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Protein

Zinc finger protein 391

Gene

ZNF391

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri109 – 13123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri137 – 15923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri165 – 18723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri193 – 21523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri221 – 24323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri249 – 27123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri277 – 29923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 391
Gene namesi
Name:ZNF391
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:18779. ZNF391.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134868215.

Polymorphism and mutation databases

BioMutaiZNF391.
DMDMi156630643.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Zinc finger protein 391PRO_0000299034Add
BLAST

Proteomic databases

EPDiQ9UJN7.
MaxQBiQ9UJN7.
PaxDbiQ9UJN7.
PeptideAtlasiQ9UJN7.
PRIDEiQ9UJN7.

PTM databases

iPTMnetiQ9UJN7.
PhosphoSiteiQ9UJN7.

Expressioni

Gene expression databases

BgeeiENSG00000124613.
CleanExiHS_ZNF391.
ExpressionAtlasiQ9UJN7. baseline and differential.
GenevisibleiQ9UJN7. HS.

Organism-specific databases

HPAiHPA050886.

Interactioni

Protein-protein interaction databases

BioGridi131374. 5 interactions.
STRINGi9606.ENSP00000244576.

Structurei

3D structure databases

ProteinModelPortaliQ9UJN7.
SMRiQ9UJN7. Positions 65-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri109 – 13123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri137 – 15923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri165 – 18723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri193 – 21523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri221 – 24323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri249 – 27123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri277 – 29923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129762.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UJN7.
OMAiLEEIFMG.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9UJN7.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UJN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLRGNTAQ GPTNEEDYKN EGQLSRQTKC PAQKKSSFEN TVVRKVSVTL
60 70 80 90 100
KEIFTGEEGP ESSEFSLSPN LDAQQKIPKG HGSPISRKNS KDNSDLIKHQ
110 120 130 140 150
RLFSQRKPCK CNECEKAFSY QSDLLVHSRI HGGEKPFECN KCGKSFSRST
160 170 180 190 200
HLIEHQRTHT GEKPYECNEC GKAFSRSTHL SLHQRIHTGE KPYECSECGK
210 220 230 240 250
AFSRSTNLSQ HQRTHTQERP YKCNECGKAF GDRSTIIQHQ RIHTGENPYE
260 270 280 290 300
CSKCGKAFSW ISSLTEHQRT HTGENPYECS ECGKVFSRSS SLTEHQRIHS
310 320 330 340 350
GEKPHECRVC GKGFSRSSSL IIHQRTHTGE KPYKCNDCGK AFCQSSTLIR

HQHLHTKE
Length:358
Mass (Da):40,659
Last modified:August 21, 2007 - v2
Checksum:iCCC67A6F7FE30187
GO

Sequence cautioni

The sequence CAB51755 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti51 – 511K → R.
Corresponds to variant rs10807020 [ dbSNP | Ensembl ].
VAR_034774
Natural varianti59 – 591G → C.
Corresponds to variant rs10807021 [ dbSNP | Ensembl ].
VAR_034775

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294965 mRNA. Translation: BAG58038.1.
AL031118 Genomic DNA. Translation: CAB51755.1. Different initiation.
CH471081 Genomic DNA. Translation: EAX03096.1.
CCDSiCCDS43429.1.
RefSeqiNP_001070249.1. NM_001076781.2.
NP_001309217.1. NM_001322288.1.
NP_001309218.1. NM_001322289.1.
NP_001309222.1. NM_001322293.1.
XP_005249139.1. XM_005249082.3.
XP_006715149.1. XM_006715086.2.
XP_011512871.1. XM_011514569.1.
UniGeneiHs.651176.
Hs.670888.

Genome annotation databases

EnsembliENST00000244576; ENSP00000244576; ENSG00000124613.
GeneIDi346157.
KEGGihsa:346157.
UCSCiuc003njf.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294965 mRNA. Translation: BAG58038.1.
AL031118 Genomic DNA. Translation: CAB51755.1. Different initiation.
CH471081 Genomic DNA. Translation: EAX03096.1.
CCDSiCCDS43429.1.
RefSeqiNP_001070249.1. NM_001076781.2.
NP_001309217.1. NM_001322288.1.
NP_001309218.1. NM_001322289.1.
NP_001309222.1. NM_001322293.1.
XP_005249139.1. XM_005249082.3.
XP_006715149.1. XM_006715086.2.
XP_011512871.1. XM_011514569.1.
UniGeneiHs.651176.
Hs.670888.

3D structure databases

ProteinModelPortaliQ9UJN7.
SMRiQ9UJN7. Positions 65-358.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131374. 5 interactions.
STRINGi9606.ENSP00000244576.

PTM databases

iPTMnetiQ9UJN7.
PhosphoSiteiQ9UJN7.

Polymorphism and mutation databases

BioMutaiZNF391.
DMDMi156630643.

Proteomic databases

EPDiQ9UJN7.
MaxQBiQ9UJN7.
PaxDbiQ9UJN7.
PeptideAtlasiQ9UJN7.
PRIDEiQ9UJN7.

Protocols and materials databases

DNASUi346157.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244576; ENSP00000244576; ENSG00000124613.
GeneIDi346157.
KEGGihsa:346157.
UCSCiuc003njf.2. human.

Organism-specific databases

CTDi346157.
GeneCardsiZNF391.
HGNCiHGNC:18779. ZNF391.
HPAiHPA050886.
neXtProtiNX_Q9UJN7.
PharmGKBiPA134868215.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129762.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UJN7.
OMAiLEEIFMG.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9UJN7.
TreeFamiTF337055.

Miscellaneous databases

ChiTaRSiZNF391. human.
GenomeRNAii346157.
PROiQ9UJN7.

Gene expression databases

BgeeiENSG00000124613.
CleanExiHS_ZNF391.
ExpressionAtlasiQ9UJN7. baseline and differential.
GenevisibleiQ9UJN7. HS.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN391_HUMAN
AccessioniPrimary (citable) accession number: Q9UJN7
Secondary accession number(s): B4DH77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: September 7, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.