PRO_0000048486Add
BLAST

Proteomic databases

MaxQBiQ9UJT0.
PaxDbiQ9UJT0.
PRIDEiQ9UJT0.

PTM databases

PhosphoSiteiQ9UJT0.

Expressioni

Gene expression databases

BgeeiQ9UJT0.
CleanExiHS_TUBE1.
GenevestigatoriQ9UJT0.

Organism-specific databases

HPAiHPA032073.
HPA032074.

Interactioni

Protein-protein interaction databases

BioGridi119353. 4 interactions.
STRINGi9606.ENSP00000357651.

Structurei

3D structure databases

ProteinModelPortaliQ9UJT0.
SMRiQ9UJT0. Positions 5-456.

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.

Phylogenomic databases

eggNOGiCOG5023.
HOGENOMiHOG000165713.
HOVERGENiHBG098062.
InParanoidiQ9UJT0.
KOiK10391.
OMAiKKKAHLH.
PhylomeDBiQ9UJT0.
TreeFamiTF330882.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR004057. Epsilon_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PTHR11588:SF13. PTHR11588:SF13. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01519. EPSLNTUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 2 hits.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UJT0-1 [UniParc]FASTAAdd to Basket

« Hide

MTQSVVVQVG QCGNQIGCCF WDLALREHAA VNQKGIYDEA ISSFFRNVDT    50
RVVGDGGSIS KGKICSLKAR AVLIDMEEGV VNEILQGPLR DVFDTKQLIT 100
DISGSGNNWA VGHKVFGSLY QDQILEKFRK SAEHCDCLQC FFIIHSMGGG 150
TGSGLGTFLL KVLEDEFPEV YRFVTSIYPS GEDDVITSPY NSILAMKELN 200
EHADCVLPID NQSLFDIISK IDLMVNSGKL GTTVKPKSLV TSSSGALKKQ 250
HKKPFDAMNN IVANLLLNLT SSARFEGSLN MDLNEISMNL VPFPQLHYLV 300
SSLTPLYTLT DVNIPPRRLD QMFSDAFSKD HQLLRADPKH SLYLACALMV 350
RGNVQISDLR RNIERLKPSL QFVSWNQEGW KTSLCSVPPV GHSHSLLALA 400
NNTCVKPTFM ELKERFMRLY KKKAHLHHYL QVEGMEESCF TEAVSSLSAL 450
IQEYDQLDAT KNMPVQDLPR LSIAM 475
Length:475
Mass (Da):52,932
Last modified:May 1, 2000 - v1
Checksum:i3E8E717CBA6AFC80
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911D → G in AAH31101. 1 Publication
Sequence conflicti469 – 4691P → R in AAH31101. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF201334 mRNA. Translation: AAF09585.1.
Z99289 Genomic DNA. Translation: CAI42327.1.
CH471051 Genomic DNA. Translation: EAW48272.1.
BC025405 mRNA. Translation: AAH25405.1.
BC031101 mRNA. Translation: AAH31101.1.
CCDSiCCDS5100.1.
RefSeqiNP_057346.1. NM_016262.4.
UniGeneiHs.34851.

Genome annotation databases

EnsembliENST00000368658; ENSP00000357647; ENSG00000264528.
ENST00000368662; ENSP00000357651; ENSG00000074935.
GeneIDi51175.
KEGGihsa:51175.
UCSCiuc003pvq.3. human.

Polymorphism databases

DMDMi8928405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF201334 mRNA. Translation: AAF09585.1 .
Z99289 Genomic DNA. Translation: CAI42327.1 .
CH471051 Genomic DNA. Translation: EAW48272.1 .
BC025405 mRNA. Translation: AAH25405.1 .
BC031101 mRNA. Translation: AAH31101.1 .
CCDSi CCDS5100.1.
RefSeqi NP_057346.1. NM_016262.4.
UniGenei Hs.34851.

3D structure databases

ProteinModelPortali Q9UJT0.
SMRi Q9UJT0. Positions 5-456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119353. 4 interactions.
STRINGi 9606.ENSP00000357651.

PTM databases

PhosphoSitei Q9UJT0.

Polymorphism databases

DMDMi 8928405.

Proteomic databases

MaxQBi Q9UJT0.
PaxDbi Q9UJT0.
PRIDEi Q9UJT0.

Protocols and materials databases

DNASUi 51175.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368658 ; ENSP00000357647 ; ENSG00000264528 .
ENST00000368662 ; ENSP00000357651 ; ENSG00000074935 .
GeneIDi 51175.
KEGGi hsa:51175.
UCSCi uc003pvq.3. human.

Organism-specific databases

CTDi 51175.
GeneCardsi GC06M112437.
HGNCi HGNC:20775. TUBE1.
HPAi HPA032073.
HPA032074.
MIMi 607345. gene.
neXtProti NX_Q9UJT0.
PharmGKBi PA134936770.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5023.
HOGENOMi HOG000165713.
HOVERGENi HBG098062.
InParanoidi Q9UJT0.
KOi K10391.
OMAi KKKAHLH.
PhylomeDBi Q9UJT0.
TreeFami TF330882.

Miscellaneous databases

GeneWikii TUBE1.
GenomeRNAii 51175.
NextBioi 54129.
PROi Q9UJT0.
SOURCEi Search...

Gene expression databases

Bgeei Q9UJT0.
CleanExi HS_TUBE1.
Genevestigatori Q9UJT0.

Family and domain databases

Gene3Di 1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProi IPR004057. Epsilon_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view ]
PANTHERi PTHR11588. PTHR11588. 1 hit.
PTHR11588:SF13. PTHR11588:SF13. 1 hit.
Pfami PF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view ]
PRINTSi PR01519. EPSLNTUBULIN.
PR01161. TUBULIN.
SMARTi SM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52490. SSF52490. 2 hits.
SSF55307. SSF55307. 1 hit.
PROSITEi PS00227. TUBULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function."
    Chang P., Stearns T.
    Nat. Cell Biol. 2:30-35(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiTBE_HUMAN
AccessioniPrimary (citable) accession number: Q9UJT0
Secondary accession number(s): Q5H8W8, Q8NEG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi