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Protein

Zinc finger protein ZFP69B

Gene

ZFP69B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri279 – 30123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri475 – 49723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri503 – 52523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZFP69B
Alternative name(s):
Zinc finger protein 643
Gene namesi
Name:ZFP69B
Synonyms:ZNF643
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28053. ZFP69B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiZFP69B.
DMDMi342187319.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534Zinc finger protein ZFP69BPRO_0000047697Add
BLAST

Proteomic databases

PaxDbiQ9UJL9.
PRIDEiQ9UJL9.

PTM databases

PhosphoSiteiQ9UJL9.

Expressioni

Gene expression databases

BgeeiQ9UJL9.
CleanExiHS_ZNF643.
ExpressionAtlasiQ9UJL9. baseline and differential.
GenevisibleiQ9UJL9. HS.

Organism-specific databases

HPAiHPA044289.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-10322364,EBI-10171697

Protein-protein interaction databases

BioGridi122409. 1 interaction.
IntActiQ9UJL9. 1 interaction.
STRINGi9606.ENSP00000399664.

Structurei

3D structure databases

ProteinModelPortaliQ9UJL9.
SMRiQ9UJL9. Positions 74-114, 250-527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 14572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri279 – 30123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri475 – 49723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri503 – 52523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129852.
HOGENOMiHOG000234617.
HOVERGENiHBG062325.
InParanoidiQ9UJL9.
KOiK09228.
OMAiSQRIHLS.
PhylomeDBiQ9UJL9.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UJL9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQQLLITLP TEASTWVKLR HPKAATERVA LWEDVTKMFK AEALLSQDAD
60 70 80 90 100
ETQGESLESR VTLGSLTAES QELLTFKDVS VDFTQEEWGQ LAPAHRNLYR
110 120 130 140 150
EVMLENYGNL VSVGCQLSKP GVISQLEKGE EPWLMERDIS GVPSSDLKSK
160 170 180 190 200
TKTKESALQN DISWEELHCG LMMERFTKGS SMYSTLGRIS KCNKLESQQE
210 220 230 240 250
NQRMGKGQIP LMCKKTFTQE RGQESNRFEK RINVKSEVMP GPIGLPRKRD
260 270 280 290 300
RKYDTPGKRS RYNIDLVNHS RSYTKMKTFE CNICEKIFKQ LIHLTEHMRI
310 320 330 340 350
HTGEKPFRCK ECGKAFSQSS SLIPHQRIHT GEKPYECKEC GKTFRHPSSL
360 370 380 390 400
TQHVRIHTGE KPYECRVCEK AFSQSIGLIQ HLRTHVREKP FTCKDCGKAF
410 420 430 440 450
FQIRHLRQHE IIHTGVKPYI CNVCSKTFSH STYLTQHQRT HTGERPYKCK
460 470 480 490 500
ECGKAFSQRI HLSIHQRVHT GVKPYECSHC GKAFRHDSSF AKHQRIHTGE
510 520 530
KPYDCNECGK AFSCSSSLIR HCKTHLRNTF SNVV
Length:534
Mass (Da):61,481
Last modified:July 27, 2011 - v2
Checksum:i7F63EF062570CEBE
GO
Isoform 2 (identifier: Q9UJL9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.

Show »
Length:432
Mass (Da):49,925
Checksum:i489F7185464A0F1C
GO

Sequence cautioni

The sequence AAH17498.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI19856.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti115 – 1151C → Y.
Corresponds to variant rs2272994 [ dbSNP | Ensembl ].
VAR_033584
Natural varianti359 – 3591G → R.
Corresponds to variant rs12407929 [ dbSNP | Ensembl ].
VAR_052884

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 102102Missing in isoform 2. 1 PublicationVSP_041647Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137241 mRNA. Translation: CAB70626.1.
AL031985 Genomic DNA. Translation: CAI19856.1. Sequence problems.
CN256362 mRNA. No translation available.
BC017498 mRNA. Translation: AAH17498.1. Different initiation.
CCDSiCCDS452.2. [Q9UJL9-1]
RefSeqiNP_075558.2. NM_023070.2. [Q9UJL9-1]
XP_005271194.1. XM_005271137.1. [Q9UJL9-1]
XP_005271196.1. XM_005271139.2. [Q9UJL9-2]
UniGeneiHs.133034.

Genome annotation databases

EnsembliENST00000361584; ENSP00000354547; ENSG00000187801. [Q9UJL9-1]
ENST00000411995; ENSP00000399664; ENSG00000187801. [Q9UJL9-1]
GeneIDi65243.
KEGGihsa:65243.
UCSCiuc001cfn.3. human. [Q9UJL9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137241 mRNA. Translation: CAB70626.1.
AL031985 Genomic DNA. Translation: CAI19856.1. Sequence problems.
CN256362 mRNA. No translation available.
BC017498 mRNA. Translation: AAH17498.1. Different initiation.
CCDSiCCDS452.2. [Q9UJL9-1]
RefSeqiNP_075558.2. NM_023070.2. [Q9UJL9-1]
XP_005271194.1. XM_005271137.1. [Q9UJL9-1]
XP_005271196.1. XM_005271139.2. [Q9UJL9-2]
UniGeneiHs.133034.

3D structure databases

ProteinModelPortaliQ9UJL9.
SMRiQ9UJL9. Positions 74-114, 250-527.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122409. 1 interaction.
IntActiQ9UJL9. 1 interaction.
STRINGi9606.ENSP00000399664.

PTM databases

PhosphoSiteiQ9UJL9.

Polymorphism and mutation databases

BioMutaiZFP69B.
DMDMi342187319.

Proteomic databases

PaxDbiQ9UJL9.
PRIDEiQ9UJL9.

Protocols and materials databases

DNASUi65243.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361584; ENSP00000354547; ENSG00000187801. [Q9UJL9-1]
ENST00000411995; ENSP00000399664; ENSG00000187801. [Q9UJL9-1]
GeneIDi65243.
KEGGihsa:65243.
UCSCiuc001cfn.3. human. [Q9UJL9-1]

Organism-specific databases

CTDi65243.
GeneCardsiZFP69B.
HGNCiHGNC:28053. ZFP69B.
HPAiHPA044289.
neXtProtiNX_Q9UJL9.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129852.
HOGENOMiHOG000234617.
HOVERGENiHBG062325.
InParanoidiQ9UJL9.
KOiK09228.
OMAiSQRIHLS.
PhylomeDBiQ9UJL9.
TreeFamiTF337055.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii65243.
NextBioi67358.
PROiQ9UJL9.

Gene expression databases

BgeeiQ9UJL9.
CleanExiHS_ZNF643.
ExpressionAtlasiQ9UJL9. baseline and differential.
GenevisibleiQ9UJL9. HS.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Rhodes S., Huckle E.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation."
    Brandenberger R., Wei H., Zhang S., Lei S., Murage J., Fisk G.J., Li Y., Xu C., Fang R., Guegler K., Rao M.S., Mandalam R., Lebkowski J., Stanton L.W.
    Nat. Biotechnol. 22:707-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-86 (ISOFORM 1).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 29-534 (ISOFORM 1).
    Tissue: B-cell.

Entry informationi

Entry nameiZF69B_HUMAN
AccessioniPrimary (citable) accession number: Q9UJL9
Secondary accession number(s): Q5QPL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.