Reviewed, UniProtKB/Swiss-Prot Q9UJM3 (ERRFI_HUMAN)

Names and origin

Protein names

Recommended name:
    ERBB receptor feedback inhibitor 1
Alternative name(s):
    Mitogen-inducible gene 6 protein
      Short name=Mig-6

Gene names

Name:	ERRFI1
Synonyms:	MIG6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	462 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Cytoplasm. Ref.1
Induction	By mitogens.
Sequence similarities	Belongs to the MIG6 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	response to stress Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Traceable author statement. Source: ProtInc
Molecular function	Rho GTPase activator activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 462

462

ERBB receptor feedback inhibitor 1

PRO_0000096487

Amino acid modifications

Modified residue

127

1

Phosphothreonine By similarity

Modified residue

131

1

Phosphothreonine By similarity

Modified residue

273

1

Phosphoserine By similarity

Modified residue

394

1

Phosphotyrosine Ref.6

Modified residue

395

1

Phosphotyrosine Ref.6

Modified residue

461

1

Phosphoserine Ref.7 Ref.8

Natural variations

Natural variant

158

1

I → L: dbSNP rs34974993.

VAR_050975

Experimental info

Sequence conflict

7

1

A → T Ref.1

Sequence conflict

36

1

S → C Ref.1

Secondary structure

1

.

.

.

462

Helix Strand Turn

Details...

Turn

356 – 358

3

Sequences

	Sequence		Length	Mass (Da)
	Q9UJM3-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 7AFA9F6CEB602912	FASTA	462	50,560
	10 20 30 40 50 60 MSIAGVAAQE IRVPLKTGFL HNGRAMGNMR KTYWSSRSEF KNNFLNIDPI TMAYSLNSSA 70 80 90 100 110 120 QERLIPLGHA SKSAPMNGHC FAENGPSQKS SLPPLLIPPS ENLGPHEEDQ VVCGFKKLTV 130 140 150 160 170 180 NGVCASTPPL TPIKNSPSLF PCAPLCERGS RPLPPLPISE ALSLDDTDCE VEFLTSSDTD 190 200 210 220 230 240 FLLEDSTLSD FKYDVPGRRS FRGCGQINYA YFDTPAVSAA DLSYVSDQNG GVPDPNPPPP 250 260 270 280 290 300 QTHRRLRRSH SGPAGSFNKP AIRISNCCIH RASPNSDEDK PEVPPRVPIP PRPVKPDYRR 310 320 330 340 350 360 WSAEVTSSTY SDEDRPPKVP PREPLSPSNS RTPSPKSLPS YLNGVMPPTQ SFAPDPKYVS 370 380 390 400 410 420 SKALQRQNSE GSASKVPCIL PIIENGKKVS STHYYLLPER PPYLDKYEKF FREAEETNGG 430 440 450 460 AQIQPLPADC GISSATEKPD SKTKMDLGGH VKRKHLSYVV SP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel mitogen-inducible gene (mig-6): regulation during G1 progression and differentiation." Wick M., Buerger C., Funk M., Mueller R. Exp. Cell Res. 219:527-535(1995) [PubMed: 7641805] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
[2]	"The gene for Mig-6 is regulated by methylmethanesulphonate and shows high expression in the liver." Van Laar T., Schouten T., van der Eb A.J., Terleth C. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 302-462. Tissue: Testis.
[6]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-394 AND TYR-395, MASS SPECTROMETRY.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461, MASS SPECTROMETRY.
[8]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBLGenBankDDBJ

AJ276373 mRNA. Translation: CAC20426.1.
AL034417 Genomic DNA. Translation: CAB52551.1.
BC025337 mRNA. Translation: AAH25337.1.
AL137274 mRNA. Translation: CAB70672.1.

IPI

IPI00004399.

PIR

T46346.

RefSeq

NP_061821.1.

UniGene

Hs.605445

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2RF9	X-ray	3.50	C/D	315-374	[»]
2RFD	X-ray	3.60	C/D	340-364	[»]
2RFE	X-ray	2.90	E/F	325-364	[»]

ModBase

Search...

PTM databases

PhosphoSite

Q9UJM3.

Proteomic databases

PRIDE

Q9UJM3.

Genome annotation databases

Ensembl

ENSG00000116285. Homo sapiens. [Contig view]

GeneID

54206.

KEGG

hsa:54206.

Organism-specific databases

GeneCards

GC01M008007.

H-InvDB

HIX0000098.

HGNC

HGNC:18185. ERRFI1.

MIM

608069. gene.

PharmGKB

PA142671904.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q9UJM3.

HOVERGEN

Q9UJM3.

OMA

Q9UJM3. RVPLKTG.

Gene expression databases

ArrayExpress

Q9UJM3.

Bgee

Q9UJM3.

CleanEx

HS_ERRFI1.

GermOnline

ENSG00000116285. Homo sapiens.

Family and domain databases

InterPro

IPR015116. GTPase_binding.
[Graphical view]

Pfam

PF09027. GTPase_binding. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

56530.

SOURCE

Search...

Entry information

Entry name

ERRFI_HUMAN

Accession

Primary (citable) accession number: Q9UJM3
Secondary accession number(s): Q9NTG9, Q9UD05

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)