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Protein

Zinc finger protein 391

Gene

ZNF391

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri109 – 131C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri137 – 159C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri165 – 187C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri193 – 215C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 271C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 391
Gene namesi
Name:ZNF391
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124613.8.
HGNCiHGNC:18779. ZNF391.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124613.
PharmGKBiPA134868215.

Polymorphism and mutation databases

BioMutaiZNF391.
DMDMi156630643.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002990341 – 358Zinc finger protein 391Add BLAST358

Proteomic databases

EPDiQ9UJN7.
MaxQBiQ9UJN7.
PaxDbiQ9UJN7.
PeptideAtlasiQ9UJN7.
PRIDEiQ9UJN7.

PTM databases

iPTMnetiQ9UJN7.
PhosphoSitePlusiQ9UJN7.

Expressioni

Gene expression databases

BgeeiENSG00000124613.
CleanExiHS_ZNF391.
ExpressionAtlasiQ9UJN7. baseline and differential.
GenevisibleiQ9UJN7. HS.

Organism-specific databases

HPAiHPA050886.

Interactioni

Protein-protein interaction databases

BioGridi131374. 5 interactors.
STRINGi9606.ENSP00000244576.

Structurei

3D structure databases

ProteinModelPortaliQ9UJN7.
SMRiQ9UJN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri109 – 131C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri137 – 159C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri165 – 187C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri193 – 215C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 271C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139349.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UJN7.
OMAiSRQTKCP.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9UJN7.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 9 hits.
SUPFAMiSSF57667. SSF57667. 5 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.

Sequencei

Sequence statusi: Complete.

Q9UJN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLRGNTAQ GPTNEEDYKN EGQLSRQTKC PAQKKSSFEN TVVRKVSVTL
60 70 80 90 100
KEIFTGEEGP ESSEFSLSPN LDAQQKIPKG HGSPISRKNS KDNSDLIKHQ
110 120 130 140 150
RLFSQRKPCK CNECEKAFSY QSDLLVHSRI HGGEKPFECN KCGKSFSRST
160 170 180 190 200
HLIEHQRTHT GEKPYECNEC GKAFSRSTHL SLHQRIHTGE KPYECSECGK
210 220 230 240 250
AFSRSTNLSQ HQRTHTQERP YKCNECGKAF GDRSTIIQHQ RIHTGENPYE
260 270 280 290 300
CSKCGKAFSW ISSLTEHQRT HTGENPYECS ECGKVFSRSS SLTEHQRIHS
310 320 330 340 350
GEKPHECRVC GKGFSRSSSL IIHQRTHTGE KPYKCNDCGK AFCQSSTLIR

HQHLHTKE
Length:358
Mass (Da):40,659
Last modified:August 21, 2007 - v2
Checksum:iCCC67A6F7FE30187
GO

Sequence cautioni

The sequence CAB51755 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03477451K → R. Corresponds to variant dbSNP:rs10807020Ensembl.1
Natural variantiVAR_03477559G → C. Corresponds to variant dbSNP:rs10807021Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK294965 mRNA. Translation: BAG58038.1.
AL031118 Genomic DNA. Translation: CAB51755.1. Different initiation.
CH471081 Genomic DNA. Translation: EAX03096.1.
CCDSiCCDS43429.1.
RefSeqiNP_001070249.1. NM_001076781.2.
NP_001309217.1. NM_001322288.1.
NP_001309218.1. NM_001322289.1.
NP_001309222.1. NM_001322293.1.
XP_005249139.1. XM_005249082.3.
XP_006715149.1. XM_006715086.2.
XP_011512871.1. XM_011514569.1.
UniGeneiHs.651176.
Hs.670888.

Genome annotation databases

EnsembliENST00000244576; ENSP00000244576; ENSG00000124613.
GeneIDi346157.
KEGGihsa:346157.
UCSCiuc003njf.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN391_HUMAN
AccessioniPrimary (citable) accession number: Q9UJN7
Secondary accession number(s): B4DH77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: September 27, 2017
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families