Reviewed, UniProtKB/Swiss-Prot Q9UJQ1 (CT103_HUMAN)

Names and origin

Protein names

Recommended name:
    LAMP family protein C20orf103

Gene names

Name:

C20orf103

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the LAMP family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UJQ1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UJQ1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     80-123: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 280	251	LAMP family protein C20orf103		PRO_0000021031
Regions
	Topological domain	30 – 235	206	Extracellular Potential
	Transmembrane	236 – 256	21	Potential
	Topological domain	257 – 280	24	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	35	1	N-linked (GlcNAc...) Potential
	Glycosylation	53	1	N-linked (GlcNAc...) Potential
	Glycosylation	127	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	80 – 123	44	Missing in isoform 2.		VSP_037186
	Natural variant	12	1	D → G: dbSNP rs2232259.		VAR_014401
	Natural variant	81	1	I → V: dbSNP rs2232263.		VAR_014402
	Natural variant	103	1	Q → E: dbSNP rs2232264.		VAR_014403
	Natural variant	158	1	S → G: dbSNP rs2232266.		VAR_014404
Experimental info
	Sequence conflict	251	1	V → A in BAG58309. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 7D811D7C04EE70B8	FASTA	280	31,472
	10 20 30 40 50 60 MDLQGRGVPS IDRLRVLLML FHTMAQIMAE QEVENLSGLS TNPEKDIFVV RENGTTCLMA 70 80 90 100 110 120 EFAAKFIVPY DVWASNYVDL ITEQADIALT RGAEVKGRCG HSQSELQVFW VDRAYALKML 130 140 150 160 170 180 FVKESHNMSK GPEATWRLSK VQFVYDSSEK THFKDAVSAG KHTANSHHLS ALVTPAGKSY 190 200 210 220 230 240 ECQAQQTISL ASSDPQKTVT MILSAVHIQP FDIISDFVFS EEHKCPVDER EQLEETLPLI 250 260 270 280 LGLILGLVIM VTLAIYHVHH KMTANQVQIP RDRSQYKHMG
	Isoform 2. Checksum: 4489CABA71A9D97E	FASTA	236	26,510
	10 20 30 40 50 60 MDLQGRGVPS IDRLRVLLML FHTMAQIMAE QEVENLSGLS TNPEKDIFVV RENGTTCLMA 70 80 90 100 110 120 EFAAKFIVPY DVWASNYVDE SHNMSKGPEA TWRLSKVQFV YDSSEKTHFK DAVSAGKHTA 130 140 150 160 170 180 NSHHLSALVT PAGKSYECQA QQTISLASSD PQKTVTMILS AVHIQPFDII SDFVFSEEHK 190 200 210 220 230 CPVDEREQLE ETLPLILGLI LGLVIMVTLA IYHVHHKMTA NQVQIPRDRS QYKHMG

References

[1]	Stavrides G.S., Huckle E.J., Deloukas P. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Caudate nucleus and Thalamus.
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL121740 mRNA. Translation: CAB57330.1. AK295336 mRNA. Translation: BAG58309.1. AK316114 mRNA. Translation: BAH14485.1. AL031652 Genomic DNA. Translation: CAC18101.1. BC050727 mRNA. Translation: AAH50727.1.
IPI	IPI00016848. IPI00929214.
RefSeq	NP_036393.1.
UniGene	Hs.22920
3D structure databases
ModBase	Search...
Proteomic databases
PeptideAtlas	Q9UJQ1.
PRIDE	Q9UJQ1.
Genome annotation databases
Ensembl	ENST00000246070; ENSP00000246070; ENSG00000125869; Homo sapiens. [Genome view]
GeneID	24141.
KEGG	hsa:24141.
UCSC	uc002wni.1. human.
Organism-specific databases
CTD	24141.
GeneCards	GC20P009443.
HGNC	HGNC:16097. C20orf103.
PharmGKB	PA25643.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG447205.
HOVERGEN	Q9UJQ1.
InParanoid	Q9UJQ1.
OMA	AEQEVEN.
OrthoDB	EOG94J54H.
Gene expression databases
ArrayExpress	Q9UJQ1.
Bgee	Q9UJQ1.
CleanEx	HS_C20orf103.
Genevestigator	Q9UJQ1.
GermOnline	ENSG00000125869. Homo sapiens.
Family and domain databases
InterPro	IPR002000. Lamp. [Graphical view]
PANTHER	PTHR11506. Lamp. 1 hit.
Pfam	PF01299. Lamp. 1 hit. [Graphical view]
PROSITE	PS00310. LAMP_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	46821.

Entry information

Entry name

CT103_HUMAN

Accession

Primary (citable) accession number: Q9UJQ1
Secondary accession number(s): B4DHZ7, B7Z9Z9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2002
Last sequence update:	May 1, 2000
Last modified:	December 15, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.