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Protein

Tubulin epsilon chain

Gene

TUBE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi148 – 154GTPSequence analysis7

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: UniProtKB-KW
  • structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

  • centrosome cycle Source: ProtInc

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin epsilon chain
Alternative name(s):
Epsilon-tubulin
Gene namesi
Name:TUBE1
Synonyms:TUBE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000074935.13
HGNCiHGNC:20775 TUBE1
MIMi607345 gene
neXtProtiNX_Q9UJT0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi51175
OpenTargetsiENSG00000074935
PharmGKBiPA134936770

Chemistry databases

DrugBankiDB00570 Vinblastine

Polymorphism and mutation databases

BioMutaiTUBE1
DMDMi8928405

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000484861 – 475Tubulin epsilon chainAdd BLAST475

Proteomic databases

EPDiQ9UJT0
MaxQBiQ9UJT0
PaxDbiQ9UJT0
PeptideAtlasiQ9UJT0
PRIDEiQ9UJT0
ProteomicsDBi84643

PTM databases

iPTMnetiQ9UJT0
PhosphoSitePlusiQ9UJT0

Expressioni

Gene expression databases

BgeeiENSG00000074935
CleanExiHS_TUBE1
ExpressionAtlasiQ9UJT0 baseline and differential
GenevisibleiQ9UJT0 HS

Organism-specific databases

HPAiHPA032073
HPA032074

Interactioni

Protein-protein interaction databases

BioGridi119353, 9 interactors
STRINGi9606.ENSP00000357651

Structurei

3D structure databases

ProteinModelPortaliQ9UJT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiKOG1375 Eukaryota
COG5023 LUCA
GeneTreeiENSGT00760000119061
HOGENOMiHOG000165713
HOVERGENiHBG098062
InParanoidiQ9UJT0
KOiK10391
OMAiKKKAHLH
OrthoDBiEOG091G06O0
PhylomeDBiQ9UJT0
TreeFamiTF330882

Family and domain databases

Gene3Di1.10.287.600, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR004057 Epsilon_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PTHR11588:SF13 PTHR11588:SF13, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01519 EPSLNTUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 2 hits
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UJT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQSVVVQVG QCGNQIGCCF WDLALREHAA VNQKGIYDEA ISSFFRNVDT
60 70 80 90 100
RVVGDGGSIS KGKICSLKAR AVLIDMEEGV VNEILQGPLR DVFDTKQLIT
110 120 130 140 150
DISGSGNNWA VGHKVFGSLY QDQILEKFRK SAEHCDCLQC FFIIHSMGGG
160 170 180 190 200
TGSGLGTFLL KVLEDEFPEV YRFVTSIYPS GEDDVITSPY NSILAMKELN
210 220 230 240 250
EHADCVLPID NQSLFDIISK IDLMVNSGKL GTTVKPKSLV TSSSGALKKQ
260 270 280 290 300
HKKPFDAMNN IVANLLLNLT SSARFEGSLN MDLNEISMNL VPFPQLHYLV
310 320 330 340 350
SSLTPLYTLT DVNIPPRRLD QMFSDAFSKD HQLLRADPKH SLYLACALMV
360 370 380 390 400
RGNVQISDLR RNIERLKPSL QFVSWNQEGW KTSLCSVPPV GHSHSLLALA
410 420 430 440 450
NNTCVKPTFM ELKERFMRLY KKKAHLHHYL QVEGMEESCF TEAVSSLSAL
460 470
IQEYDQLDAT KNMPVQDLPR LSIAM
Length:475
Mass (Da):52,932
Last modified:May 1, 2000 - v1
Checksum:i3E8E717CBA6AFC80
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91D → G in AAH31101 (PubMed:15489334).Curated1
Sequence conflicti469P → R in AAH31101 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201334 mRNA Translation: AAF09585.1
Z99289 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48272.1
BC025405 mRNA Translation: AAH25405.1
BC031101 mRNA Translation: AAH31101.1
CCDSiCCDS5100.1
RefSeqiNP_057346.1, NM_016262.4
UniGeneiHs.34851

Genome annotation databases

EnsembliENST00000368662; ENSP00000357651; ENSG00000074935
GeneIDi51175
KEGGihsa:51175
UCSCiuc003pvq.4 human

Similar proteinsi

Entry informationi

Entry nameiTBE_HUMAN
AccessioniPrimary (citable) accession number: Q9UJT0
Secondary accession number(s): Q5H8W8, Q8NEG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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